{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:25:52Z","timestamp":1792729552270,"version":"4.5.0"},"reference-count":100,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Pharmacological Sciences"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.tips.2023.07.004","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T08:17:59Z","timestamp":1690273079000},"page":"573-585","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":157,"title":["Copper homeostasis and cuproptosis in cardiovascular disease therapeutics"],"prefix":"10.1016","volume":"44","author":[{"given":"Lifang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y.H.","family":"Lip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0275-0783","authenticated-orcid":false,"given":"Jun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tips.2023.07.004_bb0005","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.711227","article-title":"Role of copper on mitochondrial function and metabolism","volume":"8","author":"Ruiz","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.tips.2023.07.004_bb0010","doi-asserted-by":"crossref","first-page":"700","DOI":"10.3390\/nu14030700","article-title":"An emerging role of defective copper metabolism in heart disease","volume":"14","author":"Liu","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.tips.2023.07.004_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114830","article-title":"The molecular mechanisms of cuproptosis and its relevance to cardiovascular disease","volume":"163","author":"Wang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tips.2023.07.004_bb0020","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.molcel.2022.05.001","article-title":"Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death","volume":"82","author":"Cobine","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tips.2023.07.004_bb0025","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.tips.2023.07.004_bb0030","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.numecd.2022.09.024","article-title":"Serum copper and the risk of cardiovascular disease death in Finnish men","volume":"33","author":"Isiozor","year":"2023","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.tips.2023.07.004_bb0035","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/ije\/dyaa230","article-title":"Long-term exposure to iron and copper in fine particulate air pollution and their combined impact on reactive oxygen species concentration in lung fluid: a population-based cohort study of cardiovascular disease incidence and mortality in Toronto, Canada","volume":"50","author":"Zhang","year":"2021","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.tips.2023.07.004_bb0040","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3109\/10715762.2014.901510","article-title":"Copper, ceruloplasmin, and long-term cardiovascular and total mortality (the Ludwigshafen Risk and Cardiovascular Health Study)","volume":"48","author":"Grammer","year":"2014","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.tips.2023.07.004_bb0045","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1007\/s12011-022-03383-4","article-title":"Overweight and obesity are positively associated with serum copper levels in Mexican schoolchildren","volume":"201","author":"Vazquez-Moreno","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tips.2023.07.004_bb0050","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.2174\/1389557520666200729160416","article-title":"Association of zinc and copper status with cardiovascular diseases and their assessment methods: a review study","volume":"20","author":"Malekahmadi","year":"2020","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.tips.2023.07.004_bb0055","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41419-023-05639-w","article-title":"Copper homeostasis and copper-induced cell death in the pathogenesis of cardiovascular disease and therapeutic strategies","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tips.2023.07.004_bb0060","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41392-022-01229-y","article-title":"Copper homeostasis and cuproptosis in health and disease","volume":"7","author":"Chen","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.tips.2023.07.004_bb0065","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4103\/0300-1652.149169","article-title":"Serum level of copper in patients with coronary artery disease","volume":"56","author":"Bagheri","year":"2015","journal-title":"Niger. Med. J."},{"key":"10.1016\/j.tips.2023.07.004_bb0070","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000519906","article-title":"Circulating serum copper is associated with atherosclerotic cardiovascular disease, but not venous thromboembolism: a prospective cohort study","volume":"9","author":"Kunutsor","year":"2021","journal-title":"Pulse Basel Switz."},{"key":"10.1016\/j.tips.2023.07.004_bb0075","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.3390\/nu12103219","article-title":"Ceruloplasmin and coronary heart disease-a systematic review","volume":"12","author":"Arenas de Larriva","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.tips.2023.07.004_bb0080","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1161\/01.ATV.0000124892.90999.cb","article-title":"Direct detection and quantification of transition metal ions in human atherosclerotic plaques: evidence for the presence of elevated levels of iron and copper","volume":"24","author":"Stadler","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tips.2023.07.004_bb0085","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2018-000784","article-title":"Copper deficiency may be a leading cause of ischaemic heart disease","volume":"5","author":"DiNicolantonio","year":"2018","journal-title":"Open Heart"},{"key":"10.1016\/j.tips.2023.07.004_bb0090","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1177\/15353702211046541","article-title":"Atherosclerotic lesion-specific copper delivery suppresses atherosclerosis in high-cholesterol-fed rabbits","volume":"246","author":"Wang","year":"2021","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.tips.2023.07.004_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.942000","article-title":"Dietary copper intake and risk of myocardial infarction in US adults: a propensity score-matched analysis","volume":"9","author":"Wen","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.tips.2023.07.004_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216157","article-title":"Cope with copper: from copper linked mechanisms to copper-based clinical cancer therapies","volume":"561","author":"Wang","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.tips.2023.07.004_bb0105","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s12011-021-02618-0","article-title":"Dietary cholesterol supplements disturb copper homeostasis in multiple organs in rabbits: aorta copper concentrations negatively correlate with the severity of atherosclerotic lesions","volume":"200","author":"Li","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tips.2023.07.004_bb0110","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fnut.2018.00029","article-title":"Associations between dietary antioxidant intake and markers of atherosclerosis in middle-aged women from North-Western Algeria","volume":"5","author":"Diaf","year":"2018","journal-title":"Front. Nutr."},{"key":"10.1016\/j.tips.2023.07.004_bb0115","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1177\/1535370218773055","article-title":"The loss of copper is associated with the increase in copper metabolism MURR domain 1 in ischemic hearts of mice","volume":"243","author":"Li","year":"2018","journal-title":"Exp. Biol. Med. Maywood NJ"},{"key":"10.1016\/j.tips.2023.07.004_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2020.126686","article-title":"Reverse regulation of hepatic ceruloplasmin production in rat model of myocardial ischemia","volume":"64","author":"Yang","year":"2021","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.tips.2023.07.004_bb0125","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1007\/s13577-023-00914-6","article-title":"Role of cuproptosis in understanding diseases","volume":"36","author":"Cao","year":"2023","journal-title":"Hum. Cell"},{"key":"10.1016\/j.tips.2023.07.004_bb0130","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/5996144","article-title":"Identification of potential biomarkers for coronary artery disease based on cuproptosis","volume":"2023","author":"Zhang","year":"2023","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.tips.2023.07.004_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.1016081","article-title":"Identification of GLS as a cuproptosis-related diagnosis gene in acute myocardial infarction","volume":"9","author":"Liu","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.tips.2023.07.004_bb0140","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3892\/mmr.2021.11991","article-title":"HIF-1\u03b1 in myocardial ischemia-reperfusion injury (Review)","volume":"23","author":"Zheng","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.tips.2023.07.004_bb0145","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s12011-020-02095-x","article-title":"Associations between copper and zinc and high blood pressure in children and adolescents aged 8\u201317 years: an exposure-response analysis of NHANES 2007\u20132016","volume":"198","author":"Yao","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tips.2023.07.004_bb0150","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/jat.3968","article-title":"Associations of exposure to metals with the risk of hypertension among an older population aged 40\u201375 years in rural southwest China","volume":"40","author":"Wang","year":"2020","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tips.2023.07.004_bb0155","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12872-020-01355-x","article-title":"Selenium, copper, zinc and hypertension: an analysis of the National Health and Nutrition Examination Survey (2011-2016)","volume":"20","author":"Bastola","year":"2020","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.tips.2023.07.004_bb0160","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jtemb.2019.01.018","article-title":"The association of serum zinc and copper with hypertension: a meta-analysis","volume":"53","author":"Li","year":"2019","journal-title":"J. Trace Elem. Med. Biol. Organ Soc. Miner. Trace Elem. GMS"},{"key":"10.1016\/j.tips.2023.07.004_bb0165","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1080\/10790268.2020.1737788","article-title":"The protective effect of betanin and copper on spinal cord ischemia\u2013reperfusion injury","volume":"44","author":"Tural","year":"2021","journal-title":"J. Spinal Cord Med."},{"key":"10.1016\/j.tips.2023.07.004_bb0170","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4149\/BLL_2020_032","article-title":"The protective effect of betanin and copper on heart and lung in end-organ ischemia reperfusion injury","volume":"121","author":"Tural","year":"2020","journal-title":"Bratisl. Med. J."},{"key":"10.1016\/j.tips.2023.07.004_bb0175","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1139\/cjpp-2021-0129","article-title":"Facile synthesis of bromelain copper nanoparticles to improve the primordial therapeutic potential of copper against acute myocardial infarction in diabetic rats","volume":"100","author":"Sahu","year":"2022","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.tips.2023.07.004_bb0180","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/s41598-020-80011-y","article-title":"The effects of meldonium on the acute ischemia\/reperfusion liver injury in rats","volume":"11","author":"\u0110ura\u0161evi\u0107","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tips.2023.07.004_bb0185","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.yjmcc.2018.07.244","article-title":"Mitochondrial complex I in the post-ischemic heart: reperfusion-mediated oxidative injury and protein cysteine sulfonation","volume":"121","author":"Kang","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.tips.2023.07.004_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112040","article-title":"Metabolomics analysis reveals the effect of copper on autophagy in myocardia of pigs","volume":"213","author":"Li","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tips.2023.07.004_bb0195","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cmet.2006.08.009","article-title":"Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function","volume":"4","author":"Nose","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.tips.2023.07.004_bb0200","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.3390\/ph15091145","article-title":"Role of trientine in hypertrophic cardiomyopathy: a review of mechanistic aspects","volume":"15","author":"Ramli","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.tips.2023.07.004_bb0205","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2021-001803","article-title":"Copper chelation in patients with hypertrophic cardiomyopathy","volume":"9","author":"Reid","year":"2022","journal-title":"Open Heart"},{"key":"10.1016\/j.tips.2023.07.004_bb0210","doi-asserted-by":"crossref","first-page":"681","DOI":"10.21037\/cdt-22-214","article-title":"Cuproptosis, the novel therapeutic mechanism for heart failure: a narrative review","volume":"12","author":"Yuan","year":"2022","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"10.1016\/j.tips.2023.07.004_bb0215","first-page":"761","article-title":"Association between serum copper and heart failure: a meta-analysis","volume":"28","author":"Huang","year":"2019","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"10.1016\/j.tips.2023.07.004_bb0220","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.3390\/molecules26113207","article-title":"Heart failure and PAHs, OHPAHs, and trace elements levels in human serum: results from a preliminary pilot study in Greek population and the possible impact of air pollution","volume":"26","author":"Chrysochou","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.tips.2023.07.004_bb0225","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.2174\/092986712800609715","article-title":"Selective divalent copper chelation for the treatment of diabetes mellitus","volume":"19","author":"Cooper","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.tips.2023.07.004_bb0230","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1039\/c9mt00223e","article-title":"Restoration of myocellular copper-trafficking proteins and mitochondrial copper enzymes repairs cardiac function in rats with diabetes-evoked heart failure","volume":"12","author":"Zhang","year":"2020","journal-title":"Metallomics"},{"key":"10.1016\/j.tips.2023.07.004_bb0235","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1177\/15353702-0322807-06","article-title":"Congestive heart failure in copper-deficient mice","volume":"228","author":"Elsherif","year":"2003","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.tips.2023.07.004_bb0240","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/joim.13456","article-title":"Micronutrient deficiencies in heart failure: mitochondrial dysfunction as a common pathophysiological mechanism?","volume":"291","author":"Bomer","year":"2022","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.tips.2023.07.004_bb0245","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.119.007382","article-title":"Cardiomyocyte-specific STIM1 (stromal interaction molecule 1) depletion in the adult heart promotes the development of arrhythmogenic discordant alternans","volume":"12","author":"Cacheux","year":"2019","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"10.1016\/j.tips.2023.07.004_bb0250","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/cvr\/cvz164","article-title":"Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis","volume":"116","author":"Rios","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tips.2023.07.004_bb0255","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jtemb.2016.07.003","article-title":"The influence of oral copper-methionine on matrix metalloproteinase-2 gene expression and activation in right-sided heart failure induced by cold temperature: a broiler chicken perspective","volume":"39","author":"Bagheri Varzaneh","year":"2017","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.tips.2023.07.004_bb0260","first-page":"667","article-title":"Associations between dietary intakes of iron, copper and zinc with risk of type 2 diabetes mellitus: a large population-based prospective cohort study","volume":"37","author":"Eshak","year":"2018","journal-title":"Clin. Nutr. Edinb. Scotl."},{"key":"10.1016\/j.tips.2023.07.004_bb0265","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.3390\/nu13082502","article-title":"Dietary copper\/zinc ratio and type 2 diabetes risk in women: the E3N Cohort Study","volume":"13","author":"Laouali","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.tips.2023.07.004_bb0270","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/jdi.13659","article-title":"Synergistic association of the copper\/zinc ratio under inflammatory conditions with diabetic kidney disease in patients with type 2 diabetes: the Asahi Diabetes Complications Study","volume":"13","author":"Takao","year":"2022","journal-title":"J. Diabetes Investig."},{"key":"10.1016\/j.tips.2023.07.004_bb0275","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s12011-022-03191-w","article-title":"Evaluation of serum selenium and copper levels with inflammatory cytokines and indices of oxidative stress in type 2 diabetes","volume":"201","author":"Pouresmaeil","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tips.2023.07.004_bb0280","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s12011-016-0877-y","article-title":"Copper in diabetes mellitus: a meta-analysis and systematic review of plasma and serum studies","volume":"177","author":"Qiu","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tips.2023.07.004_bb0285","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.3390\/nu14102055","article-title":"Dietary copper and selenium intakes and the risk of type 2 diabetes mellitus: findings from the China Health and Nutrition Survey","volume":"14","author":"Cui","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.tips.2023.07.004_bb0290","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4103\/1735-5362.329929","article-title":"Determination of plasma and erythrocyte levels of copper, magnesium and zinc by atomic absorption spectrometry in type-2 diabetes mellitus patients with metabolic syndrome","volume":"17","author":"Omidian","year":"2022","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.tips.2023.07.004_bb0295","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1135723","article-title":"Ferroptosis, necroptosis and cuproptosis: novel forms of regulated cell death in diabetic cardiomyopathy","volume":"10","author":"Ke","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.tips.2023.07.004_bb0300","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2022.888219","article-title":"The association between plasma copper concentration and prevalence of diabetes in Chinese adults with hypertension","volume":"10","author":"Cui","year":"2022","journal-title":"Front. Public Health"},{"key":"10.1016\/j.tips.2023.07.004_bb0305","doi-asserted-by":"crossref","first-page":"6643","DOI":"10.2174\/0929867326666190902122155","article-title":"The role of zinc and copper in insulin resistance and diabetes mellitus","volume":"27","author":"Bj\u00f8rklund","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.tips.2023.07.004_bb0310","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/jpm12010023","article-title":"Intersections between copper, \u03b2-arrestin-1, calcium, FBXW7, CD17, insulin resistance and atherogenicity mediate depression and anxiety due to type 2 diabetes mellitus: a nomothetic network approach","volume":"12","author":"Al-Hakeim","year":"2022","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.tips.2023.07.004_bb0315","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.3390\/ijms24021667","article-title":"ATF3\/SPI1\/SLC31A1 signaling promotes cuproptosis induced by advanced glycosylation end products in diabetic myocardial injury","volume":"24","author":"Huo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tips.2023.07.004_bb0320","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1475-2840-13-100","article-title":"Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation","volume":"13","author":"Zhang","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.tips.2023.07.004_bb0325","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5418376","article-title":"The molecular mechanisms of defective copper metabolism in diabetic cardiomyopathy","volume":"2022","author":"Cui","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.tips.2023.07.004_bb0330","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.burns.2021.09.016","article-title":"Higher baseline copper levels are associated with worse outcome in burn patients with overweight and obesity","volume":"48","author":"Dhanasekara","year":"2022","journal-title":"Burns J. Int. Soc. Burn Inj."},{"key":"10.1016\/j.tips.2023.07.004_bb0335","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1039\/C9MT00148D","article-title":"Obesity is associated with copper elevation in serum and tissues","volume":"11","author":"Yang","year":"2019","journal-title":"Met. Integr. Biometal Sci."},{"key":"10.1016\/j.tips.2023.07.004_bb0340","doi-asserted-by":"crossref","first-page":"31395","DOI":"10.1007\/s11356-022-24432-4","article-title":"The association between serum copper and obesity and all-cause mortality: the NHANES 2011-2016","volume":"30","author":"Wu","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.tips.2023.07.004_bb0345","article-title":"Associations between dietary copper intake, general obesity and abdominal obesity risk: a nationwide cohort study in China","volume":"9","author":"Wang","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.tips.2023.07.004_bb0350","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3390\/nu9020104","article-title":"Relationship between selected serum metallic elements and obesity in children and adolescent in the U.S","volume":"9","author":"Fan","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.tips.2023.07.004_bb0355","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12887-020-02473-3","article-title":"Micronutrient status and associated factors of adiposity in primary school children with normal and high body fat in Colombo municipal area, Sri Lanka","volume":"21","author":"Thillan","year":"2021","journal-title":"BMC Pediatr."},{"key":"10.1016\/j.tips.2023.07.004_bb0360","article-title":"The relationships between serum copper levels and overweight\/total obesity and central obesity in children and adolescents aged 6-18 years","volume":"61","author":"Ge","year":"2020","journal-title":"J. Trace Elem. Med. Biol. Organ Soc. Miner. Trace Elem. GMS"},{"key":"10.1016\/j.tips.2023.07.004_bb0365","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1515\/jpem-2019-0086","article-title":"Association between inflammation, oxidative stress, vitamin D, copper and zinc with pre-obesity and obesity in school children from the city of Podgorica, Montenegro","volume":"32","author":"Jaksic","year":"2019","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.tips.2023.07.004_bb0370","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5114\/pedm.2020.95627","article-title":"Low serum copper and zinc concentrations in North Indian children with overweight and obesity","volume":"26","author":"Vivek","year":"2020","journal-title":"Pediatr. Endocrinol. Diabetes Metab."},{"key":"10.1016\/j.tips.2023.07.004_bb0375","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s12011-019-01803-6","article-title":"The relationship between serum copper and overweight\/obesity: a meta-analysis","volume":"194","author":"Gu","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tips.2023.07.004_bb0380","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.advms.2015.02.002","article-title":"Pro-inflammatory adipocytokines, oxidative stress, insulin, Zn and Cu: Interrelations with obesity in Egyptian non-diabetic obese children and adolescents","volume":"60","author":"Habib","year":"2015","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.tips.2023.07.004_bb0385","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1007\/s00394-018-1876-x","article-title":"The association between serum zinc level and overweight\/obesity: a meta-analysis","volume":"58","author":"Gu","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.tips.2023.07.004_bb0390","doi-asserted-by":"crossref","first-page":"C186","DOI":"10.1152\/ajpcell.00132.2018","article-title":"Copper transporters and copper chaperones: roles in cardiovascular physiology and disease","volume":"315","author":"Fukai","year":"2018","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.tips.2023.07.004_bb0395","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.jacc.2019.06.069","article-title":"Early-life environmental exposures and blood pressure in children","volume":"74","author":"Warembourg","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.tips.2023.07.004_bb0400","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.3390\/nu11102479","article-title":"First trimester serum copper or zinc levels, and risk of pregnancy-induced hypertension","volume":"11","author":"Lewandowska","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.tips.2023.07.004_bb0405","first-page":"536","article-title":"U-shaped association between dietary copper intake and new-onset hypertension","volume":"41","author":"He","year":"2022","journal-title":"Clin. Nutr. Edinb. Scotl."},{"key":"10.1016\/j.tips.2023.07.004_bb0410","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s12603-022-1787-7","article-title":"The relationship between dietary copper intake and telomere length in hypertension","volume":"26","author":"Gong","year":"2022","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.tips.2023.07.004_bb0415","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s12011-018-1320-3","article-title":"Associations between copper and zinc and risk of hypertension in US adults","volume":"186","author":"Yao","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tips.2023.07.004_bb0420","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s12011-018-1518-4","article-title":"Association between hypertension in healthy participants and zinc and copper status: a population-based study","volume":"190","author":"Darroudi","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tips.2023.07.004_bb0425","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12890-023-02326-6","article-title":"Identification of biomarkers related to copper metabolism in patients with pulmonary arterial hypertension","volume":"23","author":"Wang","year":"2023","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.tips.2023.07.004_bb0430","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.3390\/ijms21031069","article-title":"Current biomedical use of copper chelation therapy","volume":"21","author":"Baldari","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tips.2023.07.004_bb0435","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1038\/s41418-020-0550-z","article-title":"Chemical activation of SAT1 corrects diet-induced metabolic syndrome","volume":"27","author":"Castoldi","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.tips.2023.07.004_bb0440","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1177\/1535370218813988","article-title":"Trientine selectively delivers copper to the heart and suppresses pressure overload-induced cardiac hypertrophy in rats","volume":"243","author":"Liu","year":"2018","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.tips.2023.07.004_bb0445","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1039\/C7MT00165G","article-title":"Copper-induced reduction in myocardial fibrosis is associated with increased matrix metalloproteins in a rat model of cardiac hypertrophy","volume":"10","author":"Liu","year":"2018","journal-title":"Metallomics"},{"key":"10.1016\/j.tips.2023.07.004_bb0450","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/s41574-019-0242-2","article-title":"Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus","volume":"15","author":"Foretz","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.tips.2023.07.004_bb0455","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jdiacomp.2019.04.005","article-title":"The effect of EDTA-based chelation on patients with diabetes and peripheral artery disease in the Trial to Assess Chelation Therapy (TACT)","volume":"33","author":"Ujueta","year":"2019","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.tips.2023.07.004_bb0460","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002310","article-title":"Ammonium tetrathiomolybdate following ischemia\/reperfusion injury: chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models","volume":"14","author":"Dyson","year":"2017","journal-title":"PLoS Med."},{"key":"10.1016\/j.tips.2023.07.004_bb0465","first-page":"271","article-title":"Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy","volume":"41","author":"Zheng","year":"2022","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"10.1016\/j.tips.2023.07.004_bb0470","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/BS9.0000000000000117","article-title":"Disulfiram, an aldehyde dehydrogenase inhibitor, works as a potent drug against sepsis and cancer via NETosis, pyroptosis, apoptosis, ferroptosis, and cuproptosis","volume":"4","author":"Nie","year":"2022","journal-title":"Blood Sci. Baltim. Md"},{"key":"10.1016\/j.tips.2023.07.004_bb0475","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1007\/s12011-022-03356-7","article-title":"Nano copper supplementation increases superoxide dismutase and catalase gene expression profiles and concentration of antioxidants and immune variables in Sahiwal heifers","volume":"201","author":"Kushwaha","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tips.2023.07.004_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2022.111750","article-title":"Toxicological mechanism of large amount of copper supplementation: effects on endoplasmic reticulum stress and mitochondria-mediated apoptosis by Nrf2\/HO-1 pathway-induced oxidative stress in the porcine myocardium","volume":"230","author":"Li","year":"2022","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.tips.2023.07.004_bb0485","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1007\/s12094-023-03107-7","article-title":"The huge potential of targeting copper status in the treatment of colorectal cancer","volume":"25","author":"Jiang","year":"2023","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.tips.2023.07.004_bb0490","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1039\/D1TB02000E","article-title":"Hyaluronic acid targeted and pH-responsive multifunctional nanoparticles for chemo-photothermal synergistic therapy of atherosclerosis","volume":"10","author":"Liu","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.tips.2023.07.004_bb0495","doi-asserted-by":"crossref","first-page":"13764","DOI":"10.1021\/jacs.8b08014","article-title":"A modular ionophore platform for liver-directed copper supplementation in cells and animals","volume":"140","author":"Su","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.tips.2023.07.004_bb0500","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1080\/15548627.2023.2200554","article-title":"Copper metabolism in cell death and autophagy","volume":"19","author":"Xue","year":"2023","journal-title":"Autophagy"}],"container-title":["Trends in Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614723001530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614723001530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T09:14:45Z","timestamp":1759050885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165614723001530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":100,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S0165614723001530"],"URL":"https:\/\/doi.org\/10.1016\/j.tips.2023.07.004","relation":{},"ISSN":["0165-6147"],"issn-type":[{"value":"0165-6147","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Copper homeostasis and cuproptosis in cardiovascular disease therapeutics","name":"articletitle","label":"Article Title"},{"value":"Trends in Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tips.2023.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}