{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:28:12Z","timestamp":1791268092104,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.tiv.2009.02.007","type":"journal-article","created":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T04:37:04Z","timestamp":1235882224000},"page":"697-703","source":"Crossref","is-referenced-by-count":109,"title":["Mesoporous silica nanoparticles enhance MTT formazan exocytosis in HeLa cells and astrocytes"],"prefix":"10.1016","volume":"23","author":[{"given":"Matthieu","family":"Fisichella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hinda","family":"Dabboue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjib","family":"Bhattacharyya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Louise","family":"Saboungi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Salvetat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Hevor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Guerin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2009.02.007_bib1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0168-0102(98)00055-8","article-title":"Amyloid beta protein inhibits cellular MTT reduction not by suppression of mitochondrial succinate dehydrogenase but by acceleration of MTT formazan exocytosis in cultured rat cortical astrocytes","volume":"31","author":"Abe","year":"1998","journal-title":"Neuroscience Research"},{"key":"10.1016\/j.tiv.2009.02.007_bib2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1387-2656(05)11004-7","article-title":"Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction","volume":"11","author":"Berridge","year":"2005","journal-title":"Biotechnology Annual Review"},{"key":"10.1016\/j.tiv.2009.02.007_bib3","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1166\/jnn.2004.080","article-title":"Polyplexes of polyethylenimine and per-N-methylated polyethylenimine-cytotoxicity and transfection efficiency","volume":"4","author":"Breunig","year":"2004","journal-title":"Journal of Nanoscience and Nanotechnology"},{"key":"10.1016\/j.tiv.2009.02.007_bib4","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.bbrc.2004.04.067","article-title":"Incorporation of biodegradable nanoparticles into human airway epithelium cells - in vitro study of the suitability as a vehicle for drug or gene delivery in pulmonary diseases","volume":"318","author":"Brzoska","year":"2004","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.tiv.2009.02.007_bib5","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.carbon.2007.03.033","article-title":"Spectroscopic analysis confirms the interactions between single walled carbon nanotubes and various dyes commonly used to assess cytotoxicity","volume":"45","author":"Casey","year":"2007","journal-title":"Carbon"},{"key":"10.1016\/j.tiv.2009.02.007_bib6","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1016\/j.biomaterials.2007.03.006","article-title":"The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles 3T3\u2013L1 cells and human mesenchymal stem cells","volume":"28","author":"Chung","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.tiv.2009.02.007_bib7","doi-asserted-by":"crossref","first-page":"9842","DOI":"10.1074\/jbc.273.16.9842","article-title":"Lysosomal enzyme trafficking between phagosomes, endosomes, and lysosomes in J774 macrophages - enrichment of cathepsin H in early endosomes","volume":"273","author":"Claus","year":"1998","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.tiv.2009.02.007_bib8","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.jinorgbio.2007.12.028","article-title":"Cytotoxicity of mesoporous silica nanomaterials","volume":"102","author":"Di Pasqua","year":"2008","journal-title":"Journal of Inorganic Biochemistry"},{"key":"10.1016\/j.tiv.2009.02.007_bib9","first-page":"213","article-title":"Localization of MTT formazan in lipid droplets. An alternative hypothesis about the nature of formazan granules and aggregates","volume":"51","author":"Diaz","year":"2007","journal-title":"European Journal of Histochemistry"},{"key":"10.1016\/j.tiv.2009.02.007_bib10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1387-1811(98)00255-8","article-title":"Novel pathways for the preparation of mesoporous MCM-41 materials: control of porosity and morphology","volume":"27","author":"Grun","year":"1999","journal-title":"Microporous and Mesoporous Materials"},{"key":"10.1016\/j.tiv.2009.02.007_bib11","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1096\/fj.05-4288fje","article-title":"Highly efficient cellular labeling of mesoporous nanoparticles in human mesenchymal stem cells: implication for stem cell tracking","volume":"19","author":"Huang","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.tiv.2009.02.007_bib12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0304-3940(99)00282-7","article-title":"Enhancement of MTT, a tetrazolium salt, exocytosis by amyloid beta-protein and chloroquine in cultured rat astrocytes","volume":"266","author":"Isobe","year":"1999","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.tiv.2009.02.007_bib13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0928-0987(99)00092-5","article-title":"Evaluation of absorption enhancement for a potent cyclopeptidic alpha(nu)beta(3)-antagonist in a human intestinal cell line (Caco-2)","volume":"10","author":"Kamm","year":"2000","journal-title":"European Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.tiv.2009.02.007_bib14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0197-0186(00)00071-1","article-title":"Beta-amyloid (1\u201342) affects MTT reduction in astrocytes: implications for vesicular trafficking and cell functionality","volume":"38","author":"Kerokoski","year":"2001","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.tiv.2009.02.007_bib15","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0169-328X(02)00416-3","article-title":"Amyloid beta-peptide alters the distribution of early endosomes and inhibits phosphorylation of Akt in the presence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)","volume":"106","author":"Kubo","year":"2002","journal-title":"Molecular Brain Research"},{"key":"10.1016\/j.tiv.2009.02.007_bib16","doi-asserted-by":"crossref","first-page":"10674","DOI":"10.1021\/jp800898n","article-title":"Effect of surfactant concentration on the morphology and texture of MCM-41 materials","volume":"112","author":"Lelong","year":"2008","journal-title":"The Journal of Physical Chemistry C"},{"key":"10.1016\/j.tiv.2009.02.007_bib17","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.1021\/cm051014c","article-title":"Well-ordered mesoporous silica nanoparticles as cell markers","volume":"17","author":"Lin","year":"2005","journal-title":"Chemistry of Materials"},{"key":"10.1016\/j.tiv.2009.02.007_bib18","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/emm.2005.69","article-title":"Early phase of amyloid beta 42-induced cytotoxicity in neuronal cells is associated with vacuole formation and enhancement of exocytosis","volume":"37","author":"Liu","year":"2005","journal-title":"Experimental and Molecular Medicine"},{"key":"10.1016\/j.tiv.2009.02.007_bib19","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1046\/j.1471-4159.1997.69020581.x","article-title":"Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction","volume":"69","author":"Liu","year":"1997","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.tiv.2009.02.007_bib20","doi-asserted-by":"crossref","first-page":"13266","DOI":"10.1073\/pnas.95.22.13266","article-title":"Amyloid beta peptide alters intracellular vesicle trafficking and cholesterol homeostasis","volume":"95","author":"Liu","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.tiv.2009.02.007_bib21","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1046\/j.1471-4159.1997.69062285.x","article-title":"Cytotoxic amyloid peptides inhibit cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction by enhancing MTT formazan exocytosis","volume":"69","author":"Liu","year":"1997","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.tiv.2009.02.007_bib22","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1046\/j.1471-4159.1998.71062322.x","article-title":"Steroid hormones block amyloid fibril-induced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) formazan exocytosis: relationship to neurotoxicity","volume":"71","author":"Liu","year":"1998","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.tiv.2009.02.007_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"Journal of Immunological Methods"},{"key":"10.1016\/j.tiv.2009.02.007_bib24","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1097\/00001756-199608120-00035","article-title":"Beta-amyloid-mediated inhibition of redox activity (MTT reduction) is not an indicator of astroglial degeneration","volume":"7","author":"Patel","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.tiv.2009.02.007_bib25","doi-asserted-by":"crossref","first-page":"14792","DOI":"10.1021\/ja0645943","article-title":"Effect of surface functionalization of MCM-41-type mesoporous silica nanoparticles on the endocytosis by human cancer cells","volume":"128","author":"Slowing","year":"2006","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/j.tiv.2009.02.007_bib26","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1021\/nl080250u","article-title":"Mesoporous silica nanoparticles inhibit cellular respiration","volume":"8","author":"Tao","year":"2008","journal-title":"Nano Letters"},{"key":"10.1016\/j.tiv.2009.02.007_bib27","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.tiv.2003.12.004","article-title":"Flow cytometric methods used as screening tests for basal toxicity of chemicals","volume":"18","author":"Tuschl","year":"2004","journal-title":"Toxicology in Vitro"},{"key":"10.1016\/j.tiv.2009.02.007_bib28","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1021\/nl060177c","article-title":"Oops they did it again! Carbon nanotubes hoax scientists in viability assays","volume":"6","author":"Worle-Knirsch","year":"2006","journal-title":"Nano Letters"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233309000423?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233309000423?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T06:14:01Z","timestamp":1558160041000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233309000423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S0887233309000423"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2009.02.007","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}