{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:08:34Z","timestamp":1790381314560,"version":"4.1.0"},"reference-count":86,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Pharmacological Sciences"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.tips.2017.03.007","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T09:00:20Z","timestamp":1493715620000},"page":"506-511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Unpacking \u2018Artemisinin Resistance\u2019"],"prefix":"10.1016","volume":"38","author":[{"given":"Jigang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengchao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Rong","family":"Lun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Meshnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tips.2017.03.007_bib0005","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0140-6736(13)60024-0","article-title":"Malaria","volume":"383","author":"White","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.tips.2017.03.007_bib0010","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(98)07367-X","article-title":"Averting a malaria disaster","volume":"353","author":"White","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.tips.2017.03.007_bib0015","series-title":"Status Report on Artemisinin and ACT Resistance","author":"WHO","year":"2015"},{"key":"10.1016\/j.tips.2017.03.007_bib0020","first-page":"301","article-title":"Delaying antimalarial drug resistance with combination chemotherapy","volume":"41","author":"White","year":"1999","journal-title":"Parassitologia"},{"key":"10.1016\/j.tips.2017.03.007_bib0025","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4269\/ajtmh.2007.77.181","article-title":"Artemisinin-based combination treatment of falciparum malaria","volume":"77","author":"Nosten","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.tips.2017.03.007_bib0030","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nrmicro2239","article-title":"Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria","volume":"7","author":"Eastman","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.tips.2017.03.007_bib0035","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1128\/MMBR.60.2.301-315.1996","article-title":"Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy","volume":"60","author":"Meshnick","year":"1996","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.tips.2017.03.007_bib0040","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.pt.2013.04.001","article-title":"Antidogmatic approaches to artemisinin resistance: reappraisal as treatment failure with artemisinin combination therapy","volume":"29","author":"Krishna","year":"2013","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.tips.2017.03.007_bib0045","doi-asserted-by":"crossref","first-page":"398","DOI":"10.4269\/ajtmh.1993.48.398","article-title":"Treatment of malaria in Vietnam with oral artemisinin","volume":"48","author":"Nguyen","year":"1993","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.tips.2017.03.007_bib0050","doi-asserted-by":"crossref","first-page":"818","DOI":"10.2165\/00003495-199652060-00004","article-title":"Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria","volume":"52","author":"de Vries","year":"1996","journal-title":"Drugs"},{"key":"10.1016\/j.tips.2017.03.007_bib0055","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.pt.2013.05.006","article-title":"Artemisinin resistance needs to be defined rigorously to be understood: response to dondorp and ringwald","volume":"29","author":"Krishna","year":"2013","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.tips.2017.03.007_bib0060","first-page":"129","article-title":"National guideline for use and regimen of antimalarials","volume":"15","author":"The Ministry of Health of China","year":"2002","journal-title":"Chin. J. Parasit. Dis. Control"},{"key":"10.1016\/j.tips.2017.03.007_bib0065","first-page":"17","article-title":"An exploration on the dosage and treatment course of dihydroartemisinin for falciparum malaria","volume":"7","author":"Fu","year":"1996","journal-title":"Trad. Chin. Drug Res. Clin. Pharm."},{"key":"10.1016\/j.tips.2017.03.007_bib0070","doi-asserted-by":"crossref","first-page":"690","DOI":"10.4269\/ajtmh.2001.65.690","article-title":"Artemisinin for treatment of uncomplicated falciparum malaria: is there a place for monotherapy?","volume":"65","author":"Giao","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.tips.2017.03.007_bib0075","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1056\/NEJMc0805011","article-title":"Evidence of artemisinin-resistant malaria in western Cambodia","volume":"359","author":"Noedl","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tips.2017.03.007_bib0080","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","article-title":"Artemisinin resistance in Plasmodium falciparum malaria","volume":"361","author":"Dondorp","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tips.2017.03.007_bib0085","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1314981","article-title":"Spread of artemisinin resistance in Plasmodium falciparum malaria","volume":"371","author":"Ashley","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tips.2017.03.007_bib0090","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/S0140-6736(12)60484-X","article-title":"Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study","volume":"379","author":"Phyo","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.tips.2017.03.007_bib0095","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/femsre\/fuw037","article-title":"The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spread","volume":"41","author":"Woodrow","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.tips.2017.03.007_bib0100","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1473-3099(15)00487-9","article-title":"Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study","volume":"16","author":"Amaratunga","year":"2016","journal-title":"Lancet. Infect. Dis."},{"key":"10.1016\/j.tips.2017.03.007_bib0105","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S1473-3099(15)70032-0","article-title":"Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker","volume":"15","author":"Dhorda","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.tips.2017.03.007_bib0110","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S1473-3099(15)00415-6","article-title":"Artesunate-mefloquine versus chloroquine for treatment of uncomplicated Plasmodium knowlesi malaria in Malaysia (ACT KNOW): an open-label, randomised controlled trial","volume":"16","author":"Grigg","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.tips.2017.03.007_bib0115","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S1473-3099(15)00232-7","article-title":"Artemisinin resistance in Myanmar","volume":"15","author":"Plowe","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.tips.2017.03.007_bib0120","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S1473-3099(15)70049-6","article-title":"Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study","volume":"15","author":"Spring","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.tips.2017.03.007_bib0125","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S1473-3099(12)70181-0","article-title":"Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study","volume":"12","author":"Amaratunga","year":"2012","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.tips.2017.03.007_bib0130","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1016\/S0140-6736(12)61820-0","article-title":"Artemisinin-resistant malaria in the Asia-Pacific region","volume":"381","author":"Tulloch","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.tips.2017.03.007_bib0135","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0140-6736(09)61857-2","article-title":"Artemisinin resistance on the Thai-Cambodian border","volume":"374","author":"M\u00fcller","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.tips.2017.03.007_bib0140","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.pt.2013.05.002","article-title":"Artemisinin resistance in Plasmodium falciparum: what is it really?","volume":"29","author":"Ferreira","year":"2013","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.tips.2017.03.007_bib0145","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S1473-3099(12)70349-3","article-title":"Artemisinin resistance or artemisinin-based combination therapy resistance?","volume":"13","author":"Wongsrichanalai","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.tips.2017.03.007_bib0150","doi-asserted-by":"crossref","first-page":"783","DOI":"10.4269\/ajtmh.2012.12-0388","article-title":"Perspective: artemisinin-resistant malaria and the wolf","volume":"87","author":"Meshnick","year":"2012","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.tips.2017.03.007_bib0155","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.pt.2013.04.001","article-title":"Antidogmatic approaches to artemisinin resistance: reappraisal as treatment failure with artemisinin combination therapy","volume":"29","author":"Krishna","year":"2013","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.tips.2017.03.007_bib0160","doi-asserted-by":"crossref","first-page":"10111","DOI":"10.1038\/ncomms10111","article-title":"Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum","volume":"6","author":"Wang","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tips.2017.03.007_bib0165","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1021\/acschembio.5b01043","article-title":"Profiling of multiple targets of artemisinin activated by hemin in cancer cell proteome","volume":"11","author":"Zhou","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.tips.2017.03.007_bib0170","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1073\/pnas.1600459113","article-title":"Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7","volume":"113","author":"Ismail","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tips.2017.03.007_bib0175","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1002\/anie.201512062","article-title":"A click chemistry-based proteomic approach reveals that 1,2,4-trioxolane and artemisinin antimalarials share a common protein alkylation profile","volume":"55","author":"Ismail","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.tips.2017.03.007_bib0180","doi-asserted-by":"crossref","first-page":"11405","DOI":"10.1073\/pnas.1104063108","article-title":"Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion","volume":"108","author":"Klonis","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tips.2017.03.007_bib0185","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.1073\/pnas.1217452110","article-title":"Altered temporal response of malaria parasites determines differential sensitivity to artemisinin","volume":"110","author":"Klonis","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tips.2017.03.007_bib0190","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.mib.2013.07.005","article-title":"Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins","volume":"16","author":"Klonis","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.tips.2017.03.007_bib0195","doi-asserted-by":"crossref","first-page":"13770","DOI":"10.1002\/anie.201607303","article-title":"Mechanism-guided design and synthesis of a mitochondria-targeting artemisinin analogue with enhanced anticancer activity","volume":"55","author":"Zhang","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.tips.2017.03.007_bib0200","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0020-7519(02)00194-7","article-title":"Artemisinin: mechanisms of action, resistance and toxicity","volume":"32","author":"Meshnick","year":"2002","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.tips.2017.03.007_bib0205","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1021\/ar100070k","article-title":"Heme as trigger and target for trioxane-containing antimalarial drugs","volume":"43","author":"Meunier","year":"2010","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.tips.2017.03.007_bib0210","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.3390\/molecules15031705","article-title":"The molecular mechanism of action of artemisinin \u2013 the debate continues","volume":"15","author":"O\u2019Neill","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.tips.2017.03.007_bib0215","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1128\/AAC.37.5.1108","article-title":"Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu)","volume":"37","author":"Meshnick","year":"1993","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tips.2017.03.007_bib0220","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/0006-2952(92)90713-S","article-title":"Hemin-catalyzed decomposition of artemisinin (qinghaosu)","volume":"43","author":"Zhang","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tips.2017.03.007_bib0225","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1128\/AAC.38.8.1854","article-title":"Reaction of antimalarial endoperoxides with specific parasite proteins","volume":"38","author":"Asawamahasakda","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tips.2017.03.007_bib0230","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/0006-2952(94)90287-9","article-title":"Alkylation of proteins by artemisinin","volume":"48","author":"Yang","year":"1994","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tips.2017.03.007_bib0235","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0006-2952(93)90425-V","article-title":"Alkylation of human albumin by the antimalarial artemisinin","volume":"46","author":"Ying-Zi","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tips.2017.03.007_bib0240","doi-asserted-by":"crossref","first-page":"16192","DOI":"10.1074\/jbc.273.26.16192","article-title":"The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin","volume":"273","author":"Bhisutthibhan","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2017.03.007_bib0245","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1128\/AAC.45.8.2397-2399.2001","article-title":"Immunoprecipitation of [(3)H]dihydroartemisinin translationally controlled tumor protein (TCTP) adducts from Plasmodium falciparum-infected erythrocytes by using anti-TCTP antibodies","volume":"45","author":"Bhisutthibhan","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tips.2017.03.007_bib0250","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nature01813","article-title":"Artemisinins target the SERCA of Plasmodium falciparum","volume":"424","author":"Eckstein-Ludwig","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.tips.2017.03.007_bib0255","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nature14412","article-title":"A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria","volume":"520","author":"Mbengue","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.tips.2017.03.007_bib0260","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.pharmthera.2016.01.010","article-title":"Target identification of natural and traditional medicines with quantitative chemical proteomics approaches","volume":"162","author":"Wang","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.tips.2017.03.007_bib0265","doi-asserted-by":"crossref","first-page":"5968","DOI":"10.1021\/ja970412g","article-title":"Characterization of the first covalent adduct between artemisinin and a heme model","volume":"119","author":"Robert","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.tips.2017.03.007_bib0270","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1002\/1521-3773(20010518)40:10<1954::AID-ANIE1954>3.0.CO;2-9","article-title":"Characterization of the alkylation product of heme by the antimalarial drug artemisinin","volume":"40","author":"Robert","year":"2001","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.tips.2017.03.007_bib0275","doi-asserted-by":"crossref","first-page":"13676","DOI":"10.1073\/pnas.0500972102","article-title":"The antimalarial drug artemisinin alkylates heme in infected mice","volume":"102","author":"Robert","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tips.2017.03.007_bib0280","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1128\/AAC.47.3.1175.2003","article-title":"Artemisinin antimalarials do not inhibit hemozoin formation","volume":"47","author":"Haynes","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tips.2017.03.007_bib0285","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1128\/AAC.47.8.2712-2713.2003","article-title":"Artemisinin and heme","volume":"47","author":"Letter","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tips.2017.03.007_bib0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12936-016-1206-9","article-title":"Plasmodium falciparum: multifaceted resistance to artemisinins","volume":"15","author":"Paloque","year":"2016","journal-title":"Malar. J."},{"key":"10.1016\/j.tips.2017.03.007_bib0295","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1242\/jcs.178830","article-title":"Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins","volume":"129","author":"Xie","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.tips.2017.03.007_bib0300","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1128\/AAC.50.2.480-489.2006","article-title":"Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10","volume":"50","author":"Afonso","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tips.2017.03.007_bib0305","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature12876","article-title":"A molecular marker of artemisinin-resistant Plasmodium falciparum malaria","volume":"505","author":"Ariey","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.tips.2017.03.007_bib0310","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1473-3099(02)00239-6","article-title":"Epidemiology of drug-resistant malaria","volume":"2","author":"Wongsrichanalai","year":"2002","journal-title":"Lancet. Infect. Dis."},{"key":"10.1016\/j.tips.2017.03.007_bib0315","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.pt.2008.09.005","article-title":"Recent highlights in antimalarial drug resistance and chemotherapy research","volume":"24","author":"Fidock","year":"2008","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.tips.2017.03.007_bib0320","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0140-6736(04)16767-6","article-title":"Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number","volume":"364","author":"Price","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.tips.2017.03.007_bib0325","first-page":"279028","article-title":"Occurrence of pfatpase6 single nucleotide polymorphisms associated with artemisinin resistance among field isolates of Plasmodium falciparum in North-Eastern Tanzania","volume":"2015","author":"Chilongola","year":"2015","journal-title":"Malar. Res. Treat."},{"key":"10.1016\/j.tips.2017.03.007_bib0330","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1126\/science.1260403","article-title":"Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance","volume":"347","author":"Mok","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.tips.2017.03.007_bib0335","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1126\/science.1260867","article-title":"K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates","volume":"347","author":"Straimer","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.tips.2017.03.007_bib0340","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1128\/AAC.41.7.1413","article-title":"Assessment of the pharmacodynamic properties of antimalarial drugs in vivo","volume":"41","author":"White","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tips.2017.03.007_bib0345","doi-asserted-by":"crossref","first-page":"690","DOI":"10.4269\/ajtmh.2001.65.690","article-title":"Artemisinin for treatment of uncomplicated falciparum malaria: is there a place for monotherapy?","volume":"65","author":"Giao","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.tips.2017.03.007_bib0350","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1365-3156.1997.tb00168.x","article-title":"Efficacy of artemisinin and mefloquine combinations against Plasmodium falciparum. In vitro simulation of in vivo pharmacokinetics","volume":"2","author":"Bwijo","year":"1997","journal-title":"Trop. Med. Int. Health"},{"issue":"Suppl. 1","key":"10.1016\/j.tips.2017.03.007_bib0355","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/0035-9203(94)90462-6","article-title":"Overview of clinical studies on artemisinin derivatives in Thailand","volume":"88","author":"Looareesuwan","year":"1994","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.tips.2017.03.007_bib0360","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1475-2875-10-56","article-title":"Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure","volume":"10","author":"Codd","year":"2011","journal-title":"Malar. J."},{"key":"10.1016\/j.tips.2017.03.007_bib0365","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1128\/AAC.00197-15","article-title":"Artemisinin-resistant Plasmodium falciparum parasites exhibit altered patterns of development in infected erythrocytes","volume":"59","author":"Hott","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tips.2017.03.007_bib0370","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1128\/AAC.00482-15","article-title":"Altering antimalarial drug regimens may dramatically enhance and restore drug effectiveness","volume":"59","author":"Kay","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tips.2017.03.007_bib0375","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1086\/656476","article-title":"Artemisinin-induced dormancy in Plasmodium falciparum: duration, recovery rates, and implications in treatment failure","volume":"202","author":"Teuscher","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.tips.2017.03.007_bib0380","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1128\/AAC.01636-09","article-title":"Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism","volume":"54","author":"Witkowski","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tips.2017.03.007_bib0385","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1128\/AAC.01868-12","article-title":"Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia","volume":"57","author":"Witkowski","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tips.2017.03.007_bib0390","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1128\/AAC.05540-11","article-title":"Phenotypic and genotypic analysis of in vitro-selected artemisinin-resistant progeny of Plasmodium falciparum","volume":"56","author":"Tucker","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tips.2017.03.007_bib0395","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1128\/AAC.05456-11","article-title":"Phenotypic changes in artemisinin-resistant Plasmodium falciparum lines in vitro: evidence for decreased sensitivity to dormancy and growth inhibition","volume":"56","author":"Teuscher","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tips.2017.03.007_bib0400","doi-asserted-by":"crossref","first-page":"e1002132","DOI":"10.1371\/journal.pbio.1002132","article-title":"Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance","volume":"13","author":"Dogovski","year":"2015","journal-title":"PLoS Biol."},{"key":"10.1016\/j.tips.2017.03.007_bib0405","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S1473-3099(13)70252-4","article-title":"Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies","volume":"13","author":"Witkowski","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.tips.2017.03.007_bib0410","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1128\/AAC.01868-12","article-title":"Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia","volume":"57","author":"Witkowski","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tips.2017.03.007_bib0415","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S1473-3099(15)70080-0","article-title":"Malaria resistance to non-artemisinin partner drugs: how to reACT","volume":"15","author":"van Schalkwyk","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.tips.2017.03.007_bib0420","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1073\/pnas.1301607110","article-title":"Timing is everything for artemisinin action","volume":"110","author":"Sullivan","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tips.2017.03.007_bib0425","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/infdis\/jiu540","article-title":"Efficacy and safety of triple combination therapy with artesunate-amodiaquine-methylene blue for falciparum malaria in children: a randomized controlled trial in Burkina Faso","volume":"211","author":"Coulibaly","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.tips.2017.03.007_bib0430","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S1473-3099(14)70706-6","article-title":"Artemisinin resistance in Plasmodium falciparum","volume":"14","author":"Lun","year":"2014","journal-title":"Lancet Infect. Dis."}],"container-title":["Trends in Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614717300640?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614717300640?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T15:00:52Z","timestamp":1601996452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165614717300640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":86,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0165614717300640"],"URL":"https:\/\/doi.org\/10.1016\/j.tips.2017.03.007","relation":{},"ISSN":["0165-6147"],"issn-type":[{"value":"0165-6147","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unpacking \u2018Artemisinin Resistance\u2019","name":"articletitle","label":"Article Title"},{"value":"Trends in Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tips.2017.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}