{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:29:26Z","timestamp":1761708566227,"version":"3.37.3"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.tiv.2010.08.006","type":"journal-article","created":{"date-parts":[[2010,8,22]],"date-time":"2010-08-22T08:39:31Z","timestamp":1282466371000},"page":"7-12","source":"Crossref","is-referenced-by-count":11,"title":["Valproic acid alters mitochondrial cholesterol transport in Y1 adrenocortical cells"],"prefix":"10.1016","volume":"25","author":[{"given":"L.","family":"Brion","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gorostizaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.V.","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.J.","family":"Podest\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Cornejo Maciel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Paz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2010.08.006_b0005","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1081\/ERC-200043909","article-title":"Multiple contributions from long-chain fatty acid metabolism in Y-1 and MA-10 cells","volume":"30","author":"Artemenko","year":"2004","journal-title":"Endocr. Res."},{"key":"10.1016\/j.tiv.2010.08.006_b0010","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1177\/08830738050200101501","article-title":"Serum insulin, leptin, and neuropeptide y levels in epileptic children treated with valproate","volume":"20","author":"Aydin","year":"2005","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.tiv.2010.08.006_b0015","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1210\/en.2002-220987","article-title":"Adrenocorticotropin induces mitogen-activated protein kinase phosphatase 1 in Y1 mouse adrenocortical tumor cells","volume":"144","author":"Bey","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.tiv.2010.08.006_b0020","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1080\/09513590802288259","article-title":"Polycystic ovary syndrome in women using valproate: a review","volume":"24","author":"Bilo","year":"2008","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.tiv.2010.08.006_b0025","doi-asserted-by":"crossref","first-page":"8837","DOI":"10.1074\/jbc.M709221200","article-title":"Steroidogenic activity of StAR requires contact with mitochondrial VDAC1 and phosphate carrier protein","volume":"283","author":"Bose","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2010.08.006_b0030","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1210\/jcem-62-2-413","article-title":"Steroid inhibitory effects upon human adrenal 3 beta-hydroxysteroid dehydrogenase activity","volume":"62","author":"Byrne","year":"1986","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tiv.2010.08.006_b0035","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1111\/j.1742-4658.2006.05496.x","article-title":"CAMP increases mitochondrial cholesterol transport through the induction of arachidonic acid release inside this organelle in Leydig cells","volume":"273","author":"Castillo","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.tiv.2010.08.006_b0040","doi-asserted-by":"crossref","first-page":"28314","DOI":"10.1016\/S0021-9258(18)46930-X","article-title":"The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR)","volume":"269","author":"Clark","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2010.08.006_b0045","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1677\/jme.1.01691","article-title":"An arachidonic acid-preferring acyl-CoA synthetase is a hormone-dependent and obligatory protein in the signal transduction pathway of steroidogenic hormones","volume":"34","author":"Cornejo Maciel","year":"2005","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.tiv.2010.08.006_b0050","doi-asserted-by":"crossref","first-page":"8144","DOI":"10.1016\/S0021-9258(19)70620-6","article-title":"Intracellular movement of cholesterol in rat adrenal cells. Kinetics and effects of inhibitors","volume":"255","author":"Crivello","year":"1980","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2010.08.006_b0055","doi-asserted-by":"crossref","first-page":"7284","DOI":"10.1128\/MCB.00476-07","article-title":"Histone deacetylase inhibitors reduce steroidogenesis through SCF-mediated ubiquitination and degradation of steroidogenic factor 1 (NR5A1)","volume":"27","author":"Chen","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tiv.2010.08.006_b0060","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1016\/j.febslet.2007.07.040","article-title":"An arachidonic acid generation\/export system involved in the regulation of cholesterol transport in mitochondria of steroidogenic cells","volume":"581","author":"Duarte","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tiv.2010.08.006_b0065","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.bbrc.2007.12.157","article-title":"Histone acetylation is not an accurate predictor of gene expression following treatment with histone deacetylase inhibitors","volume":"367","author":"Ellis","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tiv.2010.08.006_b0070","first-page":"5488","article-title":"Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis","volume":"50","author":"Gazdar","year":"1990","journal-title":"Cancer Res."},{"key":"10.1016\/j.tiv.2010.08.006_b0075","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1528-1157.2001.28899.x","article-title":"On the association between valproate and polycystic ovary syndrome","volume":"42","author":"Genton","year":"2001","journal-title":"Epilepsia"},{"issue":"Suppl. 1","key":"10.1016\/j.tiv.2010.08.006_b0080","article-title":"Valproic acid: an old drug newly discovered as inhibitor of histone deacetylases","volume":"83","author":"Gottlicher","year":"2004","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.tiv.2010.08.006_b0085","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0163-7258(02)00299-1","article-title":"Lithium and valproic acid: parallels and contrasts in diverse signaling contexts","volume":"96","author":"Gurvich","year":"2002","journal-title":"Pharmacol. Ther."},{"issue":"Suppl.","key":"10.1016\/j.tiv.2010.08.006_b0090","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1600-0404.2009.01206.x","article-title":"Differential effects of antiepileptic drugs on steroidogenesis in a human in vitro cell model","author":"Gustavsen","year":"2009","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.tiv.2010.08.006_b0095","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1530\/acta.0.1180381","article-title":"Neuroendocrine effects of chronic administration of sodium valproate in epileptic patients","volume":"118","author":"Invitti","year":"1988","journal-title":"Acta Endocrinol. (Copenh)"},{"key":"10.1016\/j.tiv.2010.08.006_b0100","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1016\/S0006-3495(01)76225-X","article-title":"Continuum solvent model studies of the interactions of an anticonvulsant drug with a lipid bilayer","volume":"80","author":"Kessel","year":"2001","journal-title":"Biophys. J."},{"key":"10.1016\/j.tiv.2010.08.006_b0105","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.tiv.2010.08.006_b0110","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.bbabio.2007.06.007","article-title":"Valproic acid metabolites inhibit dihydrolipoyl dehydrogenase activity leading to impaired 2-oxoglutarate-driven oxidative phosphorylation","volume":"1767","author":"Lu\u00eds","year":"2007","journal-title":"Biochim. Biophys. Acta (BBA) \u2013 Bioenerg."},{"key":"10.1016\/j.tiv.2010.08.006_b0115","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1677\/JME-08-0095","article-title":"The nuclear receptors NUR77 and SF1 play additive roles with c-JUN through distinct elements on the mouse star promoter","volume":"42","author":"Martin","year":"2009","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.tiv.2010.08.006_b0120","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bbalip.2007.02.012","article-title":"Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter","volume":"1771","author":"Miller","year":"2007","journal-title":"Biochim. Biophys. Acta (BBA) \u2013 Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.tiv.2010.08.006_b0125","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1073\/pnas.79.6.1727","article-title":"Compartmentalization of corticotropin-dependent steroidogenic factors in adrenal cortex: evidence for a post-translational cascade in stimulation of the cholesterol side-chain split","volume":"79","author":"Neher","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tiv.2010.08.006_b0130","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1210\/en.2003-0940","article-title":"Valproate potentiates androgen biosynthesis in human ovarian theca cells","volume":"145","author":"Nelson-DeGrave","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.tiv.2010.08.006_b0135","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1210\/er.18.3.361","article-title":"Steroidogenic factor 1: a key determinant of endocrine development and function","volume":"18","author":"Parker","year":"1997","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tiv.2010.08.006_b0140","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1677\/joe.0.1750793","article-title":"Protein tyrosine phosphatases are involved in LH\/chorionic gonadotropin and 8Br-cAMP regulation of steroidogenesis and StAR protein levels in MA-10 Leydig cells","volume":"175","author":"Paz","year":"2002","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.tiv.2010.08.006_b0145","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0026-895X(25)15037-2","article-title":"Membrane-disordering potency and anticonvulsant action of valproic acid and other short-chain fatty acids","volume":"26","author":"Perlman","year":"1984","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tiv.2010.08.006_b0150","doi-asserted-by":"crossref","first-page":"e1443","DOI":"10.1371\/journal.pone.0001443","article-title":"A mitochondrial kinase complex is essential to mediate an ERK1\/2-dependent phosphorylation of a key regulatory protein in steroid biosynthesis","volume":"3","author":"Poderoso","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tiv.2010.08.006_b0155","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.yebeh.2006.02.008","article-title":"Insulin-related metabolic changes during treatment with valproate in patients with epilepsy","volume":"8","author":"Pylvanen","year":"2006","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.tiv.2010.08.006_b0160","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1399-5618.2005.00201.x","article-title":"Reproductive function and risk for PCOS in women treated for bipolar disorder","volume":"7","author":"Rasgon","year":"2005","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.tiv.2010.08.006_b0165","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1212\/WNL.57.3.440","article-title":"Early hormonal changes during valproate or carbamazepine treatment: a 3-month study","volume":"57","author":"Rattya","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.tiv.2010.08.006_b0170","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0940-2993(01)80014-2","article-title":"Valproate, but not lamotrigine, induces ovarian morphological changes in Wistar rats","volume":"52","author":"Roste","year":"2001","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.tiv.2010.08.006_b0175","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0076-6879(79)58173-7","article-title":"Adrenocortical Y1 cells","volume":"58","author":"Schimmer","year":"1979","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.tiv.2010.08.006_b0180","first-page":"221","article-title":"Regulation of the acute production of steroids in steroidogenic cells","volume":"17","author":"Stocco","year":"1996","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tiv.2010.08.006_b0185","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0893-133X(00)00243-8","article-title":"Effects of sodium valproate on corticotropin-releasing factor systems in rat brain","volume":"24","author":"Stout","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.tiv.2010.08.006_b0190","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1101\/gad.12.5.599","article-title":"Histone acetylation and transcriptional regulatory mechanisms","volume":"12","author":"Struhl","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.tiv.2010.08.006_b0195","doi-asserted-by":"crossref","first-page":"7249","DOI":"10.1021\/bi9628984","article-title":"Multiple steroidogenic factor 1 binding elements in the human steroidogenic acute regulatory protein gene 5\u2032-flanking region are required for maximal promoter activity and cyclic AMP responsiveness","volume":"36","author":"Sugawara","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.tiv.2010.08.006_b0200","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1053\/seiz.2001.0545","article-title":"Morphological changes in the testis after long-term valproate treatment in male Wistar rats","volume":"10","author":"Sveberg Roste","year":"2001","journal-title":"Seizure"},{"key":"10.1016\/j.tiv.2010.08.006_b0205","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1111\/j.1528-1167.2006.00668.x","article-title":"Comparison of reproductive effects of levetiracetam and valproate studied in prepubertal porcine ovarian follicular cells","volume":"47","author":"Tauboll","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.tiv.2010.08.006_b0210","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0890-6238(02)00020-5","article-title":"Valproate irreversibly alters steroid secretion patterns from porcine follicular cells in vitro","volume":"16","author":"Tauboll","year":"2002","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tiv.2010.08.006_b0215","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/toxsci\/kfi185","article-title":"Valproic acid II: effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes","volume":"86","author":"Tong","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2010.08.006_b0220","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications","volume":"76","author":"Towbin","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tiv.2010.08.006_b0225","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/jcb.10738","article-title":"Antisteroidogenic actions of hydrogen peroxide on rat Leydig cells","volume":"90","author":"Tsai","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.tiv.2010.08.006_b0230","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1528-1167.2009.02206.x","article-title":"The metabolic syndrome in overweight epileptic patients treated with valproic acid","volume":"51","author":"Verrotti","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.tiv.2010.08.006_b0235","doi-asserted-by":"crossref","first-page":"31674","DOI":"10.1074\/jbc.M104309200","article-title":"The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth","volume":"276","author":"Yuan","year":"2001","journal-title":"J. Biol. Chem."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233310002092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233310002092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T23:01:29Z","timestamp":1740438089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233310002092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0887233310002092"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2010.08.006","relation":{},"ISSN":["0887-2333"],"issn-type":[{"type":"print","value":"0887-2333"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}