{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:17:16Z","timestamp":1768443436245,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.tiv.2014.06.009","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T12:17:19Z","timestamp":1404303439000},"page":"1507-1520","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Potential involvement of chemicals in liver cancer progression: An alternative toxicological approach combining biomarkers and innovative technologies"],"prefix":"10.1016","volume":"28","author":[{"given":"Ludovic","family":"Peyre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Zucchini-Pascal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Pascale","family":"Luzy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Rahmani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2014.06.009_b0005","unstructured":"ANSES, 2011. Etude de l\u2019alimentation totale fran\u00e7aise (EAT2). anses.fr\/Documents\/PASER2006sa0361Ra1.pdf anses.fr\/Documents\/PASER2006sa0361Ra2.pdf."},{"issue":"6","key":"10.1016\/j.tiv.2014.06.009_b0010","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/1087057106289334","article-title":"Label-free and real-time cell-based kinase assay for screening selective and potent receptor tyrosine kinase inhibitors using microelectronic sensor array","volume":"11","author":"Atienza","year":"2006","journal-title":"J. Biomol. Screen."},{"issue":"6","key":"10.1016\/j.tiv.2014.06.009_b0015","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1177\/1087057111402825","article-title":"The use of real-time cell analyzer technology in drug discovery: defining optimal cell culture conditions and assay reproducibility with different adherent cellular models","volume":"16","author":"Atienzar","year":"2011","journal-title":"J. Biomol. Screen."},{"issue":"2","key":"10.1016\/j.tiv.2014.06.009_b0020","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1182\/blood-2012-02-411470","article-title":"Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1\/5\/8 signaling","volume":"120","author":"Besson-Fournier","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.tiv.2014.06.009_b0025","doi-asserted-by":"crossref","unstructured":"Buitrago-Molina, L.E., Marhenke, S., Longerich, T., Sharma, A.D., Boukouris, A.E., Geffers, R., Guigas, B., Manns, M.P., Vogel, A. 2013. The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice. Hepatology (Baltimore, Md.) 58(3), pp. 1143\u20131152, http:\/\/dx.doi.org\/10.1002\/hep.26412.","DOI":"10.1002\/hep.26412"},{"issue":"5","key":"10.1016\/j.tiv.2014.06.009_b0030","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/j.ajpath.2012.01.016","article-title":"Co-expression of XIAP and cyclin D1 complex correlates with a poor prognosis in patients with hepatocellular carcinoma","volume":"180","author":"Che","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tiv.2014.06.009_b0035","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1186\/1471-2407-11-396","article-title":"Snail1 induces epithelial-to-mesenchymal transition and tumor initiating stem cell characteristics","volume":"11","author":"Dang","year":"2011","journal-title":"BMC Cancer"},{"issue":"40","key":"10.1016\/j.tiv.2014.06.009_b0040","doi-asserted-by":"crossref","first-page":"5570","DOI":"10.1038\/sj.onc.1209553","article-title":"Activation of the dioxin\/aryl hydrocarbon receptor (AhR) modulates cell plasticity through a JNK-dependent mechanism","volume":"25","author":"Diry","year":"2006","journal-title":"Oncogene"},{"issue":"30","key":"10.1016\/j.tiv.2014.06.009_b0045","doi-asserted-by":"crossref","first-page":"4740","DOI":"10.3748\/wjg.v11.i30.4740","article-title":"Dynamic expression of apoptosis-related genes during development of laboratory hepatocellular carcinoma and its relation to apoptosis","volume":"11","author":"Duan","year":"2005","journal-title":"World J. Gastroenterol.: WJG"},{"issue":"5","key":"10.1016\/j.tiv.2014.06.009_b0050","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3748\/wjg.15.513","article-title":"Dysregulation of apoptosis in hepatocellular carcinoma cells","volume":"15","author":"Fabregat","year":"2009","journal-title":"World J. Gastroenterol.: WJG"},{"issue":"2","key":"10.1016\/j.tiv.2014.06.009_b0055","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1478-3231.2006.01409.x","article-title":"Survival and apoptosis: a dysregulated balance in liver cancer","volume":"27","author":"Fabregat","year":"2007","journal-title":"Liver Int.: Official J. Int. Assoc. Study Liver"},{"issue":"5\u20136","key":"10.1016\/j.tiv.2014.06.009_b0060","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0887-2333(91)90090-Z","article-title":"A multicentre study of acute in vitro cytotoxicity in rat liver cells","volume":"5","author":"Fautrel","year":"1991","journal-title":"Toxicol. In Vitro: Int. J. Publ. Assoc. BIBRA"},{"key":"10.1016\/j.tiv.2014.06.009_b0065","doi-asserted-by":"crossref","unstructured":"Ferris, I.T.J., Ortega Garcia, J.A., Garcia, I.C.J., Lopez Andreu, J.A., Ribes Koninckx, C., Berbel Tornero, O., 2008. Risks factors for pediatric malignant liver tumors. Anales de pediatria (Barcelona, Spain: 2003) 68(4), 377\u2013384. (First published on Factores de riesgo para los tumores hepaticos malignos pediatricos).","DOI":"10.1157\/13117711"},{"issue":"5","key":"10.1016\/j.tiv.2014.06.009_b0070","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/carcin\/bgi043","article-title":"Integration of Ras subeffector signaling in TGF-beta mediated late stage hepatocarcinogenesis","volume":"26","author":"Fischer","year":"2005","journal-title":"Carcinogenesis"},{"issue":"7","key":"10.1016\/j.tiv.2014.06.009_b0075","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1158\/0008-5472.CAN-07-2460","article-title":"Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells","volume":"68","author":"Fuchs","year":"2008","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.tiv.2014.06.009_b0080","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1074\/jbc.R500017200","article-title":"S100A4, a mediator of metastasis","volume":"281","author":"Garrett","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.tiv.2014.06.009_b0085","first-page":"105","article-title":"Molecular genetics of hepatocellular neoplasia","volume":"2","author":"Jain","year":"2010","journal-title":"Am. J. Trans. Res."},{"issue":"4","key":"10.1016\/j.tiv.2014.06.009_b0090","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1053\/j.seminoncol.2012.05.011","article-title":"Clinical implications of cancer stem cell biology in hepatocellular carcinoma","volume":"39","author":"Ji","year":"2012","journal-title":"Semin. Oncol."},{"issue":"4","key":"10.1016\/j.tiv.2014.06.009_b0095","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.bbrc.2011.05.094","article-title":"MAPK\/ERK and Wnt\/beta-Catenin pathways are synergistically involved in proliferation of Sca-1 positive hepatic progenitor cells","volume":"409","author":"Jin","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tiv.2014.06.009_b0100","doi-asserted-by":"crossref","unstructured":"Ke, N., Wang, X., Xu, X., Abassi, Y.A., 2011. The xCELLigence system for real-time and label-free monitoring of cell viability. Methods in Molecular Biology (Clifton, N.J.) 740, pp. 33\u201343, http:\/\/dx.doi.org\/10.1007\/978-1-61779-108-6_6.","DOI":"10.1007\/978-1-61779-108-6_6"},{"issue":"2","key":"10.1016\/j.tiv.2014.06.009_b0105","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1177\/0300060513478086","article-title":"Clinicopathological significance of S100A4 expression in human hepatocellular carcinoma","volume":"41","author":"Liu","year":"2013","journal-title":"J. Int. Med. Res."},{"issue":"2","key":"10.1016\/j.tiv.2014.06.009_b0110","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.taap.2013.01.025","article-title":"Pesticides and human chronic diseases: evidences, mechanisms, and perspectives","volume":"268","author":"Mostafalou","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2014.06.009_b0115","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1038\/oncsis.2012.31","article-title":"Functional consequences of WNT3\/Frizzled7-mediated signaling in non-transformed hepatic cells","volume":"1","author":"Nambotin","year":"2012","journal-title":"Oncogenesis"},{"issue":"1","key":"10.1016\/j.tiv.2014.06.009_b0120","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.semcancer.2010.12.010","article-title":"Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad","volume":"21","author":"Nejak-Bowen","year":"2011","journal-title":"Semin. Cancer Biol."},{"issue":"9","key":"10.1016\/j.tiv.2014.06.009_b0125","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s00204-006-0091-3","article-title":"High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening","volume":"80","author":"O\u2019Brien","year":"2006","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.tiv.2014.06.009_b0130","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/rtph.2000.1399","article-title":"Concordance of the toxicity of pharmaceuticals in humans and in animals","volume":"32","author":"Olson","year":"2000","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.tiv.2014.06.009_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2013.06.026","article-title":"Anoikis molecular pathways and its role in cancer progression","author":"Paoli","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"1\u20132","key":"10.1016\/j.tiv.2014.06.009_b0140","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.tox.2012.05.008","article-title":"Effects of endosulfan on hepatoma cell adhesion: Epithelial\u2013mesenchymal transition and anoikis resistance","volume":"300","author":"Peyre","year":"2012","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.tiv.2014.06.009_b0145","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.bcp.2010.10.003","article-title":"Induction of the Ras activator Son of Sevenless 1 by environmental pollutants mediates their effects on cellular proliferation","volume":"81","author":"Pierre","year":"2011","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.tiv.2014.06.009_b0150","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/toxsci\/kfj016","article-title":"A Weight-of-evidence analysis of the cancer dose-response characteristics of 2,3,7,8-tetrachlorodibenzodioxin (TCDD)","volume":"89","author":"Popp","year":"2006","journal-title":"Toxicol. Sci.: Official J. Soc. Toxicol."},{"issue":"8","key":"10.1016\/j.tiv.2014.06.009_b0155","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0006-2952(00)00403-2","article-title":"The transcriptional signature of dioxin in human hepatoma HepG2 cells","volume":"60","author":"Puga","year":"2000","journal-title":"Biochem. Pharmacol."},{"issue":"9","key":"10.1016\/j.tiv.2014.06.009_b0160","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00432-004-0572-9","article-title":"Recent progress in predictive biomarkers for metastatic recurrence of human hepatocellular carcinoma: a review of the literature","volume":"130","author":"Qin","year":"2004","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.tiv.2014.06.009_b0165","doi-asserted-by":"crossref","unstructured":"Shi, Y.H., Ding, W.X., Zhou, J., He, J.Y., Xu, Y., Gambotto, A.A., Rabinowich, H., Fan, J., Yin, X.M., 2008. Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence. Hepatology (Baltimore, Md.) 48(2), pp. 497\u2013507, http:\/\/dx.doi.org\/10.1002\/hep.22393.","DOI":"10.1002\/hep.22393"},{"issue":"13","key":"10.1016\/j.tiv.2014.06.009_b0170","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1289\/ehp.7219","article-title":"Dioxin revisited: developments since the 1997 IARC classification of dioxin as a human carcinogen","volume":"112","author":"Steenland","year":"2004","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.tiv.2014.06.009_b0175","first-page":"46","article-title":"Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma","volume":"1835","author":"Subramaniam","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.tiv.2014.06.009_b0180","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/toxsci\/kfs083","article-title":"Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs","volume":"127","author":"Tolosa","year":"2012","journal-title":"Toxicol. Sci.: Official J. Soc. Toxicol."},{"issue":"1","key":"10.1016\/j.tiv.2014.06.009_b0185","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/toxsci\/kfn109","article-title":"Cellular imaging predictions of clinical drug-induced liver injury","volume":"105","author":"Xu","year":"2008","journal-title":"Toxicol. Sci.: Official J. Soc. Toxicol."},{"issue":"1","key":"10.1016\/j.tiv.2014.06.009_b0190","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.semcancer.2010.10.007","article-title":"The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets","volume":"21","author":"Yang","year":"2011","journal-title":"Semin. Cancer Biol."},{"issue":"10","key":"10.1016\/j.tiv.2014.06.009_b0195","doi-asserted-by":"crossref","first-page":"20768","DOI":"10.3390\/ijms141020768","article-title":"Crosstalk between beta-catenin and snail in the induction of epithelial to mesenchymal transition in hepatocarcinoma: role of the ERK1\/2 pathway","volume":"14","author":"Zucchini-Pascal","year":"2013","journal-title":"Int. J. Mol. Sci."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233314001246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233314001246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T06:23:06Z","timestamp":1565590986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233314001246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0887233314001246"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2014.06.009","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential involvement of chemicals in liver cancer progression: An alternative toxicological approach combining biomarkers and innovative technologies","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2014.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}