{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:30:26Z","timestamp":1780385426843,"version":"3.54.1"},"reference-count":108,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Pharmacological Sciences"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.tips.2012.08.002","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T05:07:10Z","timestamp":1347426430000},"page":"602-610","source":"Crossref","is-referenced-by-count":96,"title":["Target-based selection of flavonoids for neurodegenerative disorders"],"prefix":"10.1016","volume":"33","author":[{"given":"Quinton R.D.","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Warford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.P. Vasantha","family":"Rupasinghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George S.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tips.2012.08.002_bib0005","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.tips.2012.08.002_bib0010","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.molcel.2009.02.013","article-title":"PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death","volume":"33","author":"Gandhi","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tips.2012.08.002_bib0015","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1093\/hmg\/ddq288","article-title":"Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics","volume":"19","author":"Irrcher","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tips.2012.08.002_bib0020","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.mito.2004.07.040","article-title":"Mitochondrial dysfunction in hearing loss","volume":"4","author":"Fischel-Ghodsian","year":"2004","journal-title":"Mitochondrion"},{"key":"10.1016\/j.tips.2012.08.002_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/845618","article-title":"Classic and new animal models of Parkinson's disease","volume":"2012","author":"Blesa","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.tips.2012.08.002_bib0030","doi-asserted-by":"crossref","first-page":"F505","DOI":"10.1152\/ajprenal.90545.2008","article-title":"The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity","volume":"296","author":"Pabla","year":"2009","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.tips.2012.08.002_bib0035","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.2353\/ajpath.2010.090610","article-title":"Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions","volume":"176","author":"Ciarimboli","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tips.2012.08.002_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2011.10.019","article-title":"Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy","volume":"291","author":"Jaggi","year":"2012","journal-title":"Toxicology"},{"key":"10.1016\/j.tips.2012.08.002_bib0045","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1523\/JNEUROSCI.6054-09.2010","article-title":"Roles of NADPH oxidases in cisplatin-induced reactive oxygen species generation and ototoxicity","volume":"30","author":"Kim","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tips.2012.08.002_bib0050","doi-asserted-by":"crossref","first-page":"228","DOI":"10.2165\/00002018-199513040-00003","article-title":"Comparative adverse effect profiles of platinum drugs","volume":"13","author":"McKeage","year":"1995","journal-title":"Drug Saf."},{"key":"10.1016\/j.tips.2012.08.002_bib0055","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00262741","article-title":"Very high-dose cisplatin-induced ototoxicity: a preliminary report on early and long-term effects","volume":"21","author":"Pollera","year":"1988","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.tips.2012.08.002_bib0060","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/pbc.24138","article-title":"Risk factors for cisplatin-associated ototoxicity in pediatric oncology patients","volume":"59","author":"Yancey","year":"2012","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.tips.2012.08.002_bib0065","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/ng.478","article-title":"Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy","volume":"41","author":"Ross","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tips.2012.08.002_bib0070","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1474-9726.2008.00418.x","article-title":"Mitochondrial iron accumulation with age and functional consequences","volume":"7","author":"Seo","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/j.tips.2012.08.002_bib0075","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.bbagen.2009.04.012","article-title":"Response to the increase of oxidative stress and mutation of mitochondrial DNA in aging","volume":"1790","author":"Ma","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tips.2012.08.002_bib0080","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.tips.2012.03.008","article-title":"NADPH oxidases: novel therapeutic targets for neurodegenerative diseases","volume":"33","author":"Gao","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.tips.2012.08.002_bib0085","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nn.2334","article-title":"NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation","volume":"12","author":"Brennan","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tips.2012.08.002_bib0090","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1161\/01.ATV.0000170827.16296.6e","article-title":"Regulation of xanthine oxidoreductase protein expression by hydrogen peroxide and calcium","volume":"25","author":"McNally","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tips.2012.08.002_bib0095","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1523\/JNEUROSCI.4468-06.2007","article-title":"Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation","volume":"27","author":"Abramov","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tips.2012.08.002_bib0100","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1253\/circj.67.781","article-title":"Allopurinol improves cardiac dysfunction after ischemia-reperfusion via reduction of oxidative stress in isolated perfused rat hearts","volume":"67","author":"Kinugasa","year":"2003","journal-title":"Circ. J."},{"key":"10.1016\/j.tips.2012.08.002_bib0105","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.brainres.2009.09.061","article-title":"Xanthine oxidase is one of the major sources of superoxide anion radicals in blood after reperfusion in rats with forebrain ischemia\/reperfusion","volume":"1305","author":"Ono","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.tips.2012.08.002_bib0110","doi-asserted-by":"crossref","first-page":"9500","DOI":"10.1523\/JNEUROSCI.1544-10.2010","article-title":"Role of the copper transporter, CTR1, in platinum-induced ototoxicity","volume":"30","author":"More","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tips.2012.08.002_bib0115","first-page":"35","article-title":"Cellular pharmacology of cisplatin: perspectives on mechanisms of acquired resistance","volume":"2","author":"Andrews","year":"1990","journal-title":"Cancer Cells"},{"key":"10.1016\/j.tips.2012.08.002_bib0120","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0022-3565(24)36493-6","article-title":"Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain","volume":"280","author":"Kruidering","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tips.2012.08.002_bib0125","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3109\/10408441003601836","article-title":"The relationship between cisplatin-induced reactive oxygen species, glutathione, and BCL-2 and resistance to cisplatin","volume":"40","author":"Brozovic","year":"2010","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.tips.2012.08.002_bib0130","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.freeradbiomed.2011.11.001","article-title":"Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy","volume":"52","author":"Mukhopadhyay","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tips.2012.08.002_bib0135","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.freeradbiomed.2011.06.033","article-title":"Cross talk between mitochondria and NADPH oxidases","volume":"51","author":"Dikalov","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tips.2012.08.002_bib0140","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1089\/ars.2010.3110","article-title":"Transtympanic administration of short interfering (si)RNA for the NOX3 isoform of NADPH oxidase protects against cisplatin-induced hearing loss in the rat","volume":"13","author":"Mukherjea","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.tips.2012.08.002_bib0145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.heares.2004.08.002","article-title":"Reduction of acute cisplatin ototoxicity and nephrotoxicity in rats by oral administration of allopurinol and ebselen","volume":"201","author":"Lynch","year":"2005","journal-title":"Hear. Res."},{"key":"10.1016\/j.tips.2012.08.002_bib0150","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/cr.2011.27","article-title":"Cisplatin ototoxicity involves cytokines and STAT6 signaling network","volume":"21","author":"Kim","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.tips.2012.08.002_bib0155","doi-asserted-by":"crossref","first-page":"e180","DOI":"10.1038\/cddis.2011.63","article-title":"Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation","volume":"2","author":"Kaur","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tips.2012.08.002_bib0160","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1172\/JCI200215606","article-title":"TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity","volume":"110","author":"Ramesh","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tips.2012.08.002_bib0165","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/taap.2001.9171","article-title":"Cisplatin ototoxicity: involvement of iron and enhanced formation of superoxide anion radicals","volume":"174","author":"Dehne","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tips.2012.08.002_bib0170","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s12263-007-0056-z","article-title":"The interactions of flavonoids within neuronal signalling pathways","volume":"2","author":"Spencer","year":"2007","journal-title":"Genes Nutr."},{"key":"10.1016\/j.tips.2012.08.002_bib0175","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1212\/01.wnl.0000278116.37320.52","article-title":"Dietary patterns and risk of dementia: the Three-City cohort study","volume":"69","author":"Barberger-Gateau","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.tips.2012.08.002_bib0180","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1161\/STROKEAHA.111.637835","article-title":"Dietary flavonoids and risk of stroke in women","volume":"43","author":"Cassidy","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.tips.2012.08.002_bib0185","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1001\/jama.1995.03520380049034","article-title":"Protective effect of fruits and vegetables on development of stroke in men","volume":"273","author":"Gillman","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.tips.2012.08.002_bib0190","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1212\/WNL.0b013e31824f7fc4","article-title":"Habitual intake of dietary flavonoids and risk of Parkinson disease","volume":"78","author":"Gao","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.tips.2012.08.002_bib0195","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jchromb.2005.05.009","article-title":"Liquid chromatography-tandem mass spectroscopy assay for quercetin and conjugated quercetin metabolites in human plasma and urine","volume":"821","author":"Wang","year":"2005","journal-title":"J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.tips.2012.08.002_bib0200","doi-asserted-by":"crossref","first-page":"230S","DOI":"10.1093\/ajcn\/81.1.230S","article-title":"Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies","volume":"81","author":"Manach","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tips.2012.08.002_bib0205","first-page":"105","article-title":"Pharmacokinetic and chemoprevention studies on tea in humans","volume":"64","author":"Chow","year":"2011","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.tips.2012.08.002_bib0210","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1017\/S000711451000053X","article-title":"Oral bioavailability of quercetin from different quercetin glycosides in dogs","volume":"104","author":"Reinboth","year":"2010","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.tips.2012.08.002_bib0215","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1093\/ajcn\/62.6.1276","article-title":"Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers","volume":"62","author":"Hollman","year":"1995","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tips.2012.08.002_bib0220","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000089640","article-title":"Characteristics of (+)-catechin and (-)-epicatechin transport across pig intestinal brush border membranes","volume":"50","author":"Starp","year":"2006","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.tips.2012.08.002_bib0225","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/S0891-5849(00)00416-0","article-title":"Conjugation position of quercetin glucuronides and effect on biological activity","volume":"29","author":"Day","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tips.2012.08.002_bib0230","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0014-5793(98)01101-6","article-title":"Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity","volume":"436","author":"Day","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tips.2012.08.002_bib0235","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/mnfr.201100596","article-title":"Flavone deglycosylation increases their anti-inflammatory activity and absorption","volume":"56","author":"Hostetler","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.tips.2012.08.002_bib0240","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.abb.2003.11.010","article-title":"Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity","volume":"423","author":"Spencer","year":"2004","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tips.2012.08.002_bib0245","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/jsfa.5697","article-title":"The flavonoid paradox: conjugation and deconjugation as key steps for the biological activity of flavonoids","volume":"92","author":"Perez-Vizcaino","year":"2012","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.tips.2012.08.002_bib0250","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0076-6879(05)00015-7","article-title":"Glucuronidase deconjugation in inflammation","volume":"400","author":"Shimoi","year":"2005","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.tips.2012.08.002_bib0255","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0014-5793(01)02684-9","article-title":"Flavonoid glucuronides are substrates for human liver beta-glucuronidase","volume":"503","author":"O\u2019Leary","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tips.2012.08.002_bib0260","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1055\/s-0030-1249962","article-title":"Plasma levels and distribution of flavonoids in rat brain after single and repeated doses of standardized Ginkgo biloba extract EGb 761(R)","volume":"76","author":"Rangel-Ordonez","year":"2010","journal-title":"Planta Med."},{"key":"10.1016\/j.tips.2012.08.002_bib0265","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/jn\/138.8.1417","article-title":"Tissue distribution of quercetin in pigs after long-term dietary supplementation","volume":"138","author":"Bieger","year":"2008","journal-title":"J. Nutr."},{"key":"10.1016\/j.tips.2012.08.002_bib0270","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1093\/jn\/137.11.2405","article-title":"Quercetin reduces blood pressure in hypertensive subjects","volume":"137","author":"Edwards","year":"2007","journal-title":"J. Nutr."},{"key":"10.1016\/j.tips.2012.08.002_bib0275","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/sj.bjp.0704064","article-title":"Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats","volume":"133","author":"Duarte","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tips.2012.08.002_bib0280","doi-asserted-by":"crossref","first-page":"e32673","DOI":"10.1371\/journal.pone.0032673","article-title":"Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation","volume":"7","author":"Galindo","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tips.2012.08.002_bib0285","doi-asserted-by":"crossref","first-page":"9424","DOI":"10.1074\/jbc.M706571200","article-title":"Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids","volume":"283","author":"Kawai","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2012.08.002_bib0290","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jchromb.2005.12.043","article-title":"Determination of St. John's wort flavonoid-metabolites in rat brain through high performance liquid chromatography coupled with fluorescence detection","volume":"832","author":"Paulke","year":"2006","journal-title":"J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.tips.2012.08.002_bib0295","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1021\/jf050145v","article-title":"Anthocyanin metabolism in rats and their distribution to digestive area, kidney, and brain","volume":"53","author":"Talavera","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tips.2012.08.002_bib0300","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0891-5849(02)01137-1","article-title":"Uptake and metabolism of epicatechin and its access to the brain after oral ingestion","volume":"33","author":"Abd El Mohsen","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tips.2012.08.002_bib0305","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1523\/JNEUROSCI.0364-08.2008","article-title":"Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease","volume":"28","author":"Wang","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tips.2012.08.002_bib0310","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1523\/JNEUROSCI.1521-05.2005","article-title":"Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice","volume":"25","author":"Rezai-Zadeh","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tips.2012.08.002_bib0315","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.1523\/JNEUROSCI.6437-11.2012","article-title":"Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment","volume":"32","author":"Wang","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tips.2012.08.002_bib0320","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.freeradbiomed.2004.01.001","article-title":"Flavonoids: antioxidants or signalling molecules?","volume":"36","author":"Williams","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tips.2012.08.002_bib0325","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12263-009-0136-3","article-title":"Flavonoids and brain health: multiple effects underpinned by common mechanisms","volume":"4","author":"Spencer","year":"2009","journal-title":"Genes Nutr."},{"key":"10.1016\/j.tips.2012.08.002_bib0330","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.cell.2006.09.024","article-title":"Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators","volume":"127","author":"St-Pierre","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.tips.2012.08.002_bib0335","doi-asserted-by":"crossref","first-page":"e28280","DOI":"10.1371\/journal.pone.0028280","article-title":"Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3\u2032,4\u2032-hexamethoxyflavone: promotion of neurite outgrowth via cAMP\/PKA\/CREB pathway in PC12 cells","volume":"6","author":"Lai","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tips.2012.08.002_bib0340","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/0264-6021:3510095","article-title":"Specificity and mechanism of action of some commonly used protein kinase inhibitors","volume":"351","author":"Davies","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.tips.2012.08.002_bib0345","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3233\/JAD-2009-1189","article-title":"Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons","volume":"18","author":"Tchantchou","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.tips.2012.08.002_bib0350","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/j.1476-5381.2010.01143.x","article-title":"The flavonoid baicalein promotes NMDA receptor-dependent long-term potentiation and enhances memory","volume":"162","author":"Wang","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tips.2012.08.002_bib0355","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10637-008-9114-7","article-title":"Inhibitory effects of quercetin derivatives on phosphodiesterase isozymes and high-affinity [(3) H]-rolipram binding in guinea pig tissues","volume":"26","author":"Chan","year":"2008","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.tips.2012.08.002_bib0360","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1055\/s-2004-835838","article-title":"Suppressive effects of 3-O-methylquercetin on ovalbumin-induced airway hyperresponsiveness","volume":"70","author":"Ko","year":"2004","journal-title":"Planta Med."},{"key":"10.1016\/j.tips.2012.08.002_bib0365","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.tcb.2008.09.006","article-title":"Control of mitochondria dynamics and oxidative metabolism by cAMP, AKAPs and the proteasome","volume":"18","author":"Carlucci","year":"2008","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.tips.2012.08.002_bib0370","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1177\/153537020623100802","article-title":"Flavonoids attenuate cardiovascular disease, inhibit phosphodiesterase, and modulate lipid homeostasis in adipose tissue and liver","volume":"231","author":"Peluso","year":"2006","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.tips.2012.08.002_bib0375","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cell.2012.01.017","article-title":"Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases","volume":"148","author":"Park","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.tips.2012.08.002_bib0380","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/j.bcp.2004.06.030","article-title":"Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships","volume":"68","author":"Ko","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tips.2012.08.002_bib0385","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/0006-2952(92)90531-M","article-title":"Effects of flavonoids on cyclic AMP phosphodiesterase and lipid mobilization in rat adipocytes","volume":"44","author":"Kuppusamy","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tips.2012.08.002_bib0390","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-3-642-17969-3_2","article-title":"Phosphodiesterase inhibitors: factors that influence potency, selectivity, and action","volume":"204","author":"Francis","year":"2011","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.tips.2012.08.002_bib0395","doi-asserted-by":"crossref","first-page":"472897","DOI":"10.1155\/2012\/472897","article-title":"Hesperetin, a selective phosphodiesterase 4 inhibitor, effectively suppresses ovalbumin-induced airway hyperresponsiveness without influencing xylazine\/ketamine-induced anesthesia","volume":"2012","author":"Shih","year":"2012","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.tips.2012.08.002_bib0400","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ejphar.2009.10.031","article-title":"Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine\/ketamine-induced anesthesia","volume":"627","author":"Yu","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.tips.2012.08.002_bib0405","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-3-540-68964-5_5","article-title":"Phosphodiesterases in the central nervous system","volume":"191","author":"Kleppisch","year":"2009","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.tips.2012.08.002_bib0410","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1523\/JNEUROSCI.5236-10.2011","article-title":"Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling","volume":"31","author":"Li","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tips.2012.08.002_bib0415","first-page":"617472","article-title":"Mitochondrial dysfunction in Parkinson's disease: pathogenesis and neuroprotection","volume":"2011","author":"Mounsey","year":"2010","journal-title":"Parkinsons Dis."},{"key":"10.1016\/j.tips.2012.08.002_bib0420","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.2174\/092986711797535254","article-title":"Ototoxicity: mechanisms of cochlear impairment and its prevention","volume":"18","author":"Tabuchi","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.tips.2012.08.002_bib0425","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.bbabio.2011.09.022","article-title":"Complex I and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria","volume":"1807","author":"Lagoa","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tips.2012.08.002_bib0430","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jnutbio.2009.01.014","article-title":"Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid","volume":"21","author":"Fiorani","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.tips.2012.08.002_bib0435","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cbi.2012.05.006","article-title":"Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action","volume":"199","author":"Sandoval-Acuna","year":"2012","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tips.2012.08.002_bib0440","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.abb.2007.10.012","article-title":"Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase","volume":"469","author":"Steffen","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tips.2012.08.002_bib0445","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1021\/np970237h","article-title":"Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers","volume":"61","author":"Cos","year":"1998","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.tips.2012.08.002_bib0450","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0006-2952(93)90371-3","article-title":"Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures","volume":"45","author":"Morel","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tips.2012.08.002_bib0455","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1002\/jcb.21588","article-title":"Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha\/2alpha is mediated through chelation of iron","volume":"103","author":"Park","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.tips.2012.08.002_bib0460","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1124\/mol.107.034041","article-title":"Quercetin activates an angiogenic pathway, hypoxia inducible factor (HIF)-1-vascular endothelial growth factor, by inhibiting HIF-prolyl hydroxylase: a structural analysis of quercetin for inhibiting HIF-prolyl hydroxylase","volume":"71","author":"Jeon","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tips.2012.08.002_bib0465","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1089\/ars.2008.2215","article-title":"Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective antiapoptotic effect against inducers of mitochondrial oxidative stress in neurons","volume":"11","author":"Schroeder","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.tips.2012.08.002_bib0470","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1097\/MAO.0b013e3180430163","article-title":"Ginkgo biloba extract (EGb 761) protects against cisplatin-induced ototoxicity in rats","volume":"28","author":"Huang","year":"2007","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.tips.2012.08.002_bib0475","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1523\/JNEUROSCI.5842-08.2009","article-title":"Cisplatin-induced hair cell death requires STAT1 and is attenuated by epigallocatechin gallate","volume":"29","author":"Schmitt","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tips.2012.08.002_bib0480","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1007\/s10495-008-0242-5","article-title":"Epicatechin protects auditory cells against cisplatin-induced death","volume":"13","author":"Kim","year":"2008","journal-title":"Apoptosis"},{"key":"10.1016\/j.tips.2012.08.002_bib0485","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.toxlet.2010.09.013","article-title":"Epicatechin protects the auditory organ by attenuating cisplatin-induced ototoxicity through inhibition of ERK","volume":"199","author":"Lee","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tips.2012.08.002_bib0490","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1096\/fj.05-5269com","article-title":"Polyphenols enhance platelet nitric oxide by inhibiting protein kinase C-dependent NADPH oxidase activation: effect on platelet recruitment","volume":"20","author":"Pignatelli","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.tips.2012.08.002_bib0495","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.febslet.2008.12.037","article-title":"Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia\/reperfusion-induced injury","volume":"583","author":"Scarabelli","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tips.2012.08.002_bib0500","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00405-011-1582-2","article-title":"Reduction of cisplatin ototoxicity in rats by oral administration of pomegranate extract","volume":"269","author":"Yazici","year":"2012","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.tips.2012.08.002_bib0505","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jchromb.2008.09.005","article-title":"Determination of baicalin in rat cerebrospinal fluid and blood using microdialysis coupled with ultra-performance liquid chromatography-tandem mass spectrometry","volume":"874","author":"Huang","year":"2008","journal-title":"J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.tips.2012.08.002_bib0510","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.neulet.2009.12.009","article-title":"Effect of baicalein from Scutellaria baicalensis on prevention of noise-induced hearing loss","volume":"469","author":"Kang","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tips.2012.08.002_bib0515","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s12325-010-0083-9","article-title":"Efficacy and safety of flavocoxid compared with naproxen in subjects with osteoarthritis of the knee- a subset analysis","volume":"27","author":"Levy","year":"2010","journal-title":"Adv. Ther."},{"key":"10.1016\/j.tips.2012.08.002_bib0520","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ejphar.2009.10.038","article-title":"Luteolin promotes long-term potentiation and improves cognitive functions in chronic cerebral hypoperfused rats","volume":"627","author":"Xu","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.tips.2012.08.002_bib0525","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1089\/jmf.2007.591","article-title":"Luteolin suppresses cisplatin-induced apoptosis in auditory cells: possible mediation through induction of heme oxygenase-1 expression","volume":"11","author":"Choi","year":"2008","journal-title":"J. Med. Food"},{"key":"10.1016\/j.tips.2012.08.002_bib0530","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2147\/NDT.S22793","article-title":"Ginkgo biloba extract in the treatment of tinnitus: a systematic review","volume":"7","author":"von Boetticher","year":"2011","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.tips.2012.08.002_bib0535","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/1097-0215(20000815)87:4<595::AID-IJC21>3.0.CO;2-5","article-title":"Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential","volume":"87","author":"Caltagirone","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.tips.2012.08.002_bib0540","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/sj.bjc.6603994","article-title":"The effect of monohydroxyethylrutoside on doxorubicin-induced cardiotoxicity in patients treated for metastatic cancer in a phase II study","volume":"97","author":"Bruynzeel","year":"2007","journal-title":"Br. J. Cancer"}],"container-title":["Trends in Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614712001435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614712001435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T09:03:41Z","timestamp":1744103021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165614712001435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":108,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0165614712001435"],"URL":"https:\/\/doi.org\/10.1016\/j.tips.2012.08.002","relation":{},"ISSN":["0165-6147"],"issn-type":[{"value":"0165-6147","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}