{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:54:39Z","timestamp":1791453279025,"version":"4.3.3"},"reference-count":58,"publisher":"Elsevier BV","issue":"8","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.tiv.2013.08.007","type":"journal-article","created":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T20:30:29Z","timestamp":1377894629000},"page":"2213-2224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Development of a new in vitro skin sensitization assay (Epidermal Sensitization Assay; EpiSensA) using reconstructed human epidermis"],"prefix":"10.1016","volume":"27","author":[{"given":"Kazutoshi","family":"Saito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Nukada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Takenouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Miyazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2013.08.007_b0005","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/toxsci\/kfn243","article-title":"HMOX1andNQO1genesareupregulatedinresponsetocontactsensitizersin dendritic cells and THP-1 cell line: role of the Keap1\/Nrf2 pathway","volume":"107","author":"Ade","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2013.08.007_b0010","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1189\/jlb.0604352","article-title":"IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis","volume":"83","author":"Antonopoulos","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.tiv.2013.08.007_b0015","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1600-0536.2007.00944.x","article-title":"Haptens, prohaptens and prehaptens, or electrophiles and proelectrophiles","volume":"56","author":"Aptula","year":"2007","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.tiv.2013.08.007_b0020","doi-asserted-by":"crossref","first-page":"15028","DOI":"10.1074\/jbc.M200497200","article-title":"NovelsignaltransductionpathwayutilizedbyextracellularHSP70: role of toll-like receptor (TLR) 2 and TLR4","volume":"277","author":"Asea","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2013.08.007_b0025","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1177\/026119291003800403","article-title":"A comparative evaluation of in vitro skin sensitisation tests: the human cell-line activation test (h-CLAT) versus the local lymph node assay (LLNA)","volume":"38","author":"Ashikaga","year":"2010","journal-title":"Altern. Lab. Anim."},{"key":"10.1016\/j.tiv.2013.08.007_b0030","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1046\/j.1365-2133.2002.04714.x","article-title":"ProteomicanalysisofskinirritationrevealstheinductionofHSP27by sodium lauryl sulphate in humanskin","volume":"146","author":"Boxman","year":"2002","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.tiv.2013.08.007_b0035","doi-asserted-by":"crossref","first-page":"269","DOI":"10.5021\/ad.2010.22.3.269","article-title":"The roles of reactive oxygen species produced by contact allergens and irritants in monocyte-derived dendritic cells","volume":"22","author":"Byamba","year":"2010","journal-title":"Ann. Dermatol."},{"key":"10.1016\/j.tiv.2013.08.007_b0040","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1177\/026119290903700313","article-title":"Selection of chemicals for the development and evaluation of in vitro methods for skin sensitization testing","volume":"37","author":"Casati","year":"2009","journal-title":"Altern. Lab. Anim."},{"key":"10.1016\/j.tiv.2013.08.007_b0045","first-page":"836982","article-title":"Haptenation: chemical reactivity and protein binding","volume":"2011","author":"Chipinda","year":"2011","journal-title":"J. Allergy (Cairo)"},{"key":"10.1016\/j.tiv.2013.08.007_b0050","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0887-2333(02)00023-1","article-title":"Use of differential display-polymerase chain reaction to identify genes selectively modulated by chemical allergens in reconstituted human epidermis","volume":"16","author":"Corsini","year":"2002","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2013.08.007_b0055","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.tiv.2009.04.005","article-title":"Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens","volume":"23","author":"Corsini","year":"2009","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2013.08.007_b0060","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1046\/j.1365-2567.1997.00360.x","article-title":"Langerhans cells require signals from both tumour necrosis factor-alpha and interleukin-1 beta for migration","volume":"92","author":"Cumberbatch","year":"1997","journal-title":"Immunology"},{"key":"10.1016\/j.tiv.2013.08.007_b0065","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.mrgentox.2006.04.016","article-title":"Development of a method for assessing micronucleus induction in a 3D human skin model (EpiDerm)","volume":"607","author":"Curren","year":"2006","journal-title":"Mutat. Res."},{"key":"10.1016\/j.tiv.2013.08.007_b0075","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1021\/tx0341456","article-title":"Protein binding and metabolism influence the relativeskinsensitizationpotential of cinnamic compounds","volume":"17","author":"Elahi","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tiv.2013.08.007_b0070","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.taap.2010.03.009","article-title":"Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro","volume":"245","author":"Emter","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2013.08.007_b0080","doi-asserted-by":"crossref","first-page":"30730","DOI":"10.1074\/jbc.M205225200","article-title":"Identificationof avariantantioxidant responseelementin thepromoterof thehuman glutamate-cysteineligasemodifiersubunitgene.Revisionof the AREconsensussequence","volume":"277","author":"Erickson","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2013.08.007_b0085","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.mam.2008.08.009","article-title":"Structure, function, andpost-translationalregulationof thecatalyticand modifier subunits of glutamate cysteine ligase","volume":"30","author":"Franklin","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.tiv.2013.08.007_b0090","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/toxsci\/kfp192","article-title":"Investigation of peptide reactivity of pro-hapten skin sensitizers using a peroxidase-peroxide oxidation system","volume":"112","author":"Gerberick","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2013.08.007_b0095","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1084\/jem.20072254","article-title":"Activatingtranscriptionfactor3is anegativeregulatorofallergicpulmonary inflammation","volume":"205","author":"Gilchrist","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tiv.2013.08.007_b0100","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1600-0625.2012.01486.x","article-title":"Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I)","volume":"21","author":"G\u00f6tz","year":"2012","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.tiv.2013.08.007_b0105","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1600-0625.2012.01478.x","article-title":"Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes","volume":"21","author":"G\u00f6tz","year":"2012","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.tiv.2013.08.007_b0110","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2131\/jts.35.871","article-title":"Changes of cell-surface thiols and intracellular signaling in human monocytic cell line THP-1 treated with diphenylcyclopropenone","volume":"35","author":"Hirota","year":"2010","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tiv.2013.08.007_b0115","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.tiv.2010.03.013","article-title":"Xenobiotic metabolism gene expression in the EpiDerm in vitro 3D human epidermis model compared to human skin","volume":"24","author":"Hu","year":"2010","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2013.08.007_b0120","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.tiv.2013.08.007_b0125","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1356-9597.2004.00707.x","article-title":"TNFalpha-inducedATF3expressionisbidirectionallyregulatedby theJNKandERKpathways in vascularendothelialcells","volume":"9","author":"Inoue","year":"2004","journal-title":"GenesCells"},{"key":"10.1016\/j.tiv.2013.08.007_b0130","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.tiv.2011.03.012","article-title":"Characterization of enzyme activities of Cytochrome P450 enzymes, Flavin-dependent monooxygenases, N-acetyltransferases and UDP-glucuronyltransferases in human reconstructed epidermis and full-thickness skin models","volume":"25","author":"J\u00e4ckh","year":"2011","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2013.08.007_b0135","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/nar\/gkp865","article-title":"Expression of stress-response ATF3 is mediated byNrf2in astrocytes","volume":"38","author":"Kim","year":"2010","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.tiv.2013.08.007_b0140","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1034\/j.1600-0536.2002.470601.x","article-title":"The local lymph node assay: past, present and future","volume":"47","author":"Kimber","year":"2002","journal-title":"Contact Dermatitis"},{"issue":"Suppl. 1","key":"10.1016\/j.tiv.2013.08.007_b0295","doi-asserted-by":"crossref","first-page":"S238","DOI":"10.1093\/toxsci\/kfq346","article-title":"Chemical allergy: translating biology into hazard characterization","volume":"120","author":"Kimber","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2013.08.007_b0150","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysisofrelativegene expressiondatausing real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.tiv.2013.08.007_b0155","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0378-4274(95)03577-X","article-title":"Role of keratinocyte-derived cytokines in chemical toxicity","volume":"82\u201383","author":"Luster","year":"1995","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2013.08.007_b0160","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jsbmb.2009.05.011","article-title":"Expression profiles of phases 1 and 2 metabolizing enzymes in human skin and the reconstructed skin models Episkin and full thickness model from Episkin","volume":"116","author":"Luu-The","year":"2009","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.tiv.2013.08.007_b0165","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/nrc1505","article-title":"Theroleof theunfolded protein responseintumour development:friend or foe?","volume":"4","author":"Ma","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tiv.2013.08.007_b0170","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3109\/15569527.2010.483869","article-title":"A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE\/EpRE-mediated gene expression in human skin cells","volume":"29","author":"McKim","year":"2010","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.tiv.2013.08.007_b0300","first-page":"1","article-title":"An in vitro method for detecting chemical sensitization using human reconstructed skin models and its applicability to cosmetic, pharmaceutical, and medical device safety testing","author":"McKim","year":"2012","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.tiv.2013.08.007_b0180","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jdermsci.2012.08.003","article-title":"Development and validation of a new in vitro assay designed to measure contact allergen-triggered oxidative stress in dendritic cells","volume":"68","author":"Miyazawa","year":"2012","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.tiv.2013.08.007_b0185","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1038\/sj.jid.5700802","article-title":"EC-SOD suppresses contact hypersensitivity in mouse skin by impairing Langerhans cell migration","volume":"127","author":"Na","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.tiv.2013.08.007_b0190","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1046\/j.1523-1747.1999.00750.x","article-title":"Human keratinocytes constitutively express interleukin-18 and secrete biologically active interleukin-18 after treatment with pro-inflammatory mediators and dinitrochlorobenzene","volume":"113","author":"Naik","year":"1999","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.tiv.2013.08.007_b0195","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ejpb.2005.03.004","article-title":"The human epidermis models EpiSkin, SkinEthic and EpiDerm: an evaluation of morphology and their suitability for testing phototoxicity, irritancy, corrosivity, and substance transport","volume":"60","author":"Netzlaff","year":"2005","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.tiv.2013.08.007_b0200","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1248\/bpb.32.203","article-title":"Evaluationof theskinirritationusinga DNAmicroarrayon areconstructedhuman epidermal model","volume":"32","author":"Niwa","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.tiv.2013.08.007_b0205","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2131\/jts.36.313","article-title":"The relationship between CD86 and CD54 protein expression and cytotoxicity following stimulation with contact allergen in THP-1 cells","volume":"36","author":"Nukada","year":"2011","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tiv.2013.08.007_b0215","unstructured":"OECD, 2004. Guideline for Testing of Chemicals No. 431, In Vitro Skin Corrosion: Reconstructed Human Epidermis Test Method, adopted 13rd April."},{"key":"10.1016\/j.tiv.2013.08.007_b0210","unstructured":"OECD, 2010. Guideline for Testing of Chemicals No. 439, In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method, adopted 22nd July."},{"key":"10.1016\/j.tiv.2013.08.007_b0220","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00018-011-0846-8","article-title":"Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects. Current knowledge assembled at an international workshop at BfR, Germany","volume":"69","author":"Peiser","year":"2012","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.tiv.2013.08.007_b0225","doi-asserted-by":"crossref","first-page":"e310","DOI":"10.1111\/j.1600-0625.2009.01008.x","article-title":"Activating transcription factor 3(ATF3)expressionisincreasedinerythema multiformeand is regulated by IFN-gamma in human keratinocytes","volume":"19","author":"Pollack","year":"2012","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.tiv.2013.08.007_b0230","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1007\/s00018-006-6192-6","article-title":"Thediversityof theDnaJ\/Hsp40family, thecrucialpartnersforHsp70chaperones","volume":"63","author":"Qiu","year":"2006","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.tiv.2013.08.007_b0235","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.toxlet.2004.02.002","article-title":"Gene expressionchangesinperipheralblood-deriveddendritic cellsfollowingexposureto a contact allergen","volume":"150","author":"Ryan","year":"2004","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2013.08.007_b0240","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12016-007-0034-7","article-title":"Dendritic cells and contact dermatitis","volume":"33","author":"Sasaki","year":"2007","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.tiv.2013.08.007_b0245","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1373\/clinchem.2007.097386","article-title":"Microarray-based in vitro test system for the discrimination of contact allergens and irritants: identification of potential marker genes","volume":"54","author":"Szameit","year":"2008","journal-title":"Clin. Chem."},{"key":"10.1016\/j.tiv.2013.08.007_b0250","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/sj.embor.7400779","article-title":"Mediatorsofendoplasmicreticulum stress-inducedapoptosis","volume":"7","author":"Szegezdi","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1016\/j.tiv.2013.08.007_b0255","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00109-009-0520-x","article-title":"ATF3 transcription factorand its emerging roles in immunity andcancer","volume":"87","author":"Thompson","year":"2009","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.tiv.2013.08.007_b0260","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0536.2008.01443.x","article-title":"Dendritic cells: biology of the skin","volume":"60","author":"Toebak","year":"2009","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.tiv.2013.08.007_b0265","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/jnci\/djj229","article-title":"A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma","volume":"98","author":"Tsai","year":"2006","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.tiv.2013.08.007_b0270","doi-asserted-by":"crossref","first-page":"e41721","DOI":"10.1371\/journal.pone.0041721","article-title":"Elucidationofxenobioticmetabolismpathwaysinhumanskinandhumanskinmodelsbyproteomicprofiling","volume":"7","author":"van Eijl","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.tiv.2013.08.007_b0275","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/toxsci\/kfq182","article-title":"Keratinocyte gene expression profiles discriminate sensitizing and irritating chemicals","volume":"117","author":"Vandebriel","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2013.08.007_b0280","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1021\/bi800639z","article-title":"Structuralandfunctionaldiversitiesbetween membersof the human HSPB, HSPH, HSPA, and DNAJ chaperone families","volume":"47","author":"Vos","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.tiv.2013.08.007_b0285","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1042\/BJ20050795","article-title":"Tumournecrosisfactoralphainducesco-ordinated activationofratGSHsyntheticenzymesvia nuclearfactorkappaBandactivatorprotein-1","volume":"391","author":"Yang","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.tiv.2013.08.007_b0290","doi-asserted-by":"crossref","first-page":"675","DOI":"10.4049\/jimmunol.182.1.675","article-title":"Heat shock proteinsHSP27andHSP70arepresentin theskinand are important mediators of allergic contact hypersensitivity","volume":"182","author":"Yusuf","year":"2009","journal-title":"J. Immunol."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233313002075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233313002075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T23:02:29Z","timestamp":1596409349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233313002075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":58,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0887233313002075"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2013.08.007","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a new in vitro skin sensitization assay (Epidermal Sensitization Assay; EpiSensA) using reconstructed human epidermis","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2013.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}