{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T14:49:33Z","timestamp":1778078973843,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T00:00:00Z","timestamp":1548201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["tipsro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Technical Innovations & Patient Support in Radiation Oncology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.tipsro.2019.01.004","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T07:57:20Z","timestamp":1552377440000},"page":"35-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Observed high incidence of prostatic calculi with the potential to act as natural fiducials for prostate image guided radiotherapy"],"prefix":"10.1016","volume":"9","author":[{"given":"A.G.M.","family":"O'Neill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.O.","family":"Osman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.R.","family":"Hounsell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"O'Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.tipsro.2019.01.004_b0005","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.ejca.2012.12.027","article-title":"Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012","volume":"49","author":"Ferlay","year":"2013","journal-title":"Eur J Cancer"},{"issue":"1","key":"10.1016\/j.tipsro.2019.01.004_b0010","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ijrobp.2010.06.007","article-title":"Image-guided radiotherapy (IGRT) for prostate cancer comparing kV imaging of fiducial markers with cone beam computed tomography (CBCT)","volume":"80","author":"Barney","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.tipsro.2019.01.004_b0015","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.ijrobp.2006.10.039","article-title":"Comparison of localization performance with implanted fiducial markers and cone-beam computed tomography for on-line image-guided radiotherapy of the prostate","volume":"67","author":"Moseley","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys [Internet]"},{"issue":"1068","key":"10.1016\/j.tipsro.2019.01.004_b0020","doi-asserted-by":"crossref","first-page":"20160296","DOI":"10.1259\/bjr.20160296","article-title":"Fiducial marker guided prostate radiotherapy: a review","volume":"89","author":"O\u2019Neill","year":"2016","journal-title":"Br J Radiol [Internet]"},{"issue":"3","key":"10.1016\/j.tipsro.2019.01.004_b0025","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.anndiagpath.2007.07.001","article-title":"Calcifications in prostate and ejaculatory system: a study on 298 consecutive whole mount sections of prostate from radical prostatectomy or cystoprostatectomy specimens","volume":"12","author":"Suh","year":"2008","journal-title":"Ann Diagn Pathol [Internet]"},{"key":"10.1016\/j.tipsro.2019.01.004_b0030","unstructured":"Venyo AK-G. Prostatic calculi: a review of the literature. 2012 [cited 2015 Jan 28]. https:\/\/www.webmedcentral.com\/article_view\/3463."},{"issue":"4","key":"10.1016\/j.tipsro.2019.01.004_b0035","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.ijrobp.2008.07.021","article-title":"Calcifications are potential surrogates for prostate localization in image-guided radiotherapy","volume":"72","author":"Zeng","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys [Internet]"},{"issue":"3","key":"10.1016\/j.tipsro.2019.01.004_b0040","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.ijrobp.2011.03.059","article-title":"Role of intra- or periprostatic calcifications in image-guided radiotherapy for prostate cancer","volume":"82","author":"Hanna","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys [Internet]"},{"issue":"8","key":"10.1016\/j.tipsro.2019.01.004_b0045","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.canrad.2014.07.161","article-title":"Intraprostatic calcifications as natural fiducial markers in image-guided radiotherapy for prostate cancer","volume":"18","author":"Sbai","year":"2014","journal-title":"Cancer Radiother [Internet]"},{"issue":"22","key":"10.1016\/j.tipsro.2019.01.004_b0050","doi-asserted-by":"crossref","DOI":"10.1088\/0031-9155\/58\/22\/8077","article-title":". My IOPscience A novel approach for establishing benchmark CBCT\/CT deformable image registrations in prostate","volume":"8077","author":"Kim","year":"2013","journal-title":"Phys Med Biol"},{"issue":"4","key":"10.1016\/j.tipsro.2019.01.004_b0055","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.ijrobp.2009.09.068","article-title":"Prostate localization on daily cone-beam computed tomography images: accuracy assessment of similarity metrics","volume":"77","author":"Kim","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys [Internet]"},{"issue":"4","key":"10.1016\/j.tipsro.2019.01.004_b0060","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.ijrobp.2005.07.973","article-title":"Automatic prostate localization on cone-beam CT scans for high precision image-guided radiotherapy","volume":"63","author":"Smitsmans","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys [Internet]"},{"issue":"4","key":"10.1016\/j.tipsro.2019.01.004_b0065","first-page":"477","article-title":"Magnetic resonance imaging for the detection, localisation, and characterisation of prostate cancer: recommendations from a European consensus meeting","volume":"59","author":"Dickinson","year":"2011","journal-title":"Eur Urol [Internet] Eur Assoc Urol"},{"issue":"5","key":"10.1016\/j.tipsro.2019.01.004_b0070","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.acra.2014.01.006","article-title":"Detection of prostate calcification with megavoltage helical CT","volume":"21","author":"Hama","year":"2014","journal-title":"Acad Radiol [Internet]"},{"key":"10.1016\/j.tipsro.2019.01.004_b0075","first-page":"1","article-title":"The burden of prostatic calculi is more important than the presence","volume":"18","author":"Park","year":"2016","journal-title":"Asian J Androl"},{"issue":"2","key":"10.1016\/j.tipsro.2019.01.004_b0080","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0167-8140(99)00011-0","article-title":"Quantification and predictors of prostate position variability in 50 patients evaluated with multiple CT scans during conformal radiotherapy","volume":"50","author":"Zelefsky","year":"1999","journal-title":"Radiother Oncol [Internet]"},{"issue":"3","key":"10.1016\/j.tipsro.2019.01.004_b0085","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0360-3016(99)00040-1","article-title":"Evaluating the effect of rectal distension and rectal movement on prostate gland position using cine MRI","volume":"44","author":"Padhani","year":"1999","journal-title":"Int J Radiat Oncol [Internet]"},{"issue":"3","key":"10.1016\/j.tipsro.2019.01.004_b0090","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.ijrobp.2011.08.025","article-title":"Adaptive image-guided radiotherapy (IGRT) eliminates the risk of biochemical failure caused by the bias of rectal distension in prostate cancer treatment planning: clinical evidence","volume":"83","author":"Park","year":"2012","journal-title":"Int J Radiat Oncol [Internet]"},{"issue":"1","key":"10.1016\/j.tipsro.2019.01.004_b0095","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijrobp.2011.11.047","article-title":"Improved clinical outcomes with high-dose image guided radiotherapy compared with non-IGRT for the treatment of clinically localized prostate cancer","volume":"84","author":"Zelefsky","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys [Internet]"},{"issue":"37","key":"10.1016\/j.tipsro.2019.01.004_b0100","article-title":"Course of prostatic ducts and anatomy: chemical and X-ray diffraction analysis of prostatic calculi","volume":"51","author":"Huggins","year":"1944","journal-title":"J Urol"},{"issue":"1","key":"10.1016\/j.tipsro.2019.01.004_b0105","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.urology.2014.09.026","article-title":"Prevalence of prostatic calcification subtypes and association with prostate cancer","volume":"85","author":"Smolski","year":"2015","journal-title":"Urology [Internet]"},{"issue":"2","key":"10.1016\/j.tipsro.2019.01.004_b0110","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.urology.2007.04.008","article-title":"Incidence and significance of prostatic stones in men with chronic prostatitis\/chronic pelvic pain syndrome","volume":"70","author":"Shoskes","year":"2007","journal-title":"Urology [Internet]"},{"key":"10.1016\/j.tipsro.2019.01.004_b0115","first-page":"215","article-title":"Prostate calculi in cancer and BPH in a cohort of Korean men: presence of calculi did not correlate with cancer risk","volume":"2","author":"Hwang","year":"2009","journal-title":"Asian J Androl [Internet]"},{"key":"10.1016\/j.tipsro.2019.01.004_b0120","first-page":"1","volume":"8","author":"Bai","year":"2013","journal-title":"Susceptibility weighted imaging: a new tool in the diagnosis of prostate cancer and detection of prostatic calcification"},{"key":"10.1016\/j.tipsro.2019.01.004_b0125","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.1088\/0031-9155\/57\/19\/6211","article-title":"Influence of the number of elongated fiducial markers on the localization accuracy of the prostate","volume":"57","author":"de Boer","year":"2012","journal-title":"Phys Med Biol"},{"issue":"1","key":"10.1016\/j.tipsro.2019.01.004_b0130","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.eururo.2015.08.052","article-title":"PI-RADS prostate imaging? Reporting and data system: 2015, version 2","volume":"69","author":"Weinreb","year":"2016","journal-title":"Eur Urol [Internet]"}],"updated-by":[{"DOI":"10.1016\/j.tipsro.2019.10.005","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000}}],"container-title":["Technical Innovations & Patient Support in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240563241830012X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240563241830012X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T13:14:27Z","timestamp":1555506867000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S240563241830012X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":26,"alternative-id":["S240563241830012X"],"URL":"https:\/\/doi.org\/10.1016\/j.tipsro.2019.01.004","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.tipsro.2019.10.005","asserted-by":"object"}]},"ISSN":["2405-6324"],"issn-type":[{"value":"2405-6324","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Observed high incidence of prostatic calculi with the potential to act as natural fiducials for prostate image guided radiotherapy","name":"articletitle","label":"Article Title"},{"value":"Technical Innovations & Patient Support in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tipsro.2019.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2019 Published by Elsevier B.V. on behalf of European Society for Radiotherapy & Oncology.","name":"copyright","label":"Copyright"}]}}