{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:35:03Z","timestamp":1791038103563,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.tiv.2007.04.013","type":"journal-article","created":{"date-parts":[[2007,5,6]],"date-time":"2007-05-06T21:41:52Z","timestamp":1178487712000},"page":"1341-1347","source":"Crossref","is-referenced-by-count":36,"title":["Comparative in vitro cytotoxicity assessment of selected gaseous compounds in human alveolar epithelial cells"],"prefix":"10.1016","volume":"21","author":[{"given":"S.","family":"Bakand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Winder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2007.04.013_bib1","unstructured":"ACGIH, 2006a. 2006 TLVs and BEIs; Based on the documentation of threshold limit values for chemical substances and physical agents and biological exposure indices. In: American Conference of Governmental Industrial Hygienists, ACGIH Worldwide, Cincinnati, USA."},{"key":"10.1016\/j.tiv.2007.04.013_bib2","unstructured":"ACGIH, 2006b. 2006 Guide to occupational exposure values. In: American Conference of Governmental Industrial Hygienists, ACGIH Worldwide, Cincinnati, USA."},{"key":"10.1016\/j.tiv.2007.04.013_bib3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0378-4274(02)00512-X","article-title":"Novel approaches for studying pulmonary toxicity in vitro","author":"Aufderheide","year":"2003","journal-title":"Toxicology Letters"},{"key":"10.1016\/j.tiv.2007.04.013_bib4","series-title":"In Vitro Methods of Toxicology","first-page":"237","article-title":"Neutral red assay for toxicology in vitro","author":"Babich","year":"1992"},{"key":"10.1016\/j.tiv.2007.04.013_bib5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1080\/08958370500225240","article-title":"Toxicity assessment of industrial chemicals and airborne contaminants: transition from in vivo to in vitro test methods: a review","volume":"17","author":"Bakand","year":"2005","journal-title":"Inhalation Toxicology"},{"key":"10.1016\/j.tiv.2007.04.013_bib6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1191\/0748233705th223oa","article-title":"In vitro cytotoxicity testing of airborne formaldehyde collected in serum-free culture media","volume":"21","author":"Bakand","year":"2005","journal-title":"Toxicology and Industrial Health"},{"issue":"1","key":"10.1016\/j.tiv.2007.04.013_bib7","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1039\/B509812B","article-title":"A novel in vitro exposure technique for toxicity testing of selected volatile organic compounds","volume":"8","author":"Bakand","year":"2006","journal-title":"Journal of Environmental Monitoring"},{"issue":"1","key":"10.1016\/j.tiv.2007.04.013_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2006.01.008","article-title":"An experimental in vitro model for dynamic direct exposure of human cells to airborne contaminants","volume":"165","author":"Bakand","year":"2006","journal-title":"Toxicology Letters"},{"issue":"3\u20134","key":"10.1016\/j.tiv.2007.04.013_bib9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1382-6689(01)00120-X","article-title":"The applicability of in vitro-derived data in hazard identification and characterisation of chemicals","volume":"11","author":"Blaauboer","year":"2002","journal-title":"Environmental Toxicology and Pharmacology"},{"issue":"1","key":"10.1016\/j.tiv.2007.04.013_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/bmb\/ldg022","article-title":"Air pollution and infection in respiratory illness","volume":"68","author":"Chauhan","year":"2003","journal-title":"British Medical Bulletin"},{"key":"10.1016\/j.tiv.2007.04.013_bib11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.cb.04.110188.001103","article-title":"Mitochondrial membrane potential in living cells","volume":"4","author":"Chen","year":"1988","journal-title":"Annual Review of Cell Biology"},{"issue":"2","key":"10.1016\/j.tiv.2007.04.013_bib12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1006\/faat.1993.1023","article-title":"A novel system for the in vitro exposure of pulmonary cells to acid sulphate Aerosols","volume":"20","author":"Chen","year":"1993","journal-title":"Fundamental and Applied Toxicology"},{"issue":"1","key":"10.1016\/j.tiv.2007.04.013_bib13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1006\/bbrc.1993.2438","article-title":"A new method for the cytofluorometric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5\u2032,6,6\u2032-tetrachloro-1,1\u2032,3,3\u2032-tetraethylbenzimidazolcarbocyanine iodide (JC-1)","volume":"197","author":"Cossarizza","year":"1993","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.tiv.2007.04.013_bib14","series-title":"In Vitro Toxicology","author":"Gad","year":"2000"},{"issue":"6","key":"10.1016\/j.tiv.2007.04.013_bib15","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1177\/026119290403200605","article-title":"Animals and alternatives: social expectations and scientific need","volume":"32","author":"Goldberg","year":"2004","journal-title":"Alternatives to Laboratory Animals"},{"key":"10.1016\/j.tiv.2007.04.013_bib16","series-title":"Occupational, Industrial, and Environmental Toxicology","year":"2003"},{"key":"10.1016\/j.tiv.2007.04.013_bib17","series-title":"Drug Testing In Vitro-Breakthroughs and Trends in Cell Culture Techniques","first-page":"103","article-title":"Novel in vitro exposure techniques for toxicity testing and biomonitoring of airborne contaminants","author":"Hayes","year":"2007"},{"key":"10.1016\/j.tiv.2007.04.013_bib18","series-title":"Casarett and Doull\u2019s Toxicology: The Basic Science of Poisons","year":"2001"},{"key":"10.1016\/j.tiv.2007.04.013_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-4274(98)00044-7","article-title":"Development of an in vitro system for studying effects of native and photochemically transformed gaseous compounds using an air\/liquid culture technique","author":"Knebel","year":"1998","journal-title":"Toxicology Letters"},{"issue":"2","key":"10.1016\/j.tiv.2007.04.013_bib20","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1080\/00039896.1996.9936009","article-title":"Effect of sulfur dioxide on cytotoxine production of human alveolar macrophages in vitro","volume":"51","author":"Knorst","year":"1996","journal-title":"Archives of Environmental Health"},{"key":"10.1016\/j.tiv.2007.04.013_bib21","series-title":"Occupational, Industrial, and Environmental Toxicology","first-page":"622","article-title":"Outdoor air pollution","author":"McDow","year":"2003"},{"key":"10.1016\/j.tiv.2007.04.013_bib22","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1056-8719(98)00040-9","article-title":"A novel apparatus for the exposure of cultured cells to volatile agents","volume":"40","author":"Muckter","year":"1998","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.tiv.2007.04.013_bib23","unstructured":"NIOSH, 1994. NIOSH Manual of Analytical Methods (NMAM), fourth ed., http:\/\/www.cdc.gov\/niosh\/nmam\/nmammenu.html."},{"key":"10.1016\/j.tiv.2007.04.013_bib24","unstructured":"NIOSH, 2004. The Registry of Toxic Effects of Chemical Substances. US National Institue for Occupational Safety and Health. http:\/\/www.cdc.gov\/niosh\/rtecs\/."},{"key":"10.1016\/j.tiv.2007.04.013_bib25","series-title":"Methods in molecular biology. In vitro toxicity testing protocols","author":"O\u2019Hare","year":"1995"},{"key":"10.1016\/j.tiv.2007.04.013_bib26","unstructured":"OSHA, U., 1989. Sulfur Dioxide in Workplace Atmospheres, Method Number: ID-104. US Occupational Safety & Health Administration. http:\/\/www.osha.gov\/dts\/sltc\/methods\/toc_s.html."},{"key":"10.1016\/j.tiv.2007.04.013_bib27","unstructured":"Promega, 2001. CellTiter 96\u00ae Aqueous Non-Radioactive Cell Proliferation Assay: Technical Bulletin No 169. Promega Corporation, Madison, USA."},{"key":"10.1016\/j.tiv.2007.04.013_bib28","unstructured":"Promega, 2004. CellTiter-GIO Luminescent Cell Viability Assay. Technical Bulletin No. 288. Promega Corporation, Madison, USA."},{"key":"10.1016\/j.tiv.2007.04.013_bib29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1078\/0940-2993-00204","article-title":"In vitro exposure of isolated cells to native gaseous compounds \u2013 development and validation of an optimized system for human lung cells","volume":"53","author":"Ritter","year":"2001","journal-title":"Experimental and Toxicologic Pathology"},{"key":"10.1016\/j.tiv.2007.04.013_bib30","series-title":"Pulmonary Immunotoxicology","first-page":"337","article-title":"Sulfur and nitrogen oxides","author":"Schlesinger","year":"2000"},{"issue":"1","key":"10.1016\/j.tiv.2007.04.013_bib31","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0300-483X(94)02909-E","article-title":"Cytotoxicity of NO2 gas to cultured human and murine cells in an inverted monolayer exposure system","volume":"96","author":"Tu","year":"1995","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.tiv.2007.04.013_bib32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/01.jom.0000048168.87707.8b","article-title":"Hazardous ammonia releases: public health consequences and risk factors for evacuation and injury, United States, 1993\u20131998","volume":"45","author":"Weisskopf","year":"2003","journal-title":"Journal of Occupational and Environmental Medicine"},{"key":"10.1016\/j.tiv.2007.04.013_bib33","series-title":"Occupational Toxicology","first-page":"399","article-title":"Toxicology of gases, vapours and particulates","author":"Winder","year":"2004"},{"key":"10.1016\/j.tiv.2007.04.013_bib34","series-title":"Occupational Toxicology","year":"2004"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233307001488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233307001488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T18:53:36Z","timestamp":1556391216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233307001488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0887233307001488"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2007.04.013","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}