{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:32:39Z","timestamp":1791405159074,"version":"4.3.3"},"reference-count":33,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.tiv.2008.03.006","type":"journal-article","created":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T07:21:49Z","timestamp":1205738509000},"page":"1169-1176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Mass spectrometric identification of covalent adducts of the skin allergen 2,4-dinitro-1-chlorobenzene and model skin proteins"],"prefix":"10.1016","volume":"22","author":[{"given":"Maja","family":"Aleksic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla K.","family":"Pease","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Basketter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Panico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard R.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Dell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2008.03.006_bib1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000068288","article-title":"Reactivity of contact allergenic haptens to amino acid residues in a model carrier peptide, and characterisation of formed peptide-hapten adducts","volume":"16","author":"Ahlfors","year":"2003","journal-title":"Skin Pharmacol. Appl. Skin Physiol."},{"key":"10.1016\/j.tiv.2008.03.006_bib2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.tiv.2007.01.008","article-title":"Investigating protein haptenation mechanisms of skin sensitisers using human serum albumin as a model protein","volume":"21","author":"Aleksic","year":"2007","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2008.03.006_bib3","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1021\/tx0256634","volume":"16","author":"Alvarez-Sanchez","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tiv.2008.03.006_bib4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.bmcl.2003.11.002","article-title":"Covalent binding of the13 C-labelled skin sensitizers 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI) to a model peptide and glutathione","volume":"14","author":"Alvarez-Sanchez","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.tiv.2008.03.006_bib5","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1021\/tx049935+","volume":"17","author":"Alvarez-Sanchez","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tiv.2008.03.006_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.tiv.2005.07.003","article-title":"Non-enzymatic glutathione reactivity and in vitro toxicity: a non-animal approach to skin sensitization","volume":"20","author":"Aptula","year":"2006","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2008.03.006_bib7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0165-6147(00)01704-1","article-title":"Measurement of allergenic potency using the local lymph node assay","volume":"22","author":"Basketter","year":"2001","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.tiv.2008.03.006_bib8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.0105-1873.2004.00331.x","article-title":"Strong irritants masquerading as skin allergens: the case of benzalkonium chloride","volume":"50","author":"Basketter","year":"2004","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.tiv.2008.03.006_bib9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-0536.1996.tb02113.x","article-title":"Dichloronitrobenzene: a reappraisal of its skin sensitization potential","volume":"34","author":"Basketter","year":"1996","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.tiv.2008.03.006_bib10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1021\/tx050312l","article-title":"Cytosolic and nuclear protein targets of thiol-reactive electrophiles","volume":"19","author":"Dennehy","year":"2006","journal-title":"Chem. Res. Toxicol."},{"issue":"Suppl.","key":"10.1016\/j.tiv.2008.03.006_bib11","first-page":"229","article-title":"Hapten-protein binding: what do we know?","volume":"23","author":"Divkovic","year":"2006","journal-title":"ALTEX"},{"key":"10.1016\/j.tiv.2008.03.006_bib12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.0105-1873.2005.00683.x","article-title":"Hapten-protein binding: from theory to practical application in the in vitro prediction of skin sensitization","volume":"53","author":"Divkovic","year":"2005","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.tiv.2008.03.006_bib13","series-title":"Contact Dermatitis to Simple Chemicals: A Molecular Approach","author":"Dupuis","year":"1982"},{"key":"10.1016\/j.tiv.2008.03.006_bib14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1021\/tx0341456","article-title":"Protein binding and metabolism influence the relative skin sensitization potential of cinnamic compounds","volume":"17","author":"Elahi","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tiv.2008.03.006_bib15","first-page":"26","volume":"66","year":"2003","journal-title":"Official J. Eur. Union L"},{"key":"10.1016\/j.tiv.2008.03.006_bib16","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1177\/026119290403200612","article-title":"The feasibility of replacing animal testing for assessing consumer safety: a suggested future direction","volume":"32","author":"Fentem","year":"2004","journal-title":"Altern. Lab. Anim."},{"key":"10.1016\/j.tiv.2008.03.006_bib17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1021\/tx00039a005","volume":"7","author":"Franot","year":"1994","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tiv.2008.03.006_bib18","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.0105-1873.2004.00290.x","article-title":"A chemical dataset for evaluation of alternative approaches to skin-sensitization testing","volume":"50","author":"Gerberick","year":"2004","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.tiv.2008.03.006_bib19","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/toxsci\/kfh213","article-title":"Development of a peptide reactivity assay for screening contact allergens","volume":"81","author":"Gerberick","year":"2004","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.tiv.2008.03.006_bib20","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/toxsci\/kfm064","article-title":"Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach","volume":"97","author":"Gerberick","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2008.03.006_bib21","article-title":"Reactivities of contact allergenic quinones towards a model peptide and identification of the adducts","volume":"113","author":"Hanson","year":"1999","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.tiv.2008.03.006_bib22","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/jat.1146","article-title":"A future approach to measuring relative skin sensitising potency: a proposal","volume":"26","author":"Jowsey","year":"2006","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tiv.2008.03.006_bib23","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1600-0536.1992.tb00129.x","article-title":"Air oxidation of d-limonene (the citrus solvent) creates potent allergens","volume":"26","author":"Karlberg","year":"1992","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.tiv.2008.03.006_bib24","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1084\/jem.61.5.643","article-title":"Studies on the sensitisation of animals with simple chemical compounds","volume":"61","author":"Landsteiner","year":"1935","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tiv.2008.03.006_bib25","series-title":"Allergic Contact Dermatitis \u2013 The Molecular Basis","first-page":"82","article-title":"Hapten\u2013Protein Interactions","author":"Lepoittevin","year":"1998"},{"key":"10.1016\/j.tiv.2008.03.006_bib26","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1021\/tx000225n","article-title":"Studies of the chemical selectivity of hapten, reactivity, and skin sensitization potency. 1. Synthesis and studies on the reactivity toward model nucleophiles of the13 C-labelled skin sensitizers hex-1-ene- and hexane-1,3-sultones","volume":"14","author":"Meschkat","year":"2001","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tiv.2008.03.006_bib27","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1021\/tx000226f","article-title":"Studies of the chemical selectivity of hapten, reactivity, and skin sensitization potency. 2. NMR studies of the covalent binding of the13 C-labelled skin sensitizers 2-[13 C]- and 3-[13 C]hex-1-ene- and 3-[13 C]hexane-1,3-sultones to human serum albumin","volume":"14","author":"Meschkat","year":"2001","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tiv.2008.03.006_bib28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1046\/j.1365-2443.1996.05005.x","article-title":"Phosphorylation of Ser-3 of cofilin regulates its essential function on actin","volume":"1","author":"Moriyama","year":"1996","journal-title":"Genes Cells"},{"key":"10.1016\/j.tiv.2008.03.006_bib29","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.tiv.2007.03.016","article-title":"Utility and limitations of a peptide reactivity assay to predict fragrance allergens in vitro","volume":"21","author":"Natsch","year":"2007","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2008.03.006_bib30","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1021\/tx049758c","article-title":"A conjugated diene identified as a prohapten: contact allergenic activity and chemical reactivity of proposed epoxide metabolites","volume":"18","author":"Nilsson","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tiv.2008.03.006_bib31","series-title":"All about Albumin \u2013 Biochemistry, Genetics and Medical Applications","author":"Peters","year":"1996"},{"key":"10.1016\/j.tiv.2008.03.006_bib32","series-title":"Allergic Contact Dermatitis \u2013 Chemical and Metabolic Mechanisms","author":"Smith","year":"2001"},{"key":"10.1016\/j.tiv.2008.03.006_bib33","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/eji.200324241","article-title":"Morpholgical changes during dendritic cell maturation correlate with cofilin activation and translocation to the cell membrane","volume":"34","author":"Verdijk","year":"2004","journal-title":"Eur. J. Immunol."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233308000805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233308000805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:27:41Z","timestamp":1760135261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233308000805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0887233308000805"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2008.03.006","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mass spectrometric identification of covalent adducts of the skin allergen 2,4-dinitro-1-chlorobenzene and model skin proteins","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2008.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}