{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:55:25Z","timestamp":1790870125490,"version":"4.1.0"},"reference-count":91,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2025-00556031"],"award-info":[{"award-number":["RS-2025-00556031"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2023-00219399"],"award-info":[{"award-number":["RS-2023-00219399"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Pharmacological Sciences"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.tips.2026.08.014","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:32:13Z","timestamp":1788841933000},"page":"1136-1154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emerging STAT1 post-translational modifications: mechanisms and translational perspectives"],"prefix":"10.1016","volume":"47","author":[{"given":"Suyeol","family":"Im","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bumseok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Pil","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1219-6967","authenticated-orcid":false,"given":"Jong-Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tips.2026.08.014_bb0005","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41392-024-01980-4","article-title":"The multiple roles of interferon regulatory factor family in health and disease","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.tips.2026.08.014_bb0010","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1007\/s10875-023-01483-x","article-title":"JAKs and STATs from a clinical perspective: loss-of-function mutations, gain-of-function mutations, and their multidimensional consequences","volume":"43","author":"Ott","year":"2023","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.tips.2026.08.014_bb0015","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.ads2210","article-title":"Structural analysis reveals how tetrameric tyrosine-phosphorylated STAT1 is targeted by the rabies virus P-protein","volume":"18","author":"Sugiyama","year":"2025","journal-title":"Sci. Signal."},{"key":"10.1016\/j.tips.2026.08.014_bb0020","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1186\/s12964-024-01943-w","article-title":"The CCL5\/CCR5\/SHP2 axis sustains Stat1 phosphorylation and activates NF-\u03baB signaling promoting M1 macrophage polarization and exacerbating chronic prostatic inflammation","volume":"22","author":"Jin","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.tips.2026.08.014_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1732718","article-title":"Macrophage polarization: molecular mechanisms, disease implications, and targeted therapeutic strategies","volume":"16","author":"Ji","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tips.2026.08.014_bb0030","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s43018-023-00668-y","article-title":"Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy","volume":"5","author":"Ghasemi","year":"2024","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.tips.2026.08.014_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110420","article-title":"JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction","volume":"38","author":"Vogel","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.tips.2026.08.014_bb0040","article-title":"Molecular mechanisms of T helper cell differentiation and functional specialization","volume":"23","author":"Lee","year":"2023","journal-title":"Immune Netw."},{"key":"10.1016\/j.tips.2026.08.014_bb0045","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s40001-023-01144-0","article-title":"Transcriptional regulation on effector T cells in the pathogenesis of psoriasis","volume":"28","author":"Qu","year":"2023","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.tips.2026.08.014_bb0050","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-77929-y","article-title":"IL-10 promotes Th17 cell differentiation by enhancing STAT1-dependent IL-6 production via IgE-stimulated mast cells","volume":"14","author":"Numata","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tips.2026.08.014_bb0055","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1016\/j.cell.2022.09.023","article-title":"The JAK-STAT pathway at 30: much learned, much more to do","volume":"185","author":"Philips","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.tips.2026.08.014_bb0060","article-title":"Interferon lambda in respiratory viral infection: immunomodulatory functions and antiviral effects in epithelium","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tips.2026.08.014_bb0065","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1161\/CIRCRESAHA.124.325855","article-title":"Endothelial PPAR\u03b4 ablation exacerbates vascular hyperpermeability via STAT1\/CXCL10 signaling in acute lung injury","volume":"136","author":"Hong","year":"2025","journal-title":"Circ. Res."},{"key":"10.1016\/j.tips.2026.08.014_bb0070","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/art.42759","article-title":"Amino acids fueling fibroblast-like synoviocyte activation and arthritis by regulating chemokine expression and leukocyte migration","volume":"76","author":"Karonitsch","year":"2024","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.tips.2026.08.014_bb0075","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.3390\/ijms23084095","article-title":"STAT1 and its crucial role in the control of viral infections","volume":"23","author":"Tolomeo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tips.2026.08.014_bb0080","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.cell.2025.01.043","article-title":"Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response","volume":"188","author":"He","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.tips.2026.08.014_bb0085","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/j.cell.2026.01.023","article-title":"Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation","volume":"189","author":"Zuo","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.tips.2026.08.014_bb0090","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1101\/gad.364306","article-title":"Acetylation of Stat1 modulates NF-\u03baB activity","volume":"20","author":"Kr\u00e4mer","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.tips.2026.08.014_bb0095","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cell.2007.07.034","article-title":"Acetylation-dependent signal transduction for type I interferon receptor","volume":"131","author":"Tang","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.tips.2026.08.014_bb0100","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1101\/gad.479209","article-title":"A phosphorylation-acetylation switch regulates STAT1 signaling","volume":"23","author":"Kr\u00e4mer","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.tips.2026.08.014_bb0105","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/s41467-019-09024-0","article-title":"Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation","volume":"10","author":"Hansen","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tips.2026.08.014_bb0110","article-title":"Therapeutic stress triggers tumor STAT1 acetylation to disarm immunotherapy","volume":"6","author":"Chiu","year":"2025","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.tips.2026.08.014_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2026.117094","article-title":"AARS1-mediated lactylation of STAT1 drives immune evasion","volume":"45","author":"Du","year":"2026","journal-title":"Cell Rep."},{"key":"10.1016\/j.tips.2026.08.014_bb0120","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00535-026-02363-y","article-title":"Targeting the ZDHHC9-mediated STAT1 palmitoylation-phosphorylation conversion inhibits gastric cancer progression","volume":"61","author":"Bai","year":"2026","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.tips.2026.08.014_bb0125","article-title":"Endothelial-derived CCL7 promotes macrophage polarization and aggravates septic acute lung injury via CCR1-mediated STAT1 succinylation","volume":"12","author":"Li","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.tips.2026.08.014_bb0130","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s41419-024-07268-3","article-title":"\u03b2-Hydroxybutyrate suppresses M1 macrophage polarization through \u03b2-hydroxybutyrylation of the STAT1 protein","volume":"15","author":"Bai","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tips.2026.08.014_bb0135","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41423-025-01266-x","article-title":"\u03b2-Hydroxybutyrylation and O-GlcNAc modifications of STAT1 modulate antiviral defense in aging","volume":"22","author":"Zuo","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.tips.2026.08.014_bb0140","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jare.2024.07.035","article-title":"NDRG1 enhances the sensitivity to cetuximab by promoting Stat1 ubiquitylation in colorectal cancer","volume":"72","author":"Yang","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.tips.2026.08.014_bb0145","doi-asserted-by":"crossref","first-page":"17006","DOI":"10.1074\/jbc.M112.341198","article-title":"Smurf1 protein negatively regulates interferon-\u03b3 signaling through promoting STAT1 protein ubiquitination and degradation","volume":"287","author":"Yuan","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2026.08.014_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1013472","article-title":"Sec10 suppresses antiviral innate immune response by facilitating STUB1-mediated STAT1 degradation","volume":"21","author":"Sun","year":"2025","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tips.2026.08.014_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellin.2026.100322","article-title":"Viperin weakens IFN-I-induced immune activity by facilitating STAT1 degradation through E3 ligase UBE4A","volume":"5","author":"Miao","year":"2026","journal-title":"Cell Insight"},{"key":"10.1016\/j.tips.2026.08.014_bb0160","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.cellsig.2016.08.014","article-title":"E3 ubiquitin ligase NKLAM ubiquitinates STAT1 and positively regulates STAT1-mediated transcriptional activity","volume":"28","author":"Lawrence","year":"2016","journal-title":"Cell. Signal."},{"key":"10.1016\/j.tips.2026.08.014_bb0165","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/s41418-020-00609-7","article-title":"RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense","volume":"28","author":"Guo","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.tips.2026.08.014_bb0170","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41590-017-0003-0","article-title":"Nuclear RNF2 inhibits interferon function by promoting K33-linked STAT1 disassociation from DNA","volume":"19","author":"Liu","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.tips.2026.08.014_bb0175","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/s41467-020-14948-z","article-title":"Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling","volume":"11","author":"Zuo","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tips.2026.08.014_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005764","article-title":"Deubiquitinase USP2a sustains interferons antiviral activity by restricting ubiquitination of activated STAT1 in the nucleus","volume":"12","author":"Ren","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tips.2026.08.014_bb0185","doi-asserted-by":"crossref","first-page":"5927","DOI":"10.1038\/s41467-025-61028-1","article-title":"Cardiomyocyte-derived USP13 protects hearts from hypertrophy via deubiquitinating and stabilizing STAT1 in male mice","volume":"16","author":"Han","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tips.2026.08.014_bb0190","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.7150\/thno.100097","article-title":"Deubiquitinase MYSM1 drives myocardial ischemia\/reperfusion injury by stabilizing STAT1 in cardiomyocytes","volume":"15","author":"Shi","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.tips.2026.08.014_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1507989","article-title":"Ablation of the deubiquitinating enzyme cylindromatosis (CYLD) augments STAT1-mediated M1 macrophage polarization and fosters Staphylococcus aureus control","volume":"16","author":"Schmidt","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tips.2026.08.014_bb0200","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1136\/gutjnl-2025-336400","article-title":"SMYD2-mediated methylation of STAT1 protects against hepatic ischaemia\/reperfusion injury by blocking JAK-STAT1 signalling pathways","volume":"75","author":"Yang","year":"2026","journal-title":"Gut"},{"key":"10.1016\/j.tips.2026.08.014_bb0205","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1161\/CIRCULATIONAHA.125.076101","article-title":"Macrophage PRMT9 ameliorates acute myocardial infarction by promoting symmetric dimethylation and degradation of STAT1","volume":"153","author":"Bai","year":"2026","journal-title":"Circulation"},{"key":"10.1016\/j.tips.2026.08.014_bb0210","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.freeradbiomed.2018.02.005","article-title":"S-glutathionylation exerts opposing roles in the regulation of STAT1 and STAT3 signaling in reactive microglia","volume":"117","author":"Butturini","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tips.2026.08.014_bb0215","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14970-0","article-title":"Nitric oxide mediated inhibition of antigen presentation from DCs to CD4+ T cells in cancer and measurement of STAT1 nitration","volume":"7","author":"Markowitz","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tips.2026.08.014_bb0220","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.virs.2026.01.004","article-title":"Pseudorabies virus TK protein antagonizes alpha interferon response by interfering with the JAK1\u2013STAT1 interaction","volume":"41","author":"Song","year":"2026","journal-title":"Virol. Sin."},{"key":"10.1016\/j.tips.2026.08.014_bb0225","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.biochi.2026.02.006","article-title":"Molecular insights of immune evasion by Orf virus: the interaction and functional impact of viral OH1 phosphatase on STAT1","volume":"244","author":"Porley","year":"2026","journal-title":"Biochimie"},{"key":"10.1016\/j.tips.2026.08.014_bb0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011185","article-title":"Human cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection","volume":"19","author":"Zarrella","year":"2023","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tips.2026.08.014_bb0235","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1110765","article-title":"JAK\/STAT pathway: extracellular signals, diseases, immunity, and therapeutic regimens","volume":"11","author":"Hu","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.tips.2026.08.014_bb0240","doi-asserted-by":"crossref","first-page":"34133","DOI":"10.1074\/jbc.M304531200","article-title":"STATs dimerize in the absence of phosphorylation","volume":"278","author":"Braunstein","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2026.08.014_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2021.155552","article-title":"STAT1 N-terminal domain discriminatively controls type I and type II IFN signaling","volume":"144","author":"G\u00f6der","year":"2021","journal-title":"Cytokine"},{"key":"10.1016\/j.tips.2026.08.014_bb0250","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0092-8674(95)90311-9","article-title":"Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation","volume":"82","author":"Wen","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.tips.2026.08.014_bb0255","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S1074-7613(03)00322-4","article-title":"Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-gamma-dependent innate immunity","volume":"19","author":"Varinou","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.tips.2026.08.014_bb0260","doi-asserted-by":"crossref","first-page":"582","DOI":"10.7150\/ijbs.123441","article-title":"Dual phosphorylation of STAT1 at Y701\/S727 by TNF\u03b1 drives AIM2-mediated PANoptosis of renal tubular epithelial cells and fibrotic progression in renal allografts","volume":"22","author":"Han","year":"2026","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.tips.2026.08.014_bb0265","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj3887","article-title":"LATS1 is a central signal transmitter for achieving full type-I interferon activity","volume":"8","author":"Zuo","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tips.2026.08.014_bb0270","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.immuni.2012.10.017","article-title":"CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response","volume":"38","author":"Bancerek","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.tips.2026.08.014_bb0275","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.48609","article-title":"PHLPP1 counter-regulates STAT1-mediated inflammatory signaling","volume":"8","author":"Cohen Katsenelson","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.tips.2026.08.014_bb0280","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1182\/blood.2025032254","article-title":"FLT3-ITD scaffolds PKC\u03b9-STAT1 to drive noncanonical S727 phosphorylation and CD276-driven CD8+ T-cell exhaustion in AML","volume":"148","author":"Wang","year":"2026","journal-title":"Blood"},{"key":"10.1016\/j.tips.2026.08.014_bb0285","doi-asserted-by":"crossref","first-page":"44412","DOI":"10.1074\/jbc.M111.285205","article-title":"Inhibitor of \u03baB kinase \u03b5 (IKK\u03b5), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection","volume":"286","author":"Perwitasari","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2026.08.014_bb0290","doi-asserted-by":"crossref","first-page":"21170","DOI":"10.1073\/pnas.1119137109","article-title":"I\u03baB kinase \u03b5 (IKK\u03b5) regulates the balance between type I and type II interferon responses","volume":"108","author":"Ng","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tips.2026.08.014_bb0295","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.3390\/cells13181531","article-title":"Threonine phosphorylation and the Yin and Yang of STAT1: phosphorylation-dependent spectrum of STAT1 functionality in inflammatory contexts","volume":"13","author":"Elbrashy","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.tips.2026.08.014_bb0300","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aay0574","article-title":"Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production","volume":"13","author":"Metwally","year":"2020","journal-title":"Sci. Signal."},{"key":"10.1016\/j.tips.2026.08.014_bb0305","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2402226121","article-title":"Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses","volume":"121","author":"Metwally","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tips.2026.08.014_bb0310","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2511957122","article-title":"Threonine phosphorylation of STAT1 safeguards gut epithelial integrity and restricts interferon-mediated cytotoxicity","volume":"122","author":"Metwally","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tips.2026.08.014_bb0315","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/s12964-025-02484-6","article-title":"Protein acylation in inflammatory diseases: from mechanisms to therapeutic strategies","volume":"23","author":"Ding","year":"2025","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.tips.2026.08.014_bb0320","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/imm.13822","article-title":"Role of novel protein acylation modifications in immunity and its related diseases","volume":"173","author":"Li","year":"2024","journal-title":"Immunology"},{"key":"10.1016\/j.tips.2026.08.014_bb0325","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.828648","article-title":"The beginner\u2019s guide to O-GlcNAc: from nutrient sensitive pathway regulation to its impact on the immune system","volume":"13","author":"Mannino","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tips.2026.08.014_bb0330","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3390\/ijms25010299","article-title":"RanBP2\/Nup358 mediates sumoylation of STAT1 and antagonizes interferon-\u03b1-mediated antiviral innate immunity","volume":"25","author":"Li","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tips.2026.08.014_bb0335","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202301450RR","article-title":"N-MYC-interacting protein enhances type II interferon signaling by inhibiting STAT1 sumoylation","volume":"37","author":"Feng","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.tips.2026.08.014_bb0340","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1182\/blood-2006-04-020271","article-title":"Stat1 and SUMO modification","volume":"108","author":"Song","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.tips.2026.08.014_bb0345","article-title":"Mutually exclusive STAT1 modifications identified by Ubc9\/substrate dimerization-dependent SUMOylation","volume":"37","author":"Zimnik","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tips.2026.08.014_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110530","article-title":"Effects of SENP1-induced deSUMOylation of STAT1 on proliferation and invasion in nasopharyngeal carcinoma","volume":"101","author":"Zhang","year":"2023","journal-title":"Cell. Signal."},{"key":"10.1016\/j.tips.2026.08.014_bb0355","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41523-026-00911-6","article-title":"JAK\/STAT1-interferon-ISGylation networks in breast cancer resistance to inhibitors of FOXM1 and CDK4\/6","volume":"12","author":"Ziegler","year":"2026","journal-title":"NPJ Breast Cancer"},{"key":"10.1016\/j.tips.2026.08.014_bb0360","article-title":"ISGylation in innate antiviral immunity and pathogen defense responses: a review","volume":"9","author":"Zhang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tips.2026.08.014_bb0365","doi-asserted-by":"crossref","first-page":"30091","DOI":"10.1074\/jbc.M301344200","article-title":"SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation","volume":"278","author":"Rogers","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2026.08.014_bb0370","doi-asserted-by":"crossref","first-page":"18731","DOI":"10.1074\/jbc.M111.235978","article-title":"Cytokine-induced paracrystals prolong the activity of signal transducers and activators of transcription (STAT) and provide a model for the regulation of protein solubility by small ubiquitin-like modifier (SUMO)","volume":"286","author":"Droescher","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2026.08.014_bb0375","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1182\/blood-2011-04-347930","article-title":"SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFN\u03b3","volume":"118","author":"Begitt","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.tips.2026.08.014_bb0380","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3390\/antiox14121395","article-title":"ROS-driven STAT1 S-glutathionylation sustains IFN\u03b3 signaling and pro-inflammatory microglial polarization","volume":"14","author":"Brattini","year":"2025","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.tips.2026.08.014_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103543","article-title":"The covalent modification of STAT1 cysteines by sulforaphane promotes antitumor immunity via blocking IFN-\u03b3-induced PD-L1 expression","volume":"81","author":"Shi","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.tips.2026.08.014_bb0390","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0092-8674(01)00269-0","article-title":"Arginine methylation of STAT1 modulates IFN\u03b1\/\u03b2-induced transcription","volume":"104","author":"Mowen","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.tips.2026.08.014_bb0395","doi-asserted-by":"crossref","first-page":"35787","DOI":"10.1074\/jbc.C200346200","article-title":"Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase","volume":"277","author":"Zhu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2026.08.014_bb0400","doi-asserted-by":"crossref","first-page":"21700","DOI":"10.1074\/jbc.C400606200","article-title":"Are STATS arginine-methylated?","volume":"280","author":"Komyod","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tips.2026.08.014_bb0405","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252011122","article-title":"Immp2l deficiency induced granulosa cell senescence through STAT1\/ATF4 mediated UPRmt and STAT1\/(ATF4)\/HIF1\u03b1\/BNIP3 mediated mitophagy: prevented by enocyanin","volume":"25","author":"Qu","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tips.2026.08.014_bb0410","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12849","article-title":"PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation","volume":"7","author":"Iwata","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tips.2026.08.014_bb0415","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1038\/s41467-021-24225-2","article-title":"Nuclear ADP-ribosylation drives IFN\u03b3-dependent STAT1\u03b1 enhancer formation in macrophages","volume":"12","author":"Gupte","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tips.2026.08.014_bb0420","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116130","article-title":"PARP7 inhibition stabilizes STAT1\/STAT2 and relieves experimental autoimmune encephalomyelitis in mice","volume":"44","author":"Xu","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.tips.2026.08.014_bb0425","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3390\/v14051003","article-title":"A review of pseudorabies virus variants: genomics, vaccination, transmission, and zoonotic potential","volume":"14","author":"Bo","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.tips.2026.08.014_bb0430","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3390\/v17040587","article-title":"Innate immune sensing of Parapoxvirus Orf virus and viral immune evasion","volume":"17","author":"AlDaif","year":"2025","journal-title":"Viruses"},{"key":"10.1016\/j.tips.2026.08.014_bb0435","first-page":"469","article-title":"Crystal structure of monkeypox H1 phosphatase, an antiviral drug target","volume":"14","author":"Cui","year":"2023","journal-title":"Protein Cell"},{"key":"10.1016\/j.tips.2026.08.014_bb0440","doi-asserted-by":"crossref","DOI":"10.71150\/jm.2506006","article-title":"Structural analysis of dual specificity phosphatases, the only type of protein tyrosine phosphatases found in humans and across diverse microorganisms","volume":"63","author":"Ku","year":"2025","journal-title":"J. Microbiol."},{"key":"10.1016\/j.tips.2026.08.014_bb0445","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.ade7028","article-title":"Dysregulated IFN-\u03b3 signals promote autoimmunity in STAT1 gain-of-function syndrome","volume":"15","author":"Largent","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tips.2026.08.014_bb0450","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/imr.13300","article-title":"Human STAT1 gain of function with chronic mucocutaneous candidiasis: a comprehensive review for strengthening the connection between bedside observations and laboratory research","volume":"322","author":"Asano","year":"2024","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.tips.2026.08.014_bb0455","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1717692","article-title":"The T385M STAT1 gain-of-function mutation confers the most severe disease outcomes","volume":"16","author":"Torrance","year":"2025","journal-title":"Front. Immunol."}],"container-title":["Trends in Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614726002117?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614726002117?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:07:36Z","timestamp":1790867256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165614726002117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":91,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0165614726002117"],"URL":"https:\/\/doi.org\/10.1016\/j.tips.2026.08.014","relation":{},"ISSN":["0165-6147"],"issn-type":[{"value":"0165-6147","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging STAT1 post-translational modifications: mechanisms and translational perspectives","name":"articletitle","label":"Article Title"},{"value":"Trends in Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tips.2026.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}