{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:26:00Z","timestamp":1759530360806},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.tiv.2009.02.001","type":"journal-article","created":{"date-parts":[[2009,2,18]],"date-time":"2009-02-18T01:33:40Z","timestamp":1234920820000},"page":"610-616","source":"Crossref","is-referenced-by-count":5,"title":["Micromolar Zn2+ potentiates the cytotoxic action of submicromolar econazole in rat thymocytes: Possible disturbance of intracellular Ca2+ and Zn2+ homeostasis"],"prefix":"10.1016","volume":"23","author":[{"given":"Akio","family":"Kinazaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Sakanashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro M.","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruka","family":"Shibagaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiro","family":"Okano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2009.02.001_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.femsle.2005.07.022","article-title":"In vitro and ex vivo antimycobacterial potential of azole drugs against Mycobacterium tuberculosis H37Rv","volume":"251","author":"Ahmad","year":"2005","journal-title":"FEMS Microbiology Letters"},{"key":"10.1016\/j.tiv.2009.02.001_bib2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ijantimicag.2006.07.028","article-title":"Antimycobacterial activity of econazole against multidrug-resistant strains of Mycobacterium tuberculosis","volume":"28","author":"Ahmad","year":"2006","journal-title":"International Journal of Antimicrobial Agents"},{"key":"10.1016\/j.tiv.2009.02.001_bib3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.nano.2007.05.001","article-title":"Chemotherapeutic evaluation of alginate nanoparticle-encapsulated azole antifungal and antitubercular drugs against murine tuberculosis","volume":"3","author":"Ahmad","year":"2007","journal-title":"Nanomedicine"},{"key":"10.1016\/j.tiv.2009.02.001_bib4","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ijantimicag.2007.10.017","article-title":"Novel chemotherapy for tuberculosis: chemotherapeutic potential of econazole- and moxifloxacin-loaded PLG nanoparticles","volume":"31","author":"Ahmad","year":"2008","journal-title":"International Journal of Antimicrobial Agents"},{"key":"10.1016\/j.tiv.2009.02.001_bib5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1254\/jjp.71.299","article-title":"Fluorescent estimation of H2O2-induced changes in cell viability and cellular nonprotein thiol level of dissociated rat thymocytes","volume":"71","author":"Chikahisa","year":"1996","journal-title":"Japanese Journal of Pharmacology"},{"key":"10.1016\/j.tiv.2009.02.001_bib6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mrfmmm.2007.01.013","article-title":"Zinc fluxes and zinc transporter genes in chronic diseases","volume":"622","author":"Devirgiliis","year":"2007","journal-title":"Mutation Research"},{"key":"10.1016\/j.tiv.2009.02.001_bib7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.pathol.1.110304.100218","article-title":"Calcium in cell injury and death","volume":"1","author":"Dong","year":"2006","journal-title":"Annual Review of Pathology"},{"key":"10.1016\/j.tiv.2009.02.001_bib8","first-page":"943","article-title":"Characterization of zinc-binding proteins of plasma in familial hyperzincemia","volume":"100","author":"Failla","year":"1982","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"10.1016\/j.tiv.2009.02.001_bib9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0048-9697(75)90029-7","article-title":"Function and homeostasis of copper and zinc in mammals","volume":"4","author":"Fisher","year":"1975","journal-title":"Science of the Total Environment"},{"key":"10.1016\/j.tiv.2009.02.001_bib10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1615\/JEnvironPatholToxicolOncol.v25.i3.40","article-title":"The role of zinc in life: a review","volume":"25","author":"Frassinetti","year":"2006","journal-title":"Journal of Environmental Pathology, Toxicology and Oncology"},{"key":"10.1016\/j.tiv.2009.02.001_bib11","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1021\/ja011774y","article-title":"Detection and imaging of zinc secretion from pancreatic beta-cells using a new fluorescent zinc indicator","volume":"124","author":"Gee","year":"2002","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/j.tiv.2009.02.001_bib12","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/sj.cdd.4402147","article-title":"Mitochondrial Ca2+ as a key regulator of cell life and death","volume":"14","author":"Giacomello","year":"2007","journal-title":"Cell Death and Differentiation"},{"key":"10.1016\/j.tiv.2009.02.001_bib13","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/S0006-2952(01)00571-8","article-title":"Azole-antifungal binding to a novel cytochrome P450 from Mycobacterium tuberculosis: implications for treatment of tuberculosis","volume":"61","author":"Guardiola-Diaz","year":"2001","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.tiv.2009.02.001_bib14","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/oxfordjournals.jbchem.a022844","article-title":"Zinc-induced mixed types of cell death, necrosis, and apoptosis, in Molt-4 cells","volume":"128","author":"Hamatake","year":"2000","journal-title":"Journal of Biochemistry"},{"key":"10.1016\/j.tiv.2009.02.001_bib15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1677\/joe.0.1690417","article-title":"Induction of apoptosis and necrosis by zinc in human thyroid cancer cell lines","volume":"169","author":"Iitaka","year":"2001","journal-title":"Journal of Endocrinology"},{"key":"10.1016\/j.tiv.2009.02.001_bib16","doi-asserted-by":"crossref","first-page":"8179","DOI":"10.1016\/S0021-9258(18)83166-0","article-title":"Photochemically generated cytosolic calcium pulses and their detection by fluo-3","volume":"264","author":"Kao","year":"1989","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.tiv.2009.02.001_bib17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jtemb.2006.01.006","article-title":"Zinc requirements and the risks and benefits of zinc supplementation","volume":"20","author":"Maret","year":"2006","journal-title":"Journal of Trace Elements in Medicine and Biology"},{"key":"10.1016\/j.tiv.2009.02.001_bib18","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.tox.2008.03.022","article-title":"Imidazole antifungals, but not triazole antifungals, increase membrane Zn2+ permeability in rat thymocytes possible contribution to their cytotoxicity","volume":"248","author":"Matsui","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.tiv.2009.02.001_bib19","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1042\/bst0220606","article-title":"The regulation of apoptosis in thymocytes","volume":"22","author":"McConkey","year":"1994","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.tiv.2009.02.001_bib20","doi-asserted-by":"crossref","first-page":"607","DOI":"10.2174\/138945006776818683","article-title":"Zinc and its specific transporters as potential targets in airway disease","volume":"7","author":"Murgia","year":"2006","journal-title":"Current Drug Targets"},{"key":"10.1016\/j.tiv.2009.02.001_bib21","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1382-6689(01)00112-0","article-title":"Estimation of increased concentration of intracellular Cd2+ by fluo-3 in rat thymocytes exposed to CdCl2","volume":"11","author":"Oyama","year":"2002","journal-title":"Environmental Toxicology and Pharmacology"},{"key":"10.1016\/j.tiv.2009.02.001_bib22","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.tiv.2007.06.016","article-title":"Clotrimazole, an antifungal drug possessing diverse actions, increases membrane permeation of cadmium in rat thymocytes","volume":"21","author":"Oyama","year":"2007","journal-title":"Toxicology in Vitro"},{"key":"10.1016\/j.tiv.2009.02.001_bib23","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.toxlet.2007.05.003","article-title":"Synergic cytotoxic action induced by simultaneous application of zinc and clotrimazole in rat thymocytes","volume":"171","author":"Oyama","year":"2007","journal-title":"Toxicology Letters"},{"key":"10.1016\/j.tiv.2009.02.001_bib24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1023\/A:1011394304691","article-title":"Cell death in the rat thymus: a minireview","volume":"6","author":"Quaglino","year":"2001","journal-title":"Apoptosis"},{"key":"10.1016\/j.tiv.2009.02.001_bib25","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1203\/00006450-199708000-00015","article-title":"A case of hyperzincemia with functional zinc depletion: a new disorder?","volume":"42","author":"Sampson","year":"1997","journal-title":"Pediatric Research"},{"key":"10.1016\/j.tiv.2009.02.001_bib26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/clinchem\/17.6.461","article-title":"Trace element analysis in clinical chemistry","volume":"17","author":"Schroeder","year":"1971","journal-title":"Clinical Chemistry"},{"key":"10.1016\/j.tiv.2009.02.001_bib27","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1023\/A:1012993017026","article-title":"The role of zinc in caspase activation and apoptotic cell death","volume":"14","author":"Truong-Tran","year":"2001","journal-title":"Biometals"},{"key":"10.1016\/j.tiv.2009.02.001_bib28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1006\/smim.1996.0053","article-title":"Genes involved in T-cell receptor-mediated apoptosis of thymocytes and T-cell hybridomas","volume":"9","author":"Winoto","year":"1997","journal-title":"Seminars in Immunology"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233309000393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233309000393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T23:28:24Z","timestamp":1633130904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233309000393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S0887233309000393"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2009.02.001","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}