{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:17:24Z","timestamp":1778883444859,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000892","name":"Prostate Cancer Foundation","doi-asserted-by":"publisher","award":["24CHAL05"],"award-info":[{"award-number":["24CHAL05"]}],"id":[{"id":"10.13039\/100000892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["UL1TR000100"],"award-info":[{"award-number":["UL1TR000100"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["DOD\/CDMRP PC220278"],"award-info":[{"award-number":["DOD\/CDMRP PC220278"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","tipsro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Technical Innovations &amp; Patient Support in Radiation Oncology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.tipsro.2025.100353","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T16:15:02Z","timestamp":1762618502000},"page":"100353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["PrecisionPro Fusion: Clinical validation of an automated, rigid, Prostate-Specific MRI-CT Fusion system for prostate radiotherapy planning"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5943-3379","authenticated-orcid":false,"given":"Deondre","family":"Do","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Conlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madison","family":"Baxter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Christodouleas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2331-3758","authenticated-orcid":false,"given":"Robert","family":"Dess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Dragojevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-1947","authenticated-orcid":false,"given":"Mukesh","family":"Harisinghani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9283-6515","authenticated-orcid":false,"given":"Sophia","family":"Kamran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitali","family":"Moiseenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2381-6910","authenticated-orcid":false,"given":"Himanshu","family":"Nagar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6402-7585","authenticated-orcid":false,"given":"Nabih","family":"Nakrour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0076-1640","authenticated-orcid":false,"given":"Lily","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhea","family":"Rupareliya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6841-968X","authenticated-orcid":false,"given":"Steven","family":"Seyedin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5803-1254","authenticated-orcid":false,"given":"Yuze","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders M","family":"Dale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4089-7399","authenticated-orcid":false,"given":"Tyler M","family":"Seibert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.tipsro.2025.100353_b0005","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.eururo.2024.08.030","article-title":"Radical prostatectomy versus stereotactic radiotherapy for clinically localised prostate cancer: results of the PACE-A randomised trial","volume":"86","author":"van As","year":"2024","journal-title":"Eur Urol"},{"issue":"15","key":"10.1016\/j.tipsro.2025.100353_b0010","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1056\/NEJMoa2403365","article-title":"Phase 3 trial of stereotactic body radiotherapy in localized prostate cancer","volume":"391","author":"van As","year":"2024","journal-title":"N Engl J Med"},{"issue":"17","key":"10.1016\/j.tipsro.2025.100353_b0015","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJMoa2214122","article-title":"Fifteen-year outcomes after monitoring, surgery, or radiotherapy for prostate cancer","volume":"388","author":"Hamdy","year":"2023","journal-title":"N Engl J Med"},{"issue":"17","key":"10.1016\/j.tipsro.2025.100353_b0020","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1200\/JCO.22.02389","article-title":"Dose-escalated radiation alone or in combination with short-term total androgen suppression for intermediate-risk prostate cancer: Patient-reported outcomes from NRG\/Radiation Therapy Oncology Group 0815 randomized trial","volume":"41","author":"Movsas","year":"2023","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.tipsro.2025.100353_b0025","first-page":"369","article-title":"Radiographic and anatomic basis for prostate contouring errors and methods to improve prostate contouring accuracy. International Journal of Radiation Oncology* Biology*","volume":"76","author":"McLaughlin","year":"2010","journal-title":"Physics"},{"issue":"2","key":"10.1016\/j.tipsro.2025.100353_b0030","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.radonc.2007.08.001","article-title":"A study of prostate delineation referenced against a gold standard created from the visible human data","volume":"85","author":"Gao","year":"2007","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.tipsro.2025.100353_b0035","first-page":"57","article-title":"Definition of the prostate in CT and MRI: a multi-observer study. International Journal of Radiation Oncology* Biology*","volume":"43","author":"Rasch","year":"1999","journal-title":"Physics"},{"key":"10.1016\/j.tipsro.2025.100353_b0040","article-title":"Multidisciplinary consensus prostate contours on magnetic resonance imaging: educational atlas and reference standard for artificial intelligence benchmarking. International Journal of Radiation Oncology* Biology*","author":"Song","year":"2025","journal-title":"Physics"},{"issue":"7","key":"10.1016\/j.tipsro.2025.100353_b0045","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1200\/JCO.20.02873","article-title":"Focal boost to the intraprostatic tumor in external beam radiotherapy for patients with localized prostate cancer: results from the FLAME randomized phase III trial","volume":"39","author":"Kerkmeijer","year":"2021","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.tipsro.2025.100353_b0050","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.eururo.2021.12.012","article-title":"Patterns of failure following external beam radiotherapy with or without an additional focal boost in the randomized controlled FLAME trial for localized prostate cancer","volume":"82","author":"Groen","year":"2022","journal-title":"Eur Urol"},{"key":"10.1016\/j.tipsro.2025.100353_b0055","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.radonc.2021.12.027","article-title":"Urethral and bladder dose\u2013effect relations for late genitourinary toxicity following external beam radiotherapy for prostate cancer in the FLAME trial","volume":"167","author":"Groen","year":"2022","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.tipsro.2025.100353_b0060","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s13014-023-02375-5","article-title":"Use of focal radiotherapy boost for prostate cancer: radiation oncologists\u2019 perspectives and perceived barriers to implementation","volume":"18","author":"Zhong","year":"2023","journal-title":"Radiat Oncol"},{"issue":"1","key":"10.1016\/j.tipsro.2025.100353_b0065","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s00345-023-04745-w","article-title":"Focal radiotherapy boost to MR-visible tumor for prostate cancer: a systematic review","volume":"42","author":"Dornisch","year":"2024","journal-title":"World J Urol"},{"issue":"7","key":"10.1016\/j.tipsro.2025.100353_b0070","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1007\/s00330-023-10515-4","article-title":"Manual prostate MRI segmentation by readers with different experience: a study of the learning progress","volume":"34","author":"Langkilde","year":"2024","journal-title":"Eur Radiol"},{"issue":"3","key":"10.1016\/j.tipsro.2025.100353_b0075","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1120\/jacmp.v17i3.6088","article-title":"Comparison of manual and automatic MR\u2010CT registration for radiotherapy of prostate cancer","volume":"17","author":"Korsager","year":"2016","journal-title":"J Appl Clin Med Phys"},{"issue":"1","key":"10.1016\/j.tipsro.2025.100353_b0080","first-page":"e5","article-title":"An atlas-based electron density mapping method for magnetic resonance imaging (MRI)-alone treatment planning and adaptive MRI-based prostate radiation therapy. International Journal of Radiation Oncology* Biology*","volume":"83","author":"Dowling","year":"2012","journal-title":"Physics"},{"issue":"3","key":"10.1016\/j.tipsro.2025.100353_b0085","first-page":"483","article-title":"MR-CT multi-atlas registration guided by fully automated brain structure segmentation with CNNs","volume":"18","author":"Walluscheck","year":"2023","journal-title":"Int J Comput Assist Radiol Surg"},{"issue":"1","key":"10.1016\/j.tipsro.2025.100353_b0090","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1016\/j.prro.2020.05.013","article-title":"Clinical evaluation of deep learning and atlas-based auto-contouring of bladder and rectum for prostate radiation therapy","volume":"11","author":"Zabel","year":"2021","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.tipsro.2025.100353_b0095","doi-asserted-by":"crossref","unstructured":"Song, Y., Dornisch, A., Dess, R. T., Margolis, D. J., Weinberg, E. P., Barrett, T., ... & Seibert, T. M. (2024). Precise prostate contours: setting the bar and meticulously evaluating AI performance. medRxiv, 2024-10.","DOI":"10.1101\/2024.10.21.24315771"},{"key":"10.1016\/j.tipsro.2025.100353_b0100","unstructured":"OnQ Prostate Breakthrough software supporting improved prostate cancer detection. Available from: https:\/\/www.cortechs.ai\/products\/onq-prostate\/."},{"issue":"4","key":"10.1016\/j.tipsro.2025.100353_b0105","first-page":"1024","article-title":"Clinical impact of contouring variability for prostate cancer tumor boost. International Journal of Radiation Oncology* Biology*","volume":"120","author":"Zhong","year":"2024","journal-title":"Physics"},{"issue":"1068","key":"10.1016\/j.tipsro.2025.100353_b0110","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20160296","article-title":"Fiducial marker guided prostate radiotherapy: a review","volume":"89","author":"O'Neill","year":"2016","journal-title":"Br J Radiol"},{"issue":"5","key":"10.1016\/j.tipsro.2025.100353_b0115","first-page":"1248","article-title":"Marker seed migration in prostate localization. International Journal of Radiation Oncology* Biology*","volume":"56","author":"Poggi","year":"2003","journal-title":"Physics"},{"issue":"5","key":"10.1016\/j.tipsro.2025.100353_b0120","first-page":"1291","article-title":"Intraprostatic fiducials for localization of the prostate gland: monitoring intermarker distances during radiation therapy to test for marker stability. International Journal of Radiation Oncology* Biology*","volume":"62","author":"Kupelian","year":"2005","journal-title":"Physics"},{"issue":"1015","key":"10.1016\/j.tipsro.2025.100353_b0125","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1259\/bjr\/68127917","article-title":"Patient-reported complications from fiducial marker implantation for prostate image-guided radiotherapy","volume":"85","author":"Gill","year":"2012","journal-title":"Br J Radiol"},{"issue":"1","key":"10.1016\/j.tipsro.2025.100353_b0130","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s13014-021-01865-8","article-title":"Investigation of the clinical inter-observer bias in prostate fiducial marker image registration between CT and MR images","volume":"16","author":"Persson","year":"2021","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.tipsro.2025.100353_b0135","doi-asserted-by":"crossref","unstructured":"Nguyen, L., Song, Y., Dornisch, A., Baxter, M., Barrett, T., Dale, A. M., ... & Seibert, T. M. (2025). PURE-MRI: An International Study Assessing Physician Accuracy in Delineating the Prostate and Urethra on Prostate MRI. medRxiv, 2025-04.","DOI":"10.1101\/2025.04.23.25326296"},{"issue":"7","key":"10.1016\/j.tipsro.2025.100353_b0140","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1088\/0031-9155\/60\/7\/2837","article-title":"An adaptive MR-CT registration method for MRI-guided prostate cancer radiotherapy","volume":"60","author":"Zhong","year":"2015","journal-title":"Phys Med Biol"},{"issue":"20","key":"10.1016\/j.tipsro.2025.100353_b0145","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.1088\/0031-9155\/53\/20\/004","article-title":"Variation in target and rectum dose due to prostate deformation: an assessment by repeated MR imaging and treatment planning","volume":"53","author":"Kerkhof","year":"2008","journal-title":"Phys Med Biol"},{"issue":"5","key":"10.1016\/j.tipsro.2025.100353_b0150","first-page":"1145","volume":"117","author":"Lui","year":"2023","journal-title":"Physics"},{"key":"10.1016\/j.tipsro.2025.100353_b0155","first-page":"10","article-title":"Restriction Spectrum Imaging as a quantitative biomarker for prostate cancer with reliable positive predictive value","author":"Rojo Domingo","year":"2025","journal-title":"J Urol"},{"issue":"4","key":"10.1016\/j.tipsro.2025.100353_bib156","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1109\/JBHI.2016.2581881","article-title":"MRI to CT prostate registration for improved targeting in cancer external beam radiotherapy","volume":"21","author":"Commandeur","year":"2016","journal-title":"IEEE journal of biomedical and health informatics"},{"issue":"24","key":"10.1016\/j.tipsro.2025.100353_bib157","doi-asserted-by":"crossref","first-page":"24TR01","DOI":"10.1088\/1361-6560\/ad0d8a","article-title":"Review and recommendations on deformable image registration uncertainties for radiotherapy applications","volume":"68","author":"Nenoff","year":"2023","journal-title":"Physics in Medicine & Biology"},{"key":"10.1016\/j.tipsro.2025.100353_bib158","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.phro.2020.09.009","article-title":"Clinical experience and workflow challenges with magnetic resonance-only radiation therapy simulation and planning for prostate cancer","volume":"16","author":"Tyagi","year":"2020","journal-title":"Physics and imaging in radiation oncology"}],"container-title":["Technical Innovations &amp; Patient Support in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240563242500054X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240563242500054X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:48:20Z","timestamp":1778881700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S240563242500054X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":34,"alternative-id":["S240563242500054X"],"URL":"https:\/\/doi.org\/10.1016\/j.tipsro.2025.100353","relation":{},"ISSN":["2405-6324"],"issn-type":[{"value":"2405-6324","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PrecisionPro Fusion: Clinical validation of an automated, rigid, Prostate-Specific MRI-CT Fusion system for prostate radiotherapy planning","name":"articletitle","label":"Article Title"},{"value":"Technical Innovations & Patient Support in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tipsro.2025.100353","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of European Society for Radiotherapy & Oncology.","name":"copyright","label":"Copyright"}],"article-number":"100353"}}