{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:12:30Z","timestamp":1786997550877,"version":"build-2736575974"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.tiv.2006.08.005","type":"journal-article","created":{"date-parts":[[2006,9,6]],"date-time":"2006-09-06T10:32:41Z","timestamp":1157538761000},"page":"133-138","source":"Crossref","is-referenced-by-count":13,"title":["In-vitro human skin penetration of the fragrance material geranyl nitrile"],"prefix":"10.1016","volume":"21","author":[{"given":"K.R.","family":"Brain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lalko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Api","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2006.08.005_bib1","volume":"Volume I (A\u2013J)","author":"Arctander","year":"1969"},{"key":"10.1016\/j.tiv.2006.08.005_bib2","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/jps.2600751115","article-title":"Methods for in vitro percutaneous absorption studies VII: use of excised human skin","volume":"75","author":"Bronaugh","year":"1986","journal-title":"Journal of Pharmaceutical Science"},{"key":"10.1016\/j.tiv.2006.08.005_bib3","series-title":"Perfumery","author":"Calkin","year":"1994"},{"key":"10.1016\/j.tiv.2006.08.005_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/faat.1995.1139","article-title":"Pharmacokinetics of 2-ethyl-1,3-hexanediol. III. In vitro skin penetration comparisons using the excised skin of humans, rats, and rabbits","volume":"28","author":"Frantz","year":"1995","journal-title":"Fundamental Applied Toxicology"},{"key":"10.1016\/j.tiv.2006.08.005_bib5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0378-4274(82)90086-8","article-title":"Toxicity of benzyl cyanide in the rat","volume":"10","author":"Guest","year":"1982","journal-title":"Toxicology Letters"},{"key":"10.1016\/j.tiv.2006.08.005_bib6","unstructured":"IFRA (International Fragrance Association), 1997. Use Level Survey. April 1997, Brussels."},{"key":"10.1016\/j.tiv.2006.08.005_bib7","unstructured":"IFRA (International Fragrance Association), 2000. Volume of Use Survey. September 2000, Brussels."},{"key":"10.1016\/j.tiv.2006.08.005_bib8","unstructured":"IFRA (International Fragrance Association), 2004. Code Of Practice, Standard on benzyl cyanide. April 6th, Brussels."},{"key":"10.1016\/j.tiv.2006.08.005_bib9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1046\/j.1467-2494.2001.00079.x","article-title":"A physico-chemical properties based model for estimating evaporation and absorption rates of perfumes from skin","volume":"23","author":"Kasting","year":"2001","journal-title":"International Journal of Cosmetic Science"},{"key":"10.1016\/j.tiv.2006.08.005_bib10","first-page":"322","article-title":"Metabolism of geranyl nitrile and citronellyl nitrile by primary hepatocytes from mice, rats and humans","volume":"84","author":"Kemper","year":"2005","journal-title":"The Toxicologist"},{"key":"10.1016\/j.tiv.2006.08.005_bib11","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1006\/taap.2002.9373","article-title":"Percutaneous penetration and metabolism of 2-ethoxyethanol","volume":"180","author":"Lockley","year":"2002","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.tiv.2006.08.005_bib12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0278-6915(00)00125-3","article-title":"An assessment of the release of inorganic cyanide from the fragrance materials benzyl cyanide, geranyl nitrile and citronellyl nitrile dermally to the rat","volume":"39","author":"Potter","year":"2001","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.tiv.2006.08.005_bib13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0278-6915(00)00126-5","article-title":"Urinary thiocyanate levels as a biomarker for the generation of inorganic cyanide from benzyl cyanide in the rat","volume":"39","author":"Potter","year":"2001","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.tiv.2006.08.005_bib14","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1002\/jps.2600710915","article-title":"In vitro skin evaporation and penetration characteristics of mosquito repellents","volume":"71","author":"Reifenrath","year":"1982","journal-title":"Journal of Pharmaceutical Science"},{"key":"10.1016\/j.tiv.2006.08.005_bib15","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 1974a. Report on acute toxicity studies. RIFM report number 1778, December 12, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.tiv.2006.08.005_bib16","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 1974b. Report on acute oral and dermal toxicity studies. RIFM report number 2028, August 19, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.tiv.2006.08.005_bib17","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 1977. Acute toxicity study in rats, rabbits and guinea pigs. RIFM report number 11695, July 25, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.tiv.2006.08.005_bib18","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 1989. Acute toxicity studies on geranyl nitrile and citronellyl nitrile. Unpublished report from BASF. RIFM report number 9533, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.tiv.2006.08.005_bib19","series-title":"Dermatological and Transdermal Formulations","first-page":"89","article-title":"Skin Transport","author":"Roberts","year":"2002"},{"key":"10.1016\/j.tiv.2006.08.005_bib20","unstructured":"The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers (SCCNFP), 2000. Notes Of Guidance For Testing Of Cosmetic Ingredients For Their Safety Evaluation, SCCNFP\/0321\/00 Final, SCCNFP, Brussels."},{"key":"10.1016\/j.tiv.2006.08.005_bib21","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.yrtph.2004.02.004","article-title":"In vitro predictions of skin absorption of caffeine, testosterone, and benzoic acid: a multi-centre comparison study","volume":"39","author":"van de Sandt","year":"2004","journal-title":"Regulatory Toxicology and Pharmacology"},{"key":"10.1016\/j.tiv.2006.08.005_bib22","series-title":"Percutaneous Absorption","first-page":"673","article-title":"Percutaneous absorption of fragrances","author":"Yourick","year":"1999"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233306001731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233306001731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T10:21:26Z","timestamp":1547374886000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233306001731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0887233306001731"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2006.08.005","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}