{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:41:28Z","timestamp":1788871288325,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008269","name":"Michigan Institute for Clinical and Health Research (MICHR)","doi-asserted-by":"crossref","award":["UL1RR024986"],"award-info":[{"award-number":["UL1RR024986"]}],"id":[{"id":"10.13039\/100008269","id-type":"DOI","asserted-by":"crossref"}]},{"name":"UM School of Public Health"},{"name":"NIEHS Environmental Toxicology and Epidemiology Training Grant","award":["T32007062"],"award-info":[{"award-number":["T32007062"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.tiv.2012.02.005","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T08:26:08Z","timestamp":1330417568000},"page":"630-635","source":"Crossref","is-referenced-by-count":58,"title":["Variants of glutathione s-transferase pi 1 exhibit differential enzymatic activity and inhibition by heavy metals"],"prefix":"10.1016","volume":"26","author":[{"given":"Jaclyn M.","family":"Goodrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niladri","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2012.02.005_b0005","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.toxlet.2004.07.003","article-title":"The role of glutathione transferases in cadmium stress","volume":"154","author":"Adamis","year":"2004","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2012.02.005_b0010","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0006-8993(00)03185-1","article-title":"Mercuric chloride, but not methylmercury, inhibits glutamine synthetase activity in primary cultures of cortical astrocytes","volume":"891","author":"Allen","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.tiv.2012.02.005_b0015","doi-asserted-by":"crossref","first-page":"10004","DOI":"10.1074\/jbc.272.15.10004","article-title":"Molecular cloning, characterization, and expression in Escherichia coli of full length cDNAs of three human glutathione s-transferase Pi gene variants","volume":"272","author":"Ali-Osman","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2012.02.005_b0020","first-page":"99","article-title":"In vitro interaction of mercury, copper (II) and cadmium with human glutathione transferase Pi","volume":"69","author":"Almar","year":"1990","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"10.1016\/j.tiv.2012.02.005_b0025","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/0272-0590(85)90165-4","article-title":"Biliary secretion of glutathione and glutathione-metal complexes","volume":"5","author":"Ballatori","year":"1985","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.tiv.2012.02.005_b0030","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.taap.2004.09.009","article-title":"An interspecies comparison of mercury inhibition on muscarinic acetylcholine receptor binding in the cerebral cortex and cerebellum","volume":"205","author":"Basu","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2012.02.005_b0035","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.tiv.2012.02.005_b0040","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1080\/152873902760125750","article-title":"Effect of mercury vapor exposure on metallothionein and glutathione S-transferase gene expression in the kidney of nonpregnant, pregnant, and neonatal rats","volume":"65","author":"Brambila","year":"2002","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.tiv.2012.02.005_b0045","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1006\/prep.1999.1149","article-title":"Expression and purification of hexahistidine-tagged human glutathione S-transferase P1\u20131 in Escherichia coli","volume":"17","author":"Chang","year":"1999","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.tiv.2012.02.005_b0050","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2203\/dose-response.09-036.Chiang","article-title":"Defining the optimal selenium dose for prostate cancer risk reduction: Insights from the U-shaped relationship between selenium status, DNA damage, and apoptosis","volume":"8","author":"Chiang","year":"2009","journal-title":"Dose Response"},{"key":"10.1016\/j.tiv.2012.02.005_b0055","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/carcin\/bgi023","article-title":"Combinations of glutathione S-transferase genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study","volume":"26","author":"Cote","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.tiv.2012.02.005_b0060","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1080\/00039890409603438","article-title":"Polymorphisms in glutathione-related genes affect methylmercury retention","volume":"59","author":"Custodio","year":"2004","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.tiv.2012.02.005_b0065","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3200\/AEOH.60.1.17-23","article-title":"Genetic influences on the retention of inorganic mercury","volume":"60","author":"Custodio","year":"2005","journal-title":"Arch. Environ. Occup. Health"},{"key":"10.1016\/j.tiv.2012.02.005_b0070","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0300-483X(98)00080-8","article-title":"Effects of lead on rat kidney and liver: GST expression and oxidative stress","volume":"128","author":"Daggett","year":"1998","journal-title":"Toxicology"},{"key":"10.1016\/j.tiv.2012.02.005_b0075","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000459018","article-title":"In vitro inhibition of the soluble glutathione S-transferases from rat liver by heavy metals","volume":"27","author":"Dierickx","year":"1982","journal-title":"Enzyme"},{"key":"10.1016\/j.tiv.2012.02.005_b0080","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1289\/ehp.9734","article-title":"Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina","volume":"115","author":"Engstr\u00f6m","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tiv.2012.02.005_b0085","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1289\/ehp.10804","article-title":"Genetic variation in glutathione-related genes and body burden of methylmercury","volume":"116","author":"Engstr\u00f6m","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tiv.2012.02.005_b0090","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.taap.2011.09.014","article-title":"Glutathione enzyme and selenoprotein polymorphisms associate with mercury biomarker levels in Michigan dental professionals","volume":"257","author":"Goodrich","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2012.02.005_b0095","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.envres.2009.05.003","article-title":"Genetic background of lead and mercury metabolism in a group of medical students in Austria","volume":"109","author":"Gundacker","year":"2009","journal-title":"Environ. Res."},{"key":"10.1016\/j.tiv.2012.02.005_b0100","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases: the first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2012.02.005_b0105","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev.pharmtox.45.120403.095857","article-title":"Glutathione s-transferases","volume":"45","author":"Hayes","year":"2005","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.tiv.2012.02.005_b0110","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1006\/bbrc.1997.7311","article-title":"Activity of four allelic forms of glutathione s-transferase hGSTP1-1 for diol epoxides of polycyclic aromatic hydrocarbons","volume":"238","author":"Hu","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tiv.2012.02.005_b0115","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.tips.2004.02.007","article-title":"Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present, and future","volume":"25","author":"Ingelman-Sundberg","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.tiv.2012.02.005_b0120","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/00008571-200210000-00006","article-title":"Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli","volume":"12","author":"Ishimoto","year":"2002","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.tiv.2012.02.005_b0125","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1006\/jmbi.1998.1708","article-title":"Structure-activity relationships and thermal stability of human glutathione transferase P1\u20131 governed by the H-site residue 105","volume":"278","author":"Johansson","year":"1998","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.tiv.2012.02.005_b0130","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/toxsci\/kfj117","article-title":"Chronic exposure to methylated arsenicals stimulates arsenic excretion pathways and induces arsenic tolerance in rat liver cells","volume":"91","author":"Kojima","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2012.02.005_b0135","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/toxsci\/kfp066","article-title":"Cloning, expression and biochemical properties of CPOX4, a genetic variant of coproporphyrinogen oxidase that affects susceptibility to mercury toxicity in humans","volume":"109","author":"Li","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2012.02.005_b0140","first-page":"334","article-title":"Metabolic profiles in workers occupationally exposed to arsenic: role of GST polymorphisms","volume":"48","author":"Marcos","year":"2006","journal-title":"JOEM"},{"key":"10.1016\/j.tiv.2012.02.005_b0145","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.1158\/0008-5472.CAN-07-6724","article-title":"Glutathione S-transferase P1: gene sequence variation and functional genomic studies","volume":"68","author":"Moyer","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.tiv.2012.02.005_b0150","series-title":"Toxicity Testing in the 21st Century: A Vision and a Strategy","author":"National Research Council (NRC)","year":"2007"},{"key":"10.1016\/j.tiv.2012.02.005_b0155","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/jmbi.1997.1364","article-title":"The structures of human glutathione transferase P1\u20131 in complex with glutathione and various inhibitors at high resolution","volume":"274","author":"Oakley","year":"1997","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.tiv.2012.02.005_b0160","first-page":"611","article-title":"Prospects for pharmacogenetics and ecogenetics in the new millennium","volume":"29","author":"Omenn","year":"2001","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tiv.2012.02.005_b0165","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jmb.2008.04.066","article-title":"The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1\u20131: kinetic properties and crystallographic characterisation of allelic variants","volume":"380","author":"Parker","year":"2008","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.tiv.2012.02.005_b0170","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/(SICI)1099-0461(2000)14:3<169::AID-JBT7>3.0.CO;2-L","article-title":"Effects of trivalent antimony on human erythrocyte glutathione S- transferases","volume":"14","author":"Poon","year":"2000","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.tiv.2012.02.005_b0175","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/0041-008X(81)90369-0","article-title":"Cadmium, methylmercury, mercury and lead inhibition of calf liver glutathione S-transferase exhibiting selenium-independent glutathione peroxidase activity","volume":"61","author":"Reddy","year":"1981","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2012.02.005_b0180","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/abbi.1999.1217","article-title":"Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa","volume":"366","author":"Srivastava","year":"1999","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tiv.2012.02.005_b0185","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1469-1809.1987.tb01051.x","article-title":"Electrophoretic and immunological analysis of human glutathione S-transferase isozymes","volume":"51","author":"Suzuki","year":"1987","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.tiv.2012.02.005_b0190","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0378-4274(99)00230-1","article-title":"Glutathione s-transferase: genetics and role in toxicology","volume":"112\u2013113","author":"Strange","year":"2000","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2012.02.005_b0195","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1006\/bbrc.1993.1529","article-title":"Glutathione S-transferase pi facilitates the excretion of arsenic from arsenic-resistant Chinese hamster ovary cells","volume":"192","author":"Wang","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tiv.2012.02.005_b0200","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF02785294","article-title":"Comparative effects of selenite and selenate on the glutathione-related enzymes activity in pig blood platelets","volume":"57","author":"\u017bbikowska","year":"1997","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tiv.2012.02.005_b0205","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/j.1432-1033.1994.00893.x","article-title":"Naturally occurring human glutathione s-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymatic properties","volume":"224","author":"Zimniak","year":"1994","journal-title":"Eur. J. Biochem."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233312000586?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233312000586?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T13:14:28Z","timestamp":1640956468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233312000586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0887233312000586"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2012.02.005","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}