{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:18:55Z","timestamp":1791296335600,"version":"4.1.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Pharmacological Sciences"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.tips.2012.07.004","type":"journal-article","created":{"date-parts":[[2012,8,15]],"date-time":"2012-08-15T03:03:56Z","timestamp":1344999836000},"page":"583-590","source":"Crossref","is-referenced-by-count":147,"title":["Platelet GPVI: a target for antithrombotic therapy?!"],"prefix":"10.1016","volume":"33","author":[{"given":"Sebastian","family":"D\u00fctting","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Bender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Nieswandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tips.2012.07.004_bib0005","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nrd2957","article-title":"Antiplatelet therapies for the treatment of cardiovascular disease","volume":"9","author":"Michelson","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.tips.2012.07.004_bib0010","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.2515","article-title":"Arterial thrombosis \u2013 insidious, unpredictable and deadly","volume":"17","author":"Jackson","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.tips.2012.07.004_bib0015","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1113\/jphysiol.2011.212886","article-title":"Ischaemic stroke: a thrombo-inflammatory disease?","volume":"589","author":"Nieswandt","year":"2011","journal-title":"J. Physiol."},{"issue":"Suppl. 1","key":"10.1016\/j.tips.2012.07.004_bib0020","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1538-7836.2011.04361.x","article-title":"Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke","volume":"9","author":"Nieswandt","year":"2011","journal-title":"J. Thromb. Haemost."},{"issue":"Suppl. 1","key":"10.1016\/j.tips.2012.07.004_bib0025","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1538-7836.2011.04355.x","article-title":"Molecular mechanism of inside-out integrin regulation","volume":"9","author":"Ye","year":"2011","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.tips.2012.07.004_bib0030","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1161\/ATVBAHA.110.207522","article-title":"Signaling during platelet adhesion and activation","volume":"30","author":"Li","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tips.2012.07.004_bib0035","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nm.1955","article-title":"A shear gradient-dependent platelet aggregation mechanism drives thrombus formation","volume":"15","author":"Nesbitt","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.tips.2012.07.004_bib0040","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1182\/blood-2002-12-3882","article-title":"Platelet-collagen interaction: is GPVI the central receptor?","volume":"102","author":"Nieswandt","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0045","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1111\/j.1538-7836.2010.03875.x","article-title":"GPVI and CLEC-2 in hemostasis and vascular integrity","volume":"8","author":"Watson","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.tips.2012.07.004_bib0050","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ceca.2011.04.002","article-title":"STIM and Orai in platelet function","volume":"50","author":"Varga-Szabo","year":"2011","journal-title":"Cell Calcium"},{"key":"10.1016\/j.tips.2012.07.004_bib0055","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1182\/blood-2009-07-230268","article-title":"Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis: implications for thrombus formation","volume":"115","author":"Schulz","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0060","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00281-011-0288-2","article-title":"The procoagulant and proinflammatory plasma contact system","volume":"34","author":"Renne","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.tips.2012.07.004_bib0065","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1161\/ATVBAHA.107.155952","article-title":"Intrinsic pathway of coagulation and arterial thrombosis","volume":"27","author":"Gailani","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tips.2012.07.004_bib0070","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1172\/JCI114318","article-title":"A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion","volume":"84","author":"Moroi","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tips.2012.07.004_bib0075","doi-asserted-by":"crossref","first-page":"29019","DOI":"10.1074\/jbc.274.41.29019","article-title":"The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to Fc\u03b1R and the natural killer receptors","volume":"274","author":"Clemetson","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2012.07.004_bib0080","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1182\/blood.V96.5.1798","article-title":"Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily","volume":"96","author":"Jandrot-Perrus","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0085","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/j.1538-7836.2007.02449.x","article-title":"Glycoprotein VI oligomerization in cell lines and platelets","volume":"5","author":"Berlanga","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.tips.2012.07.004_bib0090","doi-asserted-by":"crossref","first-page":"46197","DOI":"10.1074\/jbc.M204029200","article-title":"Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen","volume":"277","author":"Miura","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2012.07.004_bib0095","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1182\/blood-2006-01-010215","article-title":"Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI","volume":"108","author":"Horii","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0100","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1074\/jbc.M606479200","article-title":"Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet glycoprotein VI contains two glycine-proline-hydroxyproline triplets","volume":"282","author":"Smethurst","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2012.07.004_bib0105","doi-asserted-by":"crossref","first-page":"30434","DOI":"10.1074\/jbc.M701330200","article-title":"Ligand binding rapidly induces disulfide-dependent dimerization of glycoprotein VI on the platelet plasma membrane","volume":"282","author":"Arthur","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2012.07.004_bib0110","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1161\/ATVBAHA.111.241067","article-title":"Platelet glycoprotein VI dimerization, an active process inducing receptor competence, is an indicator of platelet reactivity","volume":"32","author":"Loyau","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tips.2012.07.004_bib0115","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1161\/ATVBAHA.111.243402","article-title":"Better safe than sorry: glycoprotein VI dimerization as a novel checkpoint and early biomarker of platelet activation","volume":"32","author":"Dutting","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tips.2012.07.004_bib0120","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1182\/blood-2003-01-0308","article-title":"Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody","volume":"103","author":"Smethurst","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0125","doi-asserted-by":"crossref","first-page":"52293","DOI":"10.1074\/jbc.M406342200","article-title":"Identification of residues within human glycoprotein VI involved in the binding to collagen: evidence for the existence of distinct binding sites","volume":"279","author":"Lecut","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2012.07.004_bib0130","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1111\/j.1538-7836.2007.02590.x","article-title":"Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases","volume":"5","author":"Gardiner","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.tips.2012.07.004_bib0135","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2141.2007.06799.x","article-title":"Platelet glycoprotein VI-related clinical defects","volume":"139","author":"Arthur","year":"2007","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tips.2012.07.004_bib0140","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1182\/blood-2009-03-213504","article-title":"Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations","volume":"114","author":"Dumont","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0145","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1111\/j.1538-7836.2009.03520.x","article-title":"A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder","volume":"7","author":"Hermans","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.tips.2012.07.004_bib0150","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1182\/blood-2003-03-0717","article-title":"The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion","volume":"102","author":"Kato","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0155","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.thromres.2005.08.001","article-title":"GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism","volume":"118","author":"Lockyer","year":"2006","journal-title":"Thromb. Res."},{"key":"10.1016\/j.tips.2012.07.004_bib0160","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/j.1538-7836.2011.04328.x","article-title":"Genetic and antibody-induced glycoprotein VI deficiency equally protects mice from mechanically and FeCl(3)-induced thrombosis","volume":"9","author":"Bender","year":"2011","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.tips.2012.07.004_bib0165","doi-asserted-by":"crossref","first-page":"23998","DOI":"10.1074\/jbc.M003803200","article-title":"Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcR\u03b3 chain","volume":"275","author":"Nieswandt","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2012.07.004_bib0170","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1084\/jem.193.4.459","article-title":"Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice","volume":"193","author":"Nieswandt","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tips.2012.07.004_bib0175","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1084\/jem.20020945","article-title":"A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo","volume":"197","author":"Massberg","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tips.2012.07.004_bib0180","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1538-7836.2011.04218.x","article-title":"Mechanisms underlying FeCl3-induced arterial thrombosis","volume":"9","author":"Eckly","year":"2011","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.tips.2012.07.004_bib0185","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/clpt.2009.98","article-title":"New antithrombotic drugs","volume":"86","author":"Gross","year":"2009","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.tips.2012.07.004_bib0190","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1182\/blood-2005-10-4244","article-title":"Thrombin overcomes the thrombosis defect associated with platelet GPVI\/FcR\u03b3 deficiency","volume":"107","author":"Mangin","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0195","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1096\/fj.04-2748com","article-title":"Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI","volume":"19","author":"Penz","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.tips.2012.07.004_bib0200","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.atherosclerosis.2004.12.037","article-title":"Contribution of platelet glycoprotein VI to the thrombogenic effect of collagens in fibrous atherosclerotic lesions","volume":"181","author":"Cosemans","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.tips.2012.07.004_bib0205","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.jacc.2009.11.051","article-title":"A 2-step mechanism of arterial thrombus formation induced by human atherosclerotic plaques","volume":"55","author":"Reininger","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.tips.2012.07.004_bib0210","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1538-7836.2008.03186.x","article-title":"Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model","volume":"7","author":"Kuijpers","year":"2009","journal-title":"J. Thromb. Haemost."},{"issue":"Suppl. 1","key":"10.1016\/j.tips.2012.07.004_bib0215","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1160\/THS10-11-0730","article-title":"Comparison of two murine models of thrombosis induced by atherosclerotic plaque injury","volume":"105","author":"Hechler","year":"2011","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.tips.2012.07.004_bib0220","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1468-1331.2009.02754.x","article-title":"Expression of platelet glycoprotein VI is associated with transient ischemic attack and stroke","volume":"17","author":"Bigalke","year":"2010","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.tips.2012.07.004_bib0225","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1161\/STROKEAHA.110.602532","article-title":"Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke","volume":"42","author":"Al-Tamimi","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.tips.2012.07.004_bib0230","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1161\/CIRCULATIONAHA.107.691279","article-title":"Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb\/IIIa blockade on infarct size, functional outcome, and intracranial bleeding","volume":"115","author":"Kleinschnitz","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.tips.2012.07.004_bib0235","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1749-6632.2010.05730.x","article-title":"Combating innate inflammation: a new paradigm for acute treatment of stroke?","volume":"1207","author":"Stoll","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.tips.2012.07.004_bib0240","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1182\/blood-2010-03-276311","article-title":"von Willebrand factor promotes leukocyte extravasation","volume":"116","author":"Petri","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0245","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1182\/blood-2009-11-252643","article-title":"Platelet interleukin-1\u03b1 drives cerebrovascular inflammation","volume":"115","author":"Thornton","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0250","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.cell.2009.11.001","article-title":"Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo","volume":"139","author":"Muller","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.tips.2012.07.004_bib0255","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1126\/science.1181928","article-title":"Platelets amplify inflammation in arthritis via collagen-dependent microparticle production","volume":"327","author":"Boilard","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.tips.2012.07.004_bib0260","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1161\/ATVBAHA.110.207480","article-title":"Platelet\u2013leukocyte interactions in cardiovascular disease and beyond","volume":"30","author":"Totani","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tips.2012.07.004_bib0265","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2353\/ajpath.2010.091143","article-title":"Platelet recruitment to the inflamed glomerulus occurs via an \u03b1IIb\u03b23\/GPVI-dependent pathway","volume":"177","author":"Devi","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tips.2012.07.004_bib0270","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/cvr\/cvn169","article-title":"The immunoadhesin glycoprotein VI-Fc regulates arterial remodelling after mechanical injury in ApoE\u2212\/\u2212 mice","volume":"80","author":"Schonberger","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tips.2012.07.004_bib0275","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.yjmcc.2010.04.009","article-title":"Impact of glycoprotein VI and platelet adhesion on atherosclerosis \u2013 a possible role of fibronectin","volume":"49","author":"Bultmann","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.tips.2012.07.004_bib0280","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1161\/ATVBAHA.110.207514","article-title":"Platelets: linking hemostasis and cancer","volume":"30","author":"Jain","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tips.2012.07.004_bib0285","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1111\/j.1538-7836.2009.03559.x","article-title":"Platelet glycoprotein VI facilitates experimental lung metastasis in syngenic mouse models","volume":"7","author":"Jain","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.tips.2012.07.004_bib0290","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1161\/ATVBAHA.107.140590","article-title":"The Fab fragment of a novel anti-GPVI monoclonal antibody, OM4, reduces in vivo thrombosis without bleeding risk in rats","volume":"27","author":"Li","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tips.2012.07.004_bib0295","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1160\/TH06-05-0266","article-title":"Ex vivo evaluation of anti-GPVI antibody in cynomolgus monkeys: dissociation between anti-platelet aggregatory effect and bleeding time","volume":"96","author":"Matsumoto","year":"2006","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.tips.2012.07.004_bib0300","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/j.1538-7836.2008.02976.x","article-title":"Ex vivo inhibition of thrombus formation by an anti-glycoprotein VI Fab fragment in non-human primates without modification of glycoprotein VI expression","volume":"6","author":"Ohlmann","year":"2008","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.tips.2012.07.004_bib0305","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1182\/blood-2005-07-2937","article-title":"Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: development of a novel NOD\/SCID mouse model to evaluate the in vivo effectiveness of anti-human platelet agents","volume":"108","author":"Boylan","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0310","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1182\/blood-2006-11-058107","article-title":"Diverging signaling events control the pathway of GPVI down-regulation in vivo","volume":"110","author":"Rabie","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0315","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1182\/blood-2010-06-289108","article-title":"Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases","volume":"116","author":"Bender","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0320","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1182\/blood-2010-08-301523","article-title":"Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa","volume":"117","author":"Al-Tamimi","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0325","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1182\/blood-2011-10-386607","article-title":"Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels","volume":"119","author":"Al-Tamimi","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0330","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1182\/blood-2010-03-274969","article-title":"PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model","volume":"117","author":"Reilly","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0335","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1182\/asheducation-2010.1.265","article-title":"Signal transduction inhibitor therapy for lymphoma","volume":"2010","author":"Witzig","year":"2010","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"key":"10.1016\/j.tips.2012.07.004_bib0340","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1096\/fj.03-0464fje","article-title":"Soluble glycoprotein VI dimer inhibits platelet adhesion and aggregation to the injured vessel wall in vivo","volume":"18","author":"Massberg","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.tips.2012.07.004_bib0345","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1161\/CIRCULATIONAHA.110.980623","article-title":"Novel antiplatelet drug revacept (dimeric glycoprotein VI-Fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general hemostasis in humans","volume":"123","author":"Ungerer","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.tips.2012.07.004_bib0350","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1182\/blood-2004-06-2391","article-title":"Relative antithrombotic effect of soluble GPVI dimer compared with anti-GPVI antibodies in mice","volume":"105","author":"Gruner","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0355","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1161\/01.CIR.0000146341.63677.3C","article-title":"Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced \u03b12\u03b21 levels or concomitant aspirin therapy","volume":"110","author":"Gr\u00fcner","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.tips.2012.07.004_bib0360","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1182\/blood-2005-05-1994","article-title":"A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2","volume":"107","author":"Suzuki-Inoue","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0365","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1182\/blood-2007-09-111369","article-title":"The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6\u2212\/\u2212 mice","volume":"111","author":"Cheli","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0370","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1124\/jpet.111.189050","article-title":"A humanized glycoprotein VI (GPVI) mouse model to assess the antithrombotic efficacies of anti-GPVI agents","volume":"341","author":"Mangin","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tips.2012.07.004_bib0375","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1182\/blood-2005-09-3687","article-title":"Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo","volume":"107","author":"Dubois","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.tips.2012.07.004_bib0380","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1182\/blood.V69.6.1712.1712","article-title":"A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia","volume":"69","author":"Sugiyama","year":"1987","journal-title":"Blood"}],"container-title":["Trends in Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614712001290?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614712001290?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T15:38:28Z","timestamp":1594568308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165614712001290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":76,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0165614712001290"],"URL":"https:\/\/doi.org\/10.1016\/j.tips.2012.07.004","relation":{},"ISSN":["0165-6147"],"issn-type":[{"value":"0165-6147","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}