{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:19:26Z","timestamp":1766135966430},"reference-count":33,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.tiv.2008.09.019","type":"journal-article","created":{"date-parts":[[2008,10,8]],"date-time":"2008-10-08T18:07:05Z","timestamp":1223489225000},"page":"1840-1845","source":"Crossref","is-referenced-by-count":10,"title":["Quercetin prevents necrotic cell death induced by co-exposure to benzo(a)pyrene and UVA radiation"],"prefix":"10.1016","volume":"22","author":[{"given":"Hae Dong","family":"Woo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byeong Mo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang Jee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Joon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Jin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Hee","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Yeol","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai Won","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2008.09.019_bib1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0092-8674(00)81334-3","article-title":"Human ICE\/CED-3 protease nomenclature","volume":"87","author":"Alnemri","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.tiv.2008.09.019_bib2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/B978-0-12-364932-4.50010-1","article-title":"Apoptosis: mechanisms and roles in pathology","volume":"32","author":"Arends","year":"1991","journal-title":"International Review of Experimental Pathology"},{"key":"10.1016\/j.tiv.2008.09.019_bib3","doi-asserted-by":"crossref","first-page":"7162","DOI":"10.1073\/pnas.92.16.7162","article-title":"Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide\/superoxide in cortical cell cultures","volume":"92","author":"Bonfoco","year":"1995","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.tiv.2008.09.019_bib4","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0891-5849(00)00317-8","article-title":"Mitochondrial free radical generation, oxidative stress, and aging","volume":"29","author":"Cadenas","year":"2000","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.tiv.2008.09.019_bib6","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1021\/tx00042a017","article-title":"Enantiospecificity of covalent adduct formation by benzo[a]pyrene anti-diol epoxide with human serum albumin","volume":"7","author":"Day","year":"1994","journal-title":"Chemical Research in Toxicology"},{"key":"10.1016\/j.tiv.2008.09.019_bib7","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1111\/j.1751-1097.2007.00169.x","article-title":"Photodynamic action of benzo[a]pyrene in K562 cells","volume":"83","author":"Filgueira","year":"2007","journal-title":"Photochemistry and Photobiology"},{"key":"10.1016\/j.tiv.2008.09.019_bib8","first-page":"1835","article-title":"Intracellular ATP levels determine cell death fate by apoptosis or necrosis","volume":"57","author":"Eguchi","year":"1997","journal-title":"Cancer Research"},{"key":"10.1016\/j.tiv.2008.09.019_bib9","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1096\/fasebj.4.9.2189775","article-title":"Role of oxygen free radicals in carcinogenesis and brain ischemia","volume":"4","author":"Floyd","year":"1990","journal-title":"The FASEB Journal"},{"key":"10.1016\/j.tiv.2008.09.019_bib11","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1562\/2006-03-09-IR-840","article-title":"Photosensitized DNA damage and its protection via a novel mechanism","volume":"83","author":"Hiraku","year":"2007","journal-title":"Photochemistry and Photobiology"},{"key":"10.1016\/j.tiv.2008.09.019_bib13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF02790134","article-title":"Structure-activity relationship of flavonoids with superoxide scavenging activity","volume":"47","author":"Hu","year":"1995","journal-title":"Biological Trace Element Research"},{"key":"10.1016\/j.tiv.2008.09.019_bib14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1382-6689(01)00110-7","article-title":"Phototoxicity of benzo[a]pyrene by ultraviolet A irradiation: induction of apoptosis in Jurkat cells","volume":"11","author":"Ibuki","year":"2002","journal-title":"Environmental Toxicology and Pharmacology"},{"key":"10.1016\/j.tiv.2008.09.019_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1382-6689(02)00014-5","article-title":"Coexposure to benzo[a]pyrene plus ultraviolet A induces 8-oxo-7, 8-dihydro-2\u2019-deoxyguanosine formation in human skin fibroblasts: preventive effects of anti-oxidant agents","volume":"12","author":"Ibuki","year":"2002","journal-title":"Environmental Toxicology and Pharmacology"},{"key":"10.1016\/j.tiv.2008.09.019_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0300-483X(03)00150-1","article-title":"UV-induced skin damage","volume":"189","author":"Ichihashi","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.tiv.2008.09.019_bib17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0300-483X(00)00268-7","article-title":"The protective effect of flavonol quercetin against ultraviolet A induced oxidative stress in rats1","volume":"154","author":"Inal","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.tiv.2008.09.019_bib111","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0165-1161(89)90048-4","article-title":"The light-dependent cytotoxicity of benzo[a]pyrene: effect on human erythrocytes, Escherichia coli cells, and Haemophilus influenzae transforming DNA","volume":"216","author":"Kagan","year":"1989","journal-title":"Mutation Research"},{"key":"10.1016\/j.tiv.2008.09.019_bib18","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/jat.863","article-title":"Protective effects of quercetin on ultraviolet A light-induced oxidative stress in the blood of rat","volume":"22","author":"Kahraman","year":"2002","journal-title":"Journal of Applied Toxicology"},{"key":"10.1016\/j.tiv.2008.09.019_bib19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1383-5742(00)00059-4","article-title":"Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and aging","volume":"488","author":"Kawanishi","year":"2001","journal-title":"Mutation Research"},{"key":"10.1016\/j.tiv.2008.09.019_bib20","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1084\/jem.185.8.1481","article-title":"Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis","volume":"185","author":"Leist","year":"1997","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.tiv.2008.09.019_bib21","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00411-007-0112-5","article-title":"Inhibition of UVA-induced apoptotic signaling pathway by polypeptide from Chlamys farreri in human HaCaT keratinocytes","volume":"46","author":"Li","year":"2007","journal-title":"Radiation and Environmental Biophysics"},{"key":"10.1016\/j.tiv.2008.09.019_bib22","doi-asserted-by":"crossref","first-page":"10307","DOI":"10.1021\/bi980606o","article-title":"Benzo[a]pyrene enhances the formation of 8-hydroxy-2\u2019-deoxyguanosine by ultraviolet A radiation in calf thymus DNA and human epidermoid carcinoma cells","volume":"37","author":"Liu","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.tiv.2008.09.019_bib23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0003-2670(00)00717-0","article-title":"Spectrophotometric measurement of antioxidant properties of flavones and flavonols against superoxide anion","volume":"411","author":"Magnani","year":"2000","journal-title":"Analytica Chimica Acta"},{"key":"10.1016\/j.tiv.2008.09.019_bib24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/sj.cdd.4400265","article-title":"Energy supply and the shape of death in neurons and lymphoid cells","volume":"4","author":"Nicotera","year":"1997","journal-title":"Cell Death and Differentiation"},{"key":"10.1016\/j.tiv.2008.09.019_bib25","doi-asserted-by":"crossref","first-page":"C67","DOI":"10.1152\/ajpcell.1994.267.1.C67","article-title":"ATP depletion rather than mitochondrial depolarization mediates hepatocyte killing after metabolic inhibition","volume":"267","author":"Nieminen","year":"1994","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.tiv.2008.09.019_bib26","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0968-0004(00)01674-1","article-title":"Mitochondria, oxygen free radicals, disease and ageing","volume":"25","author":"Raha","year":"2000","journal-title":"Trends in Biochemical Sciences"},{"key":"10.1016\/j.tiv.2008.09.019_bib28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0378-4274(00)00251-4","article-title":"Interactions between benzo[a]pyrene and UVA light affecting ATP levels, cytoskeletal organization, and resistance to trypsinization","volume":"117","author":"Seagrave","year":"2000","journal-title":"Toxicology Letters"},{"key":"10.1016\/j.tiv.2008.09.019_bib30","first-page":"2161","article-title":"Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-xL","volume":"56","author":"Shimizu","year":"1996","journal-title":"Cancer Research"},{"key":"10.1016\/j.tiv.2008.09.019_bib31","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0041-008X(03)00018-8","article-title":"Synergistic enhancement of H2O2 production in human epidermoid carcinoma cells by Benzo[a]pyrene and ultraviolet A radiation","volume":"188","author":"Shyong","year":"2003","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.tiv.2008.09.019_bib32","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"308","author":"Singh","year":"1988","journal-title":"Experimental cell research"},{"key":"10.1016\/j.tiv.2008.09.019_bib34","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.bbrc.2004.07.174","article-title":"Coexposure to benzo[a]pyrene plus UVA induced DNA double strand breaks: visualization of Ku assembly in the nucleus having DNA lesions","volume":"322","author":"Toyooka","year":"2004","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.tiv.2008.09.019_bib35","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/em.20166","article-title":"Coexposure to benzo[a]pyrene and UVA induces DNA damage: first proof of double-strand breaks in a cell-free system","volume":"47","author":"Toyooka","year":"2006","journal-title":"Environmental and Molecular Mutagenesis"},{"key":"10.1016\/j.tiv.2008.09.019_bib36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jphotobiol.2005.09.004","article-title":"Induction of apoptosis by photoexcited tetracyclic compounds derivatives of benzo[b]thiophenes and pyridines","volume":"82","author":"Viola","year":"2006","journal-title":"Journal of Photochemistry and Photobiology B: Biology"},{"key":"10.1016\/j.tiv.2008.09.019_bib37","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/S0891-5849(99)00107-0","article-title":"Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader","volume":"27","author":"Wang","year":"1999","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.tiv.2008.09.019_bib38","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3390\/ijerph2006030045","article-title":"Photoirradiation of polycyclic aromatic hydrocarbons with UVA light \u2013 a pathway leading to the generation of reactive oxygen species, lipid peroxidation, and DNA damage","volume":"3","author":"Yu","year":"2006","journal-title":"International Journal of Environmental Research and Public Health"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233308002439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233308002439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T13:50:28Z","timestamp":1557841828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233308002439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0887233308002439"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2008.09.019","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}