{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:12:05Z","timestamp":1792707125078,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007355","name":"Fondation Louvain","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007355","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.tiv.2010.04.002","type":"journal-article","created":{"date-parts":[[2010,4,19]],"date-time":"2010-04-19T04:58:09Z","timestamp":1271653089000},"page":"1441-1449","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":198,"title":["Inflammatory parameters in Caco-2 cells: Effect of stimuli nature, concentration, combination and cell differentiation"],"prefix":"10.1016","volume":"24","author":[{"given":"Jacqueline","family":"Van De Walle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Hendrickx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Romier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvan","family":"Larondelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves-Jacques","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2010.04.002_bib1","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.4049\/jimmunol.167.3.1609","article-title":"Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide","volume":"167","author":"Abreu","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.tiv.2010.04.002_bib2","doi-asserted-by":"crossref","first-page":"20431","DOI":"10.1074\/jbc.M110333200","article-title":"TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells","volume":"277","author":"Abreu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2010.04.002_bib3","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.lfs.2003.10.042","article-title":"iNOS-mediated nitric oxide production and its regulation","volume":"75","author":"Aktan","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.tiv.2010.04.002_bib4","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.4049\/jimmunol.178.7.4641","article-title":"IL-1 beta causes an increase in intestinal epithelial tight junction permeability","volume":"178","author":"Al-Sadi","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.tiv.2010.04.002_bib5","first-page":"147","article-title":"A study of endotoxemia in ulcerative colitis and Crohn\u2019s disease. I. Clinical study","volume":"32","author":"Aoki","year":"1978","journal-title":"Acta Med. Okayama"},{"key":"10.1016\/j.tiv.2010.04.002_bib6","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/S0016-5085(98)70021-6","article-title":"Differential expression of interleukin 1 receptor antagonist isoforms in human intestinal epithelial cells","volume":"115","author":"B\u00f6cker","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tiv.2010.04.002_bib7","doi-asserted-by":"crossref","first-page":"12207","DOI":"10.1074\/jbc.275.16.12207","article-title":"Cellular differentiation causes a selective down-regulation of interleukin (IL)-1 beta-mediated NF-kappa B activation and IL-8 gene expression in intestinal epithelial cells","volume":"275","author":"B\u00f6cker","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2010.04.002_bib8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00384-002-0415-6","article-title":"Responsiveness of intestinal epithelial cell lines to lipopolysaccharide is correlated with Toll-like receptor 4 but not Toll-like receptor 2 or CD14 expression","volume":"18","author":"B\u00f6cker","year":"2003","journal-title":"Int. J. Colorectal. Dis."},{"key":"10.1016\/j.tiv.2010.04.002_bib9","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.4049\/jimmunol.171.11.6164","article-title":"Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms","volume":"171","author":"Bruewer","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.tiv.2010.04.002_bib1a","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1196\/annals.1326.017","article-title":"Inflammatory bowel disease and the apical junctional complex","volume":"1072","author":"Bruewer","year":"2006","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.tiv.2010.04.002_bib10","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1096\/fj.04-3260com","article-title":"Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process","volume":"19","author":"Bruewer","year":"2005","journal-title":"Faseb J."},{"key":"10.1016\/j.tiv.2010.04.002_bib11","first-page":"205","article-title":"Enteric bacteria, lipopolysaccharides and related cytokines in inflammatory bowel disease: biological and clinical significance","volume":"6","author":"Caradonna","year":"2000","journal-title":"J. Endotoxin Res."},{"key":"10.1016\/j.tiv.2010.04.002_bib12","doi-asserted-by":"crossref","first-page":"966","DOI":"10.4049\/jimmunol.164.2.966","article-title":"Lipopolysaccharide activates distinct signalling pathways in intestinal epithelial cell lines expressing Toll-like receptors","volume":"164","author":"Cario","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.tiv.2010.04.002_bib13","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/sj.bjp.0702827","article-title":"Regulation of induction of nitric oxide synthase and the inhibitory actions of dexamethasone in the human intestinal epithelial cell line, Caco-2: influence of cell differentiation","volume":"128","author":"Cavicchi","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tiv.2010.04.002_bib14","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1136\/gut.44.5.659","article-title":"Acquired interferon \u03b3 responsiveness during Caco-2 cell differentiation: effects on iNOS gene expression","volume":"44","author":"Chavez","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.tiv.2010.04.002_bib15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.bbcan.2006.05.002","article-title":"Mediators of PGE(2) synthesis and signalling downstream of COX-2 represent potential targets for the prevention\/treatment of colorectal cancer","volume":"1766","author":"Chell","year":"2006","journal-title":"Biochim. Biophys. Acta \u2013 Rev. Cancer"},{"key":"10.1016\/j.tiv.2010.04.002_bib16","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1053\/j.gastro.2005.01.046","article-title":"Interferon gamma induces translocation of commensal Escherichia coli across gut epithelial cells via a lipid raft-mediated process","volume":"128","author":"Clark","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tiv.2010.04.002_bib17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/med.20103","article-title":"Biological agents for ulcerative colitis: hypes and hopes","volume":"28","author":"Danese","year":"2008","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.tiv.2010.04.002_bib18","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.cellsig.2005.10.009","article-title":"Up-regulation of cyclooxygenase-2 by interleukin-1\u03b2 in colon carcinoma cells","volume":"18","author":"Duque","year":"2006","journal-title":"Cell Signal."},{"key":"10.1016\/j.tiv.2010.04.002_bib19","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/0016-5085(93)91064-O","article-title":"Differential cytokine expression by human intestinal epithelial cell lines \u2013 regulated expression of interleukin-8","volume":"105","author":"Eckmann","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tiv.2010.04.002_bib20","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1136\/gut.32.4.403","article-title":"Spontaneous release of interferon gamma by intestinal lamina propria lymphocytes in Crohn\u2019s disease. Kinetics of in vitro response to interferon y inducers","volume":"32","author":"Fais","year":"1991","journal-title":"Gut"},{"key":"10.1016\/j.tiv.2010.04.002_bib21","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/00024382-200203000-00004","article-title":"Lipopolysaccharide-induced enterocyte-derived nitric oxide induces intestinal monolayer permeability in an autocrine fashion","volume":"17","author":"Forsythe","year":"2002","journal-title":"Shock"},{"key":"10.1016\/j.tiv.2010.04.002_bib22","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.surg.2004.05.008","article-title":"P38 MAP kinase mediates endotoxin-induced expression of cyclooxygenase-2 in enterocytes","volume":"136","author":"Grishin","year":"2004","journal-title":"Surgery"},{"key":"10.1016\/j.tiv.2010.04.002_bib23","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00024382-200303000-00006","article-title":"Proinflammatory cytokines cause NO center dot-dependent and -independent changes in expression and localization of tight junction proteins in intestinal epithelial cells","volume":"19","author":"Han","year":"2003","journal-title":"Shock"},{"key":"10.1016\/j.tiv.2010.04.002_bib24","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/jcb.20014","article-title":"Superinduction of IL-6 by cycloheximide is associated with mRNA stabilization and sustained activation of p38 map kinase and NF-kappa B in cultured Caco-2 cells","volume":"91","author":"Hershko","year":"2004","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.tiv.2010.04.002_bib25","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1189\/jlb.72.5.847","article-title":"Multiple control of interleukin-8 gene expression","volume":"72","author":"Hoffmann","year":"2002","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.tiv.2010.04.002_bib26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI117676","article-title":"A distinct array of proinflammatory cytokines is expressed in human colon epithelial-cells in response to bacterial invasion","volume":"95","author":"Jung","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tiv.2010.04.002_bib27","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/(SICI)1521-4141(199902)29:02<530::AID-IMMU530>3.0.CO;2-Y","article-title":"C\u2013X\u2013C and C\u2013C chemokine expression and secretion by the human colonic epithelial cell line, HT-29: differential effect of T lymphocyte-derived cytokines","volume":"29","author":"Kolios","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.tiv.2010.04.002_bib28","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1365-2567.2004.01984.x","article-title":"Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle","volume":"113","author":"Kolios","year":"2004","journal-title":"Immunology"},{"key":"10.1016\/j.tiv.2010.04.002_bib29","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1136\/gut.31.6.686","article-title":"Role of interleukin-1 in inflammatory bowel-disease \u2013 enhanced production during active disease","volume":"31","author":"Ligumsky","year":"1990","journal-title":"Gut"},{"key":"10.1016\/j.tiv.2010.04.002_bib30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1152\/ajpgi.00173.2003","article-title":"TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation","volume":"286","author":"Ma","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tiv.2010.04.002_bib31","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1152\/ajpgi.00412.2004","article-title":"Mechanism of TNF-alpha modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression","volume":"288","author":"Ma","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tiv.2010.04.002_bib32","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1177\/153537020623100202","article-title":"Gastrointestinal inflammation: a central component of mucosal defense and repair","volume":"231","author":"Martin","year":"2006","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.tiv.2010.04.002_bib33","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1194\/jlr.M500564-JLR200","article-title":"Arachidonic acid cascade and epithelial barrier function during Caco-2 cell differentiation","volume":"47","author":"Martin-Venegas","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tiv.2010.04.002_bib34","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/PL00000223","article-title":"Tissue cytokine and chemokine expression in inflammatory bowel disease","volume":"50","author":"McCormack","year":"2001","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.tiv.2010.04.002_bib35","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/ibd.20148","article-title":"IL-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance","volume":"13","author":"Mudter","year":"2007","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.tiv.2010.04.002_bib36","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.trsl.2006.11.009","article-title":"Immune dysfunction in inflammatory bowel disease","volume":"149","author":"Neuman","year":"2007","journal-title":"Transl. Res."},{"key":"10.1016\/j.tiv.2010.04.002_bib37","first-page":"45","article-title":"The gut as a source of inflammatory cytokines after stimulation with endotoxin","volume":"163","author":"Ogle","year":"1997","journal-title":"Eur. J. Surg."},{"key":"10.1016\/j.tiv.2010.04.002_bib38","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1365-3083.2008.02208.x","article-title":"Contribution of intestinal epithelial cells to innate immunity of the human gut \u2013 studies on polarized monolayers of colon carcinoma cells","volume":"69","author":"Ou","year":"2009","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.tiv.2010.04.002_bib39","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.4049\/jimmunol.161.7.3675","article-title":"The regulation and functional consequence of proinflammatory cytokine binding on human intestinal epithelial cells","volume":"161","author":"Panja","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.tiv.2010.04.002_bib40","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00024382-199710000-00003","article-title":"Interleukin-1 beta and interferon-gamma regulate interleukin-6 production in cultured human intestinal epithelial cells","volume":"8","author":"Parikh","year":"1997","journal-title":"Shock"},{"key":"10.1016\/j.tiv.2010.04.002_bib41","first-page":"323","article-title":"Enterocyte-like differentiation and polarization of the human-colon carcinoma cell-line caco-2 in culture","volume":"47","author":"Pinto","year":"1983","journal-title":"Biol. Cell."},{"key":"10.1016\/j.tiv.2010.04.002_bib42","first-page":"614","article-title":"Mucosal synthesis and release of PGE2 from activated eosinophils and macrophages in ulcerative colitis","volume":"90","author":"Raub","year":"1995","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.tiv.2010.04.002_bib43","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1136\/gut.39.5.684","article-title":"Increased production of tumour necrosis factor-alpha, interleukin-1 beta, and interleukin-6 by morphologically normal intestinal biopsies from patients with Crohn\u2019s disease","volume":"39","author":"Reimund","year":"1996","journal-title":"Gut"},{"key":"10.1016\/j.tiv.2010.04.002_bib44","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1365-2249.1993.tb05997.x","article-title":"Enhanced secretion of tumor-necrosis-factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear-cells from patients with ulcerative-colitis and Crohns-disease","volume":"94","author":"Reinecker","year":"1993","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.tiv.2010.04.002_bib1b","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1017\/S0007114508966666","article-title":"Modulation of signaling NF-\u03baB activation pathway by polyphenols in human intestinal Caco-2 cells","volume":"100","author":"Romier","year":"2008","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.tiv.2010.04.002_bib45","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.fct.2009.02.015","article-title":"Inhibition of inflammatory mediators by polyphenolic plant extracts in human intestinal Caco-2 cells","volume":"47","author":"Romier-Crouzet","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tiv.2010.04.002_bib46","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1053\/gast.2003.50157","article-title":"TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells","volume":"124","author":"Rosenstiel","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tiv.2010.04.002_bib47","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0953-6205(00)00090-X","article-title":"Changes in the incidence of inflammatory bowel disease: what does it mean?","volume":"11","author":"Russel","year":"2000","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.tiv.2010.04.002_bib48","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/bss0700095","article-title":"Control of the expression of inflammatory response genes","volume":"70","author":"Saklatvala","year":"2003","journal-title":"Biochem. Soc. Symp."},{"key":"10.1016\/j.tiv.2010.04.002_bib49","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.cyto.2006.02.007","article-title":"Expression of tumor necrosis factor alpha and its receptors during cellular differentiation","volume":"33","author":"Schling","year":"2006","journal-title":"Cytokine"},{"key":"10.1016\/j.tiv.2010.04.002_bib50","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00384-003-0570-4","article-title":"Interferon gamma downregulates IL-8 production in primary human colonic epithelial cells without induction of apoptosis","volume":"19","author":"Schlottmann","year":"2004","journal-title":"Int. J. Colorectal. Dis."},{"key":"10.1016\/j.tiv.2010.04.002_bib51","first-page":"85","article-title":"Colonic epithelial cell lines as a source of interleukin-8: stimulation by inflammatory cytokines and bacterial lipopolysaccharide","volume":"81","author":"Schuerer-Maly","year":"1994","journal-title":"Immunology"},{"key":"10.1016\/j.tiv.2010.04.002_bib52","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0016-5085(98)70196-9","article-title":"Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease","volume":"115","author":"Singer","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tiv.2010.04.002_bib53","doi-asserted-by":"crossref","first-page":"12647","DOI":"10.1074\/jbc.M312972200","article-title":"Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease \u2013 evidence for involvement of the transcription factor Egr-1","volume":"279","author":"Subbaramaiah","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2010.04.002_bib54","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1128\/IAI.71.6.3503-3511.2003","article-title":"Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular Toll-like receptor 4-MD-2 complex","volume":"71","author":"Suzuki","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tiv.2010.04.002_bib55","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0090-6980(02)00024-2","article-title":"Cyclooxygenase isozymes and their gene structures and expression","volume":"68\u201369","author":"Tanabe","year":"2002","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.tiv.2010.04.002_bib56","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.toxlet.2008.01.018","article-title":"Influence of deoxynivalenol on NF-[kappa]B activation and IL-8 secretion in human intestinal Caco-2 cells","volume":"177","author":"Van De Walle","year":"2008","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2010.04.002_bib57","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0887-2333(01)00023-6","article-title":"Nitric oxide production in Caco-2 cells exposed to different inducers, inhibitors and natural toxins","volume":"15","author":"Vignoli","year":"2001","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2010.04.002_bib58","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s11626-996-0017-7","article-title":"Factors affecting Caco-2 intestinal epithelial cell interleukin-6 secretion","volume":"34","author":"Vitkus","year":"1998","journal-title":"In Vitro Cell Dev. Biol. Anim."},{"key":"10.1016\/j.tiv.2010.04.002_bib59","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1053\/j.gastro.2006.08.022","article-title":"IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction","volume":"131","author":"Wang","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tiv.2010.04.002_bib60","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/sj.bjp.0705719","article-title":"Differential regulation of prostaglandin E biosynthesis by interferon-gamma in colonic epithelial cells","volume":"141","author":"Wright","year":"2004","journal-title":"Br. J. Pharmacol."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233310000858?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233310000858?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:28:06Z","timestamp":1760135286000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233310000858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0887233310000858"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2010.04.002","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammatory parameters in Caco-2 cells: Effect of stimuli nature, concentration, combination and cell differentiation","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2010.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}