{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:32:56Z","timestamp":1777717976504,"version":"3.51.4"},"reference-count":111,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Pharmacological Sciences"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.tips.2018.03.009","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T15:47:04Z","timestamp":1524757624000},"page":"624-634","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"title":["Garlic and Gaseous Mediators"],"prefix":"10.1016","volume":"39","author":[{"given":"Peter","family":"Rose","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip Keith","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Zhun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tips.2018.03.009_bib0005","series-title":"Garlic: The Science and Therapeutic Application of Allium sativum L. and Related Species","first-page":"25","article-title":"History of garlic","author":"Kahn","year":"1996"},{"key":"10.1016\/j.tips.2018.03.009_bib0010","series-title":"Garlic in Health, History and World Cuisine","author":"Moyers","year":"1996"},{"key":"10.1016\/j.tips.2018.03.009_bib0015","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4103\/0973-7847.65321","article-title":"Extracts from the history and medical properties of garlic","volume":"4","author":"Petrovska","year":"2010","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.tips.2018.03.009_bib0020","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/anie.199211351","article-title":"The organosulfur chemistry of the genus Allium \u2013 implications for the organic chemistry of sulfur","volume":"31","author":"Block","year":"1992","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.tips.2018.03.009_bib0025","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1039\/b609523m","article-title":"A scent of therapy: pharmacological implications of natural products containing redox-active sulfur atoms","volume":"23","author":"Jacobs","year":"2006","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.tips.2018.03.009_bib0030","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1080\/10408398.2012.755149","article-title":"The health potential of fruits and vegetables phytochemicals: notable examples","volume":"56","author":"Rodriguez-Casado","year":"2016","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.tips.2018.03.009_bib0035","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1158\/1940-6207.CAPR-14-0172","article-title":"Garlic and onions: their cancer prevention properties","volume":"8","author":"Nicastro","year":"2015","journal-title":"Cancer Prev. Res. (Phila.)"},{"key":"10.1016\/j.tips.2018.03.009_bib0040","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006558","article-title":"Cruciferous and Allium vegetable intakes are inversely associated with 15-year atherosclerotic vascular disease deaths in older adult women","volume":"6","author":"Blekkenhorst","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.tips.2018.03.009_bib0045","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1097\/HJH.0000000000001356","article-title":"Allium vegetable intakes and the incidence of cardiovascular disease, hypertension, chronic kidney disease, and type 2 diabetes in adults: a longitudinal follow-up study","volume":"35","author":"Bahadoran","year":"2017","journal-title":"J. Hypertens."},{"key":"10.1016\/j.tips.2018.03.009_bib0050","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.phymed.2014.12.013","article-title":"Garlic for hypertension: a systematic review and meta-analysis of randomized controlled trials","volume":"22","author":"Xiong","year":"2016","journal-title":"Phytomedicine"},{"key":"10.1016\/j.tips.2018.03.009_bib0055","doi-asserted-by":"crossref","DOI":"10.1080\/16546628.2017.1377571","article-title":"Effect of garlic supplement in the management of type 2 diabetes mellitus (T2DM): a meta-analysis of randomized controlled trials","volume":"61","author":"Wang","year":"2017","journal-title":"Food Nutr. Res."},{"key":"10.1016\/j.tips.2018.03.009_bib0060","doi-asserted-by":"crossref","DOI":"10.1038\/srep45995","article-title":"Polysulfides (H2Sn) produced from the interaction of hydrogen sulfide (H2S) and nitric oxide (NO) activate TRPA1 channels","volume":"7","author":"Miyamoto","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tips.2018.03.009_bib0065","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.redox.2017.03.020","article-title":"Cysteine persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation","volume":"12","author":"Koike","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.tips.2018.03.009_bib0070","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1073\/pnas.1321232111","article-title":"Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling","volume":"111","author":"Ida","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tips.2018.03.009_bib0075","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.foodchem.2017.04.098","article-title":"The contribution of alliaceous and cruciferous vegetables to dietary sulphur intake","volume":"234","author":"Doleman","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.tips.2018.03.009_bib0080","doi-asserted-by":"crossref","first-page":"1020S","DOI":"10.1093\/jn\/131.3.1020S","article-title":"Garlic compounds minimize intracellular oxidative stress and inhibit nuclear factor-kappa B activation","volume":"131","author":"Ide","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.tips.2018.03.009_bib0085","doi-asserted-by":"crossref","DOI":"10.1145\/2818302","article-title":"Antimetastatic therapies of the polysulfide diallyl trisulfide against triple-negative breast cancer (TNBC) via suppressing MMP2\/9 by blocking NF-\u03baB and ERK\/MAPK signaling pathways","volume":"10","author":"Lui","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.tips.2018.03.009_bib0090","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1007\/s13277-015-4181-9","article-title":"ROS-mediated activation of JNK\/p38 contributes partially to the pro-apoptotic effect of ajoene on cells of lung adenocarcinoma","volume":"37","author":"Wang","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.tips.2018.03.009_bib0095","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.intimp.2017.05.004","article-title":"Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice","volume":"48","author":"Jiang","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tips.2018.03.009_bib0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112720","article-title":"Diallyl disulfide suppresses SRC\/Ras\/ERK signaling-mediated proliferation and metastasis in human breast cancer by up-regulating miR-34a","volume":"9","author":"Xiao","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.tips.2018.03.009_bib0105","doi-asserted-by":"crossref","first-page":"74791","DOI":"10.18632\/oncotarget.20422","article-title":"Diallyl trisulfide exerts cardioprotection against myocardial ischemia\u2013reperfusion injury in diabetic state, role of AMPK-mediated AKT\/GSK-3\u03b2\/HIF-1\u03b1 activation","volume":"8","author":"Yu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.tips.2018.03.009_bib0110","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.freeradbiomed.2004.07.021","article-title":"Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals","volume":"37","author":"Chen","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tips.2018.03.009_bib0115","article-title":"Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.tips.2018.03.009_bib0120","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.3945\/jn.110.121277","article-title":"Ajoene, a stable garlic by-product, has an antioxidant effect through Nrf2-mediated glutamate\u2013cysteine ligase induction in HepG2 cells and primary hepatocytes","volume":"140","author":"Kay","year":"2010","journal-title":"J. Nutr."},{"key":"10.1016\/j.tips.2018.03.009_bib0125","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1159\/000475640","article-title":"Allicin decreases lipopolysaccharide-induced oxidative stress and inflammation in human umbilical vein endothelial cells through suppression of mitochondrial dysfunction and activation of Nrf2","volume":"41","author":"Zhang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.tips.2018.03.009_bib0130","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/jn\/132.4.773","article-title":"Diallyl disulfide (DADS) induces the antitumorigenic NSAID-activated gene (NAG-1) by a p53-dependent mechanism in human colorectal HCT 116 cells","volume":"132","author":"Bottone","year":"2002","journal-title":"J. Nutr."},{"key":"10.1016\/j.tips.2018.03.009_bib0135","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1158\/1535-7163.1459.3.11","article-title":"Modulation of p53 in 7,12-dimethylbenz[a]anthracene-induced skin tumors by diallyl sulfide in Swiss albino mice","volume":"3","author":"Arora","year":"2004","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.tips.2018.03.009_bib0140","doi-asserted-by":"crossref","first-page":"9839","DOI":"10.1021\/jf403241s","article-title":"Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and autophagy","volume":"61","author":"Chu","year":"2013","journal-title":"J. Agric. Food. Chem."},{"key":"10.1016\/j.tips.2018.03.009_bib0145","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1089\/ars.2010.3190","article-title":"Ajoene, a stable garlic by-product, inhibits high fat diet-induced hepatic steatosis and oxidative injury through LKB1-dependent AMPK activation","volume":"14","author":"Han","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.tips.2018.03.009_bib0150","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.3945\/jn.111.146050","article-title":"Reduction of body weight by dietary garlic is associated with an increase in uncoupling protein mRNA expression and activation of AMP-activated protein kinase in diet-induced obese mice","volume":"141","author":"Lee","year":"2011","journal-title":"J. Nutr."},{"key":"10.1016\/j.tips.2018.03.009_bib0155","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.bcp.2012.11.007","article-title":"Garlic-derived diallyl disulfide modulates peroxisome proliferator activated receptor gamma co-activator 1 alpha in neuroblastoma cells","volume":"85","author":"Pagliei","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tips.2018.03.009_bib0160","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201601013","article-title":"Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK\u2013NF-\u03baB\/AP-1\/STAT-1 inactivation and PPAR-\u03b3 activation","volume":"61","author":"Shi","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.tips.2018.03.009_bib0165","doi-asserted-by":"crossref","first-page":"E464","DOI":"10.3390\/nu8080464","article-title":"Protective effect of garlic on cellular senescence in UVB-exposed HaCaT human keratinocytes","volume":"8","author":"Kim","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.tips.2018.03.009_bib0170","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0891-5849(01)00460-9","article-title":"Differential regulation of NO availability from macrophages and endothelial cells by the garlic component S-allyl cysteine","volume":"30","author":"Kim","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tips.2018.03.009_bib0175","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s00018-016-2406-8","article-title":"H2S biosynthesis and catabolism: new insights from molecular studies","volume":"74","author":"Rose","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.tips.2018.03.009_bib0180","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1124\/pr.117.014050","article-title":"International Union of Basic and Clinical Pharmacology. CII: pharmacological modulation of H2S levels: H2S donors and H2S biosynthesis inhibitors","volume":"69","author":"Szabo","year":"2017","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.tips.2018.03.009_bib0185","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1039\/b417639c","article-title":"Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents","volume":"22","author":"Rose","year":"2005","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.tips.2018.03.009_bib0190","first-page":"734","article-title":"The pharmacokinetics of the S35 labeled garlic constituents alliin, allicin and vinyldithiine","volume":"44","author":"Lachmann","year":"1994","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.tips.2018.03.009_bib0195","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1021\/jf00057a004","article-title":"Garlic chemistry: stability of S-(2-propenyl)-2-propene-1-sulfothiate (allicin) in blood, solvents, and simulated physiological fluids","volume":"43","author":"Freeman","year":"1995","journal-title":"J. Agric. Food. Chem."},{"key":"10.1016\/j.tips.2018.03.009_bib0200","doi-asserted-by":"crossref","first-page":"968S","DOI":"10.1093\/jn\/131.3.968S","article-title":"Determination of allicin, S-allylcysteine and volatile metabolites of garlic in breath, plasma or simulated gastric fluids","volume":"131","author":"Rosen","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.tips.2018.03.009_bib0205","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1021\/jf048323s","article-title":"Allicin and allicin-derived garlic compounds increase breath acetone through allyl methyl sulfide: use in measuring allicin bioavailability","volume":"53","author":"Lawson","year":"2005","journal-title":"J. Agric. Food. Chem."},{"key":"10.1016\/j.tips.2018.03.009_bib0210","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1124\/dmd.30.10.1137","article-title":"Sulfoxides as urinary metabolites of S-allyl-L-cysteine in rats: evidence for the involvement of flavin-containing monooxygenases","volume":"30","author":"Krause","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tips.2018.03.009_bib0215","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bcp.2017.12.010","article-title":"H2S and polysulfide metabolism: conventional and unconventional pathways","volume":"149","author":"Olson","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tips.2018.03.009_bib0220","doi-asserted-by":"crossref","DOI":"10.1038\/nrcardio.2017.224","article-title":"Nitric oxide signalling in cardiovascular health and disease","author":"Farah","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.tips.2018.03.009_bib0225","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1039\/C3CC49196J","article-title":"Carbon monoxide \u2013 physiology, detection and controlled release","volume":"50","author":"Heinemann","year":"2014","journal-title":"Chem. Commun. (Camb.)"},{"key":"10.1016\/j.tips.2018.03.009_bib0230","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.foodchem.2016.10.076","article-title":"Boiling enriches the linear polysulfides and the hydrogen sulphide releasing activity of garlic","volume":"221","author":"Tocmo","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.tips.2018.03.009_bib0235","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.dib.2016.11.074","article-title":"Data on the effect of boiling on the organosulfides and the hydrogen sulfide-releasing activity of garlic","volume":"10","author":"Tocmo","year":"2017","journal-title":"Data Brief"},{"key":"10.1016\/j.tips.2018.03.009_bib0240","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/bs.mie.2014.11.014","article-title":"GYY4137, a novel water-soluble, H2S-releasing molecule","volume":"554","author":"Rose","year":"2015","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.tips.2018.03.009_bib0245","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.niox.2014.04.008","article-title":"AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro","volume":"41","author":"Szczesny","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.tips.2018.03.009_bib0250","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.niox.2014.11.010","article-title":"H2S-releasing drugs: anti-inflammatory, cytoprotective and chemopreventative potential","volume":"46","author":"Gemici","year":"2015","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.tips.2018.03.009_bib0255","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1161\/01.CIR.96.8.2649","article-title":"Protective effect of chronic garlic intake on elastic properties of aorta in the elderly","volume":"96","author":"Breithaupt-Gr\u00f6gler","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.tips.2018.03.009_bib0260","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.3390\/nu7064911","article-title":"NO-rich diet for lifestyle-related diseases","volume":"7","author":"Kobayashi","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.tips.2018.03.009_bib0265","doi-asserted-by":"crossref","first-page":"403S","DOI":"10.3945\/jn.114.208066","article-title":"Garlic-derived organic polysulfides and myocardial protection","volume":"146","author":"Bradley","year":"2016","journal-title":"J. Nutr."},{"key":"10.1016\/j.tips.2018.03.009_bib0270","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1185\/03007999509111550","article-title":"Potent activation of nitric oxide synthase by garlic: a basis for its therapeutic applications","volume":"13","author":"Das","year":"1995","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.tips.2018.03.009_bib0275","doi-asserted-by":"crossref","first-page":"136S","DOI":"10.1042\/bst023136s","article-title":"Nitric oxide synthase activation is a unique mechanism of garlic action","volume":"23","author":"Das","year":"1995","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.tips.2018.03.009_bib0280","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1046\/j.1440-1681.2002.03596.x","article-title":"Garlic and its active metabolite allicin produce endothelium- and nitric oxide-dependent relaxation in rat pulmonary arteries","volume":"29","author":"Ku","year":"2002","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.tips.2018.03.009_bib0285","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0024-3205(02)01706-X","article-title":"Aged garlic extract enhances production of nitric oxide","volume":"71","author":"Morihara","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.tips.2018.03.009_bib0290","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.niox.2012.03.004","article-title":"Garlic provides protection to mice heart against isoproterenol-induced oxidative damage: role of nitric oxide","volume":"27","author":"Khatua","year":"2012","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.tips.2018.03.009_bib0295","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1046\/j.1440-1681.2000.03333.x","article-title":"Garlic elicits a nitric oxide-dependent relaxation and inhibits hypoxic pulmonary vasoconstriction in rats","volume":"27","author":"Kim-Park","year":"2000","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.tips.2018.03.009_bib0300","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.phymed.2016.11.016","article-title":"Aged garlic extract exerts endothelium-dependent vasorelaxant effect on rat aorta by increasing nitric oxide production","volume":"24","author":"Takashima","year":"2017","journal-title":"Phytomedicine"},{"key":"10.1016\/j.tips.2018.03.009_bib0305","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1002\/mnfr.200900278","article-title":"Diallyl disulfide and diallyl trisulfide protect endothelial nitric oxide synthase against damage by oxidized low-density lipoprotein","volume":"54","author":"Lei","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.tips.2018.03.009_bib0310","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1161\/CIRCULATIONAHA.116.022967","article-title":"Restoration of hydrogen sulfide production in diabetic mice improves reparative function of bone marrow cells","volume":"134","author":"Cheng","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.tips.2018.03.009_bib0315","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/bs.apha.2017.09.003","article-title":"Nitric oxide signaling in neurodegeneration and cell death","volume":"82","author":"Dawson","year":"2018","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.tips.2018.03.009_bib0320","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/j.1471-4159.2006.04431.x","article-title":"Neuronal nitric oxide synthase protects neuroblastoma cells from oxidative stress mediated by garlic derivatives","volume":"101","author":"Aquilano","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tips.2018.03.009_bib0325","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.brainresbull.2013.10.013","article-title":"Allicin protects rat cortical neurons against mechanical trauma injury by regulating nitric oxide synthase pathways","volume":"100","author":"Zhou","year":"2014","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.tips.2018.03.009_bib0330","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1039\/C4FO00761A","article-title":"Allicin protects spinal cord neurons from glutamate-induced oxidative stress through regulating the heat shock protein 70\/inducible nitric oxide synthase pathway","volume":"6","author":"Liu","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.tips.2018.03.009_bib0335","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.biopha.2017.06.036","article-title":"Inducible nitric oxide synthase: good or bad?","volume":"93","author":"Lind","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tips.2018.03.009_bib0340","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0021-9150(98)00094-X","article-title":"Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase","volume":"139","author":"Dirsch","year":"1998","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.tips.2018.03.009_bib0345","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.nut.2004.07.018","article-title":"Differential effects of organosulfur compounds from garlic oil on nitric oxide and prostaglandin E2 in stimulated macrophages","volume":"21","author":"Change","year":"2005","journal-title":"Nutrition"},{"key":"10.1016\/j.tips.2018.03.009_bib0350","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1021\/jf060043k","article-title":"DATS reduces LPS-induced iNOS expression, NO production, oxidative stress, and NF-\u03baB activation in RAW 264.7 macrophages","volume":"54","author":"Liu","year":"2006","journal-title":"J. Agric. Food. Chem."},{"key":"10.1016\/j.tips.2018.03.009_bib0355","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1042\/cs1020487","article-title":"Garlic attenuates nitric oxide production in rat cardiac myocytes through inhibition of inducible nitric oxide synthase and the arginine transporter CAT-2 (cationic amino acid transporter-2)","volume":"102","author":"Schwartz","year":"2002","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.tips.2018.03.009_bib0360","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bcp.2017.10.011","article-title":"Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation","volume":"149","author":"Ol\u00e1h","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tips.2018.03.009_bib0365","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3389\/fphar.2017.00763","article-title":"Intracellular hyper-acidification potentiated by hydrogen sulfide mediates invasive and therapy resistant cancer cell death","volume":"8","author":"Lee","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tips.2018.03.009_bib0370","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.taap.2017.11.004","article-title":"H2S protects lipopolysaccharide-induced inflammation by blocking NF\u03baB transactivation in endothelial cells","volume":"338","author":"Bourque","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tips.2018.03.009_bib0375","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1096\/fj.04-3583fje","article-title":"Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.tips.2018.03.009_bib0380","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.3892\/mmr.2017.6813","article-title":"Hydrogen sulfide reduced renal tissue fibrosis by regulating autophagy in diabetic rats","volume":"16","author":"Li","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.tips.2018.03.009_bib0385","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2169\/internalmedicine.56.7403","article-title":"Clinical implication of plasma hydrogen sulfide levels in Japanese patients with type 2 diabetes","volume":"56","author":"Suzuki","year":"2017","journal-title":"Intern. Med."},{"key":"10.1016\/j.tips.2018.03.009_bib0390","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bbi.2017.07.159","article-title":"Impaired CBS\u2013H2S signaling axis contributes to MPTP-induced neurodegeneration in a mouse model of Parkinson\u2019s disease","volume":"67","author":"Yuan","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.tips.2018.03.009_bib0395","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9049782","article-title":"Physiological importance of hydrogen sulfide: emerging potent neuroprotector and neuromodulator","volume":"2016","author":"Panthi","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tips.2018.03.009_bib0400","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1089\/ars.2013.5448","article-title":"Hydrogen sulfide is an endogenous regulator of aging in Caenorhabditis elegans","volume":"20","author":"Qabazard","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.tips.2018.03.009_bib0405","doi-asserted-by":"crossref","first-page":"E2832","DOI":"10.1073\/pnas.1524727113","article-title":"Roles for ROS and hydrogen sulfide in the longevity response to germline loss in Caenorhabditis elegans","volume":"113","author":"Wei","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tips.2018.03.009_bib0410","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1096\/fj.06-7407com","article-title":"Sulfide, the first inorganic substrate for human cells","volume":"21","author":"Goubern","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.tips.2018.03.009_bib0415","doi-asserted-by":"crossref","first-page":"17977","DOI":"10.1073\/pnas.0705710104","article-title":"Hydrogen sulfide mediates the vasoactivity of garlic","volume":"104","author":"Benavides","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tips.2018.03.009_bib0420","doi-asserted-by":"crossref","first-page":"H2410","DOI":"10.1152\/ajpheart.00044.2012","article-title":"The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability","volume":"302","author":"Predmore","year":"2012","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.tips.2018.03.009_bib0425","doi-asserted-by":"crossref","first-page":"H2693","DOI":"10.1152\/ajpheart.00853.2007","article-title":"S-Allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway","volume":"293","author":"Chuah","year":"2007","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.tips.2018.03.009_bib0430","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ijcard.2015.05.111","article-title":"Diallyl trisulfide protects against high glucose-induced cardiac apoptosis by stimulating the production of cystathionine gamma-lyase-derived hydrogen sulfide","volume":"195","author":"Tsai","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.tips.2018.03.009_bib0435","doi-asserted-by":"crossref","first-page":"E46","DOI":"10.3390\/antiox5040046","article-title":"The effects of different garlic-derived allyl sulfides on anaerobic sulfur metabolism in the mouse kidney","volume":"5","author":"Iciek","year":"2016","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.tips.2018.03.009_bib0440","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.intimp.2016.04.015","article-title":"Diallyl trisulfide protects against ethanol-induced oxidative stress and apoptosis via a hydrogen sulfide-mediated mechanism","volume":"36","author":"Chen","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tips.2018.03.009_bib0445","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/pcmr.12312","article-title":"Role of the cystathionine \u03b3 lyase\/hydrogen sulfide pathway in human melanoma progression","volume":"28","author":"Panza","year":"2015","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.tips.2018.03.009_bib0450","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1406726","article-title":"Diallyl trisulfide suppresses oxidative stress-induced activation of hepatic stellate cells through production of hydrogen sulfide","volume":"2017","author":"Zhang","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.tips.2018.03.009_bib0455","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1139\/cjpp-2015-0316","article-title":"The hydrogen sulfide releasing compounds ATB-346 and diallyl trisulfide attenuate streptozotocin-induced cognitive impairment, neuroinflammation, and oxidative stress in rats: involvement of asymmetric dimethylarginine","volume":"94","author":"Mostafa","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.tips.2018.03.009_bib0460","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1161\/CIRCULATIONAHA.116.022967","article-title":"Restoration of hydrogen sulfide production in diabetic mice improves reparative function of bone marrow cells","volume":"134","author":"Cheng","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.tips.2018.03.009_bib0465","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1253\/circj.CJ-16-1097","article-title":"Diallyl trisulfide augments ischemia-induced angiogenesis via an endothelial nitric oxide synthase-dependent mechanism","volume":"81","author":"Hayashida","year":"2017","journal-title":"Circ. J."},{"key":"10.1016\/j.tips.2018.03.009_bib0470","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1073\/pnas.1321871111","article-title":"Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase\u2013nitric oxide dependent","volume":"111","author":"King","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tips.2018.03.009_bib0475","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1080\/01902148.2017.1381780","article-title":"Intravenous controlled-release hydrogen sulfide protects against ventilator-induced lung injury","volume":"43","author":"Wang","year":"2017","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.tips.2018.03.009_bib0480","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1038\/s41598-017-03941-0","article-title":"A long-term and slow-releasing hydrogen sulfide donor protects against myocardial ischemia\/reperfusion injury","volume":"7","author":"Sun","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tips.2018.03.009_bib0485","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.jff.2015.02.007","article-title":"Hydrogen sulphide (H2S) releasing capacity of essential oils isolated from organosulphur rich fruits and vegetables","volume":"14","author":"Liang","year":"2015","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.tips.2018.03.009_bib0490","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.foodchem.2015.06.072","article-title":"Organosulfide profile and hydrogen sulfide-releasing capacity of stinky bean (Parkia speciosa) oil: effects of pH and extraction methods","volume":"190","author":"Tocmo","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.tips.2018.03.009_bib0495","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.1021\/jf500739n","article-title":"Effect of processing conditions on the organosulfides of shallot (Allium cepa L. Aggregatum group)","volume":"62","author":"Tocmo","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tips.2018.03.009_bib0500","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1021\/acs.orglett.5b01962","article-title":"Diallyl trisulfide is a fast H2S donor, but diallyl disulfide is a slow one: the reaction pathways and intermediates of glutathione with polysulfides","volume":"17","author":"Liang","year":"2015","journal-title":"Org. Lett."},{"key":"10.1016\/j.tips.2018.03.009_bib0505","doi-asserted-by":"crossref","first-page":"6359","DOI":"10.1021\/acs.jpcb.7b03683","article-title":"Computational study of H2S release in reactions of diallyl polysulfides with thiols","volume":"121","author":"Cai","year":"2017","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.tips.2018.03.009_bib0510","doi-asserted-by":"crossref","first-page":"R1212","DOI":"10.1152\/ajpregu.00061.2016","article-title":"Garlic oil polysulfides: H2S- and O2-independent prooxidants in buffer and antioxidants in cells","volume":"310","author":"DeLeon","year":"2016","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.tips.2018.03.009_bib0515","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jff.2015.05.020","article-title":"Organosulphide profile and hydrogen sulphide-releasing capacity of garlic (Allium sativum L.) scape oil: effects of pH and cooking","volume":"17","author":"Tocmo","year":"2015","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.tips.2018.03.009_bib0520","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1016\/j.bbagen.2013.06.028","article-title":"The activation of HO-1\/Nrf-2 contributes to the protective effects of diallyl disulfide (DADS) against ethanol-induced oxidative stress","volume":"1830","author":"Zeng","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"Suppl. 4","key":"10.1016\/j.tips.2018.03.009_bib0525","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/jgh.12730","article-title":"S-Allyl cysteine alleviates nonsteroidal anti-inflammatory drug-induced gastric mucosal damages by increasing cyclooxygenase-2 inhibition, heme oxygenase-1 induction, and histone deacetylation inhibition","volume":"29","author":"Park","year":"2014","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.tips.2018.03.009_bib0530","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00394-008-0762-3","article-title":"Allicin up-regulates cellular glutathione level in vascular endothelial cells","volume":"48","author":"Horev-Azaria","year":"2009","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.tips.2018.03.009_bib0535","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.nutres.2015.09.018","article-title":"Aged garlic extract enhances heme oxygenase-1 and glutamate\u2013cysteine ligase modifier subunit expression via the nuclear factor erythroid 2-related factor 2-antioxidant response element signaling pathway in human endothelial cells","volume":"36","author":"Hiramatsu","year":"2016","journal-title":"Nutr. Res."},{"key":"10.1016\/j.tips.2018.03.009_bib0540","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1748-1716.2012.02425.x","article-title":"Aged red garlic extract reduces lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages and acute pulmonary inflammation through haeme oxygenase-1 induction","volume":"205","author":"Park","year":"2012","journal-title":"Acta Physiol. (Oxf.)"},{"key":"10.1016\/j.tips.2018.03.009_bib0545","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1089\/jmf.2014.3214","article-title":"Aged red garlic extract suppresses nitric oxide production in lipopolysaccharide-treated RAW 264.7 macrophages through inhibition of NF-\u03baB","volume":"18","author":"Ryu","year":"2015","journal-title":"J. Med. Food"},{"key":"10.1016\/j.tips.2018.03.009_bib0550","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/jnc.12986","article-title":"S-Allyl cysteine activates the Nrf2-dependent antioxidant response and protects neurons against ischemic injury in vitro and in vivo","volume":"133","author":"Shi","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tips.2018.03.009_bib0555","doi-asserted-by":"crossref","first-page":"206","DOI":"10.4162\/nrp.2017.11.3.206","article-title":"Antioxidant mechanism of black garlic extract involving nuclear factor erythroid 2-like factor 2 pathway","volume":"11","author":"Ha","year":"2017","journal-title":"Nutr. Res. Pract."}],"container-title":["Trends in Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614718300610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614718300610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T02:47:57Z","timestamp":1661050077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165614718300610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":111,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S0165614718300610"],"URL":"https:\/\/doi.org\/10.1016\/j.tips.2018.03.009","relation":{},"ISSN":["0165-6147"],"issn-type":[{"value":"0165-6147","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Garlic and Gaseous Mediators","name":"articletitle","label":"Article Title"},{"value":"Trends in Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tips.2018.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}