{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:57:09Z","timestamp":1791331029133,"version":"4.3.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.tiv.2010.12.014","type":"journal-article","created":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T09:34:37Z","timestamp":1293788077000},"page":"733-744","source":"Crossref","is-referenced-by-count":110,"title":["The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: Results of a ring-study in five laboratories"],"prefix":"10.1016","volume":"25","author":[{"given":"Natsch","family":"Andreas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bauch","family":"Caroline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foertsch","family":"Leslie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerberick","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Kimberly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilberer","family":"Allison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inglis","family":"Heather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Landsiedel","family":"Robert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onken","family":"Stefan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuter","family":"Hendrik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schepky","family":"Andreas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emter","family":"Roger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2010.12.014_b0005","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/toxsci\/kfn243","article-title":"HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1\/Nrf2 pathway","volume":"107","author":"Ade","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2010.12.014_b0010","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/j.0022-202X.2004.22402.x","article-title":"Characterization of the sensitizing potential of chemicals by in vitro analysis of dendritic cell activation and skin penetration","volume":"122","author":"Aeby","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.tiv.2010.12.014_b0015","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.tiv.2005.10.012","article-title":"Development of an in vitro skin sensitization test using human cell lines: the human cell line activation test (h-CLAT) I. Optimization of the h-CLAT protocol","volume":"20","author":"Ashikaga","year":"2006","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2010.12.014_b0020","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0278-6915(01)00130-2","article-title":"Local lymph node assay \u2013 validation, conduct and use in practice","volume":"40","author":"Basketter","year":"2002","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tiv.2010.12.014_b0025","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/jat.1443","article-title":"Updating the skin sensitization in vitro data assessment paradigm in 2009","volume":"29","author":"Basketter","year":"2009","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tiv.2010.12.014_b0030","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0278-6915(99)00112-X","article-title":"Threshold for classification as a skin sensitizer in the local lymph node assay: a statistical evaluation","volume":"37","author":"Basketter","year":"1999","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tiv.2010.12.014_b0035","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1083\/jcb.106.3.761","article-title":"Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line","volume":"106","author":"Boukamp","year":"1988","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tiv.2010.12.014_b0040","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1177\/026119290903700313","article-title":"Selection of chemicals for the development and evaluation of in vitro methods for skin sensitisation testing","volume":"37","author":"Casati","year":"2009","journal-title":"Altern. Lab. Anim."},{"key":"10.1016\/j.tiv.2010.12.014_b0045","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.tiv.2009.04.005","article-title":"Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens","volume":"23","author":"Corsini","year":"2009","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2010.12.014_b0050","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.taap.2010.03.009","article-title":"Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro","volume":"245","author":"Emter","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2010.12.014_b0055","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/026119290803600210","article-title":"Chemical reactivity measurement and the predictive identification of skin sensitisers","volume":"36","author":"Gerberick","year":"2008","journal-title":"ATLA Altern. Lab. Anim."},{"key":"10.1016\/j.tiv.2010.12.014_b0060","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1038\/sj.jid.5700319","article-title":"Identification of gene expression changes induced by chemical allergens in dendritic cells: opportunities for skin sensitization testing","volume":"126","author":"Gildea","year":"2006","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.tiv.2010.12.014_b0065","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.taap.2008.03.014","article-title":"A cell-based in vitro alternative to identify skin sensitizers by gene expression","volume":"231","author":"Hooyberghs","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2010.12.014_b0070","unstructured":"ICCVAM, 2008a. ICCVAM database, downloaded in December 2008 from http:\/\/iccvam.niehs.nih.gov\/methods\/immunotox\/LLNA-pot\/appx\/LLNApotencyAppB18Jan08FD.xls."},{"key":"10.1016\/j.tiv.2010.12.014_b0075","unstructured":"ICCVAM, 2008b. Revised Draft ICCVAM LLNA Performance Standards. Downloaded in December 2008 from http:\/\/iccvam.niehs.nih.gov\/methods\/immunotox\/PerfStds\/LLNAPerfStd07Jan08FD.pdf."},{"key":"10.1016\/j.tiv.2010.12.014_b0080","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/jat.1146","article-title":"A future approach to measuring relative skin sensitising potency: a proposal","volume":"26","author":"Jowsey","year":"2006","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tiv.2010.12.014_b0085","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1021\/tx7002239","article-title":"Allergic contact dermatitis\u2013formation, structural requirements, and reactivity of skin sensitizers","volume":"21","author":"Karlberg","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tiv.2010.12.014_b0090","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1567-5769(01)00173-4","article-title":"Allergic contact dermatitis","volume":"2","author":"Kimber","year":"2002","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tiv.2010.12.014_b0095","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.taap.2009.01.026","article-title":"THP-1 monocytes but not macrophages as a potential alternative for CD34+ dendritic cells to identify chemical skin sensitizers","volume":"236","author":"Lambrechts","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2010.12.014_b0100","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/toxsci\/kfp228","article-title":"The Nrf2-Keap1-ARE toxicity pathway as a cellular sensor for skin sensitizers\u2013functional relevance and a hypothesis on innate reactions to skin sensitizers","volume":"113","author":"Natsch","year":"2010","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.tiv.2010.12.014_b0105","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/toxsci\/kfm259","article-title":"Skin sensitizers induce antioxidant response element dependent genes: application to the in vitro testing of the sensitization potential of chemicals","volume":"102","author":"Natsch","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2010.12.014_b0110","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/toxsci\/kfn204","article-title":"Filling the concept with data: integrating data from different in vitro and in silico assays on skin sensitizers to explore the battery approach for animal-free skin sensitization testing","volume":"107","author":"Natsch","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2010.12.014_b0115","doi-asserted-by":"crossref","unstructured":"Python, F., Goebel, C., Aeby, P., 2009. Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde. Toxicol. Appl. Pharmacol.","DOI":"10.1016\/j.taap.2009.06.003"},{"key":"10.1016\/j.tiv.2010.12.014_b0120","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1021\/tx700169w","article-title":"TIMES-SS \u2013 A mechanistic evaluation of an external validation study using reaction chemistry principles","volume":"20","author":"Roberts","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tiv.2010.12.014_b0125","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.toxlet.2004.02.002","article-title":"Gene expression changes in peripheral blood-derived dendritic cells following exposure to a contact allergen","volume":"150","author":"Ryan","year":"2004","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2010.12.014_b0130","unstructured":"Sens-it-iv, 2009. Sens-it-iv Newsletter 32, October, 12, 2009. Downloaded June 2010 from http:\/\/www.sens-it-iv.eu\/files\/newsletter\/Sens-it-iv_Newsletter_32.html."},{"key":"10.1016\/j.tiv.2010.12.014_b0135","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.tiv.2005.06.039","article-title":"CXCL8 secretion by dendritic cells predicts contact allergens from irritants","volume":"20","author":"Toebak","year":"2006","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2010.12.014_b0140","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.reprotox.2009.12.002","article-title":"ReProGlo: a new stem cell-based reporter assay aimed to predict embryotoxic potential of drugs and chemicals","volume":"30","author":"Uibel","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tiv.2010.12.014_b0145","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.reprotox.2010.04.012","article-title":"Optimization and prevalidation of the in vitro AR CALUX method to test androgenic and antiandrogenic activity of compounds","volume":"30","author":"van der Burg","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tiv.2010.12.014_b0150","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/toxsci\/kfq182","article-title":"Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds","volume":"117","author":"Vandebriel","year":"2010","journal-title":"Toxicol. Sci."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233310003413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233310003413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T04:41:26Z","timestamp":1592196086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233310003413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0887233310003413"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2010.12.014","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}