{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T07:10:02Z","timestamp":1745219402135,"version":"3.40.4"},"reference-count":22,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.tiv.2012.11.012","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T10:03:47Z","timestamp":1353405827000},"page":"627-631","source":"Crossref","is-referenced-by-count":2,"title":["Effects of synthetic analogues of poly-APS on contractile response of porcine coronary arteries"],"prefix":"10.1016","volume":"27","author":[{"given":"Marjana","family":"Grandi\u010d","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanka Premrov","family":"Bajuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Sep\u010di\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marinka Drobni\u010d","family":"Ko\u0161orok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Frange\u017e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2012.11.012_b0005","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0041-0101(01)00147-7","article-title":"Toxic effects of head-to-tail 3-alkylpiridinium polymers isolated from the marine sponge Raniera sarai in rat","volume":"40","author":"Bunc","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.tiv.2012.11.012_b0010","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000025626","article-title":"Binding of gold\u2013 protein ligand complexes to neurokinin receptors. Visualization with the electron microscope on pig coronary artery and rat portal vein","volume":"36","author":"Cathieni","year":"1999","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.tiv.2012.11.012_b0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1023\/A:1006862525699","article-title":"Endothelin contraction in pig coronary artery: receptor types and Ca(2+)-mobilization","volume":"176","author":"Elmoselhi","year":"1997","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.tiv.2012.11.012_b0020","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1469-7793.1999.0361m.x","article-title":"Substance P and bradykinin activate different types of KCa currents to hyperpolarize cultured porcine coronary artery endothelial cells","volume":"519","author":"Frieden","year":"1999","journal-title":"J Physiol."},{"key":"10.1016\/j.tiv.2012.11.012_b0025","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.taap.2011.06.003","article-title":"In vivo toxic and lethal cardiovascular effects of a synthetic polymeric 1,3-dodecylpyridinium salt in rodents","volume":"255","author":"Grandi\u010d","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2012.11.012_b0030","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.bmc.2012.01.027","article-title":"Binding and permeabilization of lipid bilayers by natural and synthetic 3-alkylpyridinium polymers","volume":"20","author":"Grandi\u010d","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.tiv.2012.11.012_b0035","article-title":"Toxicity of the synthetic polymeric 3-alkylpyridinium salt (APS3) is due to specific block of nicotinic acetylcholine receptors","author":"Grandi\u010d","year":"2012","journal-title":"Toxicology"},{"key":"10.1016\/j.tiv.2012.11.012_b0040","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0022-3565(25)21513-0","article-title":"Mechanisms behind the biphasic contractile response to potassium depolarization in isolated rat cerebral arteries","volume":"228","author":"Hogestatt","year":"1984","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tiv.2012.11.012_b0045","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12154-010-0036-4","article-title":"Chemical synthesis and biological activities of 3-alkyl pyridinium polymeric analogues of marine toxins","volume":"3","author":"Houssen","year":"2010","journal-title":"J. Chem. Biol."},{"key":"10.1016\/j.tiv.2012.11.012_b0050","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1113\/jphysiol.1992.sp019035","article-title":"Dihydropyridine-sensitive and omega-conotoxin-sensitive calcium channels in a mammalian neuroblastoma-glioma cell line","volume":"448","author":"Kasai","year":"1992","journal-title":"J. Physiol."},{"key":"10.1016\/j.tiv.2012.11.012_b0055","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1152\/physrev.1998.78.3.811","article-title":"Physiological features of visceral smooth muscle cells, with special reference to receptors and ion channels","volume":"78","author":"Kuriyama","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tiv.2012.11.012_b0060","first-page":"789","article-title":"Hypoxic and pharmacological preconditioning preserves vasomotor response of porcine coronary artery","volume":"56","author":"Ku\u017ener","year":"2004","journal-title":"Pol. J. Pharmacol."},{"issue":"60","key":"10.1016\/j.tiv.2012.11.012_b0065","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.toxicon.2012.07.007","article-title":"Cardiovascular effects induced by polymeric 3-alkylpyridinium salts from the marine sponge Reniera sarai","volume":"2012","author":"Lunder","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.tiv.2012.11.012_b0070","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1039\/B400782D","article-title":"Synthesis and bioactivity of linear oligomers related to polymeric alkylpyridinium metabolites from the Mediterranean sponge Reniera sarai","volume":"2","author":"Mancini","year":"2004","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.tiv.2012.11.012_b0075","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/sj.bjp.0705374","article-title":"Irreversible and reversible pore formation by polymeric alkylpyridinium salts (poly-APS) from the sponge Reniera sarai","volume":"139","author":"McClelland","year":"2003","journal-title":"Brit. J. Pharmacol"},{"key":"10.1016\/j.tiv.2012.11.012_b0080","first-page":"138","article-title":"Marine sponge-derived polymeric alkylpyridinium salts as a novel tumor chemotherapeutic targeting the cholinergic system in lung tumors","volume":"29","author":"Paleari","year":"2006","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.tiv.2012.11.012_b0085","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000336647","article-title":"Natural product extract of dicksonia sellowiana induces endothelium-dependent relaxations by a redox-sensitive Src- and Akt-dependent activation of eNOS in porcine coronary arteries","volume":"49","author":"Rattmann","year":"2012","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.tiv.2012.11.012_b0090","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1021\/np970292q","article-title":"Characterization of anticholinesterase-active 3-alkylpyridinium polymers from the marine sponge Reniera sarai in aqueous solutions","volume":"60","author":"Sep\u010di\u0107","year":"1997","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.tiv.2012.11.012_b0095","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3390\/MD504157","article-title":"Mechanisms of toxicity of 3-alkylpyridinium polymers from marine sponge Reniera sarai","volume":"5","author":"Turk","year":"2007","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.tiv.2012.11.012_b0100","doi-asserted-by":"crossref","unstructured":"Turk, T., Sep\u010di\u0107, K., Mancini, I., Guella, G., 2008. 3-alkylpyridinium and 3-alkylpyridine compounds from marine sponges, their synthesis, biological activities and potential use. In: Rahman, Atta-ur- (Ed.), Studies in Natural Product Chemistry; Bioactive natural products (Part O), Studies in Natural Products Chemistry, vol. 3. Elsevier, Amsterdam (etc.), pp. 355\u2013397.","DOI":"10.1016\/S1572-5995(08)80009-9"},{"key":"10.1016\/j.tiv.2012.11.012_b0105","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/aps.2010.127","article-title":"COX-mediated endothelium-dependent contractions: from the past to recent discoveries","volume":"31","author":"Wong","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.tiv.2012.11.012_b0110","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ibiod.2011.10.014","article-title":"Antifungal and antibacterial activity of 3-alkylpyridinium polymeric analogs of marine toxins","volume":"68","author":"Zovko","year":"2012","journal-title":"Int. Biodeter. Biodegr."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233312003232?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233312003232?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T06:53:46Z","timestamp":1745218426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233312003232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0887233312003232"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2012.11.012","relation":{},"ISSN":["0887-2333"],"issn-type":[{"type":"print","value":"0887-2333"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}