{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:38:31Z","timestamp":1791895111912,"version":"4.3.4"},"reference-count":73,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Pharmacological Sciences"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1016\/j.tips.2005.06.006","type":"journal-article","created":{"date-parts":[[2005,6,30]],"date-time":"2005-06-30T12:05:14Z","timestamp":1120133114000},"page":"412-419","source":"Crossref","is-referenced-by-count":201,"title":["Molecular tools to study melatonin pathways and actions"],"prefix":"10.1016","volume":"26","author":[{"given":"Jean A.","family":"Boutin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Audinot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Ferry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Delagrange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tips.2005.06.006_bib1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1046\/j.1365-2826.2003.01016.x","article-title":"Therapeutic perspectives for melatonin agonists and antagonists","volume":"15","author":"Delagrange","year":"2003","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.tips.2005.06.006_bib2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/00004850-200209000-00004","article-title":"Determination of the dose of agomelatine, a melatoninergic agonist and selective 5-HT(2C) antagonist, in the treatment of major depressive disorder: a placebo-controlled dose range study","volume":"17","author":"Loo","year":"2002","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.tips.2005.06.006_bib3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1515\/REVNEURO.2004.15.3.209","article-title":"Genetic aspects of melatonin biology","volume":"15","author":"Anisimov","year":"2004","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.tips.2005.06.006_bib4","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/S0024-3205(97)00030-1","article-title":"Pharmacological actions of melatonin in oxygen radical pathophysiology","volume":"60","author":"Reiter","year":"1997","journal-title":"Life Sci."},{"key":"10.1016\/j.tips.2005.06.006_bib5","first-page":"482","article-title":"The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland","volume":"52","author":"Klein","year":"1997","journal-title":"Recent Prog. Horm. Res."},{"key":"10.1016\/j.tips.2005.06.006_bib6","first-page":"113","article-title":"Neurally-mediated and neurally-independent beneficial actions of melatonin in the gastrointestinal tract","volume":"54","author":"Reiter","year":"2003","journal-title":"J. Physiol Pharmacol."},{"key":"10.1016\/j.tips.2005.06.006_bib7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1006\/geno.1996.0243","article-title":"The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissues expression","volume":"15","author":"Coon","year":"1996","journal-title":"Genomics"},{"key":"10.1016\/j.tips.2005.06.006_bib8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1097-2765(00)80171-9","article-title":"Melatonin biosynthesis: the structure of serotonin N-acetyltransferase at 2.5 A resolution suggests a catalytic mechanism","volume":"3","author":"Hickman","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tips.2005.06.006_bib9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0092-8674(00)80745-X","article-title":"The structural basis of ordered substrate binding by serotonin N- acetyltransferase: enzyme complex at 1.8 A resolution with a bisubstrate analog","volume":"97","author":"Hickman","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.tips.2005.06.006_bib10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/jmbi.2001.5371","article-title":"X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition","volume":"317","author":"Wolf","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.tips.2005.06.006_bib11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.pep.2004.07.004","article-title":"Further attempts to purify human serotonin N-acetyltransferase (EC 2.3.1.87). Comparison with other species and implication for its enzymatic behavior","volume":"38","author":"Ferry","year":"2004","journal-title":"Prot. Exp. Purif."},{"key":"10.1016\/j.tips.2005.06.006_bib12","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s00018-002-8517-4","article-title":"Characterization and regulation of a CHO cell line stably expressing the human serotonin N-acetyltransferase (EC 2.3.1.87)","volume":"59","author":"Ferry","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.tips.2005.06.006_bib13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00441-002-0579-y","article-title":"Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation","volume":"309","author":"Ganguly","year":"2003","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.tips.2005.06.006_bib14","doi-asserted-by":"crossref","first-page":"51172","DOI":"10.1074\/jbc.M309248200","article-title":"Retinal ganglion cells are autonomous circadian oscillators synthesizing N-acetylserotonin during the day","volume":"279","author":"Garbarino-Pico","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2005.06.006_bib15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0014-2999(96)00228-2","article-title":"Structure-activity relationships for substrates and inhibitors of pineal 5-hydroxytryptamine-N-acetyltransferase: preliminary studies","volume":"307","author":"Shen","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.tips.2005.06.006_bib16","doi-asserted-by":"crossref","first-page":"8794","DOI":"10.1074\/jbc.275.12.8794","article-title":"Substrate specificity and inhibition studies of human serotonin N-acetyltransferase","volume":"275","author":"Ferry","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2005.06.006_bib17","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1177\/108705710000500508","article-title":"High-capacity screening of arylalkylamine N-acetyltransferase inhibitors using a high-performance liquid chromatography system","volume":"5","author":"Ferry","year":"2000","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.tips.2005.06.006_bib18","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.2174\/0929867023370013","article-title":"Serotonin N-acetyltransferase: mechanism and inhibition","volume":"9","author":"Zheng","year":"2002","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.tips.2005.06.006_bib19","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1046\/j.1432-1033.2003.03942.x","article-title":"New substrate analogues of human serotonin N-acetyltransferase produce in situ specific and potent inhibitors","volume":"271","author":"Ferry","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.tips.2005.06.006_bib20","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/1475636021000005721","article-title":"Design, synthesis and in vitro evaluation of novel derivatives as serotonin N-acetyltransferase inhibitors","volume":"17","author":"Beaurain","year":"2002","journal-title":"J. Enz. Inhib. Med. Chem."},{"key":"10.1016\/j.tips.2005.06.006_bib21","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1016\/j.lfs.2004.06.009","article-title":"The actions of a charged melatonin receptor ligand, TMEPI, and an irreversible MT2 receptor agonist, BMNEP, on mouse hippocampal evoked potentials in vitro","volume":"75","author":"El-Sherif","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.tips.2005.06.006_bib22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00441-002-0581-4","article-title":"Mammalian melatonin receptors: molecular biology and signal transduction","volume":"309","author":"von Gall","year":"2002","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.tips.2005.06.006_bib23","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1530\/acta.0.1060152","article-title":"Development and validation of a melatonin radioimmunoassay using radioiodinated melatonin tracer","volume":"106","author":"Vakkuri","year":"1984","journal-title":"Acta Endocrinol."},{"key":"10.1016\/j.tips.2005.06.006_bib24","doi-asserted-by":"crossref","first-page":"6133","DOI":"10.1073\/pnas.91.13.6133","article-title":"Expression cloning of a high-affinity melatonin receptor from Xenopus dermal melanophores","volume":"91","author":"Ebisawa","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tips.2005.06.006_bib25","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/0896-6273(94)90055-8","article-title":"Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses","volume":"13","author":"Reppert","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.tips.2005.06.006_bib26","doi-asserted-by":"crossref","first-page":"8734","DOI":"10.1073\/pnas.92.19.8734","article-title":"Molecular characterization of a second melatonin receptor expressed in human retina and brain: The Mel1b melatonin receptor","volume":"92","author":"Reppert","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tips.2005.06.006_bib27","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00210-003-0751-2","article-title":"New selective ligands of human cloned melatonin MT1 and MT2 receptors","volume":"367","author":"Audinot","year":"2003","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.tips.2005.06.006_bib28","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/0006-8993(94)91819-8","article-title":"Daily variations of melatonin receptor density of rats pars tuberalis and suprachiasmatic nuclei are distinctly regulated","volume":"641","author":"Gauer","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.tips.2005.06.006_bib29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0896-6273(00)80350-5","article-title":"Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock","volume":"19","author":"Liu","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.tips.2005.06.006_bib30","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1128\/MCB.23.3.1054-1060.2003","article-title":"Targeted disruption of the mouse Mel1b melatonin receptor","volume":"23","author":"Jin","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tips.2005.06.006_bib31","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/S0024-3205(03)00098-5","article-title":"Melatonin receptors and their regulation: biochemical and structural mechanisms","volume":"72","author":"Witt-Enderby","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.tips.2005.06.006_bib32","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0006-2952(01)00881-4","article-title":"Dual coupling of MT(1) and MT(2) melatonin receptors to cyclic AMP and phosphoinositide signal transduction cascades and their regulation following melatonin exposure","volume":"63","author":"MacKenzie","year":"2002","journal-title":"Biochem Pharmacol."},{"key":"10.1016\/j.tips.2005.06.006_bib33","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0006-8993(01)02915-8","article-title":"Activation of melatonin receptor increases a delayed rectifier K+ current in rat cerebellar granule cells","volume":"917","author":"Huan","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.tips.2005.06.006_bib34","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1034\/j.1600-079X.2002.02919.x","article-title":"Receptor MT1 mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1","volume":"33","author":"Peschke","year":"2002","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.tips.2005.06.006_bib35","doi-asserted-by":"crossref","first-page":"d1093","DOI":"10.2741\/1089","article-title":"Molecular pharmacology, regulation and function of mammalian melatonin receptors","volume":"8","author":"Dubocovich","year":"2003","journal-title":"Front Biosci."},{"key":"10.1016\/j.tips.2005.06.006_bib36","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.bcp.2003.09.037","article-title":"Molecular pharmacology of ovine melatonin receptor. Comparison with recombinant human MT1 and MT2","volume":"67","author":"Mailliet","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tips.2005.06.006_bib37","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/PL00004956","article-title":"Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor","volume":"355","author":"Dubocovich","year":"1997","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.tips.2005.06.006_bib38","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2174\/0929867306666220330190146","article-title":"Melatonin","volume":"6","author":"Mor","year":"1999","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.tips.2005.06.006_bib39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0065-7743(04)39003-2","article-title":"Melatonin agonists for the treatment of sleep disorders and major depression","volume":"39","author":"Fitzgerald","year":"2004","journal-title":"Ann. Rep. Med. Chem."},{"key":"10.1016\/j.tips.2005.06.006_bib40","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1210\/endo-122-5-1825","article-title":"2-[125I]Isodomelatonin binding sites in hamster brain membranes: pharmacological characteristics and regional distribution","volume":"122","author":"Duncan","year":"1988","journal-title":"Endocrinology"},{"key":"10.1016\/j.tips.2005.06.006_bib41","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0014-2999(90)90154-X","article-title":"Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus","volume":"175","author":"Pickering","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.tips.2005.06.006_bib42","doi-asserted-by":"crossref","first-page":"L393","DOI":"10.1016\/0024-3205(93)90494-N","article-title":"Melatonin binding sites are functionally coupled to phosphoinositide hydrolysis in Syrian hamster RPMI 1846 melanoma cells","volume":"53","author":"Eison","year":"1993","journal-title":"Life Sci."},{"key":"10.1016\/j.tips.2005.06.006_bib43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0014-2999(95)00870-5","article-title":"2-[125I]iodo-5-methoxycarbonylamino-N-acetyltryptamine: a selective radioligand for the characterization of melatonin ML2 binding sites","volume":"301","author":"Molinari","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.tips.2005.06.006_bib44","first-page":"334","article-title":"Characterization of 2-[125I]iodomelatonin binding sites in Syrian hamster peripheral organs","volume":"290","author":"Paul","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tips.2005.06.006_bib45","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/S0006-2952(01)00615-3","article-title":"Comparative pharmacological studies at the melatonin receptors MT1, MT2 and MT3\/QR2","volume":"61","author":"Nosjean","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tips.2005.06.006_bib46","doi-asserted-by":"crossref","first-page":"31311","DOI":"10.1074\/jbc.M005141200","article-title":"Identification of the melatonin binding site MT3 as the quinone reductase 2","volume":"275","author":"Nosjean","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2005.06.006_bib47","doi-asserted-by":"crossref","first-page":"46131","DOI":"10.1074\/jbc.M208675200","article-title":"Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity","volume":"277","author":"Long","year":"2002","journal-title":"J Biol Chem."},{"key":"10.1016\/j.tips.2005.06.006_bib48","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.febslet.2004.10.083","article-title":"Organs from mice deleted for NRH: quinone oxydoreductase 2 are deprived of the melatonin binding site MT3","volume":"578","author":"Mailliet","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tips.2005.06.006_bib49","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1021\/jm011053+","article-title":"Synthesis of nitroindole derivatives as high affinity and selective MT3 melatonin receptor ligands","volume":"45","author":"Leclerc","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.tips.2005.06.006_bib50","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cbi.2005.01.002","article-title":"Quinone reductase 2 substrate specificity and inhibition pharmacology","volume":"151","author":"Boutin","year":"2005","journal-title":"Chem. Biol. Int."},{"key":"10.1016\/j.tips.2005.06.006_bib51","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/abbi.1997.0344","article-title":"Catalytic properties of NAD(P)H: quinone oxidoreductase-2 (NQO2), a dihydro-nicotinamide riboside dependent oxydoreductase","volume":"347","author":"Wu","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tips.2005.06.006_bib52","doi-asserted-by":"crossref","first-page":"11417","DOI":"10.1021\/bi049162o","article-title":"Crystal structure of quinone reductase 2 in complex with resveratrol","volume":"43","author":"Buryanovskyy","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.tips.2005.06.006_bib53","first-page":"115","article-title":"Cardioprotection of red wine: role of polyphenolic antioxidants","volume":"25","author":"Das","year":"1999","journal-title":"Drugs Exp. Clin. Res."},{"key":"10.1016\/j.tips.2005.06.006_bib54","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1600-079X.1987.tb00863.x","article-title":"The isolation, purification, and characterisation of the principal urinary metabolites of melatonin","volume":"4","author":"Leone","year":"1987","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.tips.2005.06.006_bib55","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0021-9258(19)42976-1","article-title":"In vitro and in vivo formation of two new metabolites of melatonin","volume":"249","author":"Hirata","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2005.06.006_bib56","doi-asserted-by":"crossref","first-page":"4700","DOI":"10.1016\/S0021-9258(17)30447-7","article-title":"Indoleamine-2,3-dioxygenase. Purification and some properties","volume":"253","author":"Shimizu","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2005.06.006_bib57","doi-asserted-by":"crossref","first-page":"6808","DOI":"10.1016\/S0021-9258(18)32294-4","article-title":"Monooxygenase activities of dioxygenases. Benzphetamine demethylation and aniline hydroxylation reactions catalyzed by indoleamine 2,3-dioxygenase","volume":"258","author":"Takikawa","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2005.06.006_bib58","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1006\/bbrc.2000.3993","article-title":"Myeloperoxidase-catalyzed oxidation of melatonin by activated neutrophils","volume":"279","author":"Silva","year":"2000","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"10.1016\/j.tips.2005.06.006_bib59","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1006\/bbrc.2001.4582","article-title":"Mechanism of reaction of melatonin with human myeloperoxidase","volume":"282","author":"Allegra","year":"2001","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"10.1016\/j.tips.2005.06.006_bib60","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1042\/BJ20042075","article-title":"Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan. Investigations on both indoleamine-2,3-dioxygenase and myeloperoxidase","volume":"388","author":"Ferry","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.tips.2005.06.006_bib61","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0301-0082(00)00032-0","article-title":"Kynurenines in the CNS: from endogenous obscurity to therapeutic importance","volume":"64","author":"Stone","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.tips.2005.06.006_bib62","doi-asserted-by":"crossref","first-page":"10967","DOI":"10.1021\/bi960577m","article-title":"2.3 A resolution X-ray crystal structure of the bisubstrate analogue inhibitor salicylhydroxamic acid bound to human myeloperoxidase: a model for a prereaction complex with hydrogen peroxide","volume":"35","author":"Davey","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.tips.2005.06.006_bib63","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1600-079X.1994.tb00089.x","article-title":"Characterisation of high affinity melatonin binding sites in purified cell nuclei of rat liver","volume":"16","author":"Acuna-Castroviejo","year":"1995","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.tips.2005.06.006_bib64","doi-asserted-by":"crossref","first-page":"28531","DOI":"10.1016\/S0021-9258(19)61934-4","article-title":"Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily","volume":"269","author":"Becker-Andre","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2005.06.006_bib65","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0303-7207(96)03900-7","article-title":"Are nuclear receptors in pituitary responsiveness to melatonin?","volume":"123","author":"Hazlerigg","year":"1996","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.tips.2005.06.006_bib66","doi-asserted-by":"crossref","first-page":"16707","DOI":"10.1074\/jbc.272.26.16707","article-title":"Erratum: Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily","volume":"272","author":"Becker-Andre","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2005.06.006_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/mol.104.000497.","article-title":"G protein-coupled receptor dimerization: function and ligand pharmacology","volume":"66","author":"Milligan","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tips.2005.06.006_bib68","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1124\/mol.104.000398","article-title":"Preferential formation of MT1\/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers","volume":"66","author":"Ayoub","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tips.2005.06.006_bib69","first-page":"902","article-title":"Luzindole (N-0774): a novel melatonin receptor antagonist","volume":"246","author":"Dubocovich","year":"1988","journal-title":"J. Pharmacol. Exp. Therap."},{"key":"10.1016\/j.tips.2005.06.006_bib70","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1021\/jm0255872","article-title":"Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands","volume":"46","author":"Descamps-Fran\u00e7ois","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.tips.2005.06.006_bib71","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neuropharm.2004.09.007","article-title":"Neurochemical properties of ramelteon (TAK-375), a selective MT1\/MT2 receptor agonist","volume":"48","author":"Kato","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.tips.2005.06.006_bib72","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/0003-9861(91)90142-6","article-title":"1-Methyl-DL-tryptophan, beta-(3-benzofuranyl)-DL-alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-DL-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase","volume":"291","author":"Cady","year":"1991","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tips.2005.06.006_bib73","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0165-6147(96)81563-X","article-title":"Combinatorial peptide synthesis: statistical evaluation of the peptide distribution and its relation to library size and resin bead quantities","volume":"17","author":"Boutin","year":"1996","journal-title":"Trends Pharmacol. Sci."}],"container-title":["Trends in Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614705001525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614705001525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T08:45:34Z","timestamp":1706345134000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165614705001525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":73,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S0165614705001525"],"URL":"https:\/\/doi.org\/10.1016\/j.tips.2005.06.006","relation":{},"ISSN":["0165-6147"],"issn-type":[{"value":"0165-6147","type":"print"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}