{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:05:29Z","timestamp":1791288329408,"version":"4.3.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.tiv.2006.04.005","type":"journal-article","created":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T15:16:36Z","timestamp":1147446996000},"page":"1488-1499","source":"Crossref","is-referenced-by-count":76,"title":["Modeling inflammation\u2013drug interactions in vitro: A rat Kupffer cell-hepatocyte coculture system"],"prefix":"10.1016","volume":"20","author":[{"given":"Francis F.","family":"Tukov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane F.","family":"Maddox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Amacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter F.","family":"Bobrowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia E.","family":"Ganey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2006.04.005_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0003-9861(92)90161-O","article-title":"Tumor necrosis factor induced oxidative stress in isolated mouse hepatocytes","volume":"294","author":"Adamson","year":"1992","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.tiv.2006.04.005_bib2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0014-5793(92)80909-Z","article-title":"Interleukin-8, a chemotactic and inflammatory cytokine","volume":"307","author":"Baggiolini","year":"1992","journal-title":"FEBS Letters"},{"key":"10.1016\/j.tiv.2006.04.005_bib3","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/toxsci\/58.1.208","article-title":"Lipopolysaccharide augments aflatoxin B(1)-induced liver injury through neutrophil-dependent and -independent mechanisms","volume":"58","author":"Barton","year":"2000","journal-title":"Toxicological Sciences"},{"key":"10.1016\/j.tiv.2006.04.005_bib4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1053\/jhep.2001.20643","article-title":"Bacterial lipopolysaccharide enhances aflatoxin B1 hepatotoxicity in rats by a mechanism that depends on tumor necrosis factor alpha","volume":"33","author":"Barton","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.tiv.2006.04.005_bib5","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0168-8278(00)80275-5","article-title":"Transcriptional activation of heme oxygenase-1 and its functional significance in acetaminophen-induced hepatitis and hepatocellular injury in the rat","volume":"33","author":"Bauer","year":"2000","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.tiv.2006.04.005_bib6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1006\/taap.1995.1125","article-title":"Role of proinflammatory cytokines in acetaminophen hepatotoxicity","volume":"133","author":"Blazka","year":"1995","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.tiv.2006.04.005_bib7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/019262339602400206","article-title":"Histopathology of acetaminophen-induced liver changes: role of interleukin 1 alpha and tumor necrosis factor alpha","volume":"24","author":"Blazka","year":"1996","journal-title":"Toxicologic Pathology"},{"key":"10.1016\/j.tiv.2006.04.005_bib8","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1084\/jem.174.6.1549","article-title":"Macrophage deactivation by interleukin 10","volume":"174","author":"Bogdan","year":"1991","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.tiv.2006.04.005_bib9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1034\/j.1600-065X.2000.17703.x","article-title":"The role of chemokines in the immunopathology of the liver","volume":"177","author":"Bone-Larson","year":"2000","journal-title":"Immunology Reviews"},{"key":"10.1016\/j.tiv.2006.04.005_bib10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1053\/jhep.2002.30956","article-title":"Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase","volume":"35","author":"Bourdi","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.tiv.2006.04.005_bib11","first-page":"G387","article-title":"Mechanisms of hepatic toxicity. I. TNF-induced liver injury","volume":"275","author":"Bradham","year":"1998","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.tiv.2006.04.005_bib12","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/cs0880211","article-title":"Production of eicosanoids and cytokines by Kupffer cells from young and old rats stimulated by endotoxin","volume":"88","author":"Brouwer","year":"1995","journal-title":"Clinical Science (Lond)"},{"key":"10.1016\/j.tiv.2006.04.005_bib13","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1124\/jpet.300.2.460","article-title":"Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy?","volume":"300","author":"Buchweitz","year":"2002","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.tiv.2006.04.005_bib14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1043-6618(03)00093-8","article-title":"Contradictory effects of chlorpromazine on endothelial cells in a rat model of endotoxic shock in association with its actions on serum TNF-alpha levels and antioxidant enzyme activities","volume":"48","author":"Can","year":"2003","journal-title":"Pharmacology Research"},{"key":"10.1016\/j.tiv.2006.04.005_bib15","first-page":"391","article-title":"Nitric oxide production during endotoxic shock in carbon tetrachloride-treated rats","volume":"46","author":"Chamulitrat","year":"1994","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.tiv.2006.04.005_bib16","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1053\/jhep.2002.33162","article-title":"Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse","volume":"35","author":"Dambach","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.tiv.2006.04.005_bib17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1432-1033.1990.tb19222.x","article-title":"Biologically active products of stimulated liver macrophages (Kupffer cells)","volume":"192","author":"Decker","year":"1990","journal-title":"European Journal of Biochemistry"},{"key":"10.1016\/j.tiv.2006.04.005_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.1998.8484","article-title":"Endotoxin potentiates ozone-induced mucous cell metaplasia in rat nasal epithelium","volume":"152","author":"Fanucchi","year":"1998","journal-title":"Toxicololgy and Applied Pharmacology"},{"key":"10.1016\/j.tiv.2006.04.005_bib19","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0014-5793(91)80803-B","article-title":"Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level","volume":"285","author":"Fiers","year":"1991","journal-title":"FEBS Letters"},{"key":"10.1016\/j.tiv.2006.04.005_bib20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0300-483X(01)00523-6","article-title":"Concurrent inflammation as a determinant of susceptibility to toxicity from xenobiotic agents","volume":"169","author":"Ganey","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.tiv.2006.04.005_bib21","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/taap.2001.9183","article-title":"Involvement of cyclooxygenase-2 in the potentiation of allyl alcohol-induced liver injury by bacterial lipopolysaccharide","volume":"174","author":"Ganey","year":"2001","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.tiv.2006.04.005_bib22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cbi.2004.09.002","article-title":"Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor","volume":"150","author":"Ganey","year":"2004","journal-title":"Chemico-Biological Interactions"},{"key":"10.1016\/j.tiv.2006.04.005_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/taap.2002.9474","article-title":"Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10","volume":"184","author":"Gardner","year":"2002","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.tiv.2006.04.005_bib24","doi-asserted-by":"crossref","first-page":"G991","DOI":"10.1152\/ajpgi.00298.2001","article-title":"Regulation of hepatic connexins in cholestasis: possible involvement of Kupffer cells and inflammatory mediators","volume":"282","author":"Gonz\u00e1lez","year":"2002","journal-title":"American Journal of Physiology\u2014Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.tiv.2006.04.005_bib25","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/hep.1840200228","article-title":"The role of tumor necrosis factor-alpha in acute endotoxin-induced hepatotoxicity in ethanol-fed rats","volume":"20","author":"Hansen","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.tiv.2006.04.005_bib26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1182\/blood.V93.1.157","article-title":"Antithrombin reduces ischemia\/reperfusion injury of rat liver by increasing the hepatic level of prostacyclin","volume":"93","author":"Harada","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.tiv.2006.04.005_bib27","first-page":"382","article-title":"Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides","volume":"45","author":"Hewett","year":"1993","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.tiv.2006.04.005_bib28","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1096\/fasebj.13.12.1565","article-title":"Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines","volume":"13","author":"Hogaboam","year":"1999","journal-title":"FASEB Journal"},{"key":"10.1016\/j.tiv.2006.04.005_bib29","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0002-9440(10)64995-4","article-title":"Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C\u2013C chemokine receptor 2","volume":"156","author":"Hogaboam","year":"2000","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.tiv.2006.04.005_bib30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0300-483X(97)00061-9","article-title":"Influence of acetaminophen treatment and hydrogen peroxide treatment on the release of a CINC-related protein and TNF-alpha from rat hepatocyte cultures","volume":"121","author":"Horbach","year":"1997","journal-title":"Toxicology"},{"key":"10.1016\/j.tiv.2006.04.005_bib31","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1096\/fj.02-0046com","article-title":"A pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injury","volume":"16","author":"Ishida","year":"2002","journal-title":"FASEB Journal"},{"key":"10.1016\/j.tiv.2006.04.005_bib32","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/toxsci\/65.2.166","article-title":"Mechanisms of hepatotoxicity","volume":"65","author":"Jaeschke","year":"2002","journal-title":"Toxicological Science"},{"key":"10.1016\/j.tiv.2006.04.005_bib33","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.bbrc.2003.08.085","article-title":"Interleukin 6 and hepatocyte regeneration in acetaminophen toxicity in the mouse","volume":"309","author":"James","year":"2003","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.tiv.2006.04.005_bib34","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1177\/0091270005280296","article-title":"Cytokines and Toxicity in Acetaminophen Overdose","volume":"45","author":"James","year":"2005","journal-title":"Journal of Clinical Pharmacology"},{"key":"10.1016\/j.tiv.2006.04.005_bib35","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/toxsci\/69.2.470","article-title":"Enhancement of allyl alcohol hepatotoxicity by endotoxin requires extrahepatic factors","volume":"69","author":"Kinser","year":"2002","journal-title":"Toxicological Sciences"},{"key":"10.1016\/j.tiv.2006.04.005_bib36","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1080\/15287390490443704","article-title":"Neutrophils contribute to endotoxin enhancement of allyl alcohol hepatotoxicity","volume":"67","author":"Kinser","year":"2004","journal-title":"Journal of Toxicology and Environmental Health A"},{"key":"10.1016\/j.tiv.2006.04.005_bib37","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2165\/00002018-200124070-00003","article-title":"Management of paracetamol overdose: current controversies","volume":"24","author":"Kozer","year":"2001","journal-title":"Drug Safety"},{"key":"10.1016\/j.tiv.2006.04.005_bib38","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.1016\/S0021-9258(18)60727-6","article-title":"Prostaglandin E2 regulates macrophage derived tumor necrosis factor gene expression","volume":"263","author":"Kunkel","year":"1988","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.tiv.2006.04.005_bib39","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0041-008X(86)90051-7","article-title":"Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver","volume":"86","author":"Laskin","year":"1986","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.tiv.2006.04.005_bib40","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0041-008X(86)90052-9","article-title":"Potential role of activated macrophages in acetaminophen hepatotoxicity. II. Mechanism of macrophage accumulation and activation","volume":"86","author":"Laskin","year":"1986","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.tiv.2006.04.005_bib41","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/hep.1840210424","article-title":"Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen","volume":"21","author":"Laskin","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.tiv.2006.04.005_bib42","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/toxsci\/54.2.509","article-title":"The hepatic inflammatory response after acetaminophen overdose: role of neutrophils","volume":"54","author":"Lawson","year":"2000","journal-title":"Toxicological Sciences"},{"key":"10.1016\/j.tiv.2006.04.005_bib43","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1053\/j.gastro.2004.08.053","article-title":"Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity","volume":"127","author":"Liu","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tiv.2006.04.005_bib44","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0092-8674(01)00237-9","article-title":"The TNF and TNF receptor superfamilies: integrating mammalian biology","volume":"104","author":"Locksley","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.tiv.2006.04.005_bib45","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1445-5994.1995.tb01907.x","article-title":"Disseminated intravascular coagulopathy and thrombocytopenia associated with clozapine-induced neuroleptic malignant syndrome","volume":"25","author":"Lowy","year":"1995","journal-title":"Australian and New Zealand Journal of Medicine"},{"key":"10.1016\/j.tiv.2006.04.005_bib46","doi-asserted-by":"crossref","first-page":"A418","DOI":"10.2307\/3434211","article-title":"Inflammation, tumor necrosis factor, and toxicology","volume":"106","author":"Luster","year":"1998","journal-title":"Environmental Health Perspective"},{"key":"10.1016\/j.tiv.2006.04.005_bib47","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1056\/NEJM199802123380706","article-title":"Chemokines\u2014chemotactic cytokines that mediate inflammation","volume":"338","author":"Luster","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.tiv.2006.04.005_bib48","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1124\/jpet.103.054288","article-title":"Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats","volume":"307","author":"Luyendyk","year":"2003","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.tiv.2006.04.005_bib49","first-page":"87","article-title":"Cocultures between primary parenchymal and nonparenchymal liver cells improve the reliability of results from in vitro toxicity testing","volume":"16","author":"Maier","year":"1999","journal-title":"ALTEX"},{"key":"10.1016\/j.tiv.2006.04.005_bib50","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0006-291X(03)00572-2","article-title":"Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease","volume":"304","author":"Masubuchi","year":"2003","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.tiv.2006.04.005_bib51","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/hep.510230223","article-title":"Cytokine-induced neutrophil chemoattractant release from hepatocytes is modulated by Kupffer cells","volume":"23","author":"Mawet","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.tiv.2006.04.005_bib52","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0014-2999(00)00473-8","article-title":"Lead stimulates intercellular signalling between hepatocytes and Kupffer cells","volume":"401","author":"Milosevic","year":"2000","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.tiv.2006.04.005_bib53","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0014-2999(98)00988-1","article-title":"Kupffer cell-mediated differential down-regulation of cytochrome P450 metabolism in rat hepatocytes","volume":"368","author":"Milosevic","year":"1999","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.tiv.2006.04.005_bib54","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1172\/JCI113241","article-title":"Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes","volume":"80","author":"Nathan","year":"1987","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.tiv.2006.04.005_bib55","first-page":"14","article-title":"Lipopolysaccharide potentiates acetaminophen hepatotoxicity","volume":"84","author":"Newport","year":"2005","journal-title":"The Toxicologist"},{"key":"10.1016\/j.tiv.2006.04.005_bib56","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0167-5699(91)90064-Z","article-title":"A new view of prostaglandin E regulation of the immune response","volume":"12","author":"Phipps","year":"1991","journal-title":"Immunology Today"},{"key":"10.1016\/j.tiv.2006.04.005_bib57","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.bcp.2004.11.011","article-title":"Inhibition of tumor necrosis factor alpha secretion and prevention of liver injury in ethanol-fed rats by antisense oligonucleotides","volume":"69","author":"Ponnappa","year":"2005","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.tiv.2006.04.005_bib58","first-page":"787","article-title":"Phenothiazine-induced cholestatic jaundice","volume":"6","author":"Regal","year":"1987","journal-title":"Clinical Pharmacy"},{"key":"10.1016\/j.tiv.2006.04.005_bib59","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1006\/taap.1997.8301","article-title":"Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents?","volume":"147","author":"Roth","year":"1997","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.tiv.2006.04.005_bib60","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0300-483X(00)00233-X","article-title":"Potentiation of mercury-induced nephrotoxicity by endotoxin in the Sprague-Dawley rat","volume":"149","author":"Rumbeiha","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.tiv.2006.04.005_bib61","first-page":"41","article-title":"Circulating and tissue levels of the neutrophil chemotaxin interleukin-8 are elevated in severe acute alcoholic hepatitis, and tissue levels correlate with neutrophil infiltration","volume":"18","author":"Sheron","year":"1993","journal-title":"Hepatology"},{"key":"10.1016\/j.tiv.2006.04.005_bib62","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1042\/CS20020137","article-title":"Chemokines in the pathogenesis of liver disease: so many players with poorly defined roles","volume":"104","author":"Simpson","year":"2003","journal-title":"Clinical Science"},{"key":"10.1016\/j.tiv.2006.04.005_bib63","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/taap.1997.8115","article-title":"Bacterial endotoxin enhances the hepatotoxicity of allyl alcohol","volume":"144","author":"Sneed","year":"1997","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.tiv.2006.04.005_bib64","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/toxsci\/56.1.203","article-title":"Pentoxifylline attenuates bacterial lipopolysaccharide-induced enhancement of allyl alcohol hepatotoxicity","volume":"56","author":"Sneed","year":"2000","journal-title":"Toxicological Sciences"},{"key":"10.1016\/j.tiv.2006.04.005_bib65","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/hep.20533","article-title":"Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice","volume":"41","author":"Su","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.tiv.2006.04.005_bib66","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.cyto.2004.11.001","article-title":"Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in mice","volume":"29","author":"Sudo","year":"2005","journal-title":"Cytokine"},{"key":"10.1016\/j.tiv.2006.04.005_bib67","first-page":"59","article-title":"Neuroleptics modulate cytokine and reactive oxygen species production in blood leukocytes of healthy volunteers","volume":"52","author":"Szuster-Ciesielska","year":"2004","journal-title":"Archivum Immunologiae et Therapiae Experimentalis (Warsz)"},{"key":"10.1016\/j.tiv.2006.04.005_bib68","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1007\/BF02212709","article-title":"Chemotactic factors released from hepatocytes exposed to acetaminophen","volume":"40","author":"Takada","year":"1995","journal-title":"Digestive Diseases and Science"},{"issue":"161","key":"10.1016\/j.tiv.2006.04.005_bib69","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.4049\/jimmunol.161.6.3019","article-title":"Prostaglandin E2 protects against liver injury after Escherichia coli infection but hampers the resolution of the infection in mice","volume":"15","author":"Takano","year":"1998","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.tiv.2006.04.005_bib70","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1039\/B302621C","article-title":"UVA activated 8-MOP and chlorpromazine inhibit release of TNF-alpha by post-transcriptional regulation","volume":"3","author":"Wolnicka-Glubisz","year":"2004","journal-title":"Photochemistry Photobiology Science"},{"key":"10.1016\/j.tiv.2006.04.005_bib71","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3109\/00048679609065008","article-title":"Neuroleptic malignant syndrome: two cases without muscle rigidity","volume":"30","author":"Wong","year":"1996","journal-title":"Australian and New Zealand Journal of Psychiatry"},{"key":"10.1016\/j.tiv.2006.04.005_bib72","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/taap.2000.8968","article-title":"Synergistic hepatotoxicity from coexposure to bacterial endotoxin and the pyrrolizidine alkaloid monocrotaline","volume":"166","author":"Yee","year":"2000","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.tiv.2006.04.005_bib73","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/toxsci\/71.1.124","article-title":"The role of Kupffer cells and TNF-alpha in monocrotaline and bacterial lipopolysaccharide-induced liver injury","volume":"71","author":"Yee","year":"2003","journal-title":"Toxicological Sciences"},{"key":"10.1016\/j.tiv.2006.04.005_bib74","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0378-4274(82)90184-9","article-title":"Effect of endotoxin and its degradation products on hepatic mixed-function oxidase and heme enzyme systems in mice","volume":"12","author":"Yoshida","year":"1982","journal-title":"Toxicology Letters"},{"key":"10.1016\/j.tiv.2006.04.005_bib75","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/00024382-199510000-00006","article-title":"Attenuation of hepatic neutrophil sequestration by anti-CINC antibody in endotoxic rats","volume":"4","author":"Zhang","year":"1995","journal-title":"Shock"},{"key":"10.1016\/j.tiv.2006.04.005_bib76","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/toxsci\/53.2.253","article-title":"Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs","volume":"53","author":"Zhou","year":"2000","journal-title":"Toxicological Sciences"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233306000804?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233306000804?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T12:08:51Z","timestamp":1683461331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233306000804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":76,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0887233306000804"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2006.04.005","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}