{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:00:17Z","timestamp":1791194417736,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.tiv.2012.08.005","type":"journal-article","created":{"date-parts":[[2012,8,11]],"date-time":"2012-08-11T03:50:02Z","timestamp":1344657002000},"page":"426-432","source":"Crossref","is-referenced-by-count":13,"title":["Stobadine attenuates impairment of an intestinal barrier model caused by 4-hydroxynonenal"],"prefix":"10.1016","volume":"27","author":[{"given":"Marina","family":"Cindric","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Cipak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilija","family":"Zapletal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morana","family":"Jaganjac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidija","family":"Milkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Waeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svorad","family":"Stolc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neven","family":"Zarkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunjic","family":"Suzana Borovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2012.08.005_b0005","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.3109\/10715762.2010.508495","article-title":"Natural and synthetic antioxidants: an updated overview","volume":"44","author":"Augustyniak","year":"2010","journal-title":"Free Radical Research"},{"key":"10.1016\/j.tiv.2012.08.005_b0010","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.taap.2004.11.016","article-title":"Intestinal glutathione: determinant of mucosal peroxide transport, metabolism, and oxidative susceptibility","volume":"204","author":"Aw","year":"2005","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.tiv.2012.08.005_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2007.09.012","article-title":"Lipid peroxidation: control of cell proliferation, cell differentiation and cell death","volume":"29","author":"Barrera","year":"2008","journal-title":"Molecular Aspects of Medicine"},{"key":"10.1016\/j.tiv.2012.08.005_b0020","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s12263-007-0053-2","article-title":"TGFbeta1 expression in colonic mucosa: modulation by dietary lipids","volume":"2","author":"Biasi","year":"2007","journal-title":"Genes and Nutrition"},{"key":"10.1016\/j.tiv.2012.08.005_b0025","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1136\/gut.50.3.361","article-title":"Associated changes of lipid peroxidation and transforming growth factor beta1 levels in human colon cancer during tumour progression","volume":"50","author":"Biasi","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.tiv.2012.08.005_b0030","unstructured":"Bock, U., Kottke, T., Gindorf, C., Haltner, E., 2003. Biopharmaceutics Classification, System (BCS). 1\u20137."},{"key":"10.1016\/j.tiv.2012.08.005_b0035","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/mutage\/12.4.215","article-title":"Aniline and its metabolites generate free radicals in yeast","volume":"12","author":"Brennan","year":"1997","journal-title":"Mutagenesis"},{"key":"10.1016\/j.tiv.2012.08.005_b0040","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.3109\/10715762.2010.499907","article-title":"An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples","volume":"44","author":"Breusing","year":"2010","journal-title":"Free Radical Research"},{"key":"10.1016\/j.tiv.2012.08.005_b0045","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bbalip.2008.03.010","article-title":"Adaptation to oxidative stress induced by polyunsaturated fatty acids in yeast","volume":"1781","author":"Cipak","year":"2008","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.tiv.2012.08.005_b0050","first-page":"411","article-title":"Intestinal permeability is increased in burn patients shortly after injury","volume":"107","author":"Deitch","year":"1990","journal-title":"Surgery"},{"key":"10.1016\/j.tiv.2012.08.005_b0055","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/00004836-200204000-00003","article-title":"Intestinal permeation and gastrointestinal disease","volume":"34","author":"DeMeo","year":"2002","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1016\/j.tiv.2012.08.005_b0060","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00240-005-0031-3","article-title":"Protein oxidation and lipid peroxidation after renal ischemia-reperfusion injury: protective effects of erdosteine and N-acetylcysteine","volume":"34","author":"Erdogan","year":"2006","journal-title":"Urological Research"},{"key":"10.1016\/j.tiv.2012.08.005_b0065","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/sj.bjp.0705758","article-title":"Effects of Trolox on the activity and gene expression of cytochrome P450 in hepatic ischemia\/reperfusion","volume":"142","author":"Eum","year":"2004","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.tiv.2012.08.005_b0070","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1126\/science.210504","article-title":"The biology of oxygen radicals","volume":"201","author":"Fridovich","year":"1978","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.tiv.2012.08.005_b0075","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.3109\/10715762.2010.504395","article-title":"Lipid peroxidation research in Europe and the COST B35 action \u2018Lipid Peroxidation Associated Disorders\u2019","volume":"44","author":"Grune","year":"2010","journal-title":"Free Radical Research"},{"key":"10.1016\/j.tiv.2012.08.005_b0080","first-page":"195","article-title":"Preventive effect of several antioxidants after oxidative stress on rat brain homogenates","volume":"19","author":"Horakova","year":"2000","journal-title":"General Physiology and Biophysics"},{"key":"10.1016\/j.tiv.2012.08.005_b0085","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.freeradbiomed.2004.08.027","article-title":"Signaling kinases modulated by 4-hydroxynonenal","volume":"37","author":"Leonarduzzi","year":"2004","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.tiv.2012.08.005_b0090","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1001\/archsurg.134.12.1333","article-title":"Gut-derived mesenteric lymph: a link between burn and lung injury","volume":"134","author":"Magnotti","year":"1999","journal-title":"Archives of Surgery (Chicago, Ill, 1960)"},{"key":"10.1016\/j.tiv.2012.08.005_b0095","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0304-3940(01)02299-6","article-title":"4-Hydroxynonenal impairs the permeability of an in vitro rat blood\u2013brain barrier","volume":"314","author":"Mertsch","year":"2001","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.tiv.2012.08.005_b0100","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/S0024-3205(99)00441-5","article-title":"EPR spectroscopy of free radical intermediates of antiarrhythmic\u2013antihypoxic drug stobadine, a pyridoindole derivative","volume":"65","author":"Misik","year":"1999","journal-title":"Life Sciences"},{"key":"10.1016\/j.tiv.2012.08.005_b0105","first-page":"399","article-title":"Effect of stobadine on gastric mucosal injury after ischaemia\/reperfusion","volume":"45","author":"Mojzis","year":"1996","journal-title":"Physiological Research\/Academia Scientiarum Bohemoslovaca"},{"key":"10.1016\/j.tiv.2012.08.005_b0110","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3109\/10715762.2010.498478","article-title":"Pathological aspects of lipid peroxidation","volume":"44","author":"Negre-Salvayre","year":"2010","journal-title":"Free Radical Research"},{"key":"10.1016\/j.tiv.2012.08.005_b0115","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0009-3084(87)90052-1","article-title":"Antioxidants in relation to lipid peroxidation","volume":"44","author":"Niki","year":"1987","journal-title":"Chemistry and Physics of Lipids"},{"key":"10.1016\/j.tiv.2012.08.005_b0120","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1358\/mf.2007.29.1.1063495","article-title":"Mesenteric ischemia\/reperfusion-induced intestinal and vascular damage: effect of stobadine","volume":"29","author":"Nosalova","year":"2007","journal-title":"Methods and Findings in Experimental and Clinical Pharmacology"},{"key":"10.1016\/j.tiv.2012.08.005_b0125","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1001\/archsurg.1988.01400360029003","article-title":"A single dose of endotoxin increases intestinal permeability in healthy humans","volume":"123","author":"O\u2019Dwyer","year":"1988","journal-title":"Archives of Surgery (Chicago, Ill: 1960)"},{"key":"10.1016\/j.tiv.2012.08.005_b0130","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/0005-2760(89)90228-2","article-title":"Lipid peroxidation of phosphatidylcholine liposomes depressed by the calcium channel blockers nifedipine and verapamil and by the antiarrhythmic\u2013antihypoxic drug stobadine","volume":"1003","author":"Ondrias","year":"1989","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.tiv.2012.08.005_b0135","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1445-2197.2006.04001.x","article-title":"N-acetylcysteine improves intestinal barrier in partially hepatectomized rats","volume":"77","author":"Oz","year":"2007","journal-title":"ANZ Journal of Surgery"},{"key":"10.1016\/j.tiv.2012.08.005_b0140","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/bjs.1800810619","article-title":"Increased gut permeability after multiple trauma","volume":"81","author":"Pape","year":"1994","journal-title":"The British Journal of Surgery"},{"key":"10.1016\/j.tiv.2012.08.005_b0145","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/carcin\/bgl127","article-title":"Apc mutation induces resistance of colonic cells to lipoperoxide-triggered apoptosis induced by faecal water from haem-fed rats","volume":"28","author":"Pierre","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.tiv.2012.08.005_b0150","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.tiv.2010.10.013","article-title":"Effect of ferric ions on reactive oxygen species formation, cervical cancer cell lines growth and E6\/E7 oncogene expression","volume":"25","author":"Poljak-Blazi","year":"2011","journal-title":"Toxicology In Vitro: An International Journal Published in Association with BIBRA"},{"key":"10.1016\/j.tiv.2012.08.005_b0155","doi-asserted-by":"crossref","first-page":"223","DOI":"10.18388\/abp.2010_2398","article-title":"Reduction of oxidative stress in adjuvant arthritis. Comparison of efficacy of two pyridoindoles: stobadine dipalmitate and SMe1\u00b72HCl","volume":"57","author":"Ponist","year":"2010","journal-title":"Acta Biochimica Polonica"},{"key":"10.1016\/j.tiv.2012.08.005_b0160","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1046\/j.1440-1746.2001.02444.x","article-title":"Intestinal dysfunction in liver cirrhosis: its role in spontaneous bacterial peritonitis","volume":"16","author":"Ramachandran","year":"2001","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.tiv.2012.08.005_b0165","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0022-1759(92)90008-H","article-title":"A microplate assay for the detection of oxidative products using 2\u2032,7\u2032-dichlorofluorescin-diacetate","volume":"156","author":"Rosenkranz","year":"1992","journal-title":"Journal of Immunological Methods"},{"key":"10.1016\/j.tiv.2012.08.005_b0170","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/0741-5214(93)90118-6","article-title":"Intestinal permeability is increased after major vascular surgery","volume":"17","author":"Roumen","year":"1993","journal-title":"Journal of vascular surgery: official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter"},{"key":"10.1016\/j.tiv.2012.08.005_b0175","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1006\/phrs.2002.0993","article-title":"The water-soluble vitamin E analogue Trolox protects against ischaemia\/reperfusion damage in vitro and ex vivo. A comparison with vitamin E","volume":"45","author":"Sagach","year":"2002","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.tiv.2012.08.005_b0180","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/0024-3205(95)02006-5","article-title":"4-Hydroxynonenal formation during ischemia and reperfusion of rat small intestine","volume":"57","author":"Siems","year":"1995","journal-title":"Life sciences"},{"key":"10.1016\/j.tiv.2012.08.005_b0185","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.3109\/10715762.2010.498476","article-title":"Advances in methods for the determination of biologically relevant lipid peroxidation products","volume":"44","author":"Spickett","year":"2010","journal-title":"Free Radical Research"},{"key":"10.1016\/j.tiv.2012.08.005_b0190","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1021\/tx00027a006","article-title":"Antioxidant activity of the pyridoindole stobadine. Pulse radiolytic characterization of one-electron-oxidized stobadine and quenching of singlet molecular oxygen","volume":"5","author":"Steenken","year":"1992","journal-title":"Chemical Research in Toxicology"},{"key":"10.1016\/j.tiv.2012.08.005_b0195","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/0014-5793(91)81444-D","article-title":"Pyridoindole stobadine is a potent scavenger of hydroxyl radicals","volume":"294","author":"Stefek","year":"1991","journal-title":"FEBS Letters"},{"key":"10.1016\/j.tiv.2012.08.005_b0200","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.clinbiochem.2009.06.009","article-title":"Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease","volume":"42","author":"Stojiljkovic","year":"2009","journal-title":"Clinical Biochemistry"},{"key":"10.1016\/j.tiv.2012.08.005_b0205","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1021\/mp800122b","article-title":"Biopharmaceutics classification system: validation and learnings of an in vitro permeability assay","volume":"6","author":"Thiel-Demby","year":"2009","journal-title":"Molecular Pharmaceutics"},{"key":"10.1016\/j.tiv.2012.08.005_b0210","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.freeradbiomed.2003.11.027","article-title":"Role of intestine in postsurgical complications: involvement of free radicals","volume":"36","author":"Thomas","year":"2004","journal-title":"Free radical Biology and Medicine"},{"key":"10.1016\/j.tiv.2012.08.005_b0215","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0928-0987(03)00173-8","article-title":"Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model","volume":"20","author":"Toropainen","year":"2003","journal-title":"European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences"},{"key":"10.1016\/j.tiv.2012.08.005_b0220","doi-asserted-by":"crossref","first-page":"1178997","DOI":"10.1074\/jbc.M311184200","article-title":"Role of mitogen-activated protein kinases in 4-hydroxy-2-nonenal-induced actin remodeling and barrier function in endothelial cells","volume":"279","author":"Usatyuk","year":"2004","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.tiv.2012.08.005_b0225","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.tiv.2010.04.002","article-title":"Inflammatory parameters in Caco-2 cells: effect of stimuli nature, concentration, combination and cell differentiation","volume":"24","author":"Van De Walle","year":"2010","journal-title":"Toxicology In Vitro: An International Journal Published in Association with BIBRA"},{"key":"10.1016\/j.tiv.2012.08.005_b0230","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/10715760801975743","article-title":"The distribution of 4-hydroxynonenal-modified proteins in gastric mucosa of duodenal peptic ulcer patients","volume":"42","author":"Yelisyeyeva","year":"2008","journal-title":"Free Radical Research"},{"key":"10.1016\/j.tiv.2012.08.005_b0235","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1007\/s10620-008-0563-9","article-title":"Effect of N-acetylcysteine on the murine model of colitis induced by dextran sodium sulfate through up-regulating PON1 activity","volume":"54","author":"You","year":"2009","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1016\/j.tiv.2012.08.005_b0240","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0098-2997(03)00023-2","article-title":"4-Hydroxynonenal as a bioactive marker of pathophysiological processes","volume":"24","author":"Zarkovic","year":"2003","journal-title":"Molecular Aspects of Medicine"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233312002093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233312002093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T15:17:44Z","timestamp":1562080664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233312002093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0887233312002093"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2012.08.005","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}