{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:39:50Z","timestamp":1792615190834,"version":"4.5.0"},"reference-count":179,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018557","name":"Science and Technology Project of Nantong City","doi-asserted-by":"publisher","award":["MS2025069"],"award-info":[{"award-number":["MS2025069"]}],"id":[{"id":"10.13039\/501100018557","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009156","name":"Nantong Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271054"],"award-info":[{"award-number":["32271054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571189"],"award-info":[{"award-number":["32571189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Neurosciences"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.tins.2026.08.008","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:56:06Z","timestamp":1792508166000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tumor innervation in non-central nervous system tumors: origins, mechanisms, and phenotypic plasticity"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8219-9487","authenticated-orcid":false,"given":"Yonghui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siying","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3669-5687","authenticated-orcid":false,"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tins.2026.08.008_bb0005","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1016\/j.cell.2026.03.018","article-title":"Cancer neuroscience: the past, the present, and the road ahead","volume":"189","author":"Winkler","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.tins.2026.08.008_bb0010","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/s41573-024-01017-z","article-title":"Targeting the peripheral neural-tumour microenvironment for cancer therapy","volume":"23","author":"Yaniv","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.tins.2026.08.008_bb0015","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.trecan.2020.07.005","article-title":"Tumor innervation: cancer has some nerve","volume":"6","author":"Reavis","year":"2020","journal-title":"Trends Cancer"},{"key":"10.1016\/j.tins.2026.08.008_bb0020","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1158\/2159-8290.CD-23-0397","article-title":"Nerves at play: the peripheral nervous system in extracranial malignancies","volume":"15","author":"Vermeer","year":"2025","journal-title":"Cancer Discov."},{"key":"10.1016\/j.tins.2026.08.008_bb0025","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/j.cell.2025.12.049","article-title":"Hallmarks of cancer-then and now, and beyond","volume":"189","author":"Hanahan","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.tins.2026.08.008_bb0030","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41392-025-02364-y","article-title":"Cancer neuroscience: signaling pathways and new therapeutic strategies for cancer","volume":"11","author":"Zhang","year":"2026","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.tins.2026.08.008_bb0035","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/j.neuron.2026.04.016","article-title":"A local sympathetic-immune axis inhibits melanoma growth in mice by dictating adrenergic control","volume":"114","author":"Liu","year":"2026","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2026.08.008_bb0040","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1053\/j.gastro.2026.02.033","article-title":"Ganglioside-mediated neural-acinar crosstalk facilitates pancreatic carcinogenesis via metaplastic niche remodeling","volume":"171","author":"Wei","year":"2026","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tins.2026.08.008_bb0045","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/s41586-025-08735-3","article-title":"Characterization of single neurons reprogrammed by pancreatic cancer","volume":"640","author":"Thiel","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.tins.2026.08.008_bb0050","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41422-020-00462-w","article-title":"Nerves on tr[ac]k to support pancreatic cancer metabolism","volume":"31","author":"White","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0055","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.192814","article-title":"Sympathetic nerve-fibroblast crosstalk drives nerve injury, fibroblast activation, and matrix remodeling in pancreatic cancer","volume":"11","author":"Sattler","year":"2026","journal-title":"JCI Insight"},{"key":"10.1016\/j.tins.2026.08.008_bb0060","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nrgastro.2015.166","article-title":"Neural plasticity in pancreatitis and pancreatic cancer","volume":"12","author":"Demir","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.tins.2026.08.008_bb0065","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/s41565-024-01803-1","article-title":"Targeted intervention in nerve-cancer crosstalk enhances pancreatic cancer chemotherapy","volume":"20","author":"Qin","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.tins.2026.08.008_bb0070","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.cell.2020.10.016","article-title":"Neurons release serine to support mRNA translation in pancreatic cancer","volume":"183","author":"Banh","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.tins.2026.08.008_bb0075","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bbi.2015.12.014","article-title":"Sympathetic innervation, norepinephrine content, and norepinephrine turnover in orthotopic and spontaneous models of breast cancer","volume":"53","author":"Szpunar","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.tins.2026.08.008_bb0080","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1016\/j.neuron.2026.02.028","article-title":"6-Hydroxydopamine promotes antitumor immunity through macrophage remodeling beyond sympathetic ablation","volume":"114","author":"Yu","year":"2026","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2026.08.008_bb0085","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41586-025-09176-8","article-title":"Nerve-to-cancer transfer of mitochondria during cancer metastasis","volume":"644","author":"Hoover","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.tins.2026.08.008_bb0090","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41586-024-07767-5","article-title":"Neuronal substance P drives metastasis through an extracellular RNA-TLR7 axis","volume":"633","author":"Padmanaban","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.tins.2026.08.008_bb0095","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/s41586-025-09492-z","article-title":"Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis","volume":"646","author":"Savchuk","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.tins.2026.08.008_bb0100","article-title":"Nervous system contributions to small cell lung cancer: lessons from diverse oncological studies","volume":"1880","author":"Liao","year":"2024","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.tins.2026.08.008_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217701","article-title":"Intersection between lung cancer and neuroscience: opportunities and challenges","volume":"621","author":"Xiao","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.tins.2026.08.008_bb0110","doi-asserted-by":"crossref","DOI":"10.1126\/science.1236361","article-title":"Autonomic nerve development contributes to prostate cancer progression","volume":"341","author":"Magnon","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.tins.2026.08.008_bb0115","doi-asserted-by":"crossref","first-page":"7593","DOI":"10.1158\/1078-0432.CCR-08-1164","article-title":"Cancer-related axonogenesis and neurogenesis in prostate cancer","volume":"14","author":"Ayala","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0120","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12967-025-06104-2","article-title":"Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth","volume":"23","author":"Wang","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.tins.2026.08.008_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.modpat.2024.100565","article-title":"Neuronal distribution in colorectal cancer: associations with clinicopathological parameters and survival","volume":"37","author":"Massen","year":"2024","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.tins.2026.08.008_bb0130","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1096\/fba.2021-00147","article-title":"High nerve density in breast cancer is associated with poor patient outcome","volume":"4","author":"Li","year":"2022","journal-title":"FASEB Bioadv."},{"key":"10.1016\/j.tins.2026.08.008_bb0135","doi-asserted-by":"crossref","first-page":"7390","DOI":"10.1038\/s41598-021-86831-w","article-title":"Tumor innervation and clinical outcome in pancreatic cancer","volume":"11","author":"Ferdoushi","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tins.2026.08.008_bb0140","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/1759-7714.12374","article-title":"Autonomic nervous infiltration positively correlates with pathological risk grading and poor prognosis in patients with lung adenocarcinoma","volume":"7","author":"Shao","year":"2016","journal-title":"Thorac. Cancer"},{"key":"10.1016\/j.tins.2026.08.008_bb0145","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.humpath.2014.02.009","article-title":"Biologic correlates and significance of axonogenesis in prostate cancer","volume":"45","author":"Olar","year":"2014","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.tins.2026.08.008_bb0150","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41586-025-08927-x","article-title":"Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer","volume":"642","author":"Pei","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.tins.2026.08.008_bb0155","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.ccell.2025.03.004","article-title":"Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics","volume":"43","author":"Liu","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.tins.2026.08.008_bb0160","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/s41586-025-10028-8","article-title":"Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis","volume":"650","author":"Wei","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.tins.2026.08.008_bb0165","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.3390\/cells10123491","article-title":"Intra-tumoral nerve-tracing in a novel syngeneic model of high-grade serous ovarian carcinoma","volume":"10","author":"Barr","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.tins.2026.08.008_bb0170","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/s41586-025-09434-9","article-title":"Functional synapses between neurons and small cell lung cancer","volume":"646","author":"Sakthivelu","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.tins.2026.08.008_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116258","article-title":"Next-gen tools in cancer neuroscience","volume":"44","author":"Thiel","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.tins.2026.08.008_bb0180","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/s41388-020-01578-4","article-title":"Nerve fibers in the tumor microenvironment in neurotropic cancer-pancreatic cancer and cholangiocarcinoma","volume":"40","author":"Tan","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.tins.2026.08.008_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2025.189464","article-title":"Sensory neuro-tumor crosstalk: therapeutic opportunities and emerging frontiers in cancer neuroscience","volume":"1880","author":"Wang","year":"2025","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.tins.2026.08.008_bb0190","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41388-023-02909-x","article-title":"The nerve cells in gastrointestinal cancers: from molecular mechanisms to clinical intervention","volume":"43","author":"Lyu","year":"2024","journal-title":"Oncogene"},{"key":"10.1016\/j.tins.2026.08.008_bb0195","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1096\/fba.2021-00066","article-title":"Neural regulations of the tumor microenvironment","volume":"4","author":"Restaino","year":"2021","journal-title":"FASEB Bioadv."},{"key":"10.1016\/j.tins.2026.08.008_bb0200","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1158\/0008-5472.CAN-20-2793","article-title":"Cancer-associated neurogenesis and nerve-cancer cross-talk","volume":"81","author":"Silverman","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0205","doi-asserted-by":"crossref","DOI":"10.1172\/JCI147276","article-title":"Tumor innervation: peripheral nerves take control of the tumor microenvironment","volume":"131","author":"Gysler","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tins.2026.08.008_bb0210","doi-asserted-by":"crossref","DOI":"10.1172\/JCI167725","article-title":"A brain-tumor neural circuit controls breast cancer progression in mice","volume":"133","author":"Xiong","year":"2023","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tins.2026.08.008_bb0215","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj5435","article-title":"Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases","volume":"7","author":"Kaduri","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tins.2026.08.008_bb0220","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s10549-006-9219-7","article-title":"Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells","volume":"99","author":"Erin","year":"2006","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.tins.2026.08.008_bb0225","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1016\/j.neuron.2025.08.015","article-title":"Novel approaches to clinical trial design in cancer neuroscience","volume":"113","author":"Jones","year":"2025","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2026.08.008_bb0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ccell.2024.09.014","article-title":"Integrating priorities at the intersection of cancer and neuroscience","volume":"43","author":"Hwang","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.tins.2026.08.008_bb0235","doi-asserted-by":"crossref","DOI":"10.1093\/lifemeta\/load022","article-title":"Neural innervation in adipose tissue, gut, pancreas, and liver","volume":"2","author":"Sun","year":"2023","journal-title":"Life Metab."},{"key":"10.1016\/j.tins.2026.08.008_bb0240","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41583-026-01046-0","article-title":"Wired for immunity: neuroimmune control of the lung by sensory neurons","volume":"27","author":"Ehlers","year":"2026","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.tins.2026.08.008_bb0245","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.tins.2024.11.008","article-title":"Peripheral, central, and chemotherapy-induced neuropathic changes in pancreatic cancer","volume":"48","author":"Jiang","year":"2024","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.tins.2026.08.008_bb0250","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/s41586-025-09370-8","article-title":"Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy","volume":"646","author":"Baruch","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.tins.2026.08.008_bb0255","article-title":"Cancer neuroscience: decoding neural circuitry in tumor evolution for targeted therapy","volume":"12","author":"Yuan","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.tins.2026.08.008_bb0260","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1158\/1541-7786.MCR-25-0124","article-title":"The bridging role of schwann cells in the interaction between tumors and the nervous system: a potential target for cancer therapy","volume":"23","author":"Zhang","year":"2025","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0265","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41586-025-08591-1","article-title":"Nociceptive neurons promote gastric tumour progression via a CGRP-RAMP1 axis","volume":"640","author":"Zhi","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.tins.2026.08.008_bb0270","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.1016\/j.cell.2026.04.038","article-title":"Nociceptive innervation limits tertiary lymphoid structures to promote lung cancer","volume":"189","author":"Ho","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.tins.2026.08.008_bb0275","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.ads7889","article-title":"Tumor-infiltrating nociceptor neurons promote immunosuppression","volume":"18","author":"Restaino","year":"2025","journal-title":"Sci. Signal."},{"key":"10.1016\/j.tins.2026.08.008_bb0280","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41568-025-00831-w","article-title":"Neuro-immune cross-talk in cancer","volume":"25","author":"Amit","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tins.2026.08.008_bb0285","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41389-018-0099-6","article-title":"Muscarinic acetylcholine receptor 3 mediates vagus nerve-induced gastric cancer","volume":"7","author":"Wang","year":"2018","journal-title":"Oncogenesis"},{"key":"10.1016\/j.tins.2026.08.008_bb0290","doi-asserted-by":"crossref","first-page":"G694","DOI":"10.1152\/ajpgi.00116.2019","article-title":"Human pancreatic afferent and efferent nerves: mapping and 3-D illustration of exocrine, endocrine, and adipose innervation","volume":"317","author":"Chien","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tins.2026.08.008_bb0295","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s12264-023-01082-1","article-title":"Crosstalk between peripheral innervation and pancreatic ductal adenocarcinoma","volume":"39","author":"Ni","year":"2023","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.tins.2026.08.008_bb0300","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1111\/cas.13975","article-title":"Reduction of intrapancreatic neural density in cancer tissue predicts poorer outcome in pancreatic ductal carcinoma","volume":"110","author":"Iwasaki","year":"2019","journal-title":"Cancer Sci."},{"key":"10.1016\/j.tins.2026.08.008_bb0305","doi-asserted-by":"crossref","first-page":"180","DOI":"10.21147\/j.issn.1000-9604.2016.02.05","article-title":"Parasympathetic neurogenesis is strongly associated with tumor budding and correlates with an adverse prognosis in pancreatic ductal adenocarcinoma","volume":"28","author":"Zhang","year":"2016","journal-title":"Chin. J. Cancer Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0310","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ccell.2017.11.007","article-title":"\u03b22 adrenergic-neurotrophin feedforward loop promotes pancreatic cancer","volume":"33","author":"Renz","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.tins.2026.08.008_bb0315","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1038\/s41467-022-29659-w","article-title":"Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer","volume":"13","author":"Guillot","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2026.08.008_bb0320","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1073\/pnas.1512603113","article-title":"Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer","volume":"113","author":"Saloman","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2026.08.008_bb0325","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/PRS.0000000000009306","article-title":"Innervation of the female breast and nipple: a systematic review and meta-analysis of anatomical dissection studies","volume":"150","author":"Smeele","year":"2022","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.tins.2026.08.008_bb0330","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10555-023-10095-1","article-title":"The tumor-nerve circuit in breast cancer","volume":"42","author":"Cui","year":"2023","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.tins.2026.08.008_bb0335","article-title":"Triple-negative breast cancer cells activate sensory neurons via TRPV1 to drive nerve outgrowth and tumor progression","author":"Bloomer","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.tins.2026.08.008_bb0340","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ajpath.2020.12.006","article-title":"Vascular endothelial growth factor mediates the sprouted axonogenesis of breast cancer in rat","volume":"191","author":"Han","year":"2021","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tins.2026.08.008_bb0345","article-title":"Retrograde tracing of breast cancer-associated sensory neurons","author":"Kallogjerovic","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.tins.2026.08.008_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2022.188828","article-title":"Crosstalk between the peripheral nervous system and breast cancer influences tumor progression","volume":"1877","author":"Hu","year":"2022","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.tins.2026.08.008_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217132","article-title":"The intersection of the nervous system and breast cancer","volume":"598","author":"Liu","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.tins.2026.08.008_bb0360","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.cell.2026.01.001","article-title":"Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment","volume":"189","author":"Zhang","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.tins.2026.08.008_bb0365","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/ijc.34529","article-title":"Secretome mediated interactions between sensory neurons and breast cancer cells","volume":"153","author":"Jerard","year":"2023","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.tins.2026.08.008_bb0370","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1016\/j.neuron.2025.07.002","article-title":"Social interaction in mice suppresses breast cancer progression via a corticoamygdala neural circuit","volume":"113","author":"Wen","year":"2025","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2026.08.008_bb0375","doi-asserted-by":"crossref","first-page":"7042","DOI":"10.1158\/0008-5472.CAN-10-0522","article-title":"The sympathetic nervous system induces a metastatic switch in primary breast cancer","volume":"70","author":"Sloan","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0380","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/s13046-025-03545-x","article-title":"Peripheral nerve injury-induced remodeling of the tumor-associated macrophages promotes immune evasion in breast cancer","volume":"44","author":"Jiang","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2025.101212","article-title":"Sciatic nerve stimulation enhances NK cell cytotoxicity through dopamine signaling and synergizes immunotherapy in triple-negative breast cancer","volume":"79","author":"Li","year":"2025","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.tins.2026.08.008_bb0390","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.cell.2026.01.020","article-title":"Striking a nerve: sensory neurons orchestrate ECM remodeling and immune exclusion in TNBC","volume":"189","author":"Barki","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.tins.2026.08.008_bb0395","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1095\/biolreprod51.1.99","article-title":"Growth of the rat prostate gland is facilitated by the autonomic nervous system","volume":"51","author":"McVary","year":"1994","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tins.2026.08.008_bb0400","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2024.1497735","article-title":"Sensory innervation in the prostate and a role for calcitonin gene-related peptide in prostatic epithelial proliferation","volume":"17","author":"Xia","year":"2024","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.tins.2026.08.008_bb0405","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4149\/neo_2023_231116N593","article-title":"Innervation density and types of nerves in prostate cancer","volume":"70","author":"Blasko","year":"2023","journal-title":"Neoplasma"},{"key":"10.1016\/j.tins.2026.08.008_bb0410","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/s41391-025-01042-y","article-title":"Neuroscience in prostate cancer","volume":"29","author":"Liu","year":"2026","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"10.1016\/j.tins.2026.08.008_bb0415","doi-asserted-by":"crossref","first-page":"14649","DOI":"10.1523\/JNEUROSCI.3300-10.2010","article-title":"Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain","volume":"30","author":"Jimenez-Andrade","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2026.08.008_bb0420","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41586-022-05374-w","article-title":"Nociceptor neurons affect cancer immunosurveillance","volume":"611","author":"Balood","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.tins.2026.08.008_bb0425","doi-asserted-by":"crossref","first-page":"9574","DOI":"10.1111\/jcmm.15381","article-title":"Ablation of sensory nerves favours melanoma progression","volume":"24","author":"Prazeres","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tins.2026.08.008_bb0430","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1158\/2326-6066.CIR-22-0110","article-title":"Sensory nerves impede the formation of tertiary lymphoid structures and development of protective antimelanoma immune responses","volume":"10","author":"Vats","year":"2022","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0435","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13293-026-00887-9","article-title":"Sex influences on tumor innervation","volume":"17","author":"Barclay","year":"2026","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.tins.2026.08.008_bb0440","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41568-019-0237-2","article-title":"Nerves in cancer","volume":"20","author":"Zahalka","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tins.2026.08.008_bb0445","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.stem.2015.09.003","article-title":"Adult mammalian neural stem cells and neurogenesis: five decades later","volume":"17","author":"Bond","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tins.2026.08.008_bb0450","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tins.2018.12.001","article-title":"Recalibrating the relevance of adult neurogenesis","volume":"42","author":"Snyder","year":"2019","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.tins.2026.08.008_bb0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105325","article-title":"Global and single-cell proteomics view of the co-evolution between neural progenitors and breast cancer cells in a co-culture model","volume":"108","author":"Bj\u00f8rnstad","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.tins.2026.08.008_bb0460","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41586-019-1219-y","article-title":"Progenitors from the central nervous system drive neurogenesis in cancer","volume":"569","author":"Mauffrey","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.tins.2026.08.008_bb0465","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.devcel.2024.12.003","article-title":"Tuft cells transdifferentiate to neural-like progenitor cells in the progression of pancreatic cancer","volume":"60","author":"Salas-Escabillas","year":"2025","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tins.2026.08.008_bb0470","series-title":"Wiring the Nervous System: Mechanisms of Axonal and Dendritic Remodelling in Health and Disease","author":"Tran","year":"2023"},{"key":"10.1016\/j.tins.2026.08.008_bb0475","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10555-025-10249-3","article-title":"Neuronal mimicry in tumors: lessons from neuroscience to tackle cancer","volume":"44","author":"Bloomer","year":"2025","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.tins.2026.08.008_bb0480","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12964-025-02637-7","article-title":"Targeting sensory nerves in the tumor microenvironment: a new vulnerability in cancer therapy","volume":"24","author":"Jiang","year":"2026","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.tins.2026.08.008_bb0485","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41585-019-0274-3","article-title":"Tumour innervation and neurosignalling in prostate cancer","volume":"17","author":"March","year":"2020","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.tins.2026.08.008_bb0490","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2026.1667459","article-title":"The neural niche in cancer: mechanistic insights into tumor-neuron-immune crosstalk and therapeutic opportunities","volume":"14","author":"Aysit","year":"2026","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tins.2026.08.008_bb0495","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009569","article-title":"Denervation suppresses gastric tumorigenesis","volume":"6","author":"Zhao","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tins.2026.08.008_bb0500","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/s41420-025-02523-8","article-title":"Melanoma innervation, noradrenaline and cancer progression in zebrafish xenograft model","volume":"11","author":"Lorenzini","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.tins.2026.08.008_bb0505","doi-asserted-by":"crossref","first-page":"4284","DOI":"10.1038\/s41467-018-06640-0","article-title":"Cancer exosomes induce tumor innervation","volume":"9","author":"Madeo","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2026.08.008_bb0510","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12943-025-02299-6","article-title":"Cancer neuroscience in head and neck: interactions, modulation, and therapeutic strategies","volume":"24","author":"Wang","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tins.2026.08.008_bb0515","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.97916","article-title":"Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer","volume":"13","author":"Barr","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.tins.2026.08.008_bb0520","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41586-020-1996-3","article-title":"Loss of p53 drives neuron reprogramming in head and neck cancer","volume":"578","author":"Amit","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.tins.2026.08.008_bb0525","doi-asserted-by":"crossref","first-page":"9257","DOI":"10.3390\/ijms26189257","article-title":"Tumor innervation: from bystander to emerging therapeutic target for cancer","volume":"26","author":"Ji","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tins.2026.08.008_bb0530","article-title":"Neurons generated from carcinoma stem cells support cancer progression","volume":"2","author":"Lu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.tins.2026.08.008_bb0535","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abn5535","article-title":"Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain","volume":"8","author":"Tang","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tins.2026.08.008_bb0540","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s10565-025-10035-5","article-title":"Neuron-like macrophage differentiation via the APOE-TREM2 axis contributes to chronic pain in nasopharyngeal carcinoma","volume":"41","author":"Li","year":"2025","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.tins.2026.08.008_bb0545","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41419-025-07863-y","article-title":"Direct transdifferentiation of tumorigenic melanoma cells induces tumor cell reversion","volume":"16","author":"Wang","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tins.2026.08.008_bb0550","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade4443","article-title":"Functional neuronal circuits promote disease progression in cancer","volume":"9","author":"Restaino","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tins.2026.08.008_bb0555","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.101369","article-title":"Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer","volume":"13","author":"Bhattacharya","year":"2025","journal-title":"Elife"},{"key":"10.1016\/j.tins.2026.08.008_bb0560","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.devcel.2022.12.011","article-title":"Neurons as stromal drivers of nervous system cancer formation and progression","volume":"58","author":"Anastasaki","year":"2023","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tins.2026.08.008_bb0565","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.tips.2025.10.007","article-title":"Neuron-tumor crosstalk fuels small cell lung cancer","volume":"46","author":"Cao","year":"2025","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.tins.2026.08.008_bb0570","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/s42003-025-09006-7","article-title":"Small cell lung cancer induces synaptic scaling to alter neuronal excitability","volume":"8","author":"Houcek","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.tins.2026.08.008_bb0575","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41586-019-1576-6","article-title":"Synaptic proximity enables NMDAR signalling to promote brain metastasis","volume":"573","author":"Zeng","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.tins.2026.08.008_bb0580","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ccell.2016.11.005","article-title":"Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling","volume":"31","author":"Hayakawa","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.tins.2026.08.008_bb0585","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.ne.19.030196.001445","article-title":"Physiology of the neurotrophins","volume":"19","author":"Lewin","year":"1996","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.tins.2026.08.008_bb0590","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1002\/neu.480251106","article-title":"The p75 neurotrophin receptor","volume":"25","author":"Chao","year":"1994","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.tins.2026.08.008_bb0595","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0959-4388(00)00208-7","article-title":"Trk receptors: mediators of neurotrophin action","volume":"11","author":"Patapoutian","year":"2001","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.tins.2026.08.008_bb0600","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.cell.2023.02.002","article-title":"Cancer neuroscience: state of the field, emerging directions","volume":"186","author":"Winkler","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.tins.2026.08.008_bb0605","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13046-021-02198-w","article-title":"Autophagic Schwann cells promote perineural invasion mediated by the NGF\/ATG7 paracrine pathway in pancreatic cancer","volume":"41","author":"Zhang","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0610","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41419-022-04799-5","article-title":"HGF\/c-Met pathway facilitates the perineural invasion of pancreatic cancer by activating the mTOR\/NGF axis","volume":"13","author":"Qin","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tins.2026.08.008_bb0615","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1158\/0008-5472.CAN-16-1701","article-title":"Sustained adrenergic signaling promotes intratumoral innervation through BDNF induction","volume":"78","author":"Allen","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0620","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41420-022-00930-9","article-title":"Targeting tumor innervation: premises, promises, and challenges","volume":"8","author":"Li","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.tins.2026.08.008_bb0625","doi-asserted-by":"crossref","first-page":"7094","DOI":"10.1038\/s41467-025-62299-4","article-title":"Neural function of Netrin-1 in precancerous lesions of the pancreas","volume":"16","author":"Haidar","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2026.08.008_bb0630","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1158\/0008-5472.CAN-25-2243","article-title":"Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1","volume":"86","author":"Kobayashi","year":"2026","journal-title":"Cancer Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0635","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.557","article-title":"Stromal SLIT2 impacts on pancreatic cancer-associated neural remodeling","volume":"6","author":"Secq","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tins.2026.08.008_bb0640","doi-asserted-by":"crossref","first-page":"6754","DOI":"10.1016\/j.cell.2025.09.029","article-title":"Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance","volume":"188","author":"Zhang","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.tins.2026.08.008_bb0645","doi-asserted-by":"crossref","first-page":"6101","DOI":"10.1158\/1078-0432.CCR-12-3669","article-title":"Semaphorin 4F as a critical regulator of neuroepithelial interactions and a biomarker of aggressive prostate cancer","volume":"19","author":"Ding","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0650","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41388-021-02108-6","article-title":"Tumor innervation is triggered by endoplasmic reticulum stress","volume":"41","author":"Jiang","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.tins.2026.08.008_bb0655","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1007\/s12035-022-03136-3","article-title":"5-Fluorouracil induces an acute reduction in neurogenesis and persistent neuroinflammation in a mouse model of the neuropsychological complications of chemotherapy","volume":"60","author":"Subramaniam","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.tins.2026.08.008_bb0660","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1256299","article-title":"Tempol improves optic nerve histopathology and ultrastructures in cisplatin-induced optic neuropathy in rats by targeting oxidative stress-Endoplasmic reticulum stress-Autophagy signaling pathways","volume":"17","author":"Alsemeh","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.tins.2026.08.008_bb0665","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/s41556-025-01667-0","article-title":"Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer via extracellular vesicle transfer of RNA","volume":"27","author":"Chen","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tins.2026.08.008_bb0670","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.immuni.2025.12.016","article-title":"Tumor-associated macrophages enhance peripheral nerve tumor infiltration and spinal cord repair","volume":"59","author":"Dolci","year":"2026","journal-title":"Immunity"},{"key":"10.1016\/j.tins.2026.08.008_bb0675","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/s41577-025-01164-3","article-title":"Macrophages promote nerve growth in both tumours and spinal cord","volume":"25","author":"Baleviciute","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.tins.2026.08.008_bb0680","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1007\/s12035-018-1172-z","article-title":"Effect of exosomes from rat adipose-derived mesenchymal stem cells on neurite outgrowth and sciatic nerve regeneration after crush injury","volume":"56","author":"Bucan","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.tins.2026.08.008_bb0685","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1186\/s13287-020-01872-8","article-title":"Dose-effect relationship and molecular mechanism by which BMSC-derived exosomes promote peripheral nerve regeneration after crush injury","volume":"11","author":"Zhao","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.tins.2026.08.008_bb0690","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202400625RR","article-title":"Tumor-associated genetic amplifications impact extracellular vesicle miRNA cargo and their recruitment of nerves in head and neck cancer","volume":"38","author":"Restaino","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.tins.2026.08.008_bb0695","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/j.pain.0000000000003045","article-title":"HPV+ head and neck cancer-derived small extracellular vesicles communicate with TRPV1+ neurons to mediate cancer pain","volume":"165","author":"Inyang","year":"2024","journal-title":"Pain"},{"key":"10.1016\/j.tins.2026.08.008_bb0700","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1158\/0008-5472.CAN-18-3995","article-title":"Exosomal induction of tumor innervation","volume":"79","author":"Vermeer","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0705","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ygyno.2019.04.651","article-title":"Innervation of cervical carcinoma is mediated by cancer-derived exosomes","volume":"154","author":"Lucido","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.tins.2026.08.008_bb0710","first-page":"57","article-title":"Head and neck cancer exosomes drive microRNA-mediated reprogramming of local neurons","volume":"1","author":"Hunt","year":"2020","journal-title":"Extracell. Vesicles Circ. Nucl. Acids"},{"key":"10.1016\/j.tins.2026.08.008_bb0715","article-title":"Endosomal trafficking bypassed by the RAB5B-CD109 interplay promotes axonogenesis in KRAS-mutant pancreatic cancer","volume":"11","author":"Zhang","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.tins.2026.08.008_bb0720","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202101261","article-title":"TGF\u03b2-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis","volume":"5","author":"Grelet","year":"2022","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.tins.2026.08.008_bb0725","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12967-025-06233-8","article-title":"Neuronal guanine nucleotide exchange factor promotes the axonal growth and cancer cell proliferation via Ephrin-A3\/EphA2 axis in lung adenocarcinoma","volume":"23","author":"Mi","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.tins.2026.08.008_bb0730","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217563","article-title":"SRSF12 deficiency enhances tumor innervation and accelerates pancreatic tumorigenesis","volume":"616","author":"Yang","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.tins.2026.08.008_bb0735","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41422-025-01098-4","article-title":"Nociceptor neurons promote PDAC progression and cancer pain by interaction with cancer-associated fibroblasts and suppression of natural killer cells","volume":"35","author":"Wang","year":"2025","journal-title":"Cell Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0740","article-title":"Splanchnic nerve block via transdiscal and paraspinal approach in the treatment of pain in advanced pancreatic cancer: a randomized controlled trial","volume":"104","author":"Luo","year":"2025","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.tins.2026.08.008_bb0745","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/ALN.0000000000003936","article-title":"Neurolytic splanchnic nerve block and pain relief, survival, and quality of life in unresectable pancreatic cancer: a randomized controlled trial","volume":"135","author":"Dong","year":"2021","journal-title":"Anesthesiology"},{"key":"10.1016\/j.tins.2026.08.008_bb0750","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s12264-022-00860-7","article-title":"Lighting up neural circuits by viral tracing","volume":"38","author":"Qiu","year":"2022","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.tins.2026.08.008_bb0755","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1200\/JCO.2010.33.4441","article-title":"Beta-blocker use is associated with improved relapse-free survival in patients with triple-negative breast cancer","volume":"29","author":"Melhem-Bertrandt","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.tins.2026.08.008_bb0760","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1200\/JCO.2010.33.5422","article-title":"Beta blockers and breast cancer mortality: a population-based study","volume":"29","author":"Barron","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.tins.2026.08.008_bb0765","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41413-021-00137-1","article-title":"Sympathetic activity in breast cancer and metastasis: partners in crime","volume":"9","author":"Concei\u00e7\u00e3o","year":"2021","journal-title":"Bone Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0770","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1137791","article-title":"Beta-blocker exposure and survival outcomes in patients with advanced pancreatic ductal adenocarcinoma: a retrospective cohort study (BETAPANC)","volume":"14","author":"Le Bozec","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tins.2026.08.008_bb0775","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s00423-025-03735-3","article-title":"Pancreatic resection with perioperative drug repurposing of propranolol and etodolac - the phase II randomized controlled PROSPER trial","volume":"410","author":"H\u00fcttner","year":"2025","journal-title":"Langenbeck's Arch. Surg."},{"key":"10.1016\/j.tins.2026.08.008_bb0780","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/j.ccell.2025.09.009","article-title":"Neoadjuvant nab-paclitaxel plus gemcitabine followed by modified FOLFIRINOX for resectable pancreatic cancer: a randomized phase 3 trial","volume":"43","author":"Bai","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.tins.2026.08.008_bb0785","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/S0006-2952(02)01218-2","article-title":"Glutamate antagonists limit tumor growth","volume":"64","author":"Rzeski","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tins.2026.08.008_bb0790","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12964-023-01096-2","article-title":"Serotonin acts through YAP to promote cell proliferation: mechanism and implication in colorectal cancer progression","volume":"21","author":"Yu","year":"2023","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.tins.2026.08.008_bb0795","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s13046-023-02728-8","article-title":"Chronic stress accelerates glioblastoma progression via DRD2\/ERK\/\u03b2-catenin axis and Dopamine\/ERK\/TH positive feedback loop","volume":"42","author":"Wang","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0800","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.7150\/ijbs.58135","article-title":"GABAB receptor inhibits tumor progression and epithelial-mesenchymal transition via the regulation of Hippo\/YAP1 pathway in colorectal cancer","volume":"17","author":"Wang","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.tins.2026.08.008_bb0805","doi-asserted-by":"crossref","first-page":"11437","DOI":"10.1158\/0008-5472.CAN-05-1470","article-title":"\u03b3-Aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A\/extracellular signal-regulated kinase 1\/2 pathway","volume":"65","author":"Fava","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0810","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1093\/jnci\/djaf178","article-title":"Aprepitant use during chemotherapy and association with survival in women with early breast cancer","volume":"117","author":"Botteri","year":"2025","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.tins.2026.08.008_bb0815","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s40265-018-1044-x","article-title":"Larotrectinib: first global approval","volume":"79","author":"Scott","year":"2019","journal-title":"Drugs"},{"key":"10.1016\/j.tins.2026.08.008_bb0820","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/s40265-019-01177-y","article-title":"Entrectinib: first global approval","volume":"79","author":"Al-Salama","year":"2019","journal-title":"Drugs"},{"key":"10.1016\/j.tins.2026.08.008_bb0825","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15130","article-title":"Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer","volume":"8","author":"Lei","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2026.08.008_bb0830","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1158\/2326-6066.CIR-20-0445","article-title":"Chronic adrenergic stress contributes to metabolic dysfunction and an exhausted phenotype in T cells in the tumor microenvironment","volume":"9","author":"Qiao","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.tins.2026.08.008_bb0835","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ccell.2024.01.013","article-title":"Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment","volume":"42","author":"He","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.tins.2026.08.008_bb0840","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2021.2004659","article-title":"Chronic stress promotes breast carcinoma metastasis by accumulating myeloid-derived suppressor cells through activating \u03b2-adrenergic signaling","volume":"10","author":"An","year":"2021","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.tins.2026.08.008_bb0845","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2026.106280","article-title":"Tumor-macrophage-nerve interactions drive neuroinflammation and neuropathic pain in prostate cancer perineural invasion","volume":"133","author":"Mousa","year":"2026","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.tins.2026.08.008_bb0850","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41584-020-00528-4","article-title":"The evolution of nerve growth factor inhibition in clinical medicine","volume":"17","author":"Wise","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.tins.2026.08.008_bb0855","article-title":"Impact of beta blockers on cancer neuroimmunology: a systematic review and meta-analysis of survival outcomes and immune modulation","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tins.2026.08.008_bb0860","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.3390\/cancers16193395","article-title":"Tissue-agnostic targeting of neurotrophic tyrosine receptor kinase fusions: current approvals and future directions","volume":"16","author":"Gouda","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.tins.2026.08.008_bb0865","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s10194-025-02256-0","article-title":"Decoding the long-term safety of anti-CGRP (receptor) mAbs: a meta-analysis and systematic review","volume":"27","author":"Hoehne","year":"2026","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.tins.2026.08.008_bb0870","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s10020-025-01333-z","article-title":"Nerve growth factor: what can surgeons and oncologists learn from a neurological and psychological biomarker?","volume":"31","author":"Xiong","year":"2025","journal-title":"Mol. Med."},{"key":"10.1016\/j.tins.2026.08.008_bb0875","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/emboj.2010.325","article-title":"TRPV1-lineage neurons are required for thermal sensation","volume":"30","author":"Mishra","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.tins.2026.08.008_bb0880","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuron.2025.12.017","article-title":"From tumor metabolism to brain circuits: METTL14 as a SAM sensor driving pain-depression in pancreatic cancer","volume":"114","author":"Vermeer","year":"2026","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2026.08.008_bb0885","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1038\/s43018-025-01033-x","article-title":"Colorectal cancer cells hijack a brain-gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth","volume":"6","author":"Li","year":"2025","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.tins.2026.08.008_bb0890","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41388-026-03684-1","article-title":"Brain-cancer interactions outside the CNS","volume":"45","author":"Li","year":"2026","journal-title":"Oncogene"},{"key":"10.1016\/j.tins.2026.08.008_bb0895","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1158\/2159-8290.CD-23-1495","article-title":"Next directions in the neuroscience of cancers arising outside the CNS","volume":"14","author":"Amit","year":"2024","journal-title":"Cancer Discov."}],"container-title":["Trends in Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166223626001682?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166223626001682?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:46:46Z","timestamp":1792612006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166223626001682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":179,"alternative-id":["S0166223626001682"],"URL":"https:\/\/doi.org\/10.1016\/j.tins.2026.08.008","relation":{},"ISSN":["0166-2236"],"issn-type":[{"value":"0166-2236","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor innervation in non-central nervous system tumors: origins, mechanisms, and phenotypic plasticity","name":"articletitle","label":"Article Title"},{"value":"Trends in Neurosciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tins.2026.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}