{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:36:33Z","timestamp":1790026593809,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["tipsro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Technical Innovations & Patient Support in Radiation Oncology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.tipsro.2025.100354","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T08:55:57Z","timestamp":1763628957000},"page":"100354","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Improved PTV coverage and OAR sparing with stereotactic MRI-guided online adaptive radiotherapy with elective fields in pancreatic cancer"],"prefix":"10.1016","volume":"36","author":[{"given":"Dinah","family":"Konnerth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Hojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9086-2066","authenticated-orcid":false,"given":"Frederik","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4148-2428","authenticated-orcid":false,"given":"Mohamed A.","family":"Shouman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana-Coralia","family":"Dehelean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Gaasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3779-1398","authenticated-orcid":false,"given":"Chukwuka","family":"Eze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8121-358X","authenticated-orcid":false,"given":"Sebastian N.","family":"Marschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Mansoorian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0120-8842","authenticated-orcid":false,"given":"Sebastian H.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"da Silva Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7936-9753","authenticated-orcid":false,"given":"Jan","family":"Hofmaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Niyazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Belka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8709-7252","authenticated-orcid":false,"given":"Stefanie","family":"Corradini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3351-8896","authenticated-orcid":false,"given":"Paul","family":"Rogowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tipsro.2025.100354_b0005","unstructured":"American Cancer Association, \u201cCancer facts & figures 2023,\u201d 2023."},{"issue":"19","key":"10.1016\/j.tipsro.2025.100354_b0010","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJMoa1011923","article-title":"FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer","volume":"364","author":"Conroy","year":"2011","journal-title":"N Engl J Med"},{"issue":"18","key":"10.1016\/j.tipsro.2025.100354_b0015","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa1304369","article-title":"Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine","volume":"369","author":"Von Hoff","year":"2013","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.tipsro.2025.100354_b0020","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.ijrobp.2017.12.287","article-title":"Management of borderline resectable pancreatic cancer","volume":"100","author":"Toesca","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"16","key":"10.1016\/j.tipsro.2025.100354_b0025","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1200\/JCO.19.02274","article-title":"Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: Results of the dutch randomized phase III PREOPANC trial","volume":"38","author":"Versteijne","year":"2020","journal-title":"J Clin Oncol"},{"issue":"17","key":"10.1016\/j.tipsro.2025.100354_b0030","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1001\/jama.2016.4324","article-title":"Effect of chemoradiotherapy vs chemotherapy on survival in patients with locally advanced pancreatic cancer controlled after 4 months of gemcitabine with or without erlotinib the LAP07 randomized clinical trial","volume":"315","author":"Hammel","year":"2016","journal-title":"JAMA - J American Med Assoc"},{"issue":"1","key":"10.1016\/j.tipsro.2025.100354_b0035","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s00066-020-01680-2","article-title":"R0 resection following chemo (radio)therapy improves survival of primary inoperable pancreatic cancer patients. Interim results of the German randomized CONKO-007\u00b1 trial","volume":"197","author":"Fietkau","year":"2021","journal-title":"Strahlenther Onkol"},{"issue":"10","key":"10.1016\/j.tipsro.2025.100354_b0040","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1002\/cncr.32756","article-title":"Conventionally fractionated radiation therapy versus stereotactic body radiation therapy for locally advanced pancreatic cancer(CRiSP): An international systematic review and meta-analysis","volume":"126","author":"Tchelebi","year":"2020","journal-title":"Cancer"},{"key":"10.1016\/j.tipsro.2025.100354_b0045","doi-asserted-by":"crossref","unstructured":"F. Liu, B. Erickson, C. Peng, and X. A. Li, \u201cCharacterization and management of interfractional anatomic changes for pancreatic cancer radiotherapy,\u201d Int J Radiat Oncol Biol Phys, vol. 83, no. 3, Jul. 2012, doi: 10.1016\/j.ijrobp.2011.12.073.","DOI":"10.1016\/j.ijrobp.2011.12.073"},{"key":"10.1016\/j.tipsro.2025.100354_b0050","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.radonc.2020.07.052","article-title":"ESTRO ACROP guidelines for target volume definition in pancreatic cancer","volume":"154","author":"Brunner","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.tipsro.2025.100354_b0055","doi-asserted-by":"crossref","unstructured":"P. J. Parikh et al., \u201cA Multi-Institutional Phase 2 Trial of Ablative 5-Fraction Stereotactic Magnetic Resonance\u2013Guided On-Table Adaptive Radiation Therapy for Borderline Resectable and Locally Advanced Pancreatic Cancer,\u201d International Journal of Radiation Oncology*Biology*Physics, May 2023, doi: 10.1016\/j.ijrobp.2023.05.023.","DOI":"10.1016\/j.ijrobp.2023.05.023"},{"key":"10.1016\/j.tipsro.2025.100354_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.110064","article-title":"Stereotactic MR-guided on-table adaptive radiation therapy (SMART) for borderline resectable and locally advanced pancreatic cancer: A multi-center, open-label phase 2 study","volume":"191","author":"Chuong","year":"2024","journal-title":"Radiother Oncol"},{"issue":"4","key":"10.1016\/j.tipsro.2025.100354_b0065","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.ijrobp.2023.05.023","article-title":"A multi-institutional phase 2 trial of ablative 5-fraction stereotactic magnetic resonance-guided on-table adaptive radiation therapy for borderline resectable and locally advanced pancreatic cancer","volume":"117","author":"Parikh","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.tipsro.2025.100354_b0070","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.radonc.2018.11.019","article-title":"Identification of patients with locally advanced pancreatic cancer benefitting from plan adaptation in MR-guided radiation therapy","volume":"132","author":"Bohoudi","year":"2019","journal-title":"Radiother Oncol"},{"issue":"2","key":"10.1016\/j.tipsro.2025.100354_b0075","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ijrobp.2018.06.002","article-title":"Role of daily plan adaptation in MR-guided stereotactic ablative radiation therapy for adrenal metastases","volume":"102","author":"Palacios","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.tipsro.2025.100354_b0080","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.radonc.2021.07.026","article-title":"Impact of daily plan adaptation on organ-at-risk normal tissue complication probability for adrenal lesions undergoing stereotactic ablative radiation therapy: NTCP advantages of adaptive MR-guided adrenal SABR","volume":"163","author":"Chen","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.tipsro.2025.100354_b0085","doi-asserted-by":"crossref","unstructured":"P. Rogowski et al., \u201cFeasibility and Early Clinical Experience of Online Adaptive MR-Guided Radiotherapy of Liver Tumors,\u201d pp. 1\u201311, 2021.","DOI":"10.3390\/cancers13071523"},{"key":"10.1016\/j.tipsro.2025.100354_b0090","first-page":"1","article-title":"Dosimetric benefit of MR \u2013 guided online adaptive radiotherapy in different tumor entities\u00a0: liver , lung , abdominal lymph nodes , pancreas and prost","author":"Nierer","year":"2022","journal-title":"Radiat Oncol"},{"issue":"00","key":"10.1016\/j.tipsro.2025.100354_b0095","first-page":"1","article-title":"NRG oncology international consensus contouring atlas on target volumes and dosing strategies for dose-escalated pancreatic cancer radiation therapy","volume":"000","author":"Sanford","year":"2025","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"7","key":"10.1016\/j.tipsro.2025.100354_b0100","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/cncr.29161","article-title":"Phase 2 multi-institutional trial evaluating gemcitabine and stereotactic body radiotherapy for patients with locally advanced unresectable pancreatic adenocarcinoma","volume":"121","author":"Herman","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.tipsro.2025.100354_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110473","article-title":"Dosimetric predictors of acute and late gastrointestinal toxicities in stereotactic online adaptive magnetic resonance-guided radiotherapy (SMART) for locally advanced pancreatic adenocarcinoma","volume":"200","author":"D\u2019Souza","year":"2024","journal-title":"Radiother Oncol"},{"issue":"4","key":"10.1016\/j.tipsro.2025.100354_b0110","doi-asserted-by":"crossref","first-page":"e355","DOI":"10.1016\/j.prro.2021.03.005","article-title":"Organ at risk dose constraints in SABR: A Systematic review of active clinical trials","volume":"11","author":"Gerhard","year":"2021","journal-title":"Pract Radiat Oncol"},{"issue":"March","key":"10.1016\/j.tipsro.2025.100354_b0115","first-page":"1","article-title":"Stereotactic MR-guided radiotherapy for pancreatic tumors: Dosimetric benefit of adaptation and first clinical results in a prospective registry study","volume":"12","author":"Michalet","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.tipsro.2025.100354_b0120","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tipsro.2020.06.001","article-title":"On-line adaptive MR guided radiotherapy for locally advanced pancreatic cancer: Clinical and dosimetric considerations","volume":"15","author":"Placidi","year":"2020","journal-title":"Tech Innov Patient Support Radiat Oncol"},{"issue":"August","key":"10.1016\/j.tipsro.2025.100354_b0125","first-page":"1","article-title":"Relationship of dose to vascular target volumes and local failure in pancreatic cancer patients undergoing neoadjuvant chemoradiation","volume":"12","author":"Nelson","year":"2022","journal-title":"Front Oncol"},{"issue":"3","key":"10.1016\/j.tipsro.2025.100354_b0130","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/COC.0000000000000518","article-title":"Pattern of marginal local failure in a phase II trial of neoadjuvant chemotherapy and stereotactic body radiation therapy for resectable and borderline resectable pancreas cancer","volume":"42","author":"Kharofa","year":"2019","journal-title":"American J Clinical Oncology: Cancer Clinical Trials"},{"issue":"1","key":"10.1016\/j.tipsro.2025.100354_b0135","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijrobp.2019.01.075","article-title":"Patterns of local failure after stereotactic body radiation therapy and sequential chemotherapy as initial treatment for pancreatic cancer: Implications of target volume design","volume":"104","author":"Zhu","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"10.1016\/j.tipsro.2025.100354_b0140","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.ijrobp.2013.09.005","article-title":"Mapping patterns of local recurrence after pancreaticoduodenectomy for pancreatic adenocarcinoma: A new approach to adjuvant radiation field design","volume":"87","author":"Dholakia","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"11","key":"10.1016\/j.tipsro.2025.100354_b0145","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.hpb.2017.07.007","article-title":"The TRIANGLE operation \u2013 radical surgery after neoadjuvant treatment for advanced pancreatic cancer: A single arm observational study","volume":"19","author":"Hackert","year":"2017","journal-title":"HPB"},{"issue":"3","key":"10.1016\/j.tipsro.2025.100354_b0150","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.hpb.2021.06.432","article-title":"The TRIANGLE operation for pancreatic head and body cancers: early postoperative outcomes","volume":"24","author":"Klotz","year":"2022","journal-title":"HPB"},{"issue":"5","key":"10.1016\/j.tipsro.2025.100354_b0155","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.4251\/wjgo.v16.i5.1773","article-title":"TRIANGLE operation, combined with adequate adjuvant chemotherapy, can improve the prognosis of pancreatic head cancer: A retrospective study","volume":"16","author":"Chen","year":"2024","journal-title":"World J Gastrointest Oncol"},{"issue":"7","key":"10.1016\/j.tipsro.2025.100354_b0160","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1097\/MPA.0000000000001602","article-title":"Patterns of failure after neoadjuvant stereotactic body radiation therapy or fractionated chemoradiation in resectable and borderline resectable pancreatic cancer","volume":"49","author":"Barrord","year":"2020","journal-title":"Pancreas"},{"key":"10.1016\/j.tipsro.2025.100354_b0165","doi-asserted-by":"crossref","unstructured":"S. Mao et al., \u201cUtilization of the Triangle Volume in Patients with Localized PDAC Undergoing Pre-Operative SBRT: Report of Early Outcomes Patterns of Locoregional Failure After Ablative 5-Fraction Stereotactic MR-Guided on-Table Adaptive Radiation Therapy for Pancreatic Cancer S14 Oral Scientific Sessions International Journal of Radiation Oncology Biology Physics\u201d.","DOI":"10.1016\/j.ijrobp.2023.06.230"},{"issue":"3","key":"10.1016\/j.tipsro.2025.100354_b0170","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.prro.2022.01.005","article-title":"Location, location, location: what should be targeted beyond gross disease for localized pancreatic ductal adenocarcinoma? Proposal of a standardized clinical tumor volume for pancreatic ductal adenocarcinoma of the head: The \u2018triangle volume,","volume":"12","author":"Hill","year":"2022","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.tipsro.2025.100354_b0175","doi-asserted-by":"crossref","unstructured":"A. Ogawa, M. Nakamura, H. Iramina, M. Yoshimura, and T. Mizowaki, \u201cPotential utility of cone-beam CT-guided adaptive radiotherapy under end-exhalation breath-hold conditions for pancreatic cancer,\u201d J Appl Clin Med Phys, vol. 24, no. 2, Feb. 2023, doi: 10.1002\/acm2.13827.","DOI":"10.1002\/acm2.13827"},{"issue":"2","key":"10.1016\/j.tipsro.2025.100354_b0180","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3390\/curroncol32020060","article-title":"Evaluating CBCT-guided adaptive radiotherapy for pancreatic cancer using synthetic CBCT data","volume":"32","author":"Olberg","year":"2025","journal-title":"Curr Oncol"},{"key":"10.1016\/j.tipsro.2025.100354_b0185","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.radonc.2022.08.026","article-title":"Simulated computed tomography-guided stereotactic adaptive radiotherapy (CT-STAR) for the treatment of locally advanced pancreatic cancer","volume":"175","author":"Schiff","year":"2022","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.tipsro.2025.100354_b0190","doi-asserted-by":"crossref","first-page":"Dec","DOI":"10.1186\/s13014-022-02125-z","article-title":"The first reported case of a patient with pancreatic cancer treated with cone beam computed tomography-guided stereotactic adaptive radiotherapy (CT-STAR)","volume":"17","author":"Kim","year":"2022","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.tipsro.2025.100354_b0195","article-title":"CT-guided online adaptive stereotactic body radiotherapy for pancreas ductal adenocarcinoma: Dosimetric and initial clinical experience","volume":"48","author":"Lee","year":"2024","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.tipsro.2025.100354_b0200","article-title":"Initial clinical experience building a dual CT- and MR-guided adaptive radiotherapy program","volume":"42","author":"Price","year":"2023","journal-title":"Clin Transl Radiat Oncol"}],"container-title":["Technical Innovations & Patient Support in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405632425000551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405632425000551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T06:25:52Z","timestamp":1765434352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405632425000551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":40,"alternative-id":["S2405632425000551"],"URL":"https:\/\/doi.org\/10.1016\/j.tipsro.2025.100354","relation":{},"ISSN":["2405-6324"],"issn-type":[{"value":"2405-6324","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improved PTV coverage and OAR sparing with stereotactic MRI-guided online adaptive radiotherapy with elective fields in pancreatic cancer","name":"articletitle","label":"Article Title"},{"value":"Technical Innovations & Patient Support in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tipsro.2025.100354","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of European Society for Radiotherapy & Oncology.","name":"copyright","label":"Copyright"}],"article-number":"100354"}}