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Chem."},{"key":"10.1016\/j.tips.2019.03.004_bib0460","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189154","article-title":"Alpha conotoxin-BuIA globular isomer is a competitive antagonist for oleoyl-L-alpha-lysophosphatidic acid binding to LPAR6; a molecular dynamics study","volume":"12","author":"Younis","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.tips.2019.03.004_bib0465","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.peptides.2007.10.025","article-title":"Helokinestatin: a new bradykinin B2 receptor antagonist decapeptide from lizard venom","volume":"29","author":"Kwok","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.tips.2019.03.004_bib0470","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ejphar.2009.09.064","article-title":"Apamin reduces neuromuscular transmission by activating inhibitory muscarinic M(2) receptors on motor nerve terminals","volume":"626","author":"de Matos Silva","year":"2010","journal-title":"Eur. 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