{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T19:48:04Z","timestamp":1791748084805,"version":"4.3.4"},"reference-count":132,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MR\/Y014529\/1"],"award-info":[{"award-number":["MR\/Y014529\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["UKRI3161"],"award-info":[{"award-number":["UKRI3161"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015504","name":"Simons Initiative for the Developing Brain","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015504","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014370","name":"Simons Foundation Autism Research Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Neurosciences"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.tins.2026.09.004","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:47:32Z","timestamp":1790110052000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["On the nature of GABAB receptors and their plasticity in the mammalian brain"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1980-9873","authenticated-orcid":false,"given":"Sam A.","family":"Booker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tins.2026.09.004_bb0005","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/s41380-019-0426-0","article-title":"Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders","volume":"24","author":"Sohal","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.tins.2026.09.004_bb0010","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00441-018-2882-2","article-title":"Morphological diversity and connectivity of hippocampal interneurons","volume":"373","author":"Booker","year":"2018","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.tins.2026.09.004_bb0015","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/cne.902890210","article-title":"Organization of the septal region in the rat brain: cholinergic-GABAergic interconnections and the termination of hippocampo-septal fibers","volume":"289","author":"Leranth","year":"1989","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.tins.2026.09.004_bb0020","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neuropharm.2017.10.018","article-title":"Differential distribution and function of GABABRs in somato-dendritic and axonal compartments of principal cells and interneurons in cortical circuits","volume":"136","author":"Kulik","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.tins.2026.09.004_bb0025","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1046\/j.1460-9568.1999.00481.x","article-title":"GABAB-receptor splice variants GB1a and GB1b in rat brain: developmental regulation, cellular distribution and extrasynaptic localization","volume":"11","author":"Fritschy","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0030","doi-asserted-by":"crossref","first-page":"11026","DOI":"10.1523\/JNEUROSCI.23-35-11026.2003","article-title":"Subcellular localization of metabotropic GABAB receptor subunits GABAB1a\/b and GABAB2 in the rat hippocampus","volume":"23","author":"Kulik","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0035","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/S0028-3908(99)00132-X","article-title":"Localization of GABA(B) (R1) receptors in the rat hippocampus by immunocytochemistry and high resolution autoradiography, with specific reference to its localization in identified hippocampal interneuron subpopulations","volume":"38","author":"Sloviter","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.tins.2026.09.004_bb0040","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1093\/brain\/awag141","article-title":"GABAB receptors in glial cells: from physiological regulation to pathological implications","volume":"149","author":"Wang","year":"2026","journal-title":"Brain"},{"key":"10.1016\/j.tins.2026.09.004_bb0045","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1523\/JNEUROSCI.21-04-01203.2001","article-title":"The C-terminal domains of the GABA(b) receptor subunits mediate intracellular trafficking but are not required for receptor signaling","volume":"21","author":"Calver","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0050","doi-asserted-by":"crossref","first-page":"8043","DOI":"10.1523\/JNEUROSCI.21-20-08043.2001","article-title":"GABA(B2) is essential for G-protein coupling of the GABA(B) receptor heterodimer","volume":"21","author":"Robbins","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0055","doi-asserted-by":"crossref","first-page":"14991","DOI":"10.1073\/pnas.95.25.14991","article-title":"Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels","volume":"95","author":"Kaupmann","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2026.09.004_bb0060","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1523\/JNEUROSCI.3172-09.2010","article-title":"The Sushi domains of GABAB receptors function as axonal targeting signals","volume":"30","author":"Biermann","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0065","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.neuron.2006.04.014","article-title":"Differential compartmentalization and distinct functions of GABAB receptor variants","volume":"50","author":"Vigot","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2026.09.004_bb0070","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0896-6273(88)90108-0","article-title":"Pre-and postsynaptic GABAB receptors in the hippocampus have different pharmacological properties","volume":"1","author":"Dutar","year":"1988","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2026.09.004_bb0075","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1152\/jn.1995.73.1.246","article-title":"Postnatal development of pre-and postsynaptic GABAB-mediated inhibitions in the CA3 hippocampal region of the rat","volume":"73","author":"Gaiarsa","year":"1995","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.tins.2026.09.004_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1096-9861(19990913)412:1<1::AID-CNE1>3.0.CO;2-D","article-title":"Spatial distribution of GABA(B)R1 receptor mRNA and binding sites in the rat brain","volume":"412","author":"Bischoff","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.tins.2026.09.004_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2026.150463","article-title":"Cell-specific expression of APP and GABABR1 isoforms in wild-type and the APP NL-G-F mouse model of Alzheimer\u2019s disease","volume":"1889","author":"Houmam","year":"2026","journal-title":"Brain Res."},{"key":"10.1016\/j.tins.2026.09.004_bb0090","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/hipo.10221","article-title":"Distribution of metabotropic GABA receptor subunits GABAB1a\/b and GABAB2 in the rat hippocampus during prenatal and postnatal development","volume":"14","author":"L\u00f3pez-Bendito","year":"2004","journal-title":"Hippocampus"},{"key":"10.1016\/j.tins.2026.09.004_bb0095","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0304-3940(98)00344-9","article-title":"GABAb receptors differentially regulate hippocampal CA1 excitatory synaptic transmission across postnatal development in the rat","volume":"248","author":"Dumas","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tins.2026.09.004_bb0100","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/mcne.1998.0698","article-title":"Developmental changes of agonist affinity at GABABR1 receptor variants in rat brain","volume":"12","author":"Malitschek","year":"1998","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0105","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1523\/JNEUROSCI.4561-10.2011","article-title":"GABAB receptor modulation of voltage-sensitive calcium channels in spines and dendrites","volume":"31","author":"Chalifoux","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0110","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0896-6273(00)80381-5","article-title":"G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons","volume":"19","author":"L\u00fcscher","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2026.09.004_bb0115","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1016\/j.cellsig.2007.05.004","article-title":"Dominant role of GABAB2 and G\u03b2\u03b3 for GABAB receptor-mediated-ERK1\/2\/CREB pathway in cerebellar neurons","volume":"19","author":"Tu","year":"2007","journal-title":"Cell. Signal."},{"key":"10.1016\/j.tins.2026.09.004_bb0120","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1111\/ejn.13777","article-title":"GABAB receptors in neocortical and hippocampal pyramidal neurons are coupled to different potassium channels","volume":"46","author":"Breton","year":"2017","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0125","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.2003.046524","article-title":"GABAB receptor transduction mechanisms, and cross-talk between protein kinases A and C, in GABAergic terminals synapsing onto neurons of the rat nucleus basalis of Meynert","volume":"551","author":"Kubota","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.tins.2026.09.004_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2025.106831","article-title":"Binding of HCN channels to GABAB receptors in dopamine neurons of the VTA limits synaptic inhibition and prevents the development of anxiety","volume":"206","author":"P\u00e9rez-Garci","year":"2025","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.tins.2026.09.004_bb0135","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neuron.2010.03.012","article-title":"GABAB receptors modulate NMDA receptor calcium signals in dendritic spines","volume":"66","author":"Chalifoux","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2026.09.004_bb0140","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/nn764","article-title":"GABA(B) receptor activation enhances mGluR-mediated responses at cerebellar excitatory synapses","volume":"4","author":"Hirono","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0145","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nn.4198","article-title":"Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics","volume":"19","author":"Schwenk","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0150","first-page":"2318","article-title":"KCTD12 auxiliary proteins modulate kinetics of GABAB receptor-mediated inhibition in cholecystokinin-containing interneurons","volume":"27","author":"Booker","year":"2017","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.tins.2026.09.004_bb0155","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1523\/JNEUROSCI.2181-16.2016","article-title":"KCTD hetero-oligomers confer unique kinetic properties on hippocampal GABAB receptor-induced K+ currents","volume":"37","author":"Fritzius","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0160","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/s41467-019-09164-3","article-title":"Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing","volume":"10","author":"Dinamarca","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2026.09.004_bb0165","doi-asserted-by":"crossref","DOI":"10.1126\/science.aao4827","article-title":"Secreted amyloid-\u03b2 precursor protein functions as a GABA(B)R1a ligand to modulate synaptic transmission","volume":"363","author":"Rice","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.tins.2026.09.004_bb0170","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0345-25.2026","article-title":"sAPP\u03b1 inhibits neurite outgrowth in primary mouse neurons via GABA B Receptor subunit 1a","volume":"13","author":"Barber","year":"2026","journal-title":"eneuro"},{"key":"10.1016\/j.tins.2026.09.004_bb0175","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.82082","article-title":"Soluble amyloid-\u03b2 precursor peptide does not regulate GABAB receptor activity","volume":"12","author":"Rem","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.tins.2026.09.004_bb0180","doi-asserted-by":"crossref","first-page":"4284","DOI":"10.1038\/s41467-026-70640-8","article-title":"Functional and structural basis of a negative allostery within GABAB hetero-tetramers","volume":"17","author":"Shen","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2026.09.004_bb0185","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nn833","article-title":"Cyclic AMP-dependent protein kinase phosphorylation facilitates GABA(B) receptor-effector coupling","volume":"5","author":"Couve","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0190","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1038\/sj.emboj.7601157","article-title":"Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacy","volume":"25","author":"Pontier","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.tins.2026.09.004_bb0195","doi-asserted-by":"crossref","first-page":"13924","DOI":"10.1073\/pnas.1000909107","article-title":"NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1","volume":"107","author":"Guetg","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2026.09.004_bb0200","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1523\/JNEUROSCI.2654-19.2020","article-title":"Direct interaction of PP2A phosphatase with GABAB receptors alters functional signaling","volume":"40","author":"Li","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0205","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.mcn.2008.09.004","article-title":"Constitutive, agonist-accelerated, recycling and lysosomal degradation of GABA(B) receptors in cortical neurons","volume":"39","author":"Grampp","year":"2008","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0210","doi-asserted-by":"crossref","first-page":"24641","DOI":"10.1074\/jbc.M802419200","article-title":"The availability of surface GABA B receptors is independent of \u03b3-aminobutyric acid but controlled by glutamate in central neurons","volume":"283","author":"Vargas","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tins.2026.09.004_bb0215","doi-asserted-by":"crossref","first-page":"7156","DOI":"10.1074\/jbc.M115.686907","article-title":"Post-endocytotic deubiquitination and degradation of the metabotropic \u03b3-aminobutyric acid receptor by the ubiquitin-specific protease 14","volume":"291","author":"Lahaie","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tins.2026.09.004_bb0220","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.neuron.2011.12.031","article-title":"Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA","volume":"73","author":"Padgett","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2026.09.004_bb0225","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/nm.4037","article-title":"Rescue of GABAB and GIRK function in the lateral habenula by protein phosphatase 2A inhibition ameliorates depression-like phenotypes in mice","volume":"22","author":"Lecca","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.tins.2026.09.004_bb0230","article-title":"PP2A-dependent internalisation of GABA B receptors in somatostatin interneurons regulates function and plasticity","author":"Sethumadhavan","year":"2026","journal-title":"bioRxiv"},{"key":"10.1016\/j.tins.2026.09.004_bb0235","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuropharm.2015.03.029","article-title":"Sex differences in GABA(B)R-GIRK signaling in layer 5\/6 pyramidal neurons of the mouse prelimbic cortex","volume":"95","author":"de Velasco","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.tins.2026.09.004_bb0240","doi-asserted-by":"crossref","first-page":"18840","DOI":"10.1074\/jbc.M313470200","article-title":"Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking","volume":"279","author":"Balasubramanian","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tins.2026.09.004_bb0245","doi-asserted-by":"crossref","first-page":"24157","DOI":"10.1074\/jbc.M702626200","article-title":"\u03b3-Aminobutyric acid type B receptors are constitutively internalized via the clathrin-dependent pathway and targeted to lysosomes for degradation","volume":"282","author":"Grampp","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tins.2026.09.004_bb0250","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2113929118","article-title":"The translatome of neuronal cell bodies, dendrites, and axons","volume":"118","author":"Glock","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2026.09.004_bb0255","first-page":"3382","article-title":"Transport along the dendritic endoplasmic reticulum mediates the trafficking of GABAB receptors","volume":"127","author":"Valenzuela","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.tins.2026.09.004_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108537","article-title":"COR758, a negative allosteric modulator of GABAB receptors","volume":"189","author":"Porcu","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.tins.2026.09.004_bb0265","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fnins.2014.00140","article-title":"GABAB receptor ligands for the treatment of alcohol use disorder: preclinical and clinical evidence","volume":"8","author":"Agabio","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0270","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fnsyn.2015.00006","article-title":"Compartmental distribution of GABAB receptor-mediated currents along the somatodendritic axis of hippocampal principal cells","volume":"7","author":"Degro","year":"2015","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0275","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/hipo.23628","article-title":"Postsynaptic GABAB-receptor mediated currents in diverse dentate gyrus interneuron types","volume":"34","author":"Degro","year":"2024","journal-title":"Hippocampus"},{"key":"10.1016\/j.tins.2026.09.004_bb0280","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.0953-816x.2001.01855.x","article-title":"Distinct localization of GABA(B) receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus","volume":"15","author":"Kulik","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0285","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1007\/s00429-017-1427-x","article-title":"Differential surface density and modulatory effects of presynaptic GABAB receptors in hippocampal cholecystokinin and parvalbumin basket cells","volume":"222","author":"Booker","year":"2017","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.tins.2026.09.004_bb0290","doi-asserted-by":"crossref","first-page":"7961","DOI":"10.1523\/JNEUROSCI.1186-12.2013","article-title":"Differential GABAB-receptor-mediated effects in perisomatic-and dendrite-targeting parvalbumin interneurons","volume":"33","author":"Booker","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0295","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51156","article-title":"Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network","volume":"9","author":"Booker","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.tins.2026.09.004_bb0300","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.celrep.2017.12.021","article-title":"Postsynaptic GABABRs inhibit L-type calcium channels and abolish long-term potentiation in hippocampal somatostatin interneurons","volume":"22","author":"Booker","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.tins.2026.09.004_bb0305","doi-asserted-by":"crossref","first-page":"15073","DOI":"10.1073\/pnas.1313505110","article-title":"GABA(B) autoreceptor-mediated cell type-specific reduction of inhibition in epileptic mice","volume":"110","author":"Dugladze","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tins.2026.09.004_bb0310","doi-asserted-by":"crossref","first-page":"6513","DOI":"10.1523\/JNEUROSCI.0674-18.2018","article-title":"Constitutive and synaptic activation of GIRK channels differentiates mature and newborn dentate granule cells","volume":"38","author":"Gonzalez","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0315","doi-asserted-by":"crossref","first-page":"6775","DOI":"10.1523\/JNEUROSCI.1135-05.2005","article-title":"Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area","volume":"25","author":"Price","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0320","doi-asserted-by":"crossref","first-page":"6974","DOI":"10.1523\/JNEUROSCI.4673-07.2008","article-title":"GABA(B) receptor modulation of feedforward inhibition through hippocampal neurogliaform cells","volume":"28","author":"Price","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0325","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0896-6273(00)81069-7","article-title":"GABA spillover activates postsynaptic GABA(B) receptors to control rhythmic hippocampal activity","volume":"25","author":"Scanziani","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2026.09.004_bb0330","doi-asserted-by":"crossref","first-page":"7890","DOI":"10.1113\/JP291223","article-title":"Sublayer- and pathway-specific control of CA1 input processing by VIP interneurons","volume":"604","author":"Iloun","year":"2026","journal-title":"J. Physiol."},{"key":"10.1016\/j.tins.2026.09.004_bb0335","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1152\/jn.1999.82.3.1438","article-title":"GABAB-receptor-mediated currents in interneurons of the dentate-hilus border","volume":"82","author":"Mott","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.tins.2026.09.004_bb0340","doi-asserted-by":"crossref","DOI":"10.3389\/fnsyn.2025.1656759","article-title":"GABAB receptors negatively modulate excitatory plasticity at the mossy fiber synapse onto parvalbumin-expressing basket and axo-axonic cells in the dentate gyrus","volume":"17","author":"Loureiro","year":"2025","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0345","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/cne.20188","article-title":"Independent maturation of the GABA(B) receptor subunits GABA(B1) and GABA(B2) during postnatal development in rodent brain","volume":"477","author":"Fritschy","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.tins.2026.09.004_bb0350","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.neuron.2006.04.019","article-title":"The GABAB1b isoform mediates long-lasting inhibition of dendritic Ca2+ spikes in layer 5 somatosensory pyramidal neurons","volume":"50","author":"P\u00e9rez-Garci","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2026.09.004_bb0355","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.718413","article-title":"GABA B receptor-mediated regulation of dendro-somatic synergy in layer 5 pyramidal neurons","volume":"15","author":"Schulz","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0360","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1038\/s41467-025-59262-8","article-title":"Phylogenetic divergence of GABAB receptor signaling in neocortical networks over adult life","volume":"16","author":"Wilson","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tins.2026.09.004_bb0365","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1469-7793.1999.0385t.x","article-title":"G protein-activated inwardly rectifying K+ (GIRK) currents in dendrites of rat neocortical pyramidal cells","volume":"517","author":"Takigawa","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.tins.2026.09.004_bb0370","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1113\/jphysiol.2012.245464","article-title":"Inhibition of dendritic Ca2+ spikes by GABAB receptors in cortical pyramidal neurons is mediated by a direct Gi\/o-\u03b2\u03b3-subunit interaction with Cav1 channels","volume":"591","author":"P\u00e9rez-Garci","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.tins.2026.09.004_bb0375","doi-asserted-by":"crossref","first-page":"8780","DOI":"10.1038\/s41598-023-35890-2","article-title":"Somatostatin-expressing interneurons modulate neocortical network through GABAb receptors in a synapse-specific manner","volume":"13","author":"Kanigowski","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tins.2026.09.004_bb0380","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1113\/JP286439","article-title":"Inhibition of BK channels by GABAb receptors enhances intrinsic excitability of layer 2\/3 vasoactive intestinal polypeptide-expressing interneurons in mouse neocortex","volume":"603","author":"Bogaj","year":"2025","journal-title":"J. Physiol."},{"key":"10.1016\/j.tins.2026.09.004_bb0385","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1523\/JNEUROSCI.3646-15.2016","article-title":"Opening holes in the blanket of inhibition: localized lateral disinhibition by VIP interneurons","volume":"36","author":"Karnani","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0390","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/neuro.04.004.2007","article-title":"Output of neurogliaform cells to various neuron types in the human and rat cerebral cortex","volume":"1","author":"Ol\u00e1h","year":"2007","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.tins.2026.09.004_bb0395","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1113\/jphysiol.1995.sp020759","article-title":"GABAB receptor-mediated presynaptic inhibition in Guinea-pig hippocampus is caused by reduction of presynaptic Ca2+ influx","volume":"485","author":"Wu","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/j.tins.2026.09.004_bb0400","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0022-3565(25)33331-8","article-title":"Baclofen selectively inhibits transmission at synapses made by axons of CA3 pyramidal cells in the hippocampal slice","volume":"223","author":"Ault","year":"1982","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tins.2026.09.004_bb0405","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1523\/JNEUROSCI.3697-08.2009","article-title":"The GABAB1a isoform mediates heterosynaptic depression at hippocampal mossy fiber synapses","volume":"29","author":"Guetg","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0410","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/(SICI)1098-2396(199701)25:1<62::AID-SYN8>3.0.CO;2-D","article-title":"Presynaptic and postsynaptic GABAB receptors of neocortical neurons of the rat in vitro: differences in pharmacology and ionic mechanisms","volume":"25","author":"Deisz","year":"1997","journal-title":"Synapse"},{"key":"10.1016\/j.tins.2026.09.004_bb0415","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S0306-4522(99)00203-1","article-title":"The GABA(B) receptor antagonist CGP 55845A reduces presynaptic GABA(B) actions in neocortical neurons of the rat in vitro","volume":"93","author":"Deisz","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.tins.2026.09.004_bb0420","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1152\/jn.00196.2004","article-title":"Presynaptic GABAB receptors modulate thalamic excitation of inhibitory and excitatory neurons in the mouse barrel cortex","volume":"92","author":"Porter","year":"2004","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.tins.2026.09.004_bb0425","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0006-8993(94)90865-6","article-title":"Selective suppression of intrinsic but not afferent fiber synaptic transmission by baclofen in the piriform (olfactory) cortex","volume":"659","author":"Tang","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.tins.2026.09.004_bb0430","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.cub.2015.01.035","article-title":"Neocortical somatostatin neurons reversibly silence excitatory transmission via GABAb receptors","volume":"25","author":"Urban-Ciecko","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.tins.2026.09.004_bb0435","doi-asserted-by":"crossref","first-page":"7513","DOI":"10.1523\/JNEUROSCI.6162-08.2009","article-title":"Distinct roles of GABA(A) and GABA(B) receptors in balancing and terminating persistent cortical activity","volume":"29","author":"Mann","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0440","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1113\/jphysiol.2012.248088","article-title":"Distinct roles of GABAB1a- and GABAB1b-containing GABAB receptors in spontaneous and evoked termination of persistent cortical activity","volume":"591","author":"Craig","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.tins.2026.09.004_bb0445","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1111\/j.1460-9568.1995.tb00721.x","article-title":"Properties of unitary IPSPs evoked by anatomically identified basket cells in the rat hippocampus","volume":"7","author":"Buhl","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2022.136448","article-title":"Presynaptic GABAB receptors differentially modulate GABA release from cholecystokinin and parvalbumin interneurons onto CA1 pyramidal neurons: a cell type-specific labeling and activating study","volume":"772","author":"Shao","year":"2022","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tins.2026.09.004_bb0455","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/npp.2016.273","article-title":"GABAb receptor mediates opposing adaptations of GABA release from two types of prefrontal interneurons after observational fear","volume":"42","author":"Liu","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.tins.2026.09.004_bb0460","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/sj.bjp.0700852","article-title":"Pharmacologically distinct GABAB receptors that mediate inhibition of GABA and glutamate release in human neocortex","volume":"120","author":"Bonanna","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tins.2026.09.004_bb0465","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0115-24.2024","article-title":"Somatostatin interneurons recruit pre-and postsynaptic GABAB receptors in the adult mouse dentate gyrus","volume":"11","author":"Watson","year":"2024","journal-title":"eneuro"},{"key":"10.1016\/j.tins.2026.09.004_bb0470","doi-asserted-by":"crossref","first-page":"5093","DOI":"10.1038\/s41380-025-03093-y","article-title":"Parvalbumin interneurons gate amygdala excitability and response to chronic stress via kainate receptor-driven tonic GABAB receptor-mediated inhibition","volume":"30","author":"Ryazantseva","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.tins.2026.09.004_bb0475","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tins.2003.10.010","article-title":"Interneuron diversity series: fast in, fast out\u2013temporal and spatial signal processing in hippocampal interneurons","volume":"27","author":"Jonas","year":"2004","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0480","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/(SICI)1096-9861(19960415)367:4<595::AID-CNE9>3.0.CO;2-#","article-title":"GABA plasma membrane transporters, GAT-1 and GAT-3, display different distributions in the rat hippocampus","volume":"367","author":"Ribak","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.tins.2026.09.004_bb0485","doi-asserted-by":"crossref","first-page":"16739","DOI":"10.1523\/JNEUROSCI.1612-14.2014","article-title":"GABAergic projections from the medial septum selectively inhibit interneurons in the medial entorhinal cortex","volume":"34","author":"Gonzalez-Sulser","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0490","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/0304-3940(90)90307-U","article-title":"Baclofen facilitates the development of long-term potentiation in the rat dentate gyrus","volume":"113","author":"Mott","year":"1990","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tins.2026.09.004_bb0495","article-title":"Elevated somatostatin interneuron long-term potentiation minimally regulates temporoammonic plasticity in a mouse model of fragile X syndrome","volume":"16","author":"Wilson","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tins.2026.09.004_bb0500","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00221-006-0849-0","article-title":"Suppression of LTP-like plasticity in human motor cortex by the GABAB receptor agonist baclofen","volume":"180","author":"McDonnell","year":"2007","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.tins.2026.09.004_bb0505","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-neuro-090919-022842","article-title":"Synaptic plasticity forms and functions","volume":"43","author":"Magee","year":"2020","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0510","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1126\/science.1675489","article-title":"Facilitation of the induction of long-term potentiation by GABAB receptors","volume":"252","author":"Mott","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.tins.2026.09.004_bb0515","doi-asserted-by":"crossref","first-page":"24324","DOI":"10.1074\/jbc.M111.220814","article-title":"\u03b3-Aminobutyric acid type B (GABAB) receptor internalization is regulated by the R2 subunit","volume":"286","author":"Hannan","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tins.2026.09.004_bb0520","doi-asserted-by":"crossref","first-page":"12565","DOI":"10.1074\/jbc.M311389200","article-title":"Phosphorylation and chronic agonist treatment atypically modulate GABAB receptor cell surface stability","volume":"279","author":"Fairfax","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tins.2026.09.004_bb0525","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1093\/brain\/awad336","article-title":"Extracellular glutamate and GABA transients at the transition from interictal spiking to seizures","volume":"147","author":"Shimoda","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.tins.2026.09.004_bb0530","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1002\/cne.22610","article-title":"Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain","volume":"519","author":"Metz","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.tins.2026.09.004_bb0535","doi-asserted-by":"crossref","first-page":"24848","DOI":"10.1074\/jbc.M113.476770","article-title":"Up-regulation of GABAB receptor signaling by constitutive assembly with the K+ channel tetramerization domain-containing protein 12 (KCTD12)","volume":"288","author":"Ivankova","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tins.2026.09.004_bb0540","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.neuron.2014.04.015","article-title":"Auxiliary GABAB receptor subunits uncouple G protein \u03b2\u03b3 subunits from effector channels to induce desensitization","volume":"82","author":"Turecek","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.tins.2026.09.004_bb0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105355","article-title":"The effects of Kctd12, an auxiliary subunit of GABAB receptor in dentate gyrus on behavioral response to chronic social defeat stress in mice","volume":"163","author":"Deng","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.tins.2026.09.004_bb0550","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00213-013-3204-8","article-title":"Effect of baclofen on morphine-induced conditioned place preference, extinction, and stress-induced reinstatement in chronically stressed mice","volume":"231","author":"Meng","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.tins.2026.09.004_bb0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2026.107286","article-title":"The role of auxiliary GABAB receptor subunit KCTD16 in pain modulation","volume":"220","author":"Vasconcelos","year":"2026","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.tins.2026.09.004_bb0560","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1113\/jphysiol.2007.137265","article-title":"Decrease in PIP(2) channel interactions is the final common mechanism involved in PKC- and arachidonic acid-mediated inhibitions of GABA(B)-activated K+ current","volume":"582","author":"Sohn","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.tins.2026.09.004_bb0565","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S1054-3589(10)58005-0","article-title":"Functional modulation of GABAB receptors by protein kinases and receptor trafficking","volume":"58","author":"Terunuma","year":"2010","journal-title":"Adv. Pharmacol. (1962)"},{"key":"10.1016\/j.tins.2026.09.004_bb0570","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/bpa.12802","article-title":"Reduction in the neuronal surface of post and presynaptic GABAB receptors in the hippocampus in a mouse model of Alzheimer\u2019s disease","volume":"30","author":"Mart\u00edn-Belmonte","year":"2020","journal-title":"Brain Pathol."},{"key":"10.1016\/j.tins.2026.09.004_bb0575","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0099-23.2025","article-title":"GABAB Receptor signaling in CA1 Pyramidal Cells is not Regulated by Aging in the APP\/PS1 Mouse Model of Amyloid Pathology","volume":"13","author":"Meftah","year":"2026","journal-title":"eneuro"},{"key":"10.1016\/j.tins.2026.09.004_bb0580","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1523\/JNEUROSCI.1327-15.2016","article-title":"A role for the GIRK3 subunit in methamphetamine-induced attenuation of GABAB receptor-activated GIRK currents in VTA dopamine neurons","volume":"36","author":"Munoz","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0585","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1097\/00001756-200207020-00007","article-title":"Baclofen decreases methamphetamine self-administration in rats","volume":"13","author":"Ranaldi","year":"2002","journal-title":"Neuroreport"},{"key":"10.1016\/j.tins.2026.09.004_bb0590","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1113\/jphysiol.2006.112896","article-title":"mGluR1\/5 subtype-specific calcium signalling and induction of long-term potentiation in rat hippocampal oriens\/alveus interneurones","volume":"575","author":"Topolnik","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.tins.2026.09.004_bb0595","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1152\/jn.1998.79.3.1341","article-title":"Ontogenesis of presynaptic GABAB receptor-mediated inhibition in the CA3 region of the rat hippocampus","volume":"79","author":"Caillard","year":"1998","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.tins.2026.09.004_bb0600","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0304-3940(87)90264-3","article-title":"Quantitative autoradiography of hippocampal GABAB and GABAA receptor changes in Alzheimer\u2019s disease","volume":"82","author":"Chu","year":"1987","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tins.2026.09.004_bb0605","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.neuroscience.2003.08.044","article-title":"GABAB1a, GABAB1b and GABAB2 mRNA variants expression in hippocampus resected from patients with temporal lobe epilepsy","volume":"122","author":"Princivalle","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.tins.2026.09.004_bb0610","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s42003-026-09918-y","article-title":"Reduced inhibition, bursting, and accelerated oscillations drive early hippocampal hyperactivity in Alzheimer\u2019s disease in vivo","volume":"9","author":"Meftah","year":"2026","journal-title":"Commun. Biol."},{"key":"10.1016\/j.tins.2026.09.004_bb0615","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/neup.12649","article-title":"Histological characterization of interneurons in Alzheimer\u2019s disease reveals a loss of somatostatin interneurons in the temporal cortex","volume":"40","author":"Waller","year":"2020","journal-title":"Neuropathology"},{"key":"10.1016\/j.tins.2026.09.004_bb0620","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1038\/s41593-025-01979-2","article-title":"GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy","volume":"28","author":"Chen","year":"2025","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tins.2026.09.004_bb0625","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0006-8993(89)90234-5","article-title":"Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy","volume":"495","author":"de Lanerolle","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.tins.2026.09.004_bb0630","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1111\/j.1528-1167.2010.02544.x","article-title":"Alterations of intracerebral \u03b3-aminobutyric acid (GABA) levels by titration with levetiracetam in patients with focal epilepsies","volume":"51","author":"Doelken","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.tins.2026.09.004_bb0635","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.yebeh.2006.01.003","article-title":"The impact of levetiracetam on challenging behavior","volume":"8","author":"Hurtado","year":"2006","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.tins.2026.09.004_bb0640","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00213-012-2654-8","article-title":"Behavioral characterization of escalated aggression induced by GABA(B) receptor activation in the dorsal raphe nucleus","volume":"224","author":"Takahashi","year":"2012","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.tins.2026.09.004_bb0645","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13024-024-00712-0","article-title":"Updates on mouse models of Alzheimer\u2019s disease","volume":"19","author":"Zhong","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.tins.2026.09.004_bb0650","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/j.neurobiolaging.2005.09.022","article-title":"Early neuropathology of somatostatin\/NPY GABAergic cells in the hippocampus of a PS1\u00d7 APP transgenic model of Alzheimer\u2019s disease","volume":"27","author":"Ramos","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.tins.2026.09.004_bb0655","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s13195-022-01078-5","article-title":"Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP\/PS1 mice","volume":"14","author":"Mart\u00edn-Belmonte","year":"2022","journal-title":"Alzheimer's Res. Ther."},{"key":"10.1016\/j.tins.2026.09.004_bb0660","doi-asserted-by":"crossref","DOI":"10.1111\/bpa.13279","article-title":"Nanoarchitecture of CaV2. 1 channels and GABAB receptors in the mouse hippocampus: impact of APP\/PS1 pathology","volume":"35","author":"Mart\u00edn-Belmonte","year":"2025","journal-title":"Brain Pathol."}],"container-title":["Trends in Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166223626001864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166223626001864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T19:22:13Z","timestamp":1791746533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166223626001864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":132,"alternative-id":["S0166223626001864"],"URL":"https:\/\/doi.org\/10.1016\/j.tins.2026.09.004","relation":{},"ISSN":["0166-2236"],"issn-type":[{"value":"0166-2236","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"On the nature of GABAB receptors and their plasticity in the mammalian brain","name":"articletitle","label":"Article Title"},{"value":"Trends in Neurosciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tins.2026.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}