{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T13:06:50Z","timestamp":1784380010338,"version":"3.55.0"},"reference-count":109,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness","award":["SAF2015-64146-R"],"award-info":[{"award-number":["SAF2015-64146-R"]}]},{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 La Marat\u00f3 de TV3","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Pharmacological Sciences"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.tips.2018.02.010","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T01:37:55Z","timestamp":1522287475000},"page":"452-467","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"title":["Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?"],"prefix":"10.1016","volume":"39","author":[{"given":"Xavier","family":"Palomer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Pizarro-Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"V\u00e1zquez-Carrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tips.2018.02.010_bib0005","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1001\/jama.289.2.194","article-title":"Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic","volume":"289","author":"Redfield","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.tips.2018.02.010_bib0010","doi-asserted-by":"crossref","first-page":"612","DOI":"10.2337\/diacare.28.3.612","article-title":"The association between glucose abnormalities and heart failure in the population-based Reykjavik study","volume":"28","author":"Thrainsdottir","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.tips.2018.02.010_bib0015","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3904\/kjim.2016.208","article-title":"Diabetic cardiomyopathy: where we are and where we are going","volume":"32","author":"Lee","year":"2017","journal-title":"Korean J. Intern. Med."},{"key":"10.1016\/j.tips.2018.02.010_bib0020","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1016\/j.ijcard.2013.07.150","article-title":"An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy","volume":"168","author":"Palomer","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.tips.2018.02.010_bib0025","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12933-014-0168-x","article-title":"Diastolic dysfunction in the diabetic continuum: association with insulin resistance, metabolic syndrome and type 2 diabetes","volume":"14","author":"Fontes-Carvalho","year":"2015","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.tips.2018.02.010_bib0030","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1161\/CIRCULATIONAHA.115.015357","article-title":"Diabetic cardiomyopathy: catabolism driving metabolism","volume":"131","author":"Wang","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.tips.2018.02.010_bib0035","doi-asserted-by":"crossref","first-page":"27410","DOI":"10.1074\/jbc.M802418200","article-title":"Regulation of the PDK4 isozyme by the Rb\u2013E2F1 complex","volume":"283","author":"Hsieh","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2018.02.010_bib0040","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1096\/fj.12-208991","article-title":"Insulin resistance improves metabolic and contractile efficiency in stressed rat heart","volume":"26","author":"Harmancey","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.tips.2018.02.010_bib0045","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.plefa.2011.04.018","article-title":"High fat diet induced diabetic cardiomyopathy","volume":"85","author":"Dirkx","year":"2011","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.tips.2018.02.010_bib0050","first-page":"3930","article-title":"Nuclear receptors PPARbeta\/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart","volume":"117","author":"Burkart","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tips.2018.02.010_bib0055","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.jacc.2008.07.062","article-title":"Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus","volume":"52","author":"Rijzewijk","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.tips.2018.02.010_bib0060","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/cvr\/cvr212","article-title":"Lipotoxicity in type 2 diabetic cardiomyopathy","volume":"92","author":"van de Weijer","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tips.2018.02.010_bib0065","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/652097","article-title":"Potential role of nuclear factor kappaB in diabetic cardiomyopathy","volume":"2011","author":"Lorenzo","year":"2011","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.tips.2018.02.010_bib0070","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/cvr\/cvq102","article-title":"Hyperglycaemia-induced cardiomyocyte death is mediated via MCP-1 production and induction of a novel zinc-finger protein MCPIP","volume":"87","author":"Younce","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tips.2018.02.010_bib0075","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1042\/CS20080500","article-title":"Diabetic cardiomyopathy","volume":"116","author":"Asghar","year":"2009","journal-title":"Clin. Sci."},{"key":"10.1016\/j.tips.2018.02.010_bib0080","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2337\/db10-1164","article-title":"Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo","volume":"60","author":"Tan","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.tips.2018.02.010_bib0085","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1172\/JCI18127","article-title":"Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells","volume":"112","author":"Du","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tips.2018.02.010_bib0090","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3164\/jcbn.2007008","article-title":"Involvement of endoplasmic reticulum stress in myocardial apoptosis of streptozocin-induced diabetic rats","volume":"41","author":"Li","year":"2007","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.tips.2018.02.010_bib0095","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijcard.2014.03.176","article-title":"PPARbeta\/delta attenuates palmitate-induced endoplasmic reticulum stress and induces autophagic markers in human cardiac cells","volume":"174","author":"Palomer","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.tips.2018.02.010_bib0100","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/cvr\/cvq274","article-title":"Cardiomyocyte NF-kappaB p65 promotes adverse remodelling, apoptosis, and endoplasmic reticulum stress in heart failure","volume":"89","author":"Hamid","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tips.2018.02.010_bib0105","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1469-7793.2000.00085.x","article-title":"Diminished function and expression of the cardiac Na+-Ca2+ exchanger in diabetic rats: implication in Ca2+ overload","volume":"527","author":"Hattori","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.tips.2018.02.010_bib0110","doi-asserted-by":"crossref","first-page":"608","DOI":"10.2337\/diabetes.55.03.06.db05-1284","article-title":"Mechanisms of [Ca2+]i transient decrease in cardiomyopathy of db\/db type 2 diabetic mice","volume":"55","author":"Pereira","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.tips.2018.02.010_bib0115","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1096\/fj.01-1019fje","article-title":"Transgenic overexpression of the sarcoplasmic reticulum Ca2+ATPase improves reticular Ca2+ handling in normal and diabetic rat hearts","volume":"16","author":"Vetter","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.tips.2018.02.010_bib0120","doi-asserted-by":"crossref","first-page":"H2478","DOI":"10.1152\/ajpheart.00638.2005","article-title":"Depressed cardiac myofilament function in human diabetes mellitus","volume":"289","author":"Jweied","year":"2005","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.tips.2018.02.010_bib0125","article-title":"Mitochondrial NAD+\/NADH redox state and diabetic cardiomyopathy","author":"Berthiaume","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.tips.2018.02.010_bib0130","article-title":"The relative contribution of metabolic and structural abnormalities to diastolic dysfunction in obesity","author":"Rayner","year":"2017","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.tips.2018.02.010_bib0135","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejrad.2008.03.022","article-title":"Cardiac 31P-MRS compared to echocardiographic findings in patients with hypertensive heart disease without overt systolic dysfunction \u2013 preliminary results","volume":"71","author":"Burkhard","year":"2009","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.tips.2018.02.010_bib0140","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1161\/CIRCULATIONAHA.114.012285","article-title":"Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of peroxisome proliferation-activated receptor alpha","volume":"131","author":"Liu","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.tips.2018.02.010_bib0145","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.yexmp.2015.03.022","article-title":"Pyruvate dehydrogenase kinase 4 (PDK4) could be involved in a regulatory role in apoptosis and a link between apoptosis and insulin resistance","volume":"98","author":"Dlamini","year":"2015","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.tips.2018.02.010_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019724","article-title":"The interplay between NF-kappaB and E2F1 coordinately regulates inflammation and metabolism in human cardiac cells","volume":"6","author":"Palomer","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.tips.2018.02.010_bib0155","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1159\/000443703","article-title":"Tripartite motif protein 72 regulates the proliferation and migration of rat cardiac fibroblasts via the transforming growth factor-beta signaling pathway","volume":"134","author":"Zhao","year":"2016","journal-title":"Cardiology"},{"key":"10.1016\/j.tips.2018.02.010_bib0160","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1124\/mol.117.108241","article-title":"MG53: biological function and potential as a therapeutic target","volume":"92","author":"Zhang","year":"2017","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tips.2018.02.010_bib0165","doi-asserted-by":"crossref","first-page":"H728","DOI":"10.1152\/ajpheart.00068.2016","article-title":"A systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response","volume":"312","author":"Seldin","year":"2017","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.tips.2018.02.010_bib0170","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1172\/JCI72327","article-title":"Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes","volume":"124","author":"Sala","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tips.2018.02.010_bib0175","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12872-015-0026-0","article-title":"Ischemic biomarker heart-type fatty acid binding protein (hFABP) in acute heart failure \u2013 diagnostic and prognostic insights compared to NT-proBNP and troponin I","volume":"15","author":"Hoffmann","year":"2015","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.tips.2018.02.010_bib0180","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s12020-009-9243-6","article-title":"Serum heart type fatty acid binding protein levels in metabolic syndrome","volume":"36","author":"Akbal","year":"2009","journal-title":"Endocrine"},{"key":"10.1016\/j.tips.2018.02.010_bib0185","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12933-017-0506-x","article-title":"Diagnostic approaches for diabetic cardiomyopathy","volume":"16","author":"Lorenzo-Almoros","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.tips.2018.02.010_bib0190","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/1535370217746383","article-title":"Immune response proteins as predictive biomarkers of doxorubicin-induced cardiotoxicity in breast cancer patients","volume":"243","author":"Yu","year":"2018","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.tips.2018.02.010_bib0195","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12013-012-9462-y","article-title":"Silencing of FABP3 inhibits proliferation and promotes apoptosis in embryonic carcinoma cells","volume":"66","author":"Shen","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.tips.2018.02.010_bib0200","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/cvr\/cvt173","article-title":"Activin A impairs insulin action in cardiomyocytes via up-regulation of miR-143","volume":"100","author":"Blumensatt","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tips.2018.02.010_bib0205","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/1475-2840-12-150","article-title":"Activin A is associated with impaired myocardial glucose metabolism and left ventricular remodeling in patients with uncomplicated type 2 diabetes","volume":"12","author":"Chen","year":"2013","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.tips.2018.02.010_bib0210","doi-asserted-by":"crossref","first-page":"161","DOI":"10.7150\/ijms.14141","article-title":"Role of serum biomarkers in early detection of diabetic cardiomyopathy in the West Virginian population","volume":"13","author":"Shaver","year":"2016","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.tips.2018.02.010_bib0215","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1002\/pmic.201200455","article-title":"Pilot study identifying myosin heavy chain 7, desmin, insulin-like growth factor 7, and annexin A2 as circulating biomarkers of human heart failure","volume":"13","author":"Chugh","year":"2013","journal-title":"Proteomics"},{"key":"10.1016\/j.tips.2018.02.010_bib0220","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.jchf.2016.08.002","article-title":"Insulin-like growth factor-binding protein-7 as a biomarker of diastolic dysfunction and functional capacity in heart failure with preserved ejection fraction: results from the RELAX trial","volume":"4","author":"Gandhi","year":"2016","journal-title":"JACC Heart Fail"},{"issue":"Suppl. 1","key":"10.1016\/j.tips.2018.02.010_bib0225","first-page":"S201","article-title":"Cardiac biomarkers in diabetes mellitus: new dawn for risk stratification?","volume":"11","author":"Berezin","year":"2016","journal-title":"Diabetes Metab. Syndr."},{"key":"10.1016\/j.tips.2018.02.010_bib0230","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.cell.2016.10.025","article-title":"Hematopoietic-derived galectin-3 causes cellular and systemic insulin resistance","volume":"167","author":"Li","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.tips.2018.02.010_bib0235","doi-asserted-by":"crossref","first-page":"897","DOI":"10.5114\/aoms.2016.58664","article-title":"Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3","volume":"13","author":"Hogas","year":"2017","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.tips.2018.02.010_bib0240","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.yjmcc.2004.10.016","article-title":"Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5\u2013ERK5 pathway in cultured cardiomyocytes","volume":"38","author":"Takahashi","year":"2005","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.tips.2018.02.010_bib0245","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000001218","article-title":"Plasma cardiotrophin-1 as a marker of hypertension and diabetes-induced target organ damage and cardiovascular risk","volume":"94","author":"Gamella-Pozuelo","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.tips.2018.02.010_bib0250","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1016\/j.ijcard.2013.08.112","article-title":"Increased cardiotrophin-1 in subjects with impaired glucose tolerance and newly diagnosed diabetes","volume":"169","author":"Hung","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.tips.2018.02.010_bib0255","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.jacc.2008.07.042","article-title":"Characteristics of the novel interleukin family biomarker ST2 in patients with acute heart failure","volume":"52","author":"Rehman","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.tips.2018.02.010_bib0260","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1475-2840-10-101","article-title":"Toll\/interleukin-1 receptor member ST2 exhibits higher soluble levels in type 2 diabetes, especially when accompanied with left ventricular diastolic dysfunction","volume":"10","author":"Fousteris","year":"2011","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.tips.2018.02.010_bib0265","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12933-016-0470-x","article-title":"Impact of diabetes on the predictive value of heart failure biomarkers","volume":"15","author":"Alonso","year":"2016","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.tips.2018.02.010_bib0270","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.imbio.2011.04.007","article-title":"Can YKL-40 be a new inflammatory biomarker in cardiovascular disease?","volume":"217","author":"Kastrup","year":"2012","journal-title":"Immunobiology"},{"key":"10.1016\/j.tips.2018.02.010_bib0275","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00011-005-0010-8","article-title":"YKL-40, a biomarker of inflammation, is elevated in patients with type 2 diabetes and is related to insulin resistance","volume":"55","author":"Rathcke","year":"2006","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.tips.2018.02.010_bib0280","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1042\/bj20040099","article-title":"The chitinase 3\u2013like protein human cartilage glycoprotein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha","volume":"380","author":"Ling","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.tips.2018.02.010_bib0285","doi-asserted-by":"crossref","first-page":"44058","DOI":"10.1074\/jbc.M306792200","article-title":"Transcriptional regulation of CHI3L1, a marker gene for late stages of macrophage differentiation","volume":"278","author":"Rehli","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2018.02.010_bib0290","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/s11906-003-0052-7","article-title":"Transcriptional regulation of energy substrate metabolism in normal and hypertrophied heart","volume":"5","author":"Tian","year":"2003","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.tips.2018.02.010_bib0295","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12902-017-0204-4","article-title":"Insulin treatment corrects hepcidin but not YKL-40 levels in persons with type 2 diabetes mellitus matched by body mass index, waist-to-height ratio, C-reactive protein and Creatinine","volume":"17","author":"Vela","year":"2017","journal-title":"BMC Endocr. Disord."},{"key":"10.1016\/j.tips.2018.02.010_bib0300","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ijcard.2014.01.011","article-title":"Inhibition of high-mobility group box 1 improves myocardial fibrosis and dysfunction in diabetic cardiomyopathy","volume":"172","author":"Wang","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.tips.2018.02.010_bib0305","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00395-010-0114-3","article-title":"HMGB1: the missing link between diabetes mellitus and heart failure","volume":"105","author":"Volz","year":"2010","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.tips.2018.02.010_bib0310","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1111\/jcmm.12399","article-title":"HMGB1 mediates hyperglycaemia-induced cardiomyocyte apoptosis via ERK\/Ets-1 signalling pathway","volume":"18","author":"Wang","year":"2014","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.tips.2018.02.010_bib0315","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9836860","article-title":"Reduced HMGB 1\u2013mediated pathway and oxidative stress in resveratrol-treated diabetic mice: a possible mechanism of cardioprotection of resveratrol in diabetes mellitus","volume":"2016","author":"Wu","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tips.2018.02.010_bib0320","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.3892\/etm.2017.4824","article-title":"Ulinastatin attenuates diabetes-induced cardiac dysfunction by the inhibition of inflammation and apoptosis","volume":"14","author":"Wang","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.tips.2018.02.010_bib0325","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1161\/01.HYP.0000208840.30778.00","article-title":"Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload","volume":"47","author":"Matsusaka","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.tips.2018.02.010_bib0330","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/sj.ijo.0803022","article-title":"Myocardial collagen turnover in normotensive obese patients: relation to insulin resistance","volume":"29","author":"Quilliot","year":"2005","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.tips.2018.02.010_bib0335","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/aps.2009.95","article-title":"Breviscapine ameliorates hypertrophy of cardiomyocytes induced by high glucose in diabetic rats via the PKC signaling pathway","volume":"30","author":"Wang","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.tips.2018.02.010_bib0340","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1242\/dmm.020768","article-title":"miR-146a targets c-Fos expression in human cardiac cells","volume":"8","author":"Palomer","year":"2015","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.tips.2018.02.010_bib0345","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.bbalip.2014.05.007","article-title":"c-Fos: an AP-1 transcription factor with an additional cytoplasmic, non-genomic lipid synthesis activation capacity","volume":"1841","author":"Caputto","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tips.2018.02.010_bib0350","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cytogfr.2013.05.003","article-title":"The multiple facets of the TGF-beta family cytokine growth\/differentiation factor-15\/macrophage inhibitory cytokine-1","volume":"24","author":"Unsicker","year":"2013","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.tips.2018.02.010_bib0355","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.116.003804","article-title":"Plasma and cardiac galectin-3 in patients with heart failure reflects both inflammation and fibrosis: implications for its use as a biomarker","volume":"10","author":"Besler","year":"2017","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.tips.2018.02.010_bib0360","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1161\/CIRCHEARTFAILURE.112.971168","article-title":"Genetic and pharmacological inhibition of galectin-3 prevents cardiac remodeling by interfering with myocardial fibrogenesis","volume":"6","author":"Yu","year":"2013","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.tips.2018.02.010_bib0365","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1515\/cclm-2014-0187","article-title":"Galectin-3 in diabetic patients","volume":"52","author":"Pugliese","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.tips.2018.02.010_bib0370","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/HJH.0000000000001545","article-title":"Galectin-3 pharmacological inhibition attenuates early renal damage in spontaneously hypertensive rats","volume":"36","author":"Martinez-Martinez","year":"2018","journal-title":"J. Hypertens."},{"key":"10.1016\/j.tips.2018.02.010_bib0375","doi-asserted-by":"crossref","first-page":"H958","DOI":"10.1152\/ajpheart.00956.2015","article-title":"Left ventricular pressure-volume measurements and myocardial gene expression profile in type 2 diabetic Goto-Kakizaki rats","volume":"311","author":"Korkmaz-Icoz","year":"2016","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.tips.2018.02.010_bib0380","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.2337\/dc09-0552","article-title":"Troponin T and pro-B-type natriuretic peptide in fetuses of type 1 diabetic mothers","volume":"32","author":"Russell","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.tips.2018.02.010_bib0385","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.2337\/db16-1237","article-title":"MICU1 alleviates diabetic cardiomyopathy through mitochondrial Ca2+-dependent antioxidant response","volume":"66","author":"Ji","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.tips.2018.02.010_bib0390","first-page":"660","article-title":"Paradoxal decrease and metabolic effects of BNP in obese patient","volume":"13","author":"Martin-Du-Pan","year":"2017","journal-title":"Rev. Med. Suisse"},{"key":"10.1016\/j.tips.2018.02.010_bib0395","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.2147\/CIA.S109583","article-title":"Deep analyses of the associations of a series of biomarkers with insulin resistance, metabolic syndrome, and diabetes risk in nondiabetic middle-aged and elderly individuals: results from a Chinese community-based study","volume":"11","author":"Fu","year":"2016","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.tips.2018.02.010_bib0400","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1080\/14728222.2016.1254198","article-title":"Targeting cardiac natriuretic peptides in the therapy of diabetes and obesity","volume":"20","author":"Moro","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.tips.2018.02.010_bib0405","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.biochi.2015.05.017","article-title":"Natriuretic peptide control of energy balance and glucose homeostasis","volume":"124","author":"Coue","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.tips.2018.02.010_bib0410","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6143129","article-title":"Subclinical detection of diabetic cardiomyopathy with microRNAs: challenges and perspectives","volume":"2016","author":"Leon","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.tips.2018.02.010_bib0415","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1016\/j.bbadis.2017.03.013","article-title":"Role of microRNA in diabetic cardiomyopathy: from mechanism to intervention","volume":"1863","author":"Guo","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tips.2018.02.010_bib0420","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.yexcr.2012.11.015","article-title":"miR-150 regulates high glucose-induced cardiomyocyte hypertrophy by targeting the transcriptional co-activator p300","volume":"319","author":"Duan","year":"2013","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.tips.2018.02.010_bib0425","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1161\/CIRCRESAHA.108.182535","article-title":"miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling","volume":"104","author":"Duisters","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.tips.2018.02.010_bib0430","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1007\/s12013-013-9672-y","article-title":"Relationship between downregulation of miRNAs and increase of oxidative stress in the development of diabetic cardiac dysfunction: junctin as a target protein of miR-1","volume":"67","author":"Yildirim","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.tips.2018.02.010_bib0435","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11010-016-2729-7","article-title":"miR-30c and miR-181a synergistically modulate p53\u2013p21 pathway in diabetes induced cardiac hypertrophy","volume":"417","author":"Raut","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.tips.2018.02.010_bib0440","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.430","article-title":"MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy","volume":"5","author":"Li","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tips.2018.02.010_bib0445","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.bbrc.2016.02.065","article-title":"MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1","volume":"471","author":"Jeyabal","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tips.2018.02.010_bib0450","doi-asserted-by":"crossref","first-page":"63038","DOI":"10.18632\/oncotarget.18593","article-title":"Circulating miRNA-24 and its target YKL-40 as potential biomarkers in patients with coronary heart disease and type 2 diabetes mellitus","volume":"8","author":"Deng","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.tips.2018.02.010_bib0455","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bbrc.2009.08.136","article-title":"MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes","volume":"389","author":"Horie","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tips.2018.02.010_bib0460","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/cvr\/cvq010","article-title":"MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism","volume":"86","author":"Lu","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tips.2018.02.010_bib0465","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cmet.2013.08.009","article-title":"The hypoxia-inducible microRNA cluster miR-199a approximately 214 targets myocardial PPARdelta and impairs mitochondrial fatty acid oxidation","volume":"18","author":"el Azzouzi","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.tips.2018.02.010_bib0470","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/CIRCRESAHA.116.304707","article-title":"MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1\/AMPK pathway","volume":"116","author":"Kuwabara","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.tips.2018.02.010_bib0475","doi-asserted-by":"crossref","first-page":"13514","DOI":"10.1038\/s41598-017-13875-2","article-title":"Circulating miR-19b and miR-181b are potential biomarkers for diabetic cardiomyopathy","volume":"7","author":"Copier","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tips.2018.02.010_bib0480","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/ncomms2090","article-title":"The miRNA-212\/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy","volume":"3","author":"Ucar","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tips.2018.02.010_bib0485","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nm1582","article-title":"MicroRNA-133 controls cardiac hypertrophy","volume":"13","author":"Care","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.tips.2018.02.010_bib0490","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nature10998","article-title":"A PPARgamma\u2013FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis","volume":"485","author":"Jonker","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.tips.2018.02.010_bib0495","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1038\/ncomms3019","article-title":"Fibroblast growth factor 21 protects against cardiac hypertrophy in mice","volume":"4","author":"Planavila","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tips.2018.02.010_bib0500","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1210\/en.2012-1193","article-title":"TNF-alpha represses beta-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway","volume":"153","author":"D\u00edaz-Delfin","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.tips.2018.02.010_bib0505","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/cvr\/cvu263","article-title":"Fibroblast growth factor 21 protects the heart from oxidative stress","volume":"106","author":"Planavila","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tips.2018.02.010_bib0510","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1042\/CS20170271","article-title":"FGF21 ameliorates diabetic cardiomyopathy by activating the AMPK-paraoxonase 1 signaling axis in mice","volume":"131","author":"Wu","year":"2017","journal-title":"Clin. Sci."},{"key":"10.1016\/j.tips.2018.02.010_bib0515","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"FGF23 induces left ventricular hypertrophy","volume":"121","author":"Faul","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"Suppl. 1","key":"10.1016\/j.tips.2018.02.010_bib0520","doi-asserted-by":"crossref","first-page":"S154","DOI":"10.1016\/j.dsx.2015.09.016","article-title":"Diabetes mellitus related biomarker: the predictive role of growth-differentiation factor-15","volume":"10","author":"Berezin","year":"2016","journal-title":"Diabetes Metab. Syndr."},{"key":"10.1016\/j.tips.2018.02.010_bib0525","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140222","article-title":"FGF-23\/vitamin D axis in type 1 diabetes: the potential role of mineral metabolism in arterial stiffness","volume":"10","author":"Llaurado","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.tips.2018.02.010_bib0530","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1161\/CIRCULATIONAHA.107.704080","article-title":"New drugs for the treatment of diabetes mellitus. Part I: thiazolidinediones and their evolving cardiovascular implications","volume":"117","author":"McGuire","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.tips.2018.02.010_bib0535","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1007\/s00125-007-0719-8","article-title":"Anti-inflammatory effects of atorvastatin improve left ventricular function in experimental diabetic cardiomyopathy","volume":"50","author":"Van Linthout","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.tips.2018.02.010_bib0540","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4330\/wjc.v3.i9.281","article-title":"Parallel effects of beta-adrenoceptor blockade on cardiac function and fatty acid oxidation in the diabetic heart: confronting the maze","volume":"3","author":"Sharma","year":"2011","journal-title":"World J. Cardiol."},{"key":"10.1016\/j.tips.2018.02.010_bib0545","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1758-5996-3-4","article-title":"Management of cardiac fibrosis in diabetic rats; the role of peroxisome proliferator activated receptor gamma (PPAR-gamma) and calcium channel blockers (CCBs)","volume":"3","author":"Mohamad","year":"2011","journal-title":"Diabetol. Metab. Synd."}],"container-title":["Trends in Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614718300488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614718300488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T11:54:28Z","timestamp":1604058868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165614718300488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":109,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0165614718300488"],"URL":"https:\/\/doi.org\/10.1016\/j.tips.2018.02.010","relation":{},"ISSN":["0165-6147"],"issn-type":[{"value":"0165-6147","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?","name":"articletitle","label":"Article Title"},{"value":"Trends in Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tips.2018.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}