{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:09:52Z","timestamp":1784819392093,"version":"3.55.0"},"reference-count":150,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Pharmacological Sciences"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.tips.2015.08.012","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T13:47:54Z","timestamp":1446644874000},"page":"891-905","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["NAMPT as a Therapeutic Target against Stroke"],"prefix":"10.1016","volume":"36","author":[{"given":"Pei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Yu","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tips.2015.08.012_bib0755","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0140-6736(10)60834-3","article-title":"Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study","volume":"376","author":"O\u2019Donnell","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.tips.2015.08.012_bib0760","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0140-6736(13)61953-4","article-title":"Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010","volume":"383","author":"Feigin","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.tips.2015.08.012_bib0765","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1038\/510S2a","article-title":"Statistics: a growing global burden","volume":"510","author":"Corbyn","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.tips.2015.08.012_bib0770","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1161\/STROKEAHA.111.635755","article-title":"Stroke and stroke care in China: huge burden, significant workload, and a national priority","volume":"42","author":"Liu","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.tips.2015.08.012_bib0775","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1161\/STROKEAHA.113.004075","article-title":"Found in translation preclinical stroke research predicts human pathophysiology, clinical phenotypes, and therapeutic outcomes","volume":"45","author":"Dirnagl","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.tips.2015.08.012_bib0780","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/aps.2012.107","article-title":"Role of neural precursor cells in promoting repair following stroke","volume":"34","author":"Dibajnia","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.tips.2015.08.012_bib0785","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1749-6632.2012.06691.x","article-title":"Pathobiology of injury after stroke: the neurovascular unit and beyond","volume":"1268","author":"Dirnagl","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.tips.2015.08.012_bib0790","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/ana.22236","article-title":"Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway","volume":"69","author":"Wang","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.tips.2015.08.012_bib0795","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.4161\/auto.29203","article-title":"ARRB1\/beta-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia","volume":"10","author":"Wang","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.tips.2015.08.012_bib0800","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.tips.2014.07.007","article-title":"Rethinking CNS disorders: time for new drug targets?","volume":"35","author":"Kalueff","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.tips.2015.08.012_bib0805","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0021-9258(18)64875-6","article-title":"Enzymatic synthesis of nicotinamide mononucleotide","volume":"225","author":"Preiss","year":"1957","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2015.08.012_bib0810","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1128\/JB.183.4.1168-1174.2001","article-title":"Identification of a plasmid-encoded gene from Haemophilus ducreyi which confers NAD independence","volume":"183","author":"Martin","year":"2001","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.tips.2015.08.012_bib0815","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1002\/1521-4141(200211)32:11<3225::AID-IMMU3225>3.0.CO;2-L","article-title":"Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis","volume":"32","author":"Rongvaux","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.tips.2015.08.012_bib0820","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1128\/MCB.14.2.1431","article-title":"Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor","volume":"14","author":"Samal","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tips.2015.08.012_bib0825","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1677\/jme.0.0260107","article-title":"Genomic organization of the gene coding for human pre-B-cell colony enhancing factor and expression in human fetal membranes","volume":"26","author":"Ognjanovic","year":"2001","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.tips.2015.08.012_bib0830","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10528-005-1505-2","article-title":"Molecular cloning and characterization of canine pre-B-cell colony-enhancing factor","volume":"43","author":"McGlothlin","year":"2005","journal-title":"Biochem. Genet."},{"key":"10.1016\/j.tips.2015.08.012_bib0835","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cmet.2007.09.003","article-title":"Nampt\/PBEF\/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme","volume":"6","author":"Revollo","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.tips.2015.08.012_bib0840","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/cvr\/cvn288","article-title":"Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide","volume":"81","author":"Wang","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tips.2015.08.012_bib0845","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/icb.2013.85","article-title":"Nicotinamide phosphoribosyltransferase (NAMPT) activity is essential for survival of resting lymphocytes","volume":"92","author":"Pittelli","year":"2014","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.tips.2015.08.012_bib0850","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1161\/01.RES.0000173298.38808.27","article-title":"Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation","volume":"97","author":"van der Veer","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.tips.2015.08.012_bib0855","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bbrc.2007.05.096","article-title":"Visfatin is released from 3T3-L1 adipocytes via a non-classical pathway","volume":"359","author":"Tanaka","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tips.2015.08.012_bib0860","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.bbrc.2009.11.066","article-title":"Nicotinamide phosphoribosyltransferase (NAMPT\/PBEF\/visfatin) is constitutively released from human hepatocytes","volume":"391","author":"Garten","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tips.2015.08.012_bib0865","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1007\/s00125-010-2042-z","article-title":"Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)\/pre-B cell colony (PBEF)\/visfatin linking obesity and inflammation in humans","volume":"54","author":"Friebe","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.tips.2015.08.012_bib0870","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1177\/1753425912439614","article-title":"Extracellular ATP induces P2X7-dependent nicotinamide phosphoribosyltransferase release in LPS-activated human monocytes","volume":"18","author":"Schilling","year":"2012","journal-title":"Innate Immun."},{"key":"10.1016\/j.tips.2015.08.012_bib0875","doi-asserted-by":"crossref","first-page":"e58767","DOI":"10.1371\/journal.pone.0058767","article-title":"Expression and regulation of nampt in human islets","volume":"8","author":"Kover","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tips.2015.08.012_bib0880","doi-asserted-by":"crossref","first-page":"H415","DOI":"10.1152\/ajpheart.00468.2012","article-title":"Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling","volume":"304","author":"Pillai","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tips.2015.08.012_bib0885","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/cns.12273","article-title":"Extracellular visfatin has nicotinamide phosphoribosyltransferase enzymatic activity and is neuroprotective against ischemic injury","volume":"20","author":"Zhao","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.tips.2015.08.012_bib0890","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/jcbfm.2014.119","article-title":"Neuronal NAMPT is released after cerebral ischemia and protects against white matter injury","volume":"34","author":"Jing","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tips.2015.08.012_bib0895","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1161\/STROKEAHA.115.009216","article-title":"Regenerative neurogenesis after ischemic stroke promoted by nicotinamide phosphoribosyltransferase\u2013nicotinamide adenine dinucleotide cascade","volume":"46","author":"Zhao","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.tips.2015.08.012_bib0900","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/j.1440-1681.2011.05598.x","article-title":"Introduction: Adipokines and cardiovascular disease","volume":"38","author":"Miao","year":"2011","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.tips.2015.08.012_bib0905","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tips.2015.04.014","article-title":"Adipokines in health and disease","volume":"36","author":"Fasshauer","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.tips.2015.08.012_bib0910","doi-asserted-by":"crossref","first-page":"5104","DOI":"10.1111\/febs.13050","article-title":"Novel assay for simultaneous measurement of pyridine mononucleotides synthesizing activities allows dissection of the NAD+ biosynthetic machinery in mammalian cells","volume":"281","author":"Zamporlini","year":"2014","journal-title":"FEBS J."},{"key":"10.1016\/j.tips.2015.08.012_bib0915","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.cmet.2015.04.002","article-title":"SIRT1-mediated eNAMPT secretion from adipose tissue regulates hypothalamic NAD+ and function in mice","volume":"21","author":"Yoon","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.tips.2015.08.012_bib0920","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cyto.2013.11.008","article-title":"Central visfatin potentiates glucose-stimulated insulin secretion and beta-cell mass without increasing serum visfatin levels in diabetic rats","volume":"65","author":"Kim","year":"2014","journal-title":"Cytokine"},{"key":"10.1016\/j.tips.2015.08.012_bib0925","doi-asserted-by":"crossref","first-page":"34833","DOI":"10.1074\/jbc.M805866200","article-title":"Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6\/STAT3 signaling mechanism","volume":"283","author":"Li","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2015.08.012_bib0930","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1182\/blood-2014-07-589069","article-title":"Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia","volume":"125","author":"Audrito","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.tips.2015.08.012_bib0935","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nsmb1114","article-title":"Structure of Nampt\/PBEF\/visfatin, a mammalian NAD+ biosynthetic enzyme","volume":"13","author":"Wang","year":"2006","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.tips.2015.08.012_bib0940","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nsmb1105","article-title":"Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents","volume":"13","author":"Khan","year":"2006","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.tips.2015.08.012_bib0945","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/cvr\/cvu220","article-title":"Intracellular NAMPT\u2013NAD+\u2013SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors","volume":"104","author":"Wang","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tips.2015.08.012_bib0950","doi-asserted-by":"crossref","first-page":"13748","DOI":"10.1073\/pnas.0903898106","article-title":"A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT","volume":"106","author":"Burgos","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tips.2015.08.012_bib0955","doi-asserted-by":"crossref","first-page":"11086","DOI":"10.1021\/bi801198m","article-title":"Weak coupling of ATP hydrolysis to the chemical equilibrium of human nicotinamide phosphoribosyltransferase","volume":"47","author":"Burgos","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.tips.2015.08.012_bib0960","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1476-5381.2011.01404.x","article-title":"The role of perivascular adipose tissue in vascular smooth muscle cell growth","volume":"165","author":"Miao","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tips.2015.08.012_bib0965","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.2174\/092986711795590101","article-title":"NAMPT in regulated NAD biosynthesis and its pivotal role in human metabolism","volume":"18","author":"Burgos","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.tips.2015.08.012_bib0970","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.4049\/jimmunol.181.7.4685","article-title":"Nicotinamide phosphoribosyl transferase\/pre-B cell colony-enhancing factor\/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress","volume":"181","author":"Rongvaux","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.tips.2015.08.012_bib0975","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1210\/er.2009-0026","article-title":"The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways","volume":"31","author":"Houtkooper","year":"2010","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tips.2015.08.012_bib0980","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tcb.2014.04.002","article-title":"NAD+ and sirtuins in aging and disease","volume":"24","author":"Imai","year":"2014","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.tips.2015.08.012_bib0985","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.bbapap.2015.02.021","article-title":"Regulation of NAD biosynthetic enzymes modulates NAD-sensing processes to shape mammalian cell physiology under varying biological cues","volume":"1854","author":"Ruggieri","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tips.2015.08.012_bib0990","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.2337\/db11-1180","article-title":"Loss of AMP-activated protein kinase-\u03b12 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle","volume":"61","author":"Wang","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.tips.2015.08.012_bib0995","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/gerona\/glt122","article-title":"Nicotinamide phosphoribosyltransferase is required for the calorie restriction-mediated improvements in oxidative stress, mitochondrial biogenesis, and metabolic adaptation","volume":"69","author":"Song","year":"2014","journal-title":"J. Gerontol. A: Biol. Sci. Med. Sci."},{"key":"10.1016\/j.tips.2015.08.012_bib1000","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s12576-010-0103-1","article-title":"Circulating and local visfatin\/Nampt\/PBEF levels in spontaneously hypertensive rats, stroke-prone spontaneously hypertensive rats and Wistar\u2013Kyoto rats","volume":"60","author":"Wang","year":"2010","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.tips.2015.08.012_bib1005","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1440-1681.2010.05402.x","article-title":"Visfatin is associated with lipid metabolic abnormalities in Lyon hypertensive rats","volume":"37","author":"Wang","year":"2010","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.tips.2015.08.012_bib1010","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1126\/science.1170803","article-title":"Circadian control of the NAD+ salvage pathway by CLOCK\u2013SIRT1","volume":"324","author":"Nakahata","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.tips.2015.08.012_bib1015","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1126\/science.1171641","article-title":"Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis","volume":"324","author":"Ramsey","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.tips.2015.08.012_bib1020","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.tips.2014.10.008","article-title":"Novel targets for pharmacological intervention in age-related diseases","volume":"35","author":"Polak-Jonkisz","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.tips.2015.08.012_bib1025","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cmet.2011.03.004","article-title":"PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation","volume":"13","author":"Bai","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.tips.2015.08.012_bib1030","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1096\/fj.07-8290com","article-title":"The enzyme CD38 (a NAD glycohydrolase EC 3.2.2.5) is necessary for the development of diet-induced obesity","volume":"21","author":"Barbosa","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.tips.2015.08.012_bib1035","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2337\/db12-1139","article-title":"Flavonoid apigenin is an inhibitor of the NAD+ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome","volume":"62","author":"Escande","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.tips.2015.08.012_bib1040","doi-asserted-by":"crossref","first-page":"43121","DOI":"10.1074\/jbc.M506162200","article-title":"Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2\u03b1 deacetylase activity","volume":"280","author":"Pillai","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2015.08.012_bib1045","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.brainres.2013.08.038","article-title":"Cellular NAD depletion and decline of SIRT1 activity play critical roles in PARP-1-mediated acute epileptic neuronal death in vitro","volume":"1535","author":"Wang","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.tips.2015.08.012_bib1050","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1523\/JNEUROSCI.5552-09.2010","article-title":"NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death","volume":"30","author":"Alano","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tips.2015.08.012_bib1055","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1089\/neu.2011.2228","article-title":"Prevention of traumatic brain injury-induced neuron death by intranasal delivery of nicotinamide adenine dinucleotide","volume":"29","author":"Won","year":"2012","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.tips.2015.08.012_bib1060","first-page":"1","article-title":"NAD+ administration significantly attenuates synchrotron radiation X-ray-induced DNA damage and structural alterations of rodent testes","volume":"4","author":"Sheng","year":"2012","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"10.1016\/j.tips.2015.08.012_bib1065","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1038\/jcbfm.2010.71","article-title":"Neuronal protective role of PBEF in a mouse model of cerebral ischemia","volume":"30","author":"Zhang","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tips.2015.08.012_bib1070","first-page":"1321","article-title":"Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging","volume":"33","author":"Stein","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.tips.2015.08.012_bib1075","doi-asserted-by":"crossref","first-page":"637","DOI":"10.2337\/db08-1176","article-title":"Relationship between cerebrospinal fluid visfatin (PBEF\/Nampt) levels and adiposity in humans","volume":"58","author":"Hallschmid","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.tips.2015.08.012_bib1080","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1097\/00004647-199711000-00002","article-title":"Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase","volume":"17","author":"Endres","year":"1997","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tips.2015.08.012_bib1085","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0304-3940(02)01005-4","article-title":"The effects of nicotinamide on energy metabolism following transient focal cerebral ischemia in Wistar rats","volume":"333","author":"Yang","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tips.2015.08.012_bib1090","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/jcbfm.2014.51","article-title":"Protein kinase C epsilon regulates mitochondrial pools of Nampt and NAD following resveratrol and ischemic preconditioning in the rat cortex","volume":"34","author":"Morris-Blanco","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tips.2015.08.012_bib1095","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jstrokecerebrovasdis.2009.01.003","article-title":"Elevated visfatin\/pre-B-cell colony-enhancing factor plasma concentration in ischemic stroke","volume":"18","author":"Lu","year":"2009","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.tips.2015.08.012_bib1100","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.peptides.2014.04.008","article-title":"Serum levels of novel adipokines in patients with acute ischemic stroke: potential contribution to diagnosis and prognosis","volume":"57","author":"Kadoglou","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.tips.2015.08.012_bib1105","doi-asserted-by":"crossref","first-page":"383","DOI":"10.11622\/smedj.2014091","article-title":"Increased serum visfatin as a risk factor for atherosclerosis in patients with ischaemic cerebrovascular disease","volume":"55","author":"Kong","year":"2014","journal-title":"Singapore Med. J."},{"key":"10.1016\/j.tips.2015.08.012_bib1110","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.peptides.2013.01.005","article-title":"Prognostic significance of plasma visfatin levels in patients with ischemic stroke","volume":"42","author":"Yin","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.tips.2015.08.012_bib1115","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.peptides.2012.11.006","article-title":"High concentrations of visfatin in the peripheral blood of patients with acute basal ganglia hemorrhage are associated with poor outcome","volume":"39","author":"Huang","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.tips.2015.08.012_bib1120","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cca.2013.07.025","article-title":"Admission plasma visfatin level strongly correlates with hematoma growth and early neurologic deterioration in patients with acute spontaneous basal ganglia hemorrhage","volume":"425","author":"Gu","year":"2013","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.tips.2015.08.012_bib1125","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.peptides.2012.08.016","article-title":"Change in plasma visfatin level after severe traumatic brain injury","volume":"38","author":"Chen","year":"2012","journal-title":"Peptides"},{"key":"10.1016\/j.tips.2015.08.012_bib1130","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.peptides.2012.12.017","article-title":"Plasma visfatin, associated with a genetic polymorphism \u20131535C>T, is correlated with C-reactive protein in Chinese Han patients with traumatic brain injury","volume":"40","author":"Weng","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.tips.2015.08.012_bib1135","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1210\/jc.2007-1304","article-title":"Molecular characteristics of serum visfatin and differential detection by immunoassays","volume":"92","author":"Korner","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tips.2015.08.012_bib1140","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.2174\/13816128113199990465","article-title":"The role of blood\u2013brain barrier transporters in pathophysiology and pharmacotherapy of stroke","volume":"20","author":"Shah","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.tips.2015.08.012_bib1145","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/cns.12356","article-title":"Blood\u2013brain barrier is not a barrier in the development of new drugs for ischemic stroke","volume":"20","author":"Liu","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.tips.2015.08.012_bib1150","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1016\/j.febslet.2006.06.052","article-title":"Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1","volume":"580","author":"Bae","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tips.2015.08.012_bib1155","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1136\/annrheumdis-2013-204355","article-title":"NAMPT (visfatin), a direct target of hypoxia-inducible factor-2\u03b1, is an essential catabolic regulator of osteoarthritis","volume":"74","author":"Yang","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.tips.2015.08.012_bib1160","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neulet.2011.09.014","article-title":"Visfatin induces neurite outgrowth in PC12 cells via ERK1\/2 signaling pathway","volume":"504","author":"Kang","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tips.2015.08.012_bib1165","doi-asserted-by":"crossref","first-page":"385","DOI":"10.4161\/auto.5635","article-title":"NAD depletion by FK866 induces autophagy","volume":"4","author":"Billington","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.tips.2015.08.012_bib1170","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1471-4159.2011.07566.x","article-title":"Pre-B-cell colony-enhancing factor exerts a neuronal protection through its enzymatic activity and the reduction of mitochondrial dysfunction in in vitro ischemic models","volume":"120","author":"Bi","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tips.2015.08.012_bib1175","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1161\/STROKEAHA.107.509158","article-title":"Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: role of enhanced DNA repair","volume":"39","author":"Wang","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.tips.2015.08.012_bib1180","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4161\/auto.8.1.18274","article-title":"Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia","volume":"8","author":"Wang","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.tips.2015.08.012_bib1185","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s12031-014-0486-1","article-title":"Nampt\/PBEF\/visfatin exerts neuroprotective effects against ischemia\/reperfusion injury via modulation of Bax\/Bcl-2 ratio and prevention of caspase-3 activation","volume":"56","author":"Erfani","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.tips.2015.08.012_bib1190","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.npep.2014.12.004","article-title":"Visfatin reduces hippocampal CA1 cell death and improves learning and memory deficits after transient global ischemia\/reperfusion","volume":"49","author":"Erfani","year":"2015","journal-title":"Neuropeptides"},{"key":"10.1016\/j.tips.2015.08.012_bib1195","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10989-014-9449-1","article-title":"Visfatin inhibits apoptosis and necrosis of hippocampus CA3 cells following transient global ischemia\/reperfusion in rats","volume":"21","author":"Erfani","year":"2015","journal-title":"Int. J. Pept. Res. Ther."},{"key":"10.1016\/j.tips.2015.08.012_bib1200","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2012.01.007","article-title":"NAD+ administration decreases ischemic brain damage partially by blocking autophagy in a mouse model of brain ischemia","volume":"512","author":"Zheng","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tips.2015.08.012_bib1205","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1440-1681.2007.04746.x","article-title":"Pressor and non-pressor effects of sodium loading on stroke in stroke-prone spontaneously hypertensive rats","volume":"35","author":"Zhang","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.tips.2015.08.012_bib1210","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1755-5949.2011.00287.x","article-title":"Nicotinamide postpones stroke in stroke-prone spontaneously hypertensive rats","volume":"18","author":"Guo","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.tips.2015.08.012_bib1215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/FJC.0b013e31820eb8f6","article-title":"Visfatin and cardio-cerebro-vascular disease","volume":"59","author":"Wang","year":"2012","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.tips.2015.08.012_bib1220","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/01.STR.20.4.473","article-title":"Morning increase in onset of ischemic stroke","volume":"20","author":"Marler","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.tips.2015.08.012_bib1225","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.cell.2007.07.035","article-title":"Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival","volume":"130","author":"Yang","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.tips.2015.08.012_bib1230","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tips.2013.12.004","article-title":"Small molecule SIRT1 activators for the treatment of aging and age-related diseases","volume":"35","author":"Hubbard","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.tips.2015.08.012_bib1235","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1161\/STROKEAHA.114.006265","article-title":"Silent information regulator 2 homolog 1 counters cerebral hypoperfusion injury by deacetylating endothelial nitric oxide synthase","volume":"45","author":"Hattori","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.tips.2015.08.012_bib1240","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1161\/STROKEAHA.113.001715","article-title":"Silent information regulator 1 protects the brain against cerebral ischemic damage","volume":"44","author":"Hernandez-Jimenez","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.tips.2015.08.012_bib1245","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/jcbfm.2010.229","article-title":"Pathways for ischemic cytoprotection: role of sirtuins in caloric restriction, resveratrol, and ischemic preconditioning","volume":"31","author":"Morris","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tips.2015.08.012_bib1250","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/jpi.12193","article-title":"Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice","volume":"58","author":"Yang","year":"2015","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.tips.2015.08.012_bib1255","doi-asserted-by":"crossref","DOI":"10.1038\/jcbfm.2015.123","article-title":"Sirtuin 3 mediates neuroprotection of ketones against ischemic stroke","author":"Yin","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tips.2015.08.012_bib1260","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neuroscience.2014.11.045","article-title":"SIRT3 protects cells from hypoxia via PGC-1\u03b1- and MnSOD-dependent pathways","volume":"286","author":"Wang","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.tips.2015.08.012_bib1265","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.10.006","article-title":"Sirtuin 6 is essential for sodium sulfide-mediated cytoprotective effect in ischemia\/reperfusion-stimulated brain endothelial cells","volume":"24","author":"Hu","year":"2015","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.tips.2015.08.012_bib1270","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/nm1097-1089","article-title":"Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia","volume":"3","author":"Eliasson","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.tips.2015.08.012_bib1275","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nm.2387","article-title":"Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death","volume":"17","author":"Andrabi","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.tips.2015.08.012_bib1280","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bbrc.2006.05.100","article-title":"Decreased cADPR and increased NAD+ in the Cd38\u2212\/\u2212 mouse","volume":"346","author":"Young","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tips.2015.08.012_bib1285","doi-asserted-by":"crossref","first-page":"e19046","DOI":"10.1371\/journal.pone.0019046","article-title":"CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia","volume":"6","author":"Choe","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tips.2015.08.012_bib1290","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1474-4422(09)70061-4","article-title":"Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic","volume":"8","author":"Zhang","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.tips.2015.08.012_bib1295","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bbrc.2007.03.105","article-title":"Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase 1\/2","volume":"357","author":"Kim","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tips.2015.08.012_bib1300","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/cvr\/cvm111","article-title":"Visfatin induces human endothelial VEGF and MMP-2\/9 production via MAPK and PI3K\/Akt signalling pathways: novel insights into visfatin-induced angiogenesis","volume":"78","author":"Adya","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tips.2015.08.012_bib1305","doi-asserted-by":"crossref","first-page":"E1440","DOI":"10.1152\/ajpendo.90780.2008","article-title":"Visfatin activates eNOS via Akt and MAP kinases and improves endothelial cell function and angiogenesis in vitro and in vivo: translational implications for atherosclerosis","volume":"296","author":"Lovren","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tips.2015.08.012_bib1310","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/cns.12388","article-title":"Nicotinamide phosphoribosyltransferase facilitates post-stroke angiogenesis","volume":"21","author":"Wang","year":"2015","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.tips.2015.08.012_bib1315","doi-asserted-by":"crossref","first-page":"21836","DOI":"10.1073\/pnas.1002130107","article-title":"Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)\/cohesin binding and transcription at the BDNF locus","volume":"107","author":"Chang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tips.2015.08.012_bib1320","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.nbd.2010.08.017","article-title":"Nicotinamide improves motor deficits and upregulates PGC-1\u03b1 and BDNF gene expression in a mouse model of Huntington's disease","volume":"41","author":"Hathorn","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.tips.2015.08.012_bib1325","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.1098014","article-title":"Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration","volume":"305","author":"Araki","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.tips.2015.08.012_bib1330","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1126\/science.1258366","article-title":"Neurobiology. SARM1 activation triggers axon degeneration locally via NAD+ destruction","volume":"348","author":"Gerdts","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.tips.2015.08.012_bib1335","doi-asserted-by":"crossref","first-page":"5800","DOI":"10.1523\/JNEUROSCI.4730-13.2014","article-title":"Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function","volume":"34","author":"Stein","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tips.2015.08.012_bib1340","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ab.2010.12.035","article-title":"A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase","volume":"412","author":"Zhang","year":"2011","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.tips.2015.08.012_bib1345","doi-asserted-by":"crossref","first-page":"10043","DOI":"10.1038\/srep10043","article-title":"Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase","volume":"5","author":"Xu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tips.2015.08.012_bib1350","doi-asserted-by":"crossref","first-page":"12657","DOI":"10.1038\/srep12657","article-title":"Discovery of novel inhibitors and fluorescent probe targeting NAMPT","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tips.2015.08.012_bib1355","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.pharmthera.2015.02.004","article-title":"Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer","volume":"151","author":"Sampath","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.tips.2015.08.012_bib1360","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.cell.2014.07.040","article-title":"P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage","volume":"158","author":"Wang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.tips.2015.08.012_bib1365","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2010.06.018","article-title":"Discovery of a proneurogenic, neuroprotective chemical","volume":"142","author":"Pieper","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.tips.2015.08.012_bib1370","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1021\/ja108211m","article-title":"Development of proneurogenic, neuroprotective small molecules","volume":"133","author":"MacMillan","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.tips.2015.08.012_bib1375","doi-asserted-by":"crossref","first-page":"17010","DOI":"10.1073\/pnas.1213956109","article-title":"Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease","volume":"109","author":"De Jesus-Cortes","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tips.2015.08.012_bib1380","doi-asserted-by":"crossref","first-page":"17016","DOI":"10.1073\/pnas.1213960109","article-title":"Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis","volume":"109","author":"Tesla","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tips.2015.08.012_bib1385","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.celrep.2014.08.030","article-title":"P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury","volume":"8","author":"Yin","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.tips.2015.08.012_bib1390","doi-asserted-by":"crossref","first-page":"8330","DOI":"10.1167\/iovs.14-15468","article-title":"Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243","volume":"55","author":"Dutca","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.tips.2015.08.012_bib1395","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/mp.2014.34","article-title":"The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis","volume":"20","author":"Walker","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.tips.2015.08.012_bib1400","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neulet.2015.02.008","article-title":"Chronic P7C3 treatment restores hippocampal neurogenesis","volume":"591","author":"Latchney","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tips.2015.08.012_bib1405","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neuroscience.2014.10.005","article-title":"Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury","volume":"284","author":"Kemp","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.tips.2015.08.012_bib1410","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S1474-4422(09)70054-7","article-title":"Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use","volume":"8","author":"Dirnagl","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.tips.2015.08.012_bib1415","article-title":"Ischemic conditioning-induced endogenous brain protection: applications pre-, per- or post-stroke","volume":"350","author":"Wang","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.tips.2015.08.012_bib1420","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/aps.2014.151","article-title":"The divergent roles of autophagy in ischemia and preconditioning","volume":"36","author":"Sheng","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.tips.2015.08.012_bib1425","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.bbr.2007.08.016","article-title":"Central visfatin causes orexigenic effects in chicks","volume":"186","author":"Cline","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.tips.2015.08.012_bib1430","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1111\/j.1582-4934.2008.00332.x","article-title":"The novel adipocytokine visfatin exerts direct cardioprotective effects","volume":"12","author":"Lim","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tips.2015.08.012_bib1435","doi-asserted-by":"crossref","first-page":"e85403","DOI":"10.1371\/journal.pone.0085403","article-title":"Cerebral ischemia is exacerbated by extracellular nicotinamide phosphoribosyltransferase via a non-enzymatic mechanism","volume":"8","author":"Zhao","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tips.2015.08.012_bib1440","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nm.1906","article-title":"Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner","volume":"15","author":"Van Gool","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.tips.2015.08.012_bib1445","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1742-2094-9-66","article-title":"The NAMPT inhibitor FK866 reverts the damage in spinal cord injury","volume":"9","author":"Esposito","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.tips.2015.08.012_bib1450","doi-asserted-by":"crossref","first-page":"e7897","DOI":"10.1371\/journal.pone.0007897","article-title":"Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE","volume":"4","author":"Bruzzone","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tips.2015.08.012_bib1455","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1038\/ncomms6101","article-title":"NAD+ protects against EAE by regulating CD4+ T-cell differentiation","volume":"5","author":"Tullius","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tips.2015.08.012_bib1460","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.tips.2015.03.006","article-title":"Arginase: an old enzyme with new tricks","volume":"36","author":"Caldwell","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.tips.2015.08.012_bib1465","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature10841","article-title":"Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain","volume":"483","author":"Cook","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.tips.2015.08.012_bib1470","doi-asserted-by":"crossref","first-page":"ra106","DOI":"10.1126\/scisignal.2005375","article-title":"Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65","volume":"7","author":"Shinozaki","year":"2014","journal-title":"Sci. Signal."},{"key":"10.1016\/j.tips.2015.08.012_bib1475","doi-asserted-by":"crossref","first-page":"14855","DOI":"10.1073\/pnas.0704329104","article-title":"SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase","volume":"104","author":"Mattagajasingh","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tips.2015.08.012_bib1480","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/cns.12219","article-title":"Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression","volume":"20","author":"Li","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.tips.2015.08.012_bib1485","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1111\/jth.13004","article-title":"The histone deacetylase sirtuin 2 is a new player in the regulation of platelet function","volume":"13","author":"Moscardo","year":"2015","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.tips.2015.08.012_bib1490","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1161\/CIRCULATIONAHA.112.097295","article-title":"Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner","volume":"126","author":"Barbieri","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.tips.2015.08.012_bib1495","doi-asserted-by":"crossref","first-page":"1247125","DOI":"10.1126\/science.1247125","article-title":"Organogenesis in a dish: modeling development and disease using organoid technologies","volume":"345","author":"Lancaster","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.tips.2015.08.012_bib1500","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s13311-012-0115-z","article-title":"Nonhuman primate models of stroke for translational neuroprotection research","volume":"9","author":"Cook","year":"2012","journal-title":"Neurotherapeutics"}],"container-title":["Trends in Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614715001820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614715001820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T04:41:18Z","timestamp":1653453678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165614715001820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":150,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0165614715001820"],"URL":"https:\/\/doi.org\/10.1016\/j.tips.2015.08.012","relation":{},"ISSN":["0165-6147"],"issn-type":[{"value":"0165-6147","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NAMPT as a Therapeutic Target against Stroke","name":"articletitle","label":"Article Title"},{"value":"Trends in Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tips.2015.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}