{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:01:43Z","timestamp":1787068903401,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007210","name":"Varian Medical Systems Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007210","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fund for Scientific Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["tipsro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Technical Innovations & Patient Support in Radiation Oncology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.tipsro.2024.100284","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T13:47:23Z","timestamp":1729604843000},"page":"100284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["On the trail of CBCT-guided adaptive rectal boost radiotherapy, does daily delineation require a radiation oncologist?"],"prefix":"10.1016","volume":"32","author":[{"given":"Julien","family":"Pierrard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Dechambre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel Abdel","family":"Massih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Cvilic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Da Silva Chambel Roma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Henderickx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Heylen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonore","family":"Longton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Mony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Amine","family":"Tenabene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tha\u00efs","family":"Tison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad","family":"Vandermeulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Vander Veken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniko Wale","family":"Etume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Emmanuella","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Van Ooteghem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.tipsro.2024.100284_b0005","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S1470-2045(21)00079-6","article-title":"Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial","volume":"22","author":"Conroy","year":"2021","journal-title":"Lancet Oncol"},{"issue":"1","key":"10.1016\/j.tipsro.2024.100284_b0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1470-2045(20)30555-6","article-title":"Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial","volume":"22","author":"Bahadoer","year":"2021","journal-title":"Lancet Oncol"},{"issue":"suppl_4","key":"10.1016\/j.tipsro.2024.100284_b0015","doi-asserted-by":"crossref","first-page":"iv22","DOI":"10.1093\/annonc\/mdx224","article-title":"Rectal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"28","author":"Glynne-Jones","year":"2017","journal-title":"Ann Oncol"},{"issue":"23","key":"10.1016\/j.tipsro.2024.100284_b0020","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1200\/JCO.22.00032","article-title":"Organ preservation in patients with rectal adenocarcinoma treated with total neoadjuvant therapy","volume":"40","author":"Garcia-Aguilar","year":"2022","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.tipsro.2024.100284_b0025","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1470-2045(15)00467-2","article-title":"Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis","volume":"17","author":"Renehan","year":"2016","journal-title":"Lancet Oncol"},{"issue":"1","key":"10.1016\/j.tipsro.2024.100284_b0030","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ijrobp.2012.05.017","article-title":"Radiation dose-response model for locally advanced rectal cancer after preoperative chemoradiation therapy","volume":"85","author":"Appelt","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.tipsro.2024.100284_b0035","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.ijrobp.2007.07.2332","article-title":"Phase II study of preoperative helical tomotherapy for rectal cancer","volume":"70","author":"De Ridder","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.tipsro.2024.100284_b0040","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.ijrobp.2020.06.013","article-title":"Efficacy of dose-escalated chemoradiation on complete tumor response in patients with locally advanced rectal cancer (RECTAL-BOOST): a phase 2 randomized controlled trial","volume":"108","author":"Couwenberg","year":"2020","journal-title":"International Journal of Radiation Oncology*Biology*Physics"},{"issue":"1","key":"10.1016\/j.tipsro.2024.100284_b0045","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s13014-021-01866-7","article-title":"Feasibility of conebeam CT-based online adaptive radiotherapy for neoadjuvant treatment of rectal cancer","volume":"16","author":"de Jong","year":"2021","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.tipsro.2024.100284_b0050","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.radonc.2022.08.026","article-title":"Simulated computed tomography-guided stereotactic adaptive radiotherapy (CT-STAR) for the treatment of locally advanced pancreatic cancer","volume":"175","author":"Schiff","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.tipsro.2024.100284_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2022.06.078","article-title":"In silico trial of computed tomography-guided stereotactic adaptive radiation therapy (CT-STAR) for the treatment of abdominal oligometastases","author":"Schiff","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.tipsro.2024.100284_b0060","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.radonc.2016.09.009","article-title":"Uncertainties in volume delineation in radiation oncology: a systematic review and recommendations for future studies","volume":"121","author":"Vinod","year":"2016","journal-title":"Radiother Oncol"},{"issue":"3","key":"10.1016\/j.tipsro.2024.100284_b0065","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.radonc.2014.05.011","article-title":"Consequences of anorectal cancer atlas implementation in the cooperative group setting: Radiobiologic analysis of a prospective randomized in silico target delineation study","volume":"112","author":"Mavroidis","year":"2014","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.tipsro.2024.100284_b0070","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/1748-717X-8-176","article-title":"Dosimetric impact of inter-observer variability for 3D conformal radiotherapy and volumetric modulated arc therapy: the rectal tumor target definition case","volume":"8","author":"Lobefalo","year":"2013","journal-title":"Radiat Oncol"},{"issue":"2","key":"10.1016\/j.tipsro.2024.100284_b0075","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.radonc.2016.07.017","article-title":"International consensus guidelines on clinical target volume delineation in rectal cancer","volume":"120","author":"Valentini","year":"2016","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.tipsro.2024.100284_b0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/0031-9155\/61\/1\/1","article-title":"Evolution of motion uncertainty in rectal cancer: implications for adaptive radiotherapy","volume":"61","author":"Kleijnen","year":"2016","journal-title":"Phys Med Biol"},{"issue":"4","key":"10.1016\/j.tipsro.2024.100284_b0085","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.ijrobp.2006.02.050","article-title":"Definition and delineation of the clinical target volume for rectal cancer","volume":"65","author":"Roels","year":"2006","journal-title":"International Journal of Radiation Oncology*Biology*Physics"},{"key":"10.1016\/j.tipsro.2024.100284_b0090","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.radonc.2018.11.023","article-title":"The INTERACT Trial: Long-term results of a randomised trial on preoperative capecitabine-based radiochemotherapy intensified by concomitant boost or oxaliplatin, for cT2 (distal)-cT3 rectal cancer","volume":"134","author":"Valentini","year":"2019","journal-title":"Radiother Oncol"},{"issue":"4","key":"10.1016\/j.tipsro.2024.100284_b0095","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.21873\/anticanres.14966","article-title":"Treatment volume, dose prescription and delivery techniques for dose-intensification in rectal cancer: a national survey","volume":"41","author":"Caravatta","year":"2021","journal-title":"Anticancer Res"},{"key":"10.1016\/j.tipsro.2024.100284_b0100","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13063-015-0586-4","article-title":"RandomizEd controlled trial for pre-operAtive dose-escaLation BOOST in locally advanced rectal cancer (RECTAL BOOST study): study protocol for a randomized controlled trial","volume":"16","author":"Burbach","year":"2015","journal-title":"Trials"},{"issue":"6","key":"10.1016\/j.tipsro.2024.100284_b0105","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.canrad.2011.04.003","article-title":"State of the art on dose prescription, reporting and recording in intensity-modulated radiation therapy (ICRU report No. 83)","volume":"15","author":"Gr\u00e9goire","year":"2011","journal-title":"Cancer\/Radioth\u00e9rapie"},{"issue":"1","key":"10.1016\/j.tipsro.2024.100284_b0110","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1754-9485.2009.02044.x","article-title":"Inter-observer variability of clinical target volume delineation for bladder cancer using CT and cone beam CT","volume":"53","author":"Foroudi","year":"2009","journal-title":"J Med Imaging Radiat Oncol"},{"issue":"1","key":"10.1016\/j.tipsro.2024.100284_b0115","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.radonc.2011.08.011","article-title":"Target volume delineation variation in radiotherapy for early stage rectal cancer in the Netherlands","volume":"102","author":"Nijkamp","year":"2012","journal-title":"Radiother Oncol"},{"issue":"6","key":"10.1016\/j.tipsro.2024.100284_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.adro.2024.101483","article-title":"Evaluation of deep learning clinical target volumes auto-contouring for magnetic resonance imaging-guided online adaptive treatment of rectal cancer","volume":"9","author":"Ferreira Silv\u00e9rio","year":"2024","journal-title":"Advances in Radiation Oncology"},{"issue":"1128","key":"10.1016\/j.tipsro.2024.100284_b0125","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20210350","article-title":"Interobserver variability in target volume delineation for CT\/MRI simulation and MRI-guided adaptive radiotherapy in rectal cancer","volume":"94","author":"White","year":"2021","journal-title":"Br J Radiol"},{"key":"10.1016\/j.tipsro.2024.100284_b0130","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ctro.2019.04.005","article-title":"Online MR guided radiotherapy for rectal cancer. New opportunities","volume":"18","author":"Gani","year":"2019","journal-title":"Clinical and Translational Radiat Oncol"},{"issue":"11","key":"10.1016\/j.tipsro.2024.100284_b0135","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/PL00002319","article-title":"Endoscopic pretherapeutic clipping for gastrointestinal tumors. A method for exact definition of the target volume","volume":"176","author":"Riepl","year":"2000","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.tipsro.2024.100284_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.tipsro.2023.100220","article-title":"Cone-beam computed tomography-guided online-adaptive radiotherapy for inoperable right colon cancer: first in human","author":"Pierrard","year":"2023","journal-title":"Technical Innovations & Patient Support Radiat Oncol"},{"key":"10.1016\/j.tipsro.2024.100284_b0145","first-page":"140","article-title":"The clinical introduction of MR-guided radiation therapy from a RTT perspective","volume":"18","author":"Botman","year":"2019","journal-title":"Clin Transl Radiat Oncol"},{"issue":"12","key":"10.1016\/j.tipsro.2024.100284_b0150","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.clon.2020.09.009","article-title":"The pivotal role of the therapeutic radiographer\/radiation therapist in image-guided radiotherapy research and development","volume":"32","author":"Duffton","year":"2020","journal-title":"Clin Oncol"},{"issue":"3","key":"10.1016\/j.tipsro.2024.100284_b0155","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/1754-9485.12462","article-title":"A review of interventions to reduce inter-observer variability in volume delineation in radiation oncology","volume":"60","author":"Vinod","year":"2016","journal-title":"J Med Imaging Radiat Oncol"},{"issue":"3","key":"10.1016\/j.tipsro.2024.100284_b0160","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.canrad.2018.10.004","article-title":"Reproducibility of rectal tumor volume delineation using diffusion-weighted MRI: agreement on volumes between observers","volume":"23","author":"Rosa","year":"2019","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.tipsro.2024.100284_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phro.2019.12.001","article-title":"Evaluation of measures for assessing time-saving of automatic organ-at-risk segmentation in radiotherapy","volume":"13","author":"Vaassen","year":"2020","journal-title":"Physics and Imaging in Radiation Oncology"},{"key":"10.1016\/j.tipsro.2024.100284_b0170","doi-asserted-by":"crossref","DOI":"10.3390\/life12122088","article-title":"Implementation of a commercial deep learning-based auto segmentation software in radiotherapy: evaluation of effectiveness and impact on workflow","volume":"12","author":"Radici","year":"2022","journal-title":"Life"}],"container-title":["Technical Innovations & Patient Support in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405632424000519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405632424000519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T16:22:47Z","timestamp":1734193367000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405632424000519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":34,"alternative-id":["S2405632424000519"],"URL":"https:\/\/doi.org\/10.1016\/j.tipsro.2024.100284","relation":{},"ISSN":["2405-6324"],"issn-type":[{"value":"2405-6324","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"On the trail of CBCT-guided adaptive rectal boost radiotherapy, does daily delineation require a radiation oncologist?","name":"articletitle","label":"Article Title"},{"value":"Technical Innovations & Patient Support in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tipsro.2024.100284","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V. on behalf of European Society for Radiotherapy & Oncology.","name":"copyright","label":"Copyright"}],"article-number":"100284"}}