{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:25:36Z","timestamp":1790418336364,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.tiv.2007.05.016","type":"journal-article","created":{"date-parts":[[2007,6,14]],"date-time":"2007-06-14T08:27:18Z","timestamp":1181809638000},"page":"1298-1303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Phototoxicity of bergamot oil assessed by in vitro techniques in combination with human patch tests"],"prefix":"10.1016","volume":"21","author":[{"given":"K.","family":"Kejlov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"J\u00edrov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Bendov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kand\u00e1rov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Weidenhoffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kol\u00e1\u0159ov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Liebsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2007.05.016_bib1","unstructured":"Commission Directive 2000\/33\/EC of 25 April 2000. Adapting to technical progress for the 27th time Council Directive 67\/548 E on the classification, packaging and labelling of dangerous substances. Annex V method B41 Phototoxicity \u2013 In vitro 3T3 NRU Phototoxicity Test. Official Journal of the European Communities L136, pp. 98\u2013107."},{"key":"10.1016\/j.tiv.2007.05.016_bib2","unstructured":"Council for International Organizations of Medical Sciences, 2002. International Ethical Guidelines for Biomedical Research Involving Human Subjects. Prepared by the Council for International Organizations of Medical Sciences (CIOMS) in collaboration with the World Health Organization (WHO), Geneva."},{"key":"10.1016\/j.tiv.2007.05.016_bib3","first-page":"445","article-title":"A general measure of in vitro phototoxicity derived from pairs of dose\u2013response curves and its use for predicting the in vivo phototoxicity of chemicals","volume":"25","author":"Holzh\u00fctter","year":"1997","journal-title":"ATLA"},{"key":"10.1016\/j.tiv.2007.05.016_bib4","unstructured":"International Fragrance Association, 1992. Code of Practice. Latest amendments, June 1992. International Fragrance Association, Geneva."},{"key":"10.1016\/j.tiv.2007.05.016_bib5","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.tiv.2005.06.013","article-title":"Phototoxicity of bituminous tars\u2014correspondence between results of 3T3 NRU PT, 3D skin model and experimental human data","volume":"19","author":"J\u00edrov\u00e1","year":"2005","journal-title":"Toxicology In Vitro"},{"key":"10.1016\/j.tiv.2007.05.016_bib6","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0887-2333(03)00048-1","article-title":"An assessment of the phototoxic hazard of a personal product ingredient using in vitro assays","volume":"17","author":"Jones","year":"2003","journal-title":"Toxicology In Vitro"},{"key":"10.1016\/j.tiv.2007.05.016_bib7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.14573\/altex.1997.4.165","article-title":"Entwicklung eines in vitro Tests auf dermale Phototoxizit\u00e4t in einem Modell menschlicher Epidermis (EpiDermTM)","volume":"14","author":"Liebsch","year":"1997","journal-title":"ALTEX"},{"key":"10.1016\/j.tiv.2007.05.016_bib8","unstructured":"Liebsch, M., Spielmann, H., 1998. INVITTOX Protocol No. 78: 3T3 NRU Phototoxicity Assay. European Commission DG-JRC, ECVAM, SIS Database, Last update October 2002. <http:\/\/ecvam-sis.jrc.it\/invittox\/static\/index.html>."},{"key":"10.1016\/j.tiv.2007.05.016_bib9","series-title":"Alternatives to Animal Testing II","first-page":"160","article-title":"Prevalidation of the epiderm\u2122 phototoxicity test","author":"Liebsch","year":"1999"},{"issue":"1","key":"10.1016\/j.tiv.2007.05.016_bib10","first-page":"131","article-title":"UV-Induced Effects","volume":"33","author":"Liebsch","year":"2005","journal-title":"ATLA"},{"issue":"2","key":"10.1016\/j.tiv.2007.05.016_bib11","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1006\/bbrc.1995.1067","article-title":"Detection of hydrogen peroxide and hydroxyl radicals in murine skin fibroblasts under UVB irradiation","volume":"206","author":"Masaki","year":"1995","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"February","key":"10.1016\/j.tiv.2007.05.016_bib12","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0190-9622(00)90124-5","article-title":"Photopatch testing: the 12-year experience of the German, Austrian, and Swiss photopatch test group","author":"Neumann","year":"2000","journal-title":"Journal of American Academy of Dermatology"},{"key":"10.1016\/j.tiv.2007.05.016_bib13","unstructured":"OECD, 1981.OECD Guidelines for the Testing of Chemicals Test No. 101: UV\u2013Vis Absorption Spectra (Original Guideline, adopted 12th May 1981). <http:\/\/www.oecd.org\/>."},{"key":"10.1016\/j.tiv.2007.05.016_bib14","unstructured":"OECD, 2004.OECD Guidelines for the Testing of Chemicals Test No. 432: In Vitro 3T3 NRU Phototoxicity Test (Original Guideline, adopted 13th April 2004) <http:\/\/www.oecd.org\/>."},{"key":"10.1016\/j.tiv.2007.05.016_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/faat.1996.0071","article-title":"Development of an in vitro method for skin corrosion testing","volume":"31","author":"Perkins","year":"1996","journal-title":"Fundamental and Applied Toxicology"},{"key":"10.1016\/j.tiv.2007.05.016_bib16","unstructured":"Ponec, M., 1992. Living Human Skin Models \u2013 The State of Art. In: Methodologies and In Vitro Applications for Organotypic Skin Culture Models. June 12, Grand Hyatt Hotel, New York, 13 pp."},{"issue":"1","key":"10.1016\/j.tiv.2007.05.016_bib17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000056392","article-title":"Barrier function in reconstructed epidermis and its resemblance to native human skin","volume":"14","author":"Ponec","year":"2001","journal-title":"Skin Pharmacology and Applied Skin Physiology"},{"issue":"1","key":"10.1016\/j.tiv.2007.05.016_bib18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000066682","article-title":"Characterization of reconstructed skin models","volume":"15","author":"Ponec","year":"2002","journal-title":"Skin Pharmacology and Applied Skin Physiology"},{"key":"10.1016\/j.tiv.2007.05.016_bib19","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0887-2333(98)00006-X","article-title":"The international EU\/COLIPA In vitro phototoxicity validation study: results of phase II (blind trial), Part 1: the 3T3 NRU phototoxicity test","volume":"12","author":"Spielmann","year":"1998","journal-title":"Toxicology In Vitro"},{"key":"10.1016\/j.tiv.2007.05.016_bib20","doi-asserted-by":"crossref","unstructured":"Spielmann, H., M\u00fcller, L., Averbeck, D., Balls, M., Brendler-Schwaab, S., Castell, J.V., Curren, R., de Silva, O., Gibbs, N.K., Liebsch, M., Lovell, W.W., Merk, H.F., Nash, J.F., Neumann, N.J., Pappe, W.J.W., Ulrich, P., Vohr, H.W., 2000. The second ECVAM workshop on phototoxicity testing. The report and recommendations of ECVAM workshop 42. ATLA 28, 6, 777\u2013815.","DOI":"10.1177\/026119290002800603"},{"key":"10.1016\/j.tiv.2007.05.016_bib21","series-title":"Essential Oil Safety. A Guide for Health Care Professionals","author":"Tisserand","year":"1995"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233307001671?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233307001671?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:27:23Z","timestamp":1760135243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233307001671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0887233307001671"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2007.05.016","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phototoxicity of bergamot oil assessed by in vitro techniques in combination with human patch tests","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2007.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}