{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:05:14Z","timestamp":1770509114630,"version":"3.49.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.tiv.2010.07.009","type":"journal-article","created":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T09:15:45Z","timestamp":1279271745000},"page":"1521-1531","source":"Crossref","is-referenced-by-count":28,"title":["Biological effects and comparative cytotoxicity of thermal transformed asbestos-containing materials in a human alveolar epithelial cell line"],"prefix":"10.1016","volume":"24","author":[{"given":"Federica","family":"Giantomassi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro F.","family":"Gualtieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lory","family":"Santarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Tomasetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gigliola","family":"Lusvardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guendalina","family":"Lucarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Governa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armanda","family":"Pugnaloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2010.07.009_bib1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1067\/mlc.2001.114826","article-title":"Asbestos causes apoptosis in alveolar epithelial cells: role of iron-induced free radicals","volume":"137","author":"Aljandali","year":"2001","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.tiv.2010.07.009_bib2","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.cellbi.2006.06.016","article-title":"Analysis of cycloheximide-induced apoptosis in human leukocytes: fluorescence microscopy using annexin V\/propidium iodide versus acridin orange\/ethidium bromide","volume":"30","author":"Baski\u0107","year":"2006","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.tiv.2010.07.009_bib3","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.tiv.2006.10.007","article-title":"In vitro toxicity evaluation of single walled carbon nanotubes on human A549 lung cells","volume":"21","author":"Davoren","year":"2007","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2010.07.009_bib4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/089583701753338613","article-title":"Inflammation caused by particles and fibres","volume":"14","author":"Donaldson","year":"2002","journal-title":"Inhal Toxicol"},{"key":"10.1016\/j.tiv.2010.07.009_bib5","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/oem.2004.013243","article-title":"Nanotoxicology","volume":"61","author":"Donaldson","year":"2004","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.tiv.2010.07.009_bib6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1743-8977-2-9","article-title":"ROS-mediated genotoxicity of asbestos-cement in mammalian lung cells in vitro","volume":"2","author":"Dopp","year":"2005","journal-title":"Part Fibre Toxicol"},{"key":"10.1016\/j.tiv.2010.07.009_bib7","unstructured":"D\u2019Orsi, F., 2007. Amianto. Valutazione, controllo, bonifica. Manuale per la gestione del rischio. EPC Libri."},{"key":"10.1016\/j.tiv.2010.07.009_bib8","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1002\/chem.200500709","article-title":"Interaction of bovine serum albumin with chrysotile: Spectroscopic and morphological studies","volume":"12","author":"Falini","year":"2006","journal-title":"Chemistry"},{"key":"10.1016\/j.tiv.2010.07.009_bib9","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/S0891-5849(03)00149-7","article-title":"Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis","volume":"34","author":"Fubini","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tiv.2010.07.009_bib10","first-page":"83","article-title":"Cytotoxicity and reactive oxygen species generation from aggregated carbon and carbonaceous nanoparticulate materials","volume":"3","author":"Garza","year":"2008","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.tiv.2010.07.009_bib11","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.taap.2004.11.021","article-title":"Different cellular responses evoked by natural and stoichiometric synthetic chrysotile asbestos","volume":"206","author":"Gazzano","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2010.07.009_bib12","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jhazmat.2007.12.016","article-title":"In situ ESEM study of the thermal decomposition of chrysotile asbestos in view of safe recycling of the transformation product","volume":"156","author":"Gualtieri","year":"2008","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tiv.2010.07.009_bib13","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jhazmat.2007.07.037","article-title":"The transformation sequence of cement-asbestos slates up to 1200\u00b0C and safe recycling of the reaction product in stoneware tile mixtures","volume":"152","author":"Gualtieri","year":"2008","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tiv.2010.07.009_bib14","doi-asserted-by":"crossref","unstructured":"Guthrie, G.D., Jr. and Mossman, B.T., 1994. Health Effects of Mineral Dusts. Reviews in Mineralogy, vol. 28.","DOI":"10.1515\/9781501509711"},{"key":"10.1016\/j.tiv.2010.07.009_bib15","unstructured":"Halliwell, B., Gutteridge, J.M.C., 1999. Free radicals in biology and medicine. Oxford: Oxford Univ Pr. Italian Decree D.M. 29\/07\/2004, no. 248, G.U. 05\/10\/2004, no. 234 \u201cRules and regulations regarding the determination and management of the recycling activities of the asbestos and asbestos containing products\u201d."},{"key":"10.1016\/j.tiv.2010.07.009_bib16","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1365-2133.1995.tb02748.x","article-title":"Prognostic value of Ki67 antigen expression in basal cell carcinomas","volume":"133","author":"Healy","year":"1995","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.tiv.2010.07.009_bib17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.trsl.2009.01.004","article-title":"Asbestos-induced lung diseases: An update","volume":"153","author":"Kamp","year":"2009","journal-title":"Transl Res"},{"key":"10.1016\/j.tiv.2010.07.009_bib18","first-page":"6","article-title":"Comparative toxicity of 24 manufactured nanoparticles in human alveolar epithelial and macrophage cell lines","volume":"30","author":"Lanone","year":"2009","journal-title":"Part Fibre Toxicol"},{"key":"10.1016\/j.tiv.2010.07.009_bib19","doi-asserted-by":"crossref","unstructured":"Liu, G, Beri R, Mueller, A, Kamp, DW. Molecular mechanisms of asbestos-induced lung epithelial cell apoptosis. Chem Biol Interact. 2010 Apr 7. [Epub ahead of print].","DOI":"10.1016\/j.cbi.2010.03.047"},{"key":"10.1016\/j.tiv.2010.07.009_bib20","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1126\/science.2153315","article-title":"Asbestos scientific developments and implications for public policy","volume":"248","author":"Mossman","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.tiv.2010.07.009_bib21","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0005-2760(79)90061-4","article-title":"Cell line A549 as a model of the type II pneumocyte. Phospholipid biosynthesis from native and organometallic precursors","volume":"573","author":"Nardone","year":"1979","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tiv.2010.07.009_bib22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0162-0134(00)00191-4","article-title":"Free radical activity of natural and heat treated amphibole asbestos","volume":"83","author":"Otero Are\u00e1n","year":"2001","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.tiv.2010.07.009_bib23","doi-asserted-by":"crossref","unstructured":"\u00d8vrevik J, Refsnes M, Namork E, Becher R, Sandnes D, Schwarze PE, L\u00e5g M. Mechanisms of silica-induced IL-8 release from A549 cells: initial kinase-activation does not require EGFR activation or particle uptake. Toxicology. 2006 Oct 3;227(1-2):105-16. Epub 2006 Aug 11.","DOI":"10.1016\/j.tox.2006.07.029"},{"key":"10.1016\/j.tiv.2010.07.009_bib24","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1165\/rcmb.2005-0352OC","article-title":"P53 mediates amosite asbestos-induced alveolar epithelial cell mitochondria-regulated apoptosis","volume":"34","author":"Panduri","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.tiv.2010.07.009_bib25","first-page":"100","article-title":"Production of oxygen radicals by the reduction of oxygen arising from the surface activity of mineral fibres","volume":"90","author":"Pezerat","year":"1989","journal-title":"IARC Sci. Publ."},{"key":"10.1016\/j.tiv.2010.07.009_bib26","unstructured":"Pugnaloni, A., Lucarini, G., Giantomassi, F., Lombardo, L., Capella, S., Belluso, E., Zizzi, A., Panico, A.M., Biagini, G., Cardile, V., 2007. In vitro study of biofunctional indicators after exposure to asbestos-like fluoro-edenite fibres. Cell Mol Biol (Noisy-le-grand) 53 Suppl,OL965-80."},{"issue":"2","key":"10.1016\/j.tiv.2010.07.009_bib27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.acthis.2008.10.002","article-title":"Effects of asbestiform antigorite on human alveolar epithelial A549 cells: A morphological and immunohistochemical study","volume":"112","author":"Pugnaloni","year":"2010","journal-title":"Acta Histochem."},{"key":"10.1016\/j.tiv.2010.07.009_bib28","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1023\/A:1007429904664","article-title":"Apoptosis: Identification of dying cells","volume":"14","author":"Renvoize","year":"1998","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.tiv.2010.07.009_bib29","series-title":"Asbestos in the Natural Environment","author":"Schreier","year":"1989"},{"issue":"9","key":"10.1016\/j.tiv.2010.07.009_bib30","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0891-5849(03)00060-1","article-title":"Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases","volume":"34","author":"Shukla","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tiv.2010.07.009_bib31","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/1420326X03037003","article-title":"Mineralogy of asbestos minerals","volume":"12","author":"Skinner","year":"2003","journal-title":"Indoor and Built Environment"},{"key":"10.1016\/j.tiv.2010.07.009_bib32","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0887-2333(03)00118-8","article-title":"Effects of the new-identified amphibole fluoro-edenite in lung epithelial cells","volume":"17","author":"Travaglione","year":"2003","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2010.07.009_bib33","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1177\/153537020322800602","article-title":"Asbestos-induced pulmonary toxicity: role of DNA damage and apoptosis","volume":"228","author":"Upadhyay","year":"2006","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.tiv.2010.07.009_bib34","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1289\/ehp.8351357","article-title":"Thermal modification of chrysotile asbestos: evidence for decreased cytotoxicity","volume":"51","author":"Valentine","year":"1983","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tiv.2010.07.009_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2005.12.009","article-title":"Free radicals, metals and antioxidants in oxidative stress-induced cancer","volume":"10","author":"Valko","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tiv.2010.07.009_bib36","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/00007611-199206000-00009","article-title":"Asbestos-related lung disease","volume":"85","author":"Westerfied","year":"1992","journal-title":"South Medical Journal"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233310001700?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233310001700?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T04:10:57Z","timestamp":1559275857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233310001700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0887233310001700"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2010.07.009","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}