{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:47:15Z","timestamp":1788817635720,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.tiv.2010.06.012","type":"journal-article","created":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T04:48:52Z","timestamp":1277959732000},"page":"1-6","source":"Crossref","is-referenced-by-count":14,"title":["Hexavalent chromium inhibited the expression of RKIP of heart in vivo and in vitro"],"prefix":"10.1016","volume":"25","author":[{"given":"Huoy-Rou","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Der-An","family":"Tsao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chang","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2010.06.012_b0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0300-483X(02)00378-5","article-title":"Cytotoxicity and oxidative mechanisms of different forms of chromium","volume":"180","author":"Bagchi","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.tiv.2010.06.012_b0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1462-9011(02)00028-X","article-title":"Chromium-based regulations and greening in metal finishing industries in the USA","volume":"5","author":"Baral","year":"2002","journal-title":"Environ. Sci. Policy"},{"key":"10.1016\/j.tiv.2010.06.012_b0015","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1081\/CLT-100102418","article-title":"Chromium","volume":"37","author":"Barceloux","year":"1999","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.tiv.2010.06.012_b0020","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0041-008X(91)90279-N","article-title":"Distribution of chromium within cells of the blood","volume":"108","author":"Coogan","year":"1991","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2010.06.012_b0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1006\/enrs.1998.3840","article-title":"in vitro reduction kinetics of hexavalent chromium in human blood","volume":"78","author":"Corbett","year":"1998","journal-title":"Environ. Res."},{"key":"10.1016\/j.tiv.2010.06.012_b0030","doi-asserted-by":"crossref","unstructured":"Corbit, K.C., Trakul, N., Eves, E.M., Diaz, B., Marshall, M., Rosner, M.R., 2003. Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein. J. Biol. Chem. M210015200.","DOI":"10.1074\/jbc.M210015200"},{"key":"10.1016\/j.tiv.2010.06.012_b0035","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3109\/10408449709078442","article-title":"Toxicity and carcinogenicity of Cr (VI) in animal models and humans","volume":"27","author":"Costa","year":"1997","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.tiv.2010.06.012_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0041-008X(03)00011-5","article-title":"Potential hazards of hexavalent chromate in our drinking water","volume":"188","author":"Costa","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2010.06.012_b0045","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0378-4274(90)90069-X","article-title":"Testicular toxicity following short-term exposure to tri- and hexavalent chromium: an experimental study in the rat","volume":"51","author":"Ernst","year":"1990","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2010.06.012_b0050","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1556\/AVet.49.2001.2.10","article-title":"Absorption of inorganic, trivalent and hexavalent chromium following oral and intrajejunal doses in rats","volume":"49","author":"Febel","year":"2001","journal-title":"Acta Vet. Hung."},{"key":"10.1016\/j.tiv.2010.06.012_b0055","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2174\/157016106777698351","article-title":"Vascular effects of ambient pollutant particles and metals","volume":"4","author":"Huang","year":"2006","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.tiv.2010.06.012_b0060","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.envpol.2007.06.012","article-title":"Human health effects of air pollution","volume":"151","author":"Kampa","year":"2008","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tiv.2010.06.012_b0065","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.bcp.2004.04.024","article-title":"The role of Raf kinase inhibitor protein (RKIP) in health and disease","volume":"68","author":"Keller","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tiv.2010.06.012_b0070","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/jcb.20169","article-title":"The biology of a prostate cancer metastasis suppressor protein: Raf kinase inhibitor protein","volume":"94","author":"Keller","year":"2005","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.tiv.2010.06.012_b0075","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0041-008X(96)80020-2","article-title":"Absorption and elimination of trivalent and hexavalent chromium in humans following ingestion of a bolus dose in drinking water","volume":"141","author":"Kerger","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"43","key":"10.1016\/j.tiv.2010.06.012_b0080","doi-asserted-by":"crossref","first-page":"39772","DOI":"10.1074\/jbc.M106991200","article-title":"Human phosphatidylethanolamine-binding protein facilitates heterotrimeric G protein-dependent signaling","volume":"276","author":"Kroslak","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"6966","key":"10.1016\/j.tiv.2010.06.012_b0085","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/nature02158","article-title":"Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2","volume":"426","author":"Lorenz","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.tiv.2010.06.012_b0090","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1289\/ehp.02110875","article-title":"The association of particulate air metal concentrations with heart rate variability","volume":"110","author":"Magari","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tiv.2010.06.012_b0095","first-page":"742","article-title":"Acute pulmonary complications following inhalation of chromic acid mist","volume":"2","author":"Meyers","year":"1950","journal-title":"Ann. Ind. Hyg. Occup. Med."},{"key":"10.1016\/j.tiv.2010.06.012_b0100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mrfmmm.2003.09.006","article-title":"Complexities of chromium carcinogenesis: role of cellular response, repair and recovery mechanisms","volume":"533","author":"O\u2019Brien","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.tiv.2010.06.012_b0105","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0065-230X(04)91005-6","article-title":"Raf-1 kinase inhibitor protein: structure, function, regulation of cell signaling, and pivotal role in apoptosis","volume":"91","author":"Odabaei","year":"2004","journal-title":"Adv. Cancer Res."},{"issue":"1\/2","key":"10.1016\/j.tiv.2010.06.012_b0110","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0006-8993(95)00951-6","article-title":"Demonstration of deacetylated hippocampal cholinergic neurostimulating peptide and its precursor protein in rat tissues","volume":"701","author":"Ojika","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.tiv.2010.06.012_b0115","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1080\/15287390306388","article-title":"Human health risk and exposure assessment of chromium (VI) in tap water","volume":"66","author":"Paustenbach","year":"2003","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.tiv.2010.06.012_b0120","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.envres.2009.12.004","article-title":"Cadmium exposure in association with history of stroke and heart failure","volume":"110","author":"Peters","year":"2010","journal-title":"Environ. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.tiv.2010.06.012_b0125","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/08958370701495238","article-title":"Cardiovascular effects of fine particulate matter components in highway patrol officers","volume":"19","author":"Riediker","year":"2007","journal-title":"Inhalation Toxicol."},{"key":"10.1016\/j.tiv.2010.06.012_b0130","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/10590500600614337","article-title":"Review of the evidence regarding the carcinogenicity of hexavalent chromium in drinking water","volume":"24","author":"Sedman","year":"2006","journal-title":"J. Environ. Sci. Health, Part C"},{"key":"10.1016\/j.tiv.2010.06.012_b0135","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1385\/BTER:74:1:41","article-title":"Rats retain chromium in tissues following chronic ingestion of drinking water containing hexavalent chromium","volume":"74","author":"Sutherland","year":"2000","journal-title":"Biol. Trace Elem. Res."},{"issue":"2","key":"10.1016\/j.tiv.2010.06.012_b0140","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0169-328X(95)00029-R","article-title":"Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid binding protein. Brain Res","volume":"30","author":"Tohdoh","year":"1995","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.tiv.2010.06.012_b0145","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/sj.cr.7290258","article-title":"Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein","volume":"15","author":"Trakul","year":"2005","journal-title":"Cell Res."},{"key":"10.1016\/j.tiv.2010.06.012_b0150","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0300-483X(00)00254-7","article-title":"Chromium (VI) induces oxidative stress in the mouse brain","volume":"150","author":"Travacio","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.tiv.2010.06.012_b0155","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/taap.1999.8871","article-title":"The change of beta-adrenergic system in lead-induced hypertension","volume":"164","author":"Tsao","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2010.06.012_b0160","doi-asserted-by":"crossref","first-page":"839","DOI":"10.3109\/00498258609038965","article-title":"Disposition of a soluble chromate in the isolated perfused rat liver","volume":"16","author":"Wiegand","year":"1986","journal-title":"Xenobiotica"},{"key":"10.1016\/j.tiv.2010.06.012_b0165","doi-asserted-by":"crossref","first-page":"6749","DOI":"10.1038\/43686","article-title":"Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP","volume":"401","author":"Yeung","year":"1999","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.tiv.2010.06.012_b0170","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1128\/MCB.20.9.3079-3085.2000","article-title":"Mechanism of suppression of the Raf\/MEK\/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein","volume":"20","author":"Yeung","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tiv.2010.06.012_b0175","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1023\/A:1022504826342","article-title":"Chromium in the environment: factors affecting biological remediation","volume":"249","author":"Zayed","year":"2003","journal-title":"Plant Soil"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233310001542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233310001542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T12:49:10Z","timestamp":1559220550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233310001542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0887233310001542"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2010.06.012","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}