{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:57:45Z","timestamp":1770044265393,"version":"3.49.0"},"reference-count":252,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Pharmacological Sciences"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.tips.2015.09.003","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T04:25:14Z","timestamp":1445919914000},"page":"17-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":112,"title":["Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome"],"prefix":"10.1016","volume":"37","author":[{"given":"Nader G.","family":"Abraham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua M.","family":"Junge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George S.","family":"Drummond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tips.2015.09.003_bib1000","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1161\/01.HYP.0000052314.95497.78","article-title":"The kidney, hypertension, and obesity","volume":"41","author":"Hall","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.tips.2015.09.003_bib1380","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1001\/jama.295.13.1549","article-title":"Prevalence of overweight and obesity in the United States, 1999\u20132004","volume":"295","author":"Ogden","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.tips.2015.09.003_bib1385","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.2337\/db06-1656","article-title":"Visceral fat adipokine secretion is associated with systemic inflammation in obese humans","volume":"56","author":"Fontana","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.tips.2015.09.003_bib1390","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.2337\/db07-1764","article-title":"Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance","volume":"57","author":"Li","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.tips.2015.09.003_bib1395","doi-asserted-by":"crossref","first-page":"12345","DOI":"10.1021\/bi9015555","article-title":"Disulfide-dependent self-assembly of adiponectin octadecamers from trimers and presence of stable octadecameric adiponectin lacking disulfide bonds in vitro","volume":"48","author":"Briggs","year":"2009","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.tips.2015.09.003_bib1400","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1161\/HYPERTENSIONAHA.107.099424","article-title":"Adiponectin, cardiovascular function, and hypertension","volume":"51","author":"Wang","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.tips.2015.09.003_bib1405","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1042\/CS20090395","article-title":"Obesity is the major contributor to vascular dysfunction and inflammation in high fat diet hypertensive rats","volume":"118","author":"Elmarakby","year":"2010","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.tips.2015.09.003_bib1410","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1161\/01.HYP.0000090123.55365.BA","article-title":"Downregulation of renal CYP-derived eicosanoid synthesis in rats with diet-induced hypertension","volume":"42","author":"Wang","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.tips.2015.09.003_bib1415","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.1074\/jbc.M411863200","article-title":"The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species","volume":"280","author":"Lin","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2015.09.003_bib1420","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1161\/01.RES.0000091828.36599.34","article-title":"Heme oxygenase-1 attenuates glucose-mediated cell growth arrest and apoptosis in human microvessel endothelial cells","volume":"93","author":"Abraham","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.tips.2015.09.003_bib1425","doi-asserted-by":"crossref","first-page":"H2468","DOI":"10.1152\/ajpheart.01187.2003","article-title":"Overexpression of human heme oxygenase-1 attenuates endothelial cell sloughing in experimental diabetes","volume":"287","author":"Abraham","year":"2004","journal-title":"Am. J Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1430","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0092-8674(81)90039-8","article-title":"Hemin enhances the differentiation of mouse 3T3 cells to adipocytes","volume":"26","author":"Chen","year":"1981","journal-title":"Cell"},{"key":"10.1016\/j.tips.2015.09.003_bib1435","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1210\/en.2009-0800","article-title":"Regulation of adipogenesis by natural and synthetic REV-ERB ligands","volume":"151","author":"Kumar","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.tips.2015.09.003_bib1440","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1124\/pr.107.07104","article-title":"Pharmacological and clinical aspects of heme oxygenase","volume":"60","author":"Abraham","year":"2008","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.tips.2015.09.003_bib1445","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11906-008-0019-9","article-title":"Local adipose tissue renin-angiotensin system","volume":"10","author":"Cassis","year":"2008","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.tips.2015.09.003_bib1450","doi-asserted-by":"crossref","first-page":"R943","DOI":"10.1152\/ajpregu.00265.2004","article-title":"Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension","volume":"287","author":"Boustany","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1455","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1074\/jbc.M108921200","article-title":"Glucose deprivation induces heme oxygenase-1 gene expression by a pathway independent of the unfolded protein response","volume":"277","author":"Chang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2015.09.003_bib1460","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1042\/bj20021731","article-title":"Haem oxygenase 1 gene induction by glucose deprivation is mediated by reactive oxygen species via the mitochondrial electron-transport chain","volume":"371","author":"Chang","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.tips.2015.09.003_bib1465","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbrc.2004.01.086","article-title":"Heme oxygenase-1 prevents superoxide anion-associated endothelial cell sloughing in diabetic rats","volume":"315","author":"Quan","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tips.2015.09.003_bib1470","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1124\/jpet.106.107482","article-title":"Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects","volume":"319","author":"Kruger","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tips.2015.09.003_bib1475","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2210-4-26","article-title":"Peroxynitrite-mediated inactivation of heme oxygenases","volume":"4","author":"Kinobe","year":"2004","journal-title":"BMC Pharmacol."},{"key":"10.1016\/j.tips.2015.09.003_bib1480","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/oby.20559","article-title":"Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21","volume":"22","author":"Hinds","year":"2014","journal-title":"Obesity"},{"key":"10.1016\/j.tips.2015.09.003_bib1485","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2174\/138161208783597371","article-title":"Heme oxygenase: a target gene for anti-diabetic and obesity","volume":"14","author":"Abraham","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.tips.2015.09.003_bib1490","doi-asserted-by":"crossref","first-page":"359732","DOI":"10.1155\/2010\/359732","article-title":"Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity","volume":"2010","author":"Ndisang","year":"2010","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.tips.2015.09.003_bib1495","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000154819","article-title":"The biological significance and physiological role of heme oxygenase","volume":"6","author":"Abraham","year":"1996","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.tips.2015.09.003_bib1500","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.tips.2008.12.003","article-title":"Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin","volume":"30","author":"Kapitulnik","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.tips.2015.09.003_bib1505","doi-asserted-by":"crossref","first-page":"9226","DOI":"10.1074\/jbc.M108239200","article-title":"Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress","volume":"277","author":"Ahmad","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2015.09.003_bib1510","doi-asserted-by":"crossref","first-page":"10919","DOI":"10.1073\/pnas.94.20.10919","article-title":"Heme oxygenase 1 is required for mammalian iron reutilization","volume":"94","author":"Poss","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tips.2015.09.003_bib1515","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1161\/CIRCRESAHA.107.158998","article-title":"Heme oxygenase-1 deficiency accelerates formation of arterial thrombosis through oxidative damage to the endothelium, which is rescued by inhaled carbon monoxide","volume":"101","author":"True","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.tips.2015.09.003_bib1520","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/89068","article-title":"Heme oxygenase-1 protects against vascular constriction and proliferation","volume":"7","author":"Duckers","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.tips.2015.09.003_bib1525","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nm0196-87","article-title":"Heme oxygenase: a novel target for the modulation of the inflammatory response","volume":"2","author":"Willis","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.tips.2015.09.003_bib1530","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1164\/rccm.200404-465SO","article-title":"Heme oxygenase-1: from bench to bedside","volume":"172","author":"Morse","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.tips.2015.09.003_bib1535","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fphar.2012.00081","article-title":"Heme oxygenase, inflammation, and fibrosis: the good, the bad, and the ugly?","volume":"3","author":"Lundvig","year":"2012","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tips.2015.09.003_bib1540","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1172\/JCI4165","article-title":"Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency","volume":"103","author":"Yachie","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tips.2015.09.003_bib1545","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1681\/ASN.2007101099","article-title":"Heme oxygenase-1 deficiency promotes epithelial-mesenchymal transition and renal fibrosis","volume":"19","author":"Kie","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.tips.2015.09.003_bib1550","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0002-9440(10)63365-2","article-title":"Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse","volume":"165","author":"Kapturczak","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tips.2015.09.003_bib1555","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.2353\/ajpath.2010.090647","article-title":"Enhanced metabolic flexibility associated with elevated adiponectin levels","volume":"176","author":"Asterholm","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tips.2015.09.003_bib1560","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1172\/JCI448","article-title":"Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2","volume":"101","author":"Dennery","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tips.2015.09.003_bib1565","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1681\/ASN.2004121082","article-title":"Heme oxygenase-2 deficiency contributes to diabetes-mediated increase in superoxide anion and renal dysfunction","volume":"17","author":"Goodman","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.tips.2015.09.003_bib1570","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1124\/jpet.109.157545","article-title":"Epoxyeicosatrienoic acid agonist rescues the metabolic syndrome phenotype of HO-2-null mice","volume":"331","author":"Sodhi","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tips.2015.09.003_bib1575","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.metabol.2006.02.022","article-title":"Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome","volume":"55","author":"Roberts","year":"2006","journal-title":"Metabolism"},{"key":"10.1016\/j.tips.2015.09.003_bib1580","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1172\/JCI112309","article-title":"Control of heme metabolism with synthetic metalloporphyrins","volume":"77","author":"Kappas","year":"1986","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tips.2015.09.003_bib1585","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1542\/peds.113.1.119","article-title":"A method for interdicting the development of severe jaundice in newborns by inhibiting the production of bilirubin","volume":"113","author":"Kappas","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.tips.2015.09.003_bib1590","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1126\/science.6896768","article-title":"Chemoprevention of neonatal jaundice: potency of tin-protoporphyrin in an animal model","volume":"217","author":"Drummond","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.tips.2015.09.003_bib1595","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1432-1033.1990.tb19263.x","article-title":"Regulation of heme oxygenase gene expression by cobalt in rat liver and kidney","volume":"192","author":"Lin","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.tips.2015.09.003_bib1600","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.vph.2015.02.011","article-title":"HIF-regulated HO-1 gene transfer improves the post-ischemic limb recovery and diminishes TLR-triggered immune responses \u2013 effects modified by concomitant VEGF overexpression","volume":"71","author":"Jazwa","year":"2015","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.tips.2015.09.003_bib1605","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1007\/s00395-011-0208-6","article-title":"Gene transfer as a strategy to achieve permanent cardioprotection II: rAAV-mediated gene therapy with heme oxygenase-1 limits infarct size 1 year later without adverse functional consequences","volume":"106","author":"Li","year":"2011","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1610","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1016\/j.transproceed.2007.03.114","article-title":"Adenovirus-mediated heme oxygenase transfer inhibits graft arteriosclerosis in rat aortic transplants","volume":"39","author":"Du","year":"2007","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.tips.2015.09.003_bib1615","doi-asserted-by":"crossref","first-page":"H48","DOI":"10.1152\/ajpheart.00741.2006","article-title":"Preemptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function 1 yr after acute myocardial infarction","volume":"293","author":"Liu","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1620","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1159\/000374011","article-title":"CYP2J2 and EETs protect against lung ischemia\/reperfusion injury via anti-inflammatory effects in vivo and in vitro","volume":"35","author":"Chen","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.tips.2015.09.003_bib1625","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1161\/HYPERTENSIONAHA.112.193805","article-title":"Heme oxygenase gene targeting to adipocytes attenuates adiposity and vascular dysfunction in mice fed a high-fat diet","volume":"60","author":"Cao","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.tips.2015.09.003_bib1630","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.3029864","article-title":"Bilirubin is an antioxidant of possible physiological importance","volume":"235","author":"Stocker","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.tips.2015.09.003_bib1635","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1161\/01.ATV.16.2.250","article-title":"Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease","volume":"16","author":"Hopkins","year":"1996","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tips.2015.09.003_bib1640","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1126\/science.7678352","article-title":"Carbon monoxide: a putative neural messenger","volume":"259","author":"Verma","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.tips.2015.09.003_bib1645","doi-asserted-by":"crossref","first-page":"L1029","DOI":"10.1152\/ajplung.2000.279.6.L1029","article-title":"Heme oxygenase: colors of defense against cellular stress","volume":"279","author":"Otterbein","year":"2000","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1650","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1161\/01.ATV.0000066132.32063.F2","article-title":"Role of JNK, p38, and ERK in platelet-derived growth factor-induced vascular proliferation, migration, and gene expression","volume":"23","author":"Zhan","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tips.2015.09.003_bib1655","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1471-4906(03)00181-9","article-title":"Heme oxygenase-1: unleashing the protective properties of heme","volume":"24","author":"Otterbein","year":"2003","journal-title":"Trends Immunol."},{"key":"10.1016\/j.tips.2015.09.003_bib1660","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev.pharmtox.46.120604.141053","article-title":"CO as a cellular signaling molecule","volume":"46","author":"Kim","year":"2006","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.tips.2015.09.003_bib1665","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1152\/physrev.00011.2005","article-title":"Heme oxygenase-1\/carbon monoxide: from basic science to therapeutic applications","volume":"86","author":"Ryter","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tips.2015.09.003_bib1670","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1016\/S0041-1345(02)03506-6","article-title":"TNF-alpha-mediated cell death is attenuated by retrovirus delivery of human heme oxygenase-1 gene into human microvessel endothelial cells","volume":"34","author":"Kushida","year":"2002","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.tips.2015.09.003_bib1675","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/hep.20480","article-title":"Biliverdin therapy protects rat livers from ischemia and reperfusion injury","volume":"40","author":"Fondevila","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.tips.2015.09.003_bib1680","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1096\/fj.07-8472com","article-title":"Heme oxygenase-1, carbon monoxide, and bilirubin induce tolerance in recipients toward islet allografts by modulating T regulatory cells","volume":"21","author":"Lee","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.tips.2015.09.003_bib1685","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1210\/en.2005-0632","article-title":"Bilirubin can induce tolerance to islet allografts","volume":"147","author":"Wang","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.tips.2015.09.003_bib1690","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tem.2015.02.001","article-title":"Biliverdin reductase isozymes in metabolism","volume":"26","author":"O\u2019Brien","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.tips.2015.09.003_bib1695","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1096\/fj.10-166454","article-title":"The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters beta-adrenergic receptor ligand-mediated cardiac dysfunction","volume":"25","author":"Ding","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.tips.2015.09.003_bib1700","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.2337\/db14-1391","article-title":"Unconjugated bilirubin mediates heme oxygenase-1-induced vascular benefits in diabetic mice","volume":"64","author":"Liu","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.tips.2015.09.003_bib1705","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fphar.2013.00050","article-title":"Mesobiliverdin IXalpha enhances rat pancreatic islet yield and function","volume":"4","author":"Ito","year":"2013","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tips.2015.09.003_bib1710","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1210\/en.2013-1667","article-title":"Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation","volume":"155","author":"Dong","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.tips.2015.09.003_bib1715","doi-asserted-by":"crossref","first-page":"H643","DOI":"10.1152\/ajpheart.2000.278.2.H643","article-title":"Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction","volume":"278","author":"Clark","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1720","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1089\/104454902753759726","article-title":"Heme oxygenase and the kidney","volume":"21","author":"Hill-Kapturczak","year":"2002","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.tips.2015.09.003_bib1725","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2005.03.010","article-title":"Heme oxygenase and the cardiovascular\u2013renal system","volume":"39","author":"Abraham","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tips.2015.09.003_bib1730","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fphar.2012.00055","article-title":"The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases","volume":"3","author":"Vitek","year":"2012","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tips.2015.09.003_bib1735","doi-asserted-by":"crossref","first-page":"16712","DOI":"10.1016\/S0021-9258(19)89449-8","article-title":"Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation","volume":"269","author":"Neuzil","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2015.09.003_bib1740","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1124\/pr.57.4.3","article-title":"Carbon monoxide: endogenous production, physiological functions, and pharmacological applications","volume":"57","author":"Wu","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.tips.2015.09.003_bib1745","doi-asserted-by":"crossref","first-page":"15394","DOI":"10.1016\/S0021-9258(18)82270-0","article-title":"Cold-induced brain edema in mice. Involvement of extracellular superoxide dismutase and nitric oxide","volume":"268","author":"Oury","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2015.09.003_bib1750","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/364626a0","article-title":"A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds","volume":"364","author":"Lipton","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.tips.2015.09.003_bib1755","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1124\/mol.53.1.123","article-title":"Mechanism of YC-1-induced activation of soluble guanylyl cylase","volume":"53","author":"Friebe","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tips.2015.09.003_bib1760","first-page":"52","article-title":"Endothelium-dependent and -independent vasodilation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light","volume":"28","author":"Furchgott","year":"1991","journal-title":"Blood Vessels"},{"key":"10.1016\/j.tips.2015.09.003_bib1765","first-page":"H1641","article-title":"Carbon monoxide and cerebral microvascular tone in newborn pigs","volume":"276","author":"Leffler","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1770","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s00395-014-0450-9","article-title":"Heme oxygenase-1: an emerging therapeutic target to curb cardiac pathology","volume":"109","author":"Czibik","year":"2014","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1775","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1089\/ars.2013.5658","article-title":"Heme oxygenase-1 as a target for drug discovery","volume":"20","author":"Motterlini","year":"2014","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.tips.2015.09.003_bib1780","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ijo.2013.61","article-title":"Chronic carbon monoxide treatment attenuates development of obesity and remodels adipocytes in mice fed a high-fat diet","volume":"38","author":"Hosick","year":"2014","journal-title":"Int. J. Obes. (Lond.)"},{"key":"10.1016\/j.tips.2015.09.003_bib1785","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/21623945.2015.1038443","article-title":"Chronic treatment with a carbon monoxide releasing molecular revereses dietary induced obesity in mice","volume":"5","author":"Hosick","year":"2016","journal-title":"Adipocyte"},{"key":"10.1016\/j.tips.2015.09.003_bib1790","doi-asserted-by":"crossref","first-page":"E1055","DOI":"10.1152\/ajpendo.00498.2002","article-title":"Carbon monoxide stimulates insulin release and propagates Ca2+ signals between pancreatic beta-cells","volume":"285","author":"Lundquist","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tips.2015.09.003_bib1795","doi-asserted-by":"crossref","first-page":"17950","DOI":"10.1074\/jbc.M108317200","article-title":"Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis","volume":"277","author":"Brouard","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2015.09.003_bib1800","doi-asserted-by":"crossref","first-page":"R207","DOI":"10.1152\/ajpregu.00517.2011","article-title":"Heme oxygenase, a novel target for the treatment of hypertension and obesity?","volume":"302","author":"Hosick","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1805","first-page":"648","article-title":"Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species","volume":"64","author":"Balla","year":"1991","journal-title":"Lab. Invest."},{"key":"10.1016\/j.tips.2015.09.003_bib1810","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2174\/0929867053764635","article-title":"Metals, toxicity and oxidative stress","volume":"12","author":"Valko","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.tips.2015.09.003_bib1815","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00702-010-0426-3","article-title":"The link between iron, metabolic syndrome, and Alzheimer's disease","volume":"118","author":"Grunblatt","year":"2011","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.tips.2015.09.003_bib1820","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/11072","article-title":"Haem oxygenase-1 prevents cell death by regulating cellular iron","volume":"1","author":"Ferris","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tips.2015.09.003_bib1825","first-page":"35","article-title":"Function and regulation of transferrin and ferritin","volume":"35","author":"Ponka","year":"1998","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.tips.2015.09.003_bib1830","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1089\/ars.2004.6.967","article-title":"Heme degradation by reactive oxygen species","volume":"6","author":"Nagababu","year":"2004","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.tips.2015.09.003_bib1835","first-page":"1","article-title":"Endothelial cell heme oxygenase and ferritin induction by heme proteins: a possible mechanism for limiting shock damage","volume":"105","author":"Balla","year":"1992","journal-title":"Trans. Assoc. Am. Phys."},{"key":"10.1016\/j.tips.2015.09.003_bib1840","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1073\/pnas.88.3.688","article-title":"Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron","volume":"88","author":"Eisenstein","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tips.2015.09.003_bib1845","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/dc07-2126","article-title":"Serum bilirubin and ferritin levels link heme oxygenase-1 gene promoter polymorphism and susceptibility to coronary artery disease in diabetic patients","volume":"31","author":"Chen","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.tips.2015.09.003_bib1850","doi-asserted-by":"crossref","first-page":"14678","DOI":"10.1016\/S0021-9258(18)82386-9","article-title":"Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin","volume":"268","author":"Vile","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2015.09.003_bib1855","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1471-4159.2006.04230.x","article-title":"Induction of haem oxygenase-1 causes cortical non-haem iron increase in experimental pneumococcal meningitis: evidence that concomitant ferritin up-regulation prevents iron-induced oxidative damage","volume":"100","author":"Ren","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tips.2015.09.003_bib1860","doi-asserted-by":"crossref","first-page":"E195","DOI":"10.1208\/aapsj070118","article-title":"L-methionine reduces oxidant stress in endothelial cells: role of heme oxygenase-1, ferritin, and nitric oxide","volume":"7","author":"Erdmann","year":"2005","journal-title":"AAPS J."},{"key":"10.1016\/j.tips.2015.09.003_bib1865","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1089\/ars.2013.5666","article-title":"Coupling heme and iron metabolism via ferritin H chain","volume":"20","author":"Gozzelino","year":"2014","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.tips.2015.09.003_bib1870","doi-asserted-by":"crossref","first-page":"18148","DOI":"10.1016\/S0021-9258(19)37165-0","article-title":"Ferritin: a cytoprotective antioxidant strategm of endothelium","volume":"267","author":"Balla","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2015.09.003_bib1875","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00109-014-1147-0","article-title":"Mice lacking mitochondrial ferritin are more sensitive to doxorubicin-mediated cardiotoxicity","volume":"92","author":"Maccarinelli","year":"2014","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.tips.2015.09.003_bib1880","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1016\/j.humpath.2013.05.008","article-title":"Association between hemoglobin scavenger receptor and heme oxygenase-1-related anti-inflammatory mediators in human coronary stable and unstable plaques","volume":"44","author":"Yunoki","year":"2013","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.tips.2015.09.003_bib1885","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1002\/jcb.24061","article-title":"Heme induced oxidative stress attenuates sirtuin1 and enhances adipogenesis in mesenchymal stem cells and mouse pre-adipocytes","volume":"113","author":"Puri","year":"2012","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.tips.2015.09.003_bib1890","first-page":"905","article-title":"Hemin stimulation of hemopoiesis in murine long-term bone marrow culture","volume":"19","author":"Chertkov","year":"1991","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.tips.2015.09.003_bib1895","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/ajh.2830440307","article-title":"Synergistic effect of heme and IL-1 on hematopoietic stromal regeneration after radiation","volume":"44","author":"Lutton","year":"1993","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.tips.2015.09.003_bib1900","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s00774-009-0134-y","article-title":"Overexpression of heme oxygenase-1 increases human osteoblast stem cell differentiation","volume":"28","author":"Barbagallo","year":"2010","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.tips.2015.09.003_bib1905","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.bone.2009.10.012","article-title":"HO-1 expression increases mesenchymal stem cell-derived osteoblasts but decreases adipocyte lineage","volume":"46","author":"Vanella","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.tips.2015.09.003_bib1910","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000337591","article-title":"Heme oxygenase (HO-1) rescue of adipocyte dysfunction in HO-2 deficient mice via recruitment of epoxyeicosatrienoic acids (EETs) and adiponectin","volume":"29","author":"Burgess","year":"2012","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.tips.2015.09.003_bib1915","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1089\/scd.2010.0098","article-title":"Epoxyeicosatrienoic acid agonist regulates human mesenchymal stem cell-derived adipocytes through activation of HO-1\u2013pAKT signaling and a decrease in PPARgamma","volume":"19","author":"Kim","year":"2010","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.tips.2015.09.003_bib1920","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.prostaglandins.2011.07.005","article-title":"Crosstalk between EET and HO-1 downregulates Bach1 and adipogenic marker expression in mesenchymal stem cell derived adipocytes","volume":"96","author":"Vanella","year":"2011","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.tips.2015.09.003_bib1925","first-page":"R1388","article-title":"Regulation of food intake and body weight in rats by the synthetic heme analogue cobalt protoporphyrin","volume":"261","author":"Galbraith","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1930","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1161\/ATVBAHA.107.142638","article-title":"Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors","volume":"27","author":"Kronke","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tips.2015.09.003_bib1935","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/HYPERTENSIONAHA.110.151423","article-title":"Adipocyte heme oxygenase-1 induction attenuates metabolic syndrome in both male and female obese mice","volume":"56","author":"Burgess","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.tips.2015.09.003_bib1940","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1194\/jlr.M800046-JLR200","article-title":"L-4F treatment reduces adiposity, increases adiponectin levels, and improves insulin sensitivity in obese mice","volume":"49","author":"Peterson","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tips.2015.09.003_bib1945","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1161\/HYPERTENSIONAHA.108.124701","article-title":"Heme oxygenase-1 induction remodels adipose tissue and improves insulin sensitivity in obesity-induced diabetic rats","volume":"53","author":"Nicolai","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.tips.2015.09.003_bib1950","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/scrt176","article-title":"Increased heme-oxygenase 1 expression decreases adipocyte differentiation and lipid accumulation in mesenchymal stem cells via upregulation of the canonical Wnt signaling cascade","volume":"4","author":"Vanella","year":"2013","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.tips.2015.09.003_bib1955","doi-asserted-by":"crossref","first-page":"957235","DOI":"10.1155\/2012\/957235","article-title":"Induction of hemeoxygenase-1 reduces renal oxidative stress and inflammation in diabetic spontaneously hypertensive rats","volume":"2012","author":"Elmarakby","year":"2012","journal-title":"Int. J. Hypertens."},{"key":"10.1016\/j.tips.2015.09.003_bib1960","doi-asserted-by":"crossref","first-page":"F791","DOI":"10.1152\/ajprenal.00472.2011","article-title":"Induction of hemeoxygenase-1 reduces glomerular injury and apoptosis in diabetic spontaneously hypertensive rats","volume":"302","author":"Elmarakby","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1965","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.urology.2007.11.123","article-title":"Cobalt protoporphyrin attenuates rat obstructive nephropathy: role of cellular infiltration","volume":"72","author":"Iwai","year":"2008","journal-title":"Urology"},{"key":"10.1016\/j.tips.2015.09.003_bib1970","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jhep.2015.05.018","article-title":"Sirt1 mediates the effect of the heme oxygenase inducer, cobalt protoporphyrin, on ameliorating liver metabolic damage caused by a high-fat diet","volume":"63","author":"Liu","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tips.2015.09.003_bib1975","doi-asserted-by":"crossref","first-page":"e0128648","DOI":"10.1371\/journal.pone.0128648","article-title":"Fructose mediated non-alcoholic fatty liver is attenuated by HO-1\u2013SIRT1 module in murine hepatocytes and mice fed a high fructose diet","volume":"10","author":"Sodhi","year":"2015","journal-title":"PLoS. ONE"},{"key":"10.1016\/j.tips.2015.09.003_bib1980","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.prostaglandins.2011.12.004","article-title":"EET agonist prevents adiposity and vascular dysfunction in rats fed a high fat diet via a decrease in Bach 1 and an increase in HO-1 levels","volume":"98","author":"Sodhi","year":"2012","journal-title":"Prost. Other Lipid Mediat."},{"key":"10.1016\/j.tips.2015.09.003_bib1985","doi-asserted-by":"crossref","first-page":"e107656","DOI":"10.1371\/journal.pone.0107656","article-title":"Pro-inflammatory and pro-oxidant status of pancreatic islet in vitro is controlled by TLR-4 and HO-1 pathways","volume":"9","author":"Vivot","year":"2014","journal-title":"PLoS. ONE"},{"key":"10.1016\/j.tips.2015.09.003_bib1990","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1007\/s00125-012-2598-x","article-title":"Adiponectin: mechanistic insights and clinical implications","volume":"55","author":"Turer","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.tips.2015.09.003_bib1995","first-page":"1645","article-title":"Adiponectin regulates albuminuria and podocyte function in mice","volume":"118","author":"Sharma","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tips.2015.09.003_bib2000","doi-asserted-by":"crossref","first-page":"L707","DOI":"10.1152\/ajplung.00145.2014","article-title":"Heme oxygenase-1 attenuates acute pulmonary inflammation by decreasing the release of segmented neutrophils from the bone marrow","volume":"307","author":"Konrad","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib2005","doi-asserted-by":"crossref","first-page":"H701","DOI":"10.1152\/ajpheart.00024.2005","article-title":"Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes","volume":"289","author":"Turkseven","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib2010","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jhep.2014.06.007","article-title":"Protective role of HO-1 and carbon monoxide in ethanol-induced hepatocyte cell death and liver injury in mice","volume":"61","author":"Bakhautdin","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tips.2015.09.003_bib2015","doi-asserted-by":"crossref","first-page":"H18","DOI":"10.1152\/ajpheart.00260.2010","article-title":"Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2","volume":"299","author":"Ungvari","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib2020","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1089\/ars.2011.4360","article-title":"Potential therapeutic effects of natural heme oxygenase-1 inducers in cardiovascular diseases","volume":"18","author":"Barbagallo","year":"2013","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.tips.2015.09.003_bib2025","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.freeradbiomed.2013.09.027","article-title":"A functional link between heme oxygenase-1 and tristetraprolin in the anti-inflammatory effects of nicotine","volume":"65","author":"Jamal","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tips.2015.09.003_bib2030","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1089\/ars.2012.5138","article-title":"Resveratrol induces hepatic mitochondrial biogenesis through the sequential activation of nitric oxide and carbon monoxide production","volume":"20","author":"Kim","year":"2014","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.tips.2015.09.003_bib2035","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.3390\/ijms14022684","article-title":"Effects of heme oxygenase-1 upregulation on blood pressure and cardiac function in an animal model of hypertensive myocardial infarction","volume":"14","author":"Chen","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tips.2015.09.003_bib2040","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1042\/CS20100519","article-title":"Haem oxygenase-1 counteracts the effects of interleukin-1beta on inflammatory and senescence markers in cartilage-subchondral bone explants from osteoarthritic patients","volume":"122","author":"Clerigues","year":"2012","journal-title":"Clin. Sci."},{"key":"10.1016\/j.tips.2015.09.003_bib2045","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1016\/j.molimm.2010.06.013","article-title":"Heme oxygenase-1 upregulation improves lipopolysaccharide-induced acute lung injury involving suppression of macrophage migration inhibitory factor","volume":"47","author":"Yin","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.tips.2015.09.003_bib2050","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/08923970801946824","article-title":"Heme oxygenase-1 attenuates contact hypersensitivity induced by 2,4-dinitrofluorobenzene in mice","volume":"30","author":"Pae","year":"2008","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.tips.2015.09.003_bib2055","doi-asserted-by":"crossref","first-page":"R769","DOI":"10.1152\/ajpregu.00132.2014","article-title":"The heme oxygenases: important regulators of pregnancy and preeclampsia","volume":"307","author":"George","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib2060","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1172\/JCI6163","article-title":"Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice","volume":"103","author":"Yet","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tips.2015.09.003_bib2065","doi-asserted-by":"crossref","first-page":"33720","DOI":"10.1074\/jbc.M112.385542","article-title":"The heme oxygenase 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-regulated kinase (ERK)\/NRF2 signaling pathway and cytokine release","volume":"287","author":"Cai","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2015.09.003_bib2070","doi-asserted-by":"crossref","first-page":"H522","DOI":"10.1152\/ajpheart.00274.2005","article-title":"HO-1 induction by HIF-1: a new mechanism for delayed cardioprotection?","volume":"289","author":"Dawn","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib2075","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.yjmcc.2011.11.005","article-title":"Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium","volume":"52","author":"Stein","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.tips.2015.09.003_bib2080","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1161\/CIRCULATIONAHA.108.808618","article-title":"Heme oxygenase 1 determines atherosclerotic lesion progression into a vulnerable plaque","volume":"119","author":"Cheng","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.tips.2015.09.003_bib2085","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/nature14569","article-title":"Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment","volume":"523","author":"Li","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.tips.2015.09.003_bib2090","doi-asserted-by":"crossref","first-page":"5987","DOI":"10.1073\/pnas.91.13.5987","article-title":"Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene","volume":"91","author":"Lavrovsky","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tips.2015.09.003_bib2095","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1006\/bbrc.1996.0135","article-title":"Downregulation of the human heme oxygenase gene by glucocorticoids and identification of 56b regulatory elements","volume":"218","author":"Lavrovsky","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tips.2015.09.003_bib2100","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1182\/blood.V78.6.1461.1461","article-title":"Modulation of erythropoiesis by novel human bone marrow cytochrome P450-dependent metabolites of arachidonic acid","volume":"78","author":"Abraham","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.tips.2015.09.003_bib2105","doi-asserted-by":"crossref","first-page":"H1402","DOI":"10.1152\/ajpheart.00882.2014","article-title":"Induction and functional significance of the heme oxygenase system in pathological shear stress in vivo","volume":"308","author":"Kang","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib2110","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/sj.ki.5001565","article-title":"Heme oxygenase-1: a provenance for cytoprotective pathways in the kidney and other tissues","volume":"70","author":"Nath","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.tips.2015.09.003_bib2115","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1681\/ASN.V115965","article-title":"Renal response to tissue injury: lessons from heme oxygenase-1 GeneAblation and expression","volume":"11","author":"Agarwal","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.tips.2015.09.003_bib2120","doi-asserted-by":"crossref","first-page":"273","DOI":"10.18388\/abp.2005_3440","article-title":"Heme oxygenase-1 expression in disease states","volume":"52","author":"Deshane","year":"2005","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.tips.2015.09.003_bib2125","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1172\/JCI11218","article-title":"Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors","volume":"107","author":"Kaide","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tips.2015.09.003_bib2130","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1161\/01.HYP.38.2.210","article-title":"Human heme oxygenase-1 gene transfer lowers blood pressure and promotes growth in spontaneously hypertensive rats","volume":"38","author":"Sabaawy","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.tips.2015.09.003_bib2135","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1161\/01.HYP.0000250086.06137.fb","article-title":"Role of renal medullary heme oxygenase in the regulation of pressure natriuresis and arterial blood pressure","volume":"49","author":"Li","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.tips.2015.09.003_bib2140","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1161\/01.HYP.0000085785.40581.1A","article-title":"Effects of exogenous heme on renal function. Role of heme oxygenase and cyclooxygenase","volume":"42","author":"Rodriguez","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.tips.2015.09.003_bib2145","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1161\/01.HYP.0000111721.97169.97","article-title":"Nitric oxide synthesis inhibition promotes renal production of carbon monoxide","volume":"43","author":"Rodriguez","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.tips.2015.09.003_bib2150","first-page":"H1132","article-title":"Heme oxygenase substrates acutely lower blood pressure in hypertensive rats","volume":"271","author":"Johnson","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib2155","doi-asserted-by":"crossref","first-page":"H1471","DOI":"10.1152\/ajpheart.00962.2012","article-title":"Upregulation of heme oxygenase-1 potentiates EDH-type relaxations in the mesenteric artery of the spontaneously hypertensive rat","volume":"305","author":"Li","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib2160","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1161\/01.HYP.0000135658.57547.bb","article-title":"Vascular CO counterbalances the sensitizing influence of 20-HETE on agonist-induced vasoconstriction","volume":"44","author":"Kaide","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.tips.2015.09.003_bib2165","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1681\/ASN.2011050455","article-title":"Expression of heme oxygenase-1 in thick ascending loop of henle attenuates angiotensin II-dependent hypertension","volume":"23","author":"Stec","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.tips.2015.09.003_bib2170","doi-asserted-by":"crossref","first-page":"36059","DOI":"10.1074\/jbc.R100030200","article-title":"Epoxygenase pathways of arachidonic acid metabolism","volume":"276","author":"Zeldin","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2015.09.003_bib2175","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0022-2275(20)32049-6","article-title":"Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase","volume":"41","author":"Capdevila","year":"2000","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tips.2015.09.003_bib2180","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1126\/science.285.5431.1276","article-title":"Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids","volume":"285","author":"Node","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.tips.2015.09.003_bib2185","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.abb.2004.10.009","article-title":"Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids","volume":"433","author":"Spiecker","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tips.2015.09.003_bib2190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.prostaglandins.2011.10.002","article-title":"Epoxyeicosatrienoic acids and heme oxygenase-1 interaction attenuates diabetes and metabolic syndrome complications","volume":"97","author":"Burgess","year":"2012","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.tips.2015.09.003_bib2195","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1161\/HYPERTENSIONAHA.114.03884","article-title":"CYP2J2 targeting to endothelial cells attenuates adiposity and vascular dysfunction in mice fed a high-fat diet by reprogramming adipocyte phenotype","volume":"64","author":"Abraham","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.tips.2015.09.003_bib2200","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2012.09.010","article-title":"Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria","volume":"151","author":"Fedorenko","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.tips.2015.09.003_bib2205","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/jcb.22486","article-title":"Improved myocardial perfusion in chronic diabetic mice by the up-regulation of pLKB1 and AMPK signaling","volume":"109","author":"Kusmic","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.tips.2015.09.003_bib2210","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1172\/JCI5342","article-title":"Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury","volume":"103","author":"Otterbein","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tips.2015.09.003_bib2215","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1210\/en.2003-1336","article-title":"Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans","volume":"145","author":"Fain","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.tips.2015.09.003_bib2220","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.2174\/13816128113199990552","article-title":"The heme oxygenase system and type-1 diabetes","volume":"20","author":"Tiwari","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.tips.2015.09.003_bib2225","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.2174\/13816128113199990559","article-title":"A critical and comprehensive insight on heme oxygenase and related products including carbon monoxide, bilirubin, biliverdin and ferritin in type-1 and type-2 diabetes","volume":"20","author":"Mishra","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.tips.2015.09.003_bib2230","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/oby.2011.365","article-title":"High-fat diet exacerbates renal dysfunction in SHR: reversal by induction of HO-1\u2013adiponectin axis","volume":"20","author":"Cao","year":"2012","journal-title":"Obesity"},{"key":"10.1016\/j.tips.2015.09.003_bib2235","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/ijo.2011.78","article-title":"Chronic HO-1 induction with cobalt protoporphyrin (CoPP) treatment increases oxygen consumption, activity, heat production and lowers body weight in obese melanocortin-4 receptor-deficient mice","volume":"36","author":"Csongradi","year":"2012","journal-title":"Int. J. Obes. (Lond.)"},{"key":"10.1016\/j.tips.2015.09.003_bib2240","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1194\/jlr.M800610-JLR200","article-title":"The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice","volume":"50","author":"Peterson","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tips.2015.09.003_bib2245","doi-asserted-by":"crossref","first-page":"e87936","DOI":"10.1371\/journal.pone.0087936","article-title":"The heme oxygenase system suppresses perirenal visceral adiposity, abates renal inflammation and ameliorates diabetic nephropathy in Zucker diabetic fatty rats","volume":"9","author":"Ndisang","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tips.2015.09.003_bib2250","doi-asserted-by":"crossref","first-page":"e79270","DOI":"10.1371\/journal.pone.0079270","article-title":"The heme oxygenase system rescues hepatic deterioration in the condition of obesity co-morbid with type-2 diabetes","volume":"8","author":"Salley","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tips.2015.09.003_bib2255","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1124\/jpet.107.135285","article-title":"Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines, tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells","volume":"325","author":"Kim","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tips.2015.09.003_bib1005","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1089\/hum.2010.059","article-title":"Lentiviral-human heme oxygenase targeting endothelium improved vascular function in angiotensin II animal model of hypertension","volume":"22","author":"Cao","year":"2011","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.tips.2015.09.003_bib1010","doi-asserted-by":"crossref","first-page":"e55369","DOI":"10.1371\/journal.pone.0055369","article-title":"Adipose overexpression of heme oxygenase-1 does not protect against high fat diet-induced insulin resistance in mice","volume":"8","author":"Huang","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tips.2015.09.003_bib1015","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/01.RES.0000249616.10603.d6","article-title":"CD163-Mediated hemoglobin-heme uptake activates macrophage HO-1, providing an antiinflammatory function","volume":"99","author":"Abraham","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.tips.2015.09.003_bib1020","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1161\/01.RES.0000109414.78907.F9","article-title":"Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis: antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery","volume":"94","author":"Philippidis","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.tips.2015.09.003_bib1025","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/ijo.2009.160","article-title":"Diminished upregulation of visceral adipose heme oxygenase-1 correlates with waist-to-hip ratio and insulin resistance","volume":"33","author":"Shakeri-Manesch","year":"2009","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.tips.2015.09.003_bib1030","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/MBC.0000000000000194","article-title":"Bariatric patients have plasmatic hypercoagulability and systemic upregulation of heme oxygenase activity","volume":"26","author":"Nielsen","year":"2015","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"10.1016\/j.tips.2015.09.003_bib1035","first-page":"2","article-title":"Sources of carbon monoxide (CO) in biological systems and applications of CO detection technologies","volume":"18","author":"Rodgers","year":"1994","journal-title":"Semin. Perinatol."},{"key":"10.1016\/j.tips.2015.09.003_bib1040","doi-asserted-by":"crossref","first-page":"15687","DOI":"10.1074\/jbc.M510595200","article-title":"Heme oxygenase-1 enhances renal mitochondrial transport carriers and cytochrome c oxidase activity in experimental diabetes","volume":"281","author":"Di Noia","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2015.09.003_bib1045","doi-asserted-by":"crossref","first-page":"E896","DOI":"10.1152\/ajpendo.00047.2004","article-title":"Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes","volume":"287","author":"Shen","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tips.2015.09.003_bib1050","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.2337\/diabetes.54.7.1926","article-title":"A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle","volume":"54","author":"Sparks","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.tips.2015.09.003_bib1055","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.2337\/diabetes.54.7.2179","article-title":"Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process","volume":"54","author":"Detaille","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.tips.2015.09.003_bib1060","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1096\/fj.05-4204fje","article-title":"HO-1 is located in liver mitochondria and modulates mitochondrial heme content and metabolism","volume":"20","author":"Converso","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.tips.2015.09.003_bib1065","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/ki.2012.102","article-title":"In vivo regulation of the heme oxygenase-1 gene in humanized transgenic mice","volume":"82","author":"Kim","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.tips.2015.09.003_bib1070","doi-asserted-by":"crossref","first-page":"H1744","DOI":"10.1152\/ajpheart.01088.2004","article-title":"Hyperglycemia Alters PI3k and Akt Signaling and Leads to Endothelial Cell Proliferative Dysfunction","volume":"289","author":"Varma","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1075","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1007\/s00125-004-1572-7","article-title":"Antioxidative treatment prevents activation of death-receptor- and mitochondrion-dependent apoptosis in the hearts of diabetic rats","volume":"47","author":"Bojunga","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.tips.2015.09.003_bib1080","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1210\/en.2003-1274","article-title":"Insulin-like growth factor (IGF)-I\/IGF-binding protein-3 complex: therapeutic efficacy and mechanism of protection against type 1 diabetes","volume":"145","author":"Chen","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.tips.2015.09.003_bib1085","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.2337\/diabetes.49.11.1932","article-title":"Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction","volume":"49","author":"Srinivasan","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.tips.2015.09.003_bib1090","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mcn.2004.08.009","article-title":"Insulin enhances mitochondrial inner membrane potential and increases ATP levels through phosphoinositide 3-kinase in adult sensory neurons","volume":"28","author":"Huang","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.tips.2015.09.003_bib1095","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1093\/nar\/21.5.1103","article-title":"Ultraviolet A (320\u2013380nm) radiation causes an alteration in the binding of a specific protein\/protein complex to a short region of the promoter of the human heme oxygenase 1 gene","volume":"21","author":"Nascimento","year":"1993","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tips.2015.09.003_bib1100","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1161\/CIRCULATIONAHA.107.698316","article-title":"Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis","volume":"117","author":"Dulak","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.tips.2015.09.003_bib1105","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/BF02342435","article-title":"Cytotoxic effects of cytokines on rat islets: evidence for involvement of free radicals and lipid peroxidation","volume":"35","author":"Rabinovitch","year":"1992","journal-title":"Diabetologia"},{"key":"10.1016\/j.tips.2015.09.003_bib1110","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbrc.2004.12.106","article-title":"Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression","volume":"327","author":"Choi","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tips.2015.09.003_bib1115","doi-asserted-by":"crossref","first-page":"4744","DOI":"10.4049\/jimmunol.172.8.4744","article-title":"Carbon monoxide produced by heme oxygenase-1 suppresses T cell proliferation via inhibition of IL-2 production","volume":"172","author":"Pae","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.tips.2015.09.003_bib1120","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.1073\/pnas.0502407102","article-title":"Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway","volume":"102","author":"Chen","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tips.2015.09.003_bib1125","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1182\/blood-2005-02-0494","article-title":"Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression","volume":"106","author":"Chauveau","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.tips.2015.09.003_bib1130","doi-asserted-by":"crossref","first-page":"e78209","DOI":"10.1371\/journal.pone.0078209","article-title":"Administration of heme arginate ameliorates murine type 2 diabetes independently of heme oxygenase activity","volume":"8","author":"Choudhary","year":"2013","journal-title":"PLoS. ONE"},{"key":"10.1016\/j.tips.2015.09.003_bib1135","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.2337\/diabetes.50.9.1983","article-title":"Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation","volume":"50","author":"Pileggi","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.tips.2015.09.003_bib1140","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1111\/j.1742-4658.2006.05224.x","article-title":"Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase\/Akt pathway and the Nrf2 transcription factor in renal cells","volume":"273","author":"Harrison","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.tips.2015.09.003_bib1145","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nm1029","article-title":"Adiponectin acts in the brain to decrease body weight","volume":"10","author":"Qi","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.tips.2015.09.003_bib1150","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.2337\/db08-1750","article-title":"Systemic fate of the adipocyte-derived factor adiponectin","volume":"58","author":"Halberg","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.tips.2015.09.003_bib1155","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1172\/JCI31021","article-title":"Obesity-associated improvements in metabolic profile through expansion of adipose tissue","volume":"117","author":"Kim","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tips.2015.09.003_bib1160","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1074\/jbc.M505311200","article-title":"Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists","volume":"281","author":"Nawrocki","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2015.09.003_bib1165","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1086\/302729","article-title":"Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema","volume":"66","author":"Yamada","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.tips.2015.09.003_bib1170","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/152660280100800501","article-title":"Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with restenosis after percutaneous transluminal angioplasty","volume":"8","author":"Exner","year":"2001","journal-title":"J. Endovasc. Ther."},{"key":"10.1016\/j.tips.2015.09.003_bib1175","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1001\/jama.298.12.1398-b","article-title":"Relationship between Gilbert syndrome and prevalence of vascular complications in patients with diabetes","volume":"298","author":"Inoguchi","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.tips.2015.09.003_bib1180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00439-002-0769-4","article-title":"Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients","volume":"111","author":"Chen","year":"2002","journal-title":"Hum. Genet."},{"key":"10.1016\/j.tips.2015.09.003_bib1185","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1161\/01.ATV.0000033515.96747.6F","article-title":"Heme oxygenase-1 gene promoter polymorphism is associated with coronary artery disease in Japanese patients with coronary risk factors","volume":"22","author":"Kaneda","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tips.2015.09.003_bib1190","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1160\/TH03-05-0291","article-title":"A microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with increased bilirubin and HDL levels but not with coronary artery disease","volume":"91","author":"Endler","year":"2004","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.tips.2015.09.003_bib1195","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1093\/eurheartj\/ehm036","article-title":"Heme oxygenase-1 gene promoter polymorphism and restenosis following coronary stenting","volume":"28","author":"Tiroch","year":"2007","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.tips.2015.09.003_bib1200","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1111\/j.1600-6143.2006.01726.x","article-title":"Association of functional heme oxygenase-1 gene promoter polymorphism with renal transplantation outcomes","volume":"7","author":"Courtney","year":"2007","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.tips.2015.09.003_bib1205","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.atherosclerosis.2003.11.021","article-title":"A promoter variant of the heme oxygenase-1 gene may reduce the incidence of ischemic heart disease in Japanese","volume":"173","author":"Ono","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.tips.2015.09.003_bib1210","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/01.fpc.0000205001.07054.fa","article-title":"Restenosis after percutaneous coronary intervention is associated with the angiotensin-II type-1 receptor 1166A\/C polymorphism but not with polymorphisms of angiotensin-converting enzyme, angiotensin-II receptor, angiotensinogen or heme oxygenase-1","volume":"16","author":"Wijpkema","year":"2006","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.tips.2015.09.003_bib1215","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1161\/ATVBAHA.114.304729","article-title":"Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease","volume":"35","author":"Pechlaner","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tips.2015.09.003_bib1220","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1096\/fj.13-247015","article-title":"Human biliverdin reductase-based peptides activate and inhibit glucose uptake through direct interaction with the kinase domain of insulin receptor","volume":"28","author":"Gibbs","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.tips.2015.09.003_bib1225","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1161\/01.hyp.0000126287.62060.e6","article-title":"Heme oxygenase-1 gene expression modulates angiotensin II-induced increase in blood pressure","volume":"43","author":"Yang","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.tips.2015.09.003_bib1230","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1161\/hc0502.103363","article-title":"Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene","volume":"105","author":"Melo","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.tips.2015.09.003_bib1235","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1177\/107424840501000405","article-title":"A vigilant, hypoxia-regulated heme oxygenase-1 gene vector in the heart limits cardiac injury after ischemia-reperfusion in vivo","volume":"10","author":"Tang","year":"2005","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.tips.2015.09.003_bib1240","doi-asserted-by":"crossref","first-page":"F778","DOI":"10.1152\/ajprenal.00215.2004","article-title":"Protective effects of exogenous bilirubin on ischemia-reperfusion injury in the isolated, perfused rat kidney","volume":"288","author":"Adin","year":"2005","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1245","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1161\/CIRCULATIONAHA.111.053108","article-title":"Niacin inhibits vascular inflammation via the induction of heme oxygenase-1","volume":"125","author":"Wu","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.tips.2015.09.003_bib1250","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1002\/jcb.24223","article-title":"Statins modulate transcriptional activity of heme-oxygenase-1 promoter in NIH 3T3 Cells","volume":"113","author":"Mrad","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.tips.2015.09.003_bib1255","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0268-960X(91)90004-V","article-title":"Molecular regulation \u2013 biological role of heme in hematopoiesis","volume":"5","author":"Abraham","year":"1991","journal-title":"Blood Rev."},{"key":"10.1016\/j.tips.2015.09.003_bib1260","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.4049\/jimmunol.174.9.5181","article-title":"An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cells","volume":"174","author":"Brusko","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.tips.2015.09.003_bib1265","doi-asserted-by":"crossref","first-page":"154","DOI":"10.2353\/ajpath.2008.070963","article-title":"Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells","volume":"173","author":"George","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tips.2015.09.003_bib1270","doi-asserted-by":"crossref","first-page":"8798","DOI":"10.1073\/pnas.161272598","article-title":"Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia","volume":"98","author":"Minamino","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tips.2015.09.003_bib1275","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.4049\/jimmunol.172.6.3553","article-title":"Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation","volume":"172","author":"Soares","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.tips.2015.09.003_bib1280","doi-asserted-by":"crossref","first-page":"H1999","DOI":"10.1152\/ajpheart.00082.2006","article-title":"Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase","volume":"291","author":"Sacerdoti","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1285","doi-asserted-by":"crossref","first-page":"L1117","DOI":"10.1152\/ajplung.00365.2001","article-title":"Modulation of cGMP by human HO-1 retrovirus gene transfer in pulmonary microvessel endothelial cells","volume":"283","author":"Abraham","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1290","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1634\/stemcells.2008-0800","article-title":"Diabetes impairs the vascular recruitment of normal stem cells by oxidant damage; reversed by increases in pAMPK, heme oxygenase-1 and adiponectin","volume":"27","author":"Sambuceti","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.tips.2015.09.003_bib1295","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.3390\/ijms9122388","article-title":"Upregulation of heme oxygenase-1 combined with increased adiponectin lowers blood pressure in diabetic spontaneously hypertensive rats through a reduction in endothelial cell dysfunction, apoptosis and oxidative stress","volume":"9","author":"Cao","year":"2008","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tips.2015.09.003_bib1300","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1161\/CIRCULATIONAHA.104.517102","article-title":"D-4F induces heme oxygenase-1 and extracellular superoxide dismutase, decreases endothelial cell sloughing, and improves vascular reactivity in rat model of diabetes","volume":"111","author":"Kruger","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.tips.2015.09.003_bib1305","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1096\/fj.05-4435com","article-title":"Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function","volume":"20","author":"Liu","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.tips.2015.09.003_bib1310","doi-asserted-by":"crossref","first-page":"C897","DOI":"10.1152\/ajpcell.00032.2006","article-title":"HO-2 provides endogenous protection against oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells","volume":"291","author":"Basuroy","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1315","doi-asserted-by":"crossref","first-page":"F863","DOI":"10.1152\/ajprenal.00385.2002","article-title":"Proinflammatory effects of oxidative stress in chronic kidney disease: role of additional angiotensin II blockade","volume":"284","author":"Agarwal","year":"2003","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1320","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1177\/15353702-0322805-31","article-title":"Heme oxygenase-1 gene expression attenuates angiotensin II-mediated DNA damage in endothelial cells","volume":"228","author":"Mazza","year":"2003","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.tips.2015.09.003_bib1325","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0049-3848(03)00417-1","article-title":"Heme oxygenase attenuated angiotensin II-mediated increase in cyclooxygenase activity and decreased isoprostane F2alpha in endothelial cells","volume":"110","author":"Abraham","year":"2003","journal-title":"Thromb. Res."},{"key":"10.1016\/j.tips.2015.09.003_bib1330","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1111\/j.1523-1755.2004.00562.x","article-title":"Expression of human heme oxygenase-1 in the thick ascending limb attenuates angiotensin II-mediated increase in oxidative injury","volume":"65","author":"Quan","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.tips.2015.09.003_bib1335","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1161\/01.RES.80.4.557","article-title":"Nitric oxide induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth cells","volume":"80","author":"Durante","year":"1997","journal-title":"Circ. Res."},{"key":"10.1016\/j.tips.2015.09.003_bib1340","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0006-291X(02)02054-5","article-title":"Differential effect of heme oxygenase-1 in endothelial and smooth muscle cell cycle progression","volume":"296","author":"Li Volti","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tips.2015.09.003_bib1345","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/hc0102.101369","article-title":"Adenovirus-mediated heme oxygenase-1 gene expression stimulates apoptosis in vascular smooth muscle cells","volume":"105","author":"Liu","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.tips.2015.09.003_bib1350","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S0008-6363(02)00410-8","article-title":"Carbon monoxide inhibits apoptosis in vascular smooth muscle cells","volume":"55","author":"Liu","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tips.2015.09.003_bib1355","doi-asserted-by":"crossref","first-page":"32804","DOI":"10.1074\/jbc.272.52.32804","article-title":"Carbon monoxide controls the proliferation of hypoxic smooth muscle cells","volume":"272","author":"Morita","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2015.09.003_bib1360","doi-asserted-by":"crossref","first-page":"H962","DOI":"10.1152\/ajpheart.01218.2003","article-title":"Interaction between endothelial heme oxygenase-2 and endothelin-1 in altered aortic reactivity after hypoxia in rats","volume":"288","author":"Govindaraju","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1365","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ejphar.2003.12.026","article-title":"Carbon monoxide inhibits endothelin-1 release by human pulmonary artery smooth muscle cells","volume":"486","author":"Stanford","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.tips.2015.09.003_bib1370","doi-asserted-by":"crossref","first-page":"H137","DOI":"10.1152\/ajpheart.00678.2002","article-title":"CO modulates pulmonary vascular response to acute hypoxia: relation to endothelin","volume":"286","author":"Zhang","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tips.2015.09.003_bib1375","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.freeradbiomed.2007.08.012","article-title":"Carbon monoxide donors or heme oxygenase-1 (HO-1) overexpression blocks interleukin-18-mediated NF-kappaB-PTEN-dependent human cardiac endothelial cell death","volume":"44","author":"Zabalgoitia","year":"2008","journal-title":"Free Radic. Biol. Med."}],"container-title":["Trends in Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614715002023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614715002023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T01:32:16Z","timestamp":1718155936000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165614715002023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":252,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0165614715002023"],"URL":"https:\/\/doi.org\/10.1016\/j.tips.2015.09.003","relation":{},"ISSN":["0165-6147"],"issn-type":[{"value":"0165-6147","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome","name":"articletitle","label":"Article Title"},{"value":"Trends in Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tips.2015.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}