{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:59:50Z","timestamp":1791975590102,"version":"4.4.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006310","name":"Swedish Medical Research Council","doi-asserted-by":"publisher","award":["62X-00715-50-3"],"award-info":[{"award-number":["62X-00715-50-3"]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Parkinson Fonden"},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"crossref","award":["F02018-0286"],"award-info":[{"award-number":["F02018-0286"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Karolinska Institutet Forskningsstiftelser"},{"name":"Institute of Pharmacology"},{"DOI":"10.13039\/501100004382","name":"Polish Academy of Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004382","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Pharmacological Sciences"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.tips.2018.10.007","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T09:20:17Z","timestamp":1540804817000},"page":"1008-1020","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction"],"prefix":"10.1016","volume":"39","author":[{"given":"Dasiel O.","family":"Borroto-Escuela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Wydra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Filip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"Fuxe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tips.2018.10.007_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tips.2012.11.004","article-title":"GPCRs signal a Nobel Prize","volume":"34","author":"Schaffhausen","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.tips.2018.10.007_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S2005-2901(09)60011-X","article-title":"Brain receptor mosaics and their intramembrane receptor-receptor interactions: molecular integration in transmission and novel targets for drug development","volume":"2","author":"Fuxe","year":"2009","journal-title":"J. Acupunct. Meridian Stud."},{"key":"10.1016\/j.tips.2018.10.007_bib0015","doi-asserted-by":"crossref","first-page":"8570","DOI":"10.3390\/ijms15058570","article-title":"The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components","volume":"15","author":"Borroto-Escuela","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tips.2018.10.007_bib0020","series-title":"Receptor-Receptor Interactions in the Central Nervous System","author":"Fuxe","year":"2018"},{"key":"10.1016\/j.tips.2018.10.007_bib0025","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/npp.2015.244","article-title":"Heteroreceptor complexes and their allosteric receptor-receptor interactions as a novel biological principle for integration of communication in the CNS: targets for drug development","volume":"41","author":"Fuxe","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.tips.2018.10.007_bib0030","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/npp.2013.242","article-title":"Moonlighting proteins and protein-protein interactions as neurotherapeutic targets in the G protein-coupled receptor field","volume":"39","author":"Fuxe","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.tips.2018.10.007_bib0035","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/B978-0-444-63425-2.00008-8","article-title":"Dopamine receptor heteromeric complexes and their emerging functions","volume":"211","author":"George","year":"2014","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.tips.2018.10.007_bib0040","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.bbrc.2010.10.122","article-title":"Characterization of the A2AR-D2R interface: focus on the role of the C-terminal tail and the transmembrane helices","volume":"402","author":"Borroto-Escuela","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tips.2018.10.007_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2018.00829","article-title":"Mapping the interface of a GPCR dimer: a structural model of the A2A adenosine and D2 dopamine receptor heteromer","volume":"9","author":"Borroto-Escuela","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tips.2018.10.007_bib0050","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.neubiorev.2012.01.002","article-title":"The persistence of maladaptive memory: addiction, drug memories and anti-relapse treatments","volume":"36","author":"Milton","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.tips.2018.10.007_bib0055","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2014.0183","article-title":"The role of transmitter diffusion and flow versus extracellular vesicles in volume transmission in the brain neural\u2013glial networks","volume":"370","author":"Borroto-Escuela","year":"2015","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.tips.2018.10.007_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7243\/2052-6946-2-6","article-title":"Receptor-receptor interactions in heteroreceptor complexes: a new principle in biology. Focus on their role in learning and memory","volume":"2","author":"Fuxe","year":"2014","journal-title":"Neurosci. Discov."},{"key":"10.1016\/j.tips.2018.10.007_bib0065","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pbb.2017.03.003","article-title":"Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1 R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder","volume":"155","author":"Borroto-Escuela","year":"2017","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.tips.2018.10.007_bib0070","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pbb.2016.03.004","article-title":"Cocaine self-administration differentially affects allosteric A2A-D2 receptor-receptor interactions in the striatum. Relevance for cocaine use disorder","volume":"144","author":"Pintsuk","year":"2016","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.tips.2018.10.007_bib0075","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.1007\/s12035-018-0887-1","article-title":"Disruption of A2AR-D2R heteroreceptor complexes after A2AR transmembrane 5 peptide administration enhances cocaine self-administration in rats","volume":"55","author":"Borroto-Escuela","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.tips.2018.10.007_bib0080","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1124\/pr.116.012484","article-title":"The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis","volume":"68","author":"Scofield","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.tips.2018.10.007_bib0085","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.pharep.2018.04.002","article-title":"Glutamate heteroreceptor complexes in the brain","volume":"70","author":"Borroto-Escuela","year":"2018","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.tips.2018.10.007_bib0090","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s12640-014-9502-z","article-title":"Withdrawal from cocaine self-administration and yoked cocaine delivery dysregulates glutamatergic mGlu5 and NMDA receptors in the rat brain","volume":"27","author":"Pomierny-Chamiolo","year":"2015","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.tips.2018.10.007_bib0095","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.cell.2012.12.004","article-title":"Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine","volume":"152","author":"Kourrich","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.tips.2018.10.007_bib0100","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.tins.2012.09.007","article-title":"The sigma-1 receptor: roles in neuronal plasticity and disease","volume":"35","author":"Kourrich","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.tips.2018.10.007_bib0105","doi-asserted-by":"crossref","first-page":"18676","DOI":"10.1073\/pnas.1008911107","article-title":"Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine","volume":"107","author":"Navarro","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tips.2018.10.007_bib0110","doi-asserted-by":"crossref","first-page":"S609","DOI":"10.1016\/S0924-977X(15)30860-9","article-title":"Dopamine D2 receptor dynamic and modulation in the D2R-Sigma1R heteroreceptor complexes: role in cocaine actions","volume":"25","author":"Pinton","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.tips.2018.10.007_bib0115","doi-asserted-by":"crossref","first-page":"E6562","DOI":"10.1073\/pnas.1518894112","article-title":"Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope","volume":"112","author":"Tsai","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tips.2018.10.007_bib0120","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s12640-014-9497-5","article-title":"A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants","volume":"27","author":"Sadakierska-Chudy","year":"2015","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.tips.2018.10.007_bib0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061245","article-title":"Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers","volume":"8","author":"Navarro","year":"2013","journal-title":"PLoS One"},{"issue":"Suppl 1","key":"10.1016\/j.tips.2018.10.007_bib0130","doi-asserted-by":"crossref","first-page":"P37","DOI":"10.1186\/2193-1801-4-S1-P37","article-title":"Evidence for the existence of dopamine D2R and Sigma 1 allosteric receptor-receptor interaction in the rat brain: role in brain plasticity and cocaine action","volume":"4","author":"Pinton","year":"2015","journal-title":"SpringerPlus"},{"key":"10.1016\/j.tips.2018.10.007_bib0135","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.cellsig.2017.09.007","article-title":"Cocaine modulates allosteric D2-sigma1 receptor-receptor interactions on dopamine and glutamate nerve terminals from rat striatum","volume":"40","author":"Beggiato","year":"2017","journal-title":"Cell Signal."},{"key":"10.1016\/j.tips.2018.10.007_bib0140","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1038\/npp.2012.33","article-title":"A novel mechanism of cocaine to enhance dopamine D-2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study","volume":"37","author":"Ferraro","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.tips.2018.10.007_bib0145","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00213-014-3675-2","article-title":"On the role of adenosine (A)(2A) receptors in cocaine-induced reward: a pharmacological and neurochemical analysis in rats","volume":"232","author":"Wydra","year":"2015","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.tips.2018.10.007_bib0150","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.pbb.2012.05.001","article-title":"Time and sex-dependent effects of an adenosine A2A\/A1 receptor antagonist on motivation to self-administer cocaine in rats","volume":"102","author":"Doyle","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.tips.2018.10.007_bib0155","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1007\/s00213-014-3489-2","article-title":"Persistent reduction of cocaine seeking by pharmacological manipulation of adenosine A(1) and A(2A) receptors during extinction training in rats","volume":"231","author":"O\u2019Neill","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.tips.2018.10.007_bib0160","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1007\/s00213-014-3818-5","article-title":"On the role of A(2A) and D-2 receptors in control of cocaine and food-seeking behaviors in rats","volume":"232","author":"Wydra","year":"2015","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.tips.2018.10.007_bib0165","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pbb.2016.03.004","article-title":"Cocaine self-administration differentially affects allosteric A2A-D2 receptor-receptor interactions in the striatum. Relevance for cocaine use disorder","volume":"144","author":"Pintsuk","year":"2016","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.tips.2018.10.007_bib0170","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jmb.2011.01.022","article-title":"On the existence of a possible A2A-D2-beta-Arrestin2 complex: A2A agonist modulation of D2 agonist-induced beta-arrestin2 recruitment","volume":"406","author":"Borroto-Escuela","year":"2011","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.tips.2018.10.007_bib0175","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/FJC.0000000000000482","article-title":"G protein-coupled receptor signaling through beta-arrestin-dependent mechanisms","volume":"70","author":"Jean-Charles","year":"2017","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.tips.2018.10.007_bib0180","doi-asserted-by":"crossref","first-page":"11940","DOI":"10.1073\/pnas.172393799","article-title":"Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function","volume":"99","author":"Ferre","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tips.2018.10.007_bib0185","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.brainresrev.2007.11.007","article-title":"Receptor-receptor interactions within receptor mosaics. Impact on neuropsychopharmacology","volume":"58","author":"Fuxe","year":"2008","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.tips.2018.10.007_bib0190","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0893-133X(01)00391-8","article-title":"Involvement of the sigma(1) receptor in cocaine-induced conditioned place preference: possible dependence on dopamine uptake blockade","volume":"26","author":"Romieu","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.tips.2018.10.007_bib0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(03)01723-0","article-title":"Sigma receptors: potential medications development target for anti-cocaine agents","volume":"469","author":"Matsumoto","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.tips.2018.10.007_bib0200","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/mp.2014.58","article-title":"Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers","volume":"19","author":"Volkow","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.tips.2018.10.007_bib0205","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1124\/jpet.105.084525","article-title":"Cocaine up-regulates Fra-2 and sigma-1 receptor gene and protein expression in brain regions involved in addiction and reward","volume":"314","author":"Liu","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tips.2018.10.007_bib0210","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1124\/jpet.108.141051","article-title":"Alterations in fos-related antigen 2 and sigma1 receptor gene and protein expression are associated with the development of cocaine-induced behavioral sensitization: time course and regional distribution studies","volume":"327","author":"Liu","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tips.2018.10.007_bib0215","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1126\/science.1188472","article-title":"Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward","volume":"330","author":"Lobo","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.tips.2018.10.007_bib0220","doi-asserted-by":"crossref","first-page":"13593","DOI":"10.18632\/oncotarget.24423","article-title":"Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors","volume":"9","author":"Hinz","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.tips.2018.10.007_bib0225","first-page":"48","article-title":"Action of caffeine and theophyllamine on supersensitive dopamine receptors: considerable enhancement of receptor response to treatment with DOPA and dopamine receptor agonists","volume":"52","author":"Fuxe","year":"1974","journal-title":"Med. Biol."},{"key":"10.1016\/j.tips.2018.10.007_bib0230","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF02769180","article-title":"Receptor-receptor interactions as an integrative mechanism in nerve cells","volume":"7","author":"Zoli","year":"1993","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.tips.2018.10.007_bib0235","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/B978-0-12-391862-8.00015-6","article-title":"G protein-coupled receptor heterodimerization in the brain","volume":"521","author":"Borroto-Escuela","year":"2013","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.tips.2018.10.007_bib0240","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2144\/000113719","article-title":"Detection of antigen interactions ex vivo by proximity ligation assay: endogenous dopamine D2-adenosine A2A receptor complexes in the striatum","volume":"51","author":"Trifilieff","year":"2011","journal-title":"BioTechniques"},{"key":"10.1016\/j.tips.2018.10.007_bib0245","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nature10136","article-title":"Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation","volume":"474","author":"Lebon","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.tips.2018.10.007_bib0250","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nature25758","article-title":"Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone","volume":"555","author":"Wang","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.tips.2018.10.007_bib0255","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1126\/science.1197410","article-title":"Structure of the human dopamine D3 receptor in complex with a D2\/D3 selective antagonist","volume":"330","author":"Chien","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.tips.2018.10.007_bib0260","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0959-4388(97)80007-4","article-title":"Dopamine neurons and their role in reward mechanisms","volume":"7","author":"Schultz","year":"1997","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.tips.2018.10.007_bib0265","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0006-8993(70)90186-1","article-title":"Depletion of catecholamines in vivo induced by electrical stimulation of central monoamine pathways","volume":"24","author":"Arbuthnott","year":"1970","journal-title":"Brain Res."},{"key":"10.1016\/j.tips.2018.10.007_bib0270","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/scientificamerican0304-78","article-title":"The addicted brain","volume":"290","author":"Nestler","year":"2004","journal-title":"Sci. Am."},{"key":"10.1016\/j.tips.2018.10.007_bib0275","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1523\/JNEUROSCI.4037-08.2009","article-title":"Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice","volume":"29","author":"Thomsen","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tips.2018.10.007_bib0280","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0306-4522(88)90339-9","article-title":"Organization of the afferent connections of the mediodorsal thalamic nucleus in the rat, related to the mediodorsal-prefrontal topography","volume":"24","author":"Groenewegen","year":"1988","journal-title":"Neuroscience"},{"key":"10.1016\/j.tips.2018.10.007_bib0285","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/nn.3100","article-title":"Distinct roles for direct and indirect pathway striatal neurons in reinforcement","volume":"15","author":"Kravitz","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tips.2018.10.007_bib0290","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.neubiorev.2016.05.021","article-title":"Reappraising striatal D1- and D2-neurons in reward and aversion","volume":"68","author":"Soares-Cunha","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.tips.2018.10.007_bib0295","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.psych.59.103006.093548","article-title":"Addiction and the brain antireward system","volume":"59","author":"Koob","year":"2008","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.tips.2018.10.007_bib0300","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1038\/nn.4068","article-title":"Coding the direct\/indirect pathways by D1 and D2 receptors is not valid for accumbens projections","volume":"18","author":"Kupchik","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tips.2018.10.007_bib0305","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1098\/rstb.2008.0089","article-title":"Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction","volume":"363","author":"Everitt","year":"2008","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.tips.2018.10.007_bib0310","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.biopsych.2017.09.013","article-title":"Drug cues, conditioned reinforcement, and drug seeking: the sequelae of a collaborative venture with Athina Markou","volume":"83","author":"Everitt","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.tips.2018.10.007_bib0315","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-psych-122414-033457","article-title":"Drug addiction: updating actions to habits to compulsions ten years on","volume":"67","author":"Everitt","year":"2016","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.tips.2018.10.007_bib0320","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0893-133X(00)00195-0","article-title":"Drug addiction, dysregulation of reward, and allostasis","volume":"24","author":"Koob","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.tips.2018.10.007_bib0325","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.282.5387.298","article-title":"Transition from moderate to excessive drug intake: change in hedonic set point","volume":"282","author":"Ahmed","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.tips.2018.10.007_bib0330","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.brainres.2007.01.079","article-title":"Increase in A2A receptors in the nucleus accumbens after extended cocaine self-administration and its disappearance after cocaine withdrawal","volume":"1143","author":"Marcellino","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.tips.2018.10.007_bib0335","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1369-1600.2012.00452.x","article-title":"Effects of cocaine self-administration and extinction on D2 -like and A2A receptor recognition and D2 \u2212like\/Gi protein coupling in rat striatum","volume":"18","author":"Frankowska","year":"2013","journal-title":"Addict. Biol."},{"key":"10.1016\/j.tips.2018.10.007_bib0340","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/syn.890140210","article-title":"Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers","volume":"14","author":"Volkow","year":"1993","journal-title":"Synapse"},{"key":"10.1016\/j.tips.2018.10.007_bib0345","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/nn1737","article-title":"PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys","volume":"9","author":"Nader","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tips.2018.10.007_bib0350","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-201X.1971.tb11000.x","article-title":"Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system","volume":"367","author":"Ungerstedt","year":"1971","journal-title":"Acta Physiol. Scand. Suppl."}],"container-title":["Trends in Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614718301858?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614718301858?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T09:06:50Z","timestamp":1759050410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165614718301858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":70,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0165614718301858"],"URL":"https:\/\/doi.org\/10.1016\/j.tips.2018.10.007","relation":{},"ISSN":["0165-6147"],"issn-type":[{"value":"0165-6147","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction","name":"articletitle","label":"Article Title"},{"value":"Trends in Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tips.2018.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}