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(Lond.)"},{"key":"10.1016\/j.tins.2026.08.002_bb0350","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.3390\/cells12232726","article-title":"The role of cortisol in chronic stress, neurodegenerative diseases, and psychological disorders","volume":"12","author":"Knezevic","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.tins.2026.08.002_bb0355","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1111\/j.1365-2826.2010.02039.x","article-title":"Long-term infusion of brain-derived neurotrophic factor reduces food intake and body weight via a corticotrophin-releasing hormone pathway in the paraventricular nucleus of the hypothalamus","volume":"22","author":"Toriya","year":"2010","journal-title":"J. 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Med."},{"key":"10.1016\/j.tins.2026.08.002_bb0450","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/jcsm.12615","article-title":"Cancer cachexia in a mouse model of oxidative stress","volume":"11","author":"Brown","year":"2020","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.tins.2026.08.002_bb0455","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1249\/MSS.0000000000002286","article-title":"Modification of neuromuscular junction protein expression by exercise and doxorubicin","volume":"52","author":"Huertas","year":"2020","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.tins.2026.08.002_bb0460","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1172\/JCI128411","article-title":"Neuromuscular junctions are stable in patients with cancer cachexia","volume":"130","author":"Boehm","year":"2020","journal-title":"J. Clin. 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