{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:48:24Z","timestamp":1772642904608,"version":"3.50.1"},"reference-count":15,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Pharmacological Sciences"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.tips.2020.05.003","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T08:28:41Z","timestamp":1590740921000},"page":"506-508","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Small Molecules Restore Telomeres in Patient Stem Cells"],"prefix":"10.1016","volume":"41","author":[{"given":"Kirsten Ann","family":"Brenner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayakrishnan","family":"Nandakumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tips.2020.05.003_bb0005","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1080\/17474086.2019.1662720","article-title":"An update on the biology and management of dyskeratosis congenita and related telomere biology disorders","volume":"12","author":"Niewisch","year":"2019","journal-title":"Expert. Rev. Hematol."},{"key":"10.1016\/j.tips.2020.05.003_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2020.03.016","article-title":"Small-molecule PAPD5 inhibitors restore telomerase activity in patient stem cells","author":"Nagpal","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tips.2020.05.003_bb0015","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.7605428","article-title":"Specific association of human telomerase activity with immortal cells and cancer","volume":"266","author":"Kim","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.tips.2020.05.003_bb0020","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1126\/science.7544491","article-title":"The RNA component of human telomerase","volume":"269","author":"Feng","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.tips.2020.05.003_bb0025","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/ng.3278","article-title":"Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening","volume":"47","author":"Stuart","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tips.2020.05.003_bb0030","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1038\/ng.3423","article-title":"Poly(A)-specific ribonuclease (PARN) mediates 3\u2032-end maturation of the telomerase RNA component","volume":"47","author":"Moon","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tips.2020.05.003_bb0035","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1172\/JCI78963","article-title":"Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita","volume":"125","author":"Tummala","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tips.2020.05.003_bb0040","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.molcel.2019.02.033","article-title":"Disruption of telomerase RNA maturation kinetics precipitates disease","volume":"74","author":"Roake","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tips.2020.05.003_bb0045","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1016\/j.celrep.2015.10.075","article-title":"Human telomerase RNA processing and quality control","volume":"13","author":"Tseng","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.tips.2020.05.003_bb0050","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1172\/JCI87547","article-title":"Posttranscriptional manipulation of TERC reverses molecular hallmarks of telomere disease","volume":"126","author":"Boyraz","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tips.2020.05.003_bb0055","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nsmb.3184","article-title":"Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects","volume":"23","author":"Shukla","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.tips.2020.05.003_bb0060","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1182\/blood-2018-11-885368","article-title":"Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita","volume":"133","author":"Fok","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.tips.2020.05.003_bb0065","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1002\/hep.30329","article-title":"PAPD5\/7 are host factors that are required for hepatitis B virus RNA stabilization","volume":"69","author":"Mueller","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.tips.2020.05.003_bb0070","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/ng0598-32","article-title":"X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions","volume":"19","author":"Heiss","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tips.2020.05.003_bb0075","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/990141","article-title":"A telomerase component is defective in the human disease dyskeratosis congenita","volume":"402","author":"Mitchell","year":"1999","journal-title":"Nature"}],"container-title":["Trends in Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614720301279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614720301279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T09:10:08Z","timestamp":1759050608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165614720301279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0165614720301279"],"URL":"https:\/\/doi.org\/10.1016\/j.tips.2020.05.003","relation":{},"ISSN":["0165-6147"],"issn-type":[{"value":"0165-6147","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small Molecules Restore Telomeres in Patient Stem Cells","name":"articletitle","label":"Article Title"},{"value":"Trends in Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tips.2020.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}