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Neurochem."},{"key":"10.1016\/j.tips.2021.03.003_bb0540","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1021\/jm010261z","article-title":"Synthesis and in vitro pharmacology of substituted quinoline-2,4-dicarboxylic acids as inhibitors of vesicular glutamate transport","volume":"45","author":"Carrigan","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.tips.2021.03.003_bb0545","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1016\/S0960-894X(99)00444-8","article-title":"Quinoline-2,4-dicarboxylic acids: synthesis and evaluation as inhibitors of the glutamate vesicular transport system","volume":"9","author":"Carrigan","year":"1999","journal-title":"Bioorg. Med. Chem. 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