{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:50:03Z","timestamp":1791503403159,"version":"4.3.4"},"reference-count":10,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["305758\/2021-7"],"award-info":[{"award-number":["305758\/2021-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2025\/26187-7"],"award-info":[{"award-number":["2025\/26187-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2023\/08735-1"],"award-info":[{"award-number":["2023\/08735-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2023\/12246-6"],"award-info":[{"award-number":["2023\/12246-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Pharmacological Sciences"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.tips.2026.09.008","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:15:55Z","timestamp":1791375355000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emerging tumor resistance mechanisms to antimetabolite treatment"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8384-6551","authenticated-orcid":false,"given":"Juan L.","family":"Coelho-Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-4311","authenticated-orcid":false,"given":"Diego A.","family":"Pereira-Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2937-8109","authenticated-orcid":false,"given":"Jo\u00e3o A.","family":"Machado-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tips.2026.09.008_bb0005","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1038\/s42255-026-01578-w","article-title":"Mitochondrial metabolism determines chemotherapy sensitivity in colorectal cancer","volume":"8","author":"Moss","year":"2026","journal-title":"Nat. Metab."},{"key":"10.1016\/j.tips.2026.09.008_bb0010","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41586-026-10790-3","article-title":"Metabolite glues as a means of purine sensing and chemotherapeutic response","volume":"655","author":"Witus","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.tips.2026.09.008_bb0015","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tips.2025.10.013","article-title":"Molecular glues evolve from serendipity to rational design","volume":"47","author":"Shrivastav","year":"2026","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.tips.2026.09.008_bb0020","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1016\/j.cmet.2024.05.014","article-title":"Electron transport chain inhibition increases cellular dependence on purine transport and salvage","volume":"36","author":"Wu","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.tips.2026.09.008_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.115179","article-title":"mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase","volume":"44","author":"Pham","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.tips.2026.09.008_bb0030","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cell.2015.07.016","article-title":"An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis","volume":"162","author":"Birsoy","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.tips.2026.09.008_bb0035","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1042\/BCJ20260185","article-title":"Re-evaluating the rationale for targeting oxidative phosphorylation in acute myeloid leukemia","volume":"483","author":"Chrest","year":"2026","journal-title":"Biochem. J."},{"key":"10.1016\/j.tips.2026.09.008_bb0040","article-title":"The impact of metformin use on survival outcomes in colorectal cancer: a systematic review and meta-analysis","volume":"46","author":"Rahmanian","year":"2026","journal-title":"Cancer Treat. Res. Commun."},{"key":"10.1016\/j.tips.2026.09.008_bb0045","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41392-025-02303-x","article-title":"High mtDNA content identifies oxidative phosphorylation-driven acute myeloid leukemias and represents a therapeutic vulnerability","volume":"10","author":"Pereira-Martins","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.tips.2026.09.008_bb0050","first-page":"2319","article-title":"Potent synergy of DHODH and SREBP inhibition in acute myeloid leukemia via disruption of cholesterol and lipid metabolism","volume":"111","author":"Hogeling","year":"2026","journal-title":"Haematologica"}],"container-title":["Trends in Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614726002373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165614726002373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:08:21Z","timestamp":1791500901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165614726002373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":10,"alternative-id":["S0165614726002373"],"URL":"https:\/\/doi.org\/10.1016\/j.tips.2026.09.008","relation":{},"ISSN":["0165-6147"],"issn-type":[{"value":"0165-6147","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging tumor resistance mechanisms to antimetabolite treatment","name":"articletitle","label":"Article Title"},{"value":"Trends in Pharmacological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tips.2026.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}