{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:26:47Z","timestamp":1792794407980,"version":"4.5.0"},"reference-count":80,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.tiv.2014.12.016","type":"journal-article","created":{"date-parts":[[2015,1,3]],"date-time":"2015-01-03T06:46:05Z","timestamp":1420267565000},"page":"489-501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro"],"prefix":"10.1016","volume":"29","author":[{"given":"Wim F.P.M.","family":"Van den Hof","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainhoa","family":"Ruiz-Aracama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Van Summeren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyel G.J.","family":"Jennen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stan","family":"Gaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten L.J.","family":"Coonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Brauers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Will K.W.H.","family":"Wodzig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost H.M.","family":"van Delft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos C.S.","family":"Kleinjans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.tiv.2014.12.016_b0005","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/toxsci\/kfn268","article-title":"Bile acid sulfation: a pathway of bile acid elimination and detoxification","volume":"108","author":"Alnouti","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2014.12.016_b0010","series-title":"Handbook of Clinical Drug Data","first-page":"275","author":"Anderson","year":"2002"},{"issue":"1","key":"10.1016\/j.tiv.2014.12.016_b0015","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/abbi.1998.0792","article-title":"Analysis of human CYP7A1 mRNA decay in HepG2 cells by reverse transcription-polymerase chain reaction","volume":"357","author":"Andreou","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"issue":"9","key":"10.1016\/j.tiv.2014.12.016_b0020","doi-asserted-by":"crossref","first-page":"e13008","DOI":"10.1371\/journal.pone.0013008","article-title":"Cyclosporine A-sensitive, cyclophilin B-dependent endoplasmic reticulum-associated degradation","volume":"5","author":"Bernasconi","year":"2010","journal-title":"PLOS ONE"},{"issue":"Suppl. 1","key":"10.1016\/j.tiv.2014.12.016_b0025","first-page":"D149","article-title":"The microRNA.org resource: targets and expression","volume":"36","author":"Betel","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tiv.2014.12.016_b0030","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0065-2571(94)90023-X","article-title":"ATP-dependent export pumps and their inhibition by cyclosporins","volume":"34","author":"B\u00f6hme","year":"1994","journal-title":"Adv. Enzyme Regul."},{"issue":"2","key":"10.1016\/j.tiv.2014.12.016_b0035","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/toxsci\/58.2.399","article-title":"Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells","volume":"58","author":"Burczynski","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2014.12.016_b0040","doi-asserted-by":"crossref","DOI":"10.1093\/toxsci\/kfs223","article-title":"A decade of toxicogenomic research and its contribution to toxicological science","author":"Chen","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2014.12.016_b0045","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jtbi.2011.08.009","article-title":"In vitro transcriptomic prediction of hepatotoxicity for early drug discovery","volume":"290","author":"Cheng","year":"2011","journal-title":"J. Theor. Biol."},{"issue":"10","key":"10.1016\/j.tiv.2014.12.016_b0050","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1194\/jlr.R900010-JLR200","article-title":"Bile acids: regulation of synthesis","volume":"50","author":"Chiang","year":"2009","journal-title":"J. Lipid Res."},{"issue":"9","key":"10.1016\/j.tiv.2014.12.016_b0055","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1002\/pmic.200900674","article-title":"Identification of toxicological biomarkers of di(2-ethylhexyl) phthalate in proteins secreted by HepG2 cells using proteomic analysis","volume":"10","author":"Choi","year":"2010","journal-title":"Proteomics"},{"issue":"1","key":"10.1016\/j.tiv.2014.12.016_b0060","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jpba.2003.12.019","article-title":"Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse","volume":"35","author":"Coen","year":"2004","journal-title":"J. Pharmaceut. Biomed."},{"issue":"3","key":"10.1016\/j.tiv.2014.12.016_b0065","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.taap.2009.04.002","article-title":"Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity","volume":"237","author":"Cosgrove","year":"2009","journal-title":"Toxicol. Appl. Pharm."},{"issue":"4","key":"10.1016\/j.tiv.2014.12.016_b0070","doi-asserted-by":"crossref","first-page":"573","DOI":"10.2217\/pgs.10.37","article-title":"Use of transcriptomics in understanding mechanisms of drug-induced toxicity","volume":"11","author":"Cui","year":"2010","journal-title":"Pharmacogenomics"},{"issue":"20","key":"10.1016\/j.tiv.2014.12.016_b0075","doi-asserted-by":"crossref","first-page":"e175","DOI":"10.1093\/nar\/gni179","article-title":"Evolving gene\/transcript definitions significantly alter the interpretation of GeneChip data","volume":"33","author":"Dai","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.tiv.2014.12.016_b0080","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1358\/dnp.2002.15.3.840012","article-title":"Gene-expression \u2013 based responses to drug treatment","volume":"15","author":"De Backer","year":"2002","journal-title":"Drug News Perspect"},{"issue":"13","key":"10.1016\/j.tiv.2014.12.016_b0085","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1021\/ac051632c","article-title":"Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. Application in 1H NMR metabonomics","volume":"78","author":"Dieterle","year":"2006","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.tiv.2014.12.016_b0090","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene expression omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.tiv.2014.12.016_b0095","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"issue":"6","key":"10.1016\/j.tiv.2014.12.016_b0100","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/0006-2952(92)90374-R","article-title":"Inhibition of biliary lipid and protein secretion by cyclosporine a in the rat","volume":"44","author":"Gal\u00e1n","year":"1992","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.tiv.2014.12.016_b0105","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10565-011-9208-4","article-title":"Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins","volume":"28","author":"Gerets","year":"2012","journal-title":"Cell Biol. Toxicol."},{"issue":"9","key":"10.1016\/j.tiv.2014.12.016_b0110","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/nbt1238","article-title":"Rat toxicogenomic study reveals analytical consistency across microarray platforms","volume":"24","author":"Guo","year":"2006","journal-title":"Nat. Biotechnol."},{"issue":"4","key":"10.1016\/j.tiv.2014.12.016_b0115","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/01926230590958146","article-title":"Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis","volume":"33","author":"Heijne","year":"2005","journal-title":"Toxicol. Pathol."},{"issue":"3","key":"10.1016\/j.tiv.2014.12.016_b0120","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/00498250310001657568","article-title":"Phase I and II enzyme characterization of two sources of HepG2 cell lines","volume":"34","author":"Hewitt","year":"2004","journal-title":"Xenobiotica"},{"issue":"1","key":"10.1016\/j.tiv.2014.12.016_b0125","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/03602530601093489","article-title":"Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies","volume":"39","author":"Hewitt","year":"2007","journal-title":"Drug Metab. Rev."},{"issue":"8","key":"10.1016\/j.tiv.2014.12.016_b0130","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1124\/dmd.107.014902","article-title":"Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines","volume":"35","author":"Hilgendorf","year":"2007","journal-title":"Drug Metab. Dispos."},{"issue":"2","key":"10.1016\/j.tiv.2014.12.016_b0135","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1089\/omi.2008.0060","article-title":"Interlaboratory and interplatform comparison of microarray gene expression analysis of HepG2 cells exposed to benzo(a)pyrene","volume":"13","author":"Hockley","year":"2009","journal-title":"OMICS"},{"issue":"1","key":"10.1016\/j.tiv.2014.12.016_b0140","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0887-2333(02)00122-4","article-title":"Discriminating two classes of toxicants through expression analysis of HepG2 cells with DNA arrays","volume":"17","author":"Hong","year":"2003","journal-title":"Toxicol. In Vitro"},{"issue":"2","key":"10.1016\/j.tiv.2014.12.016_b0145","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"issue":"1","key":"10.1016\/j.tiv.2014.12.016_b0150","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/1752-0509-5-139","article-title":"Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells","volume":"5","author":"Jennen","year":"2011","journal-title":"BMC Syst. Biol."},{"issue":"7","key":"10.1016\/j.tiv.2014.12.016_b0155","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1016\/j.tiv.2013.07.010","article-title":"Baseline and genotoxic compound induced gene expression profiles in HepG2 and HepaRG compared to primary human hepatocytes","volume":"27","author":"Jetten","year":"2013","journal-title":"Toxicol. In Vitro"},{"issue":"20","key":"10.1016\/j.tiv.2014.12.016_b0160","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1093\/bioinformatics\/btr499","article-title":"Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA","volume":"27","author":"Kamburov","year":"2011","journal-title":"Bioinformatics"},{"issue":"21","key":"10.1016\/j.tiv.2014.12.016_b0165","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1242\/jcs.028654","article-title":"Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress","volume":"121","author":"Kim","year":"2008","journal-title":"J. Cell Sci."},{"issue":"9","key":"10.1016\/j.tiv.2014.12.016_b0170","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1124\/dmd.108.024778","article-title":"Effect of membrane cholesterol on BSEP\/Bsep activity: species specificity studies for substrates and inhibitors","volume":"37","author":"Kis","year":"2009","journal-title":"Drug Metab. Dispos."},{"issue":"1\u20133","key":"10.1016\/j.tiv.2014.12.016_b0175","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.tox.2004.02.008","article-title":"Use of human-derived liver cell lines for the detection of environmental and dietary genotoxicants; current state of knowledge","volume":"198","author":"Knasm\u00fcller","year":"2004","journal-title":"Toxicology"},{"issue":"5","key":"10.1016\/j.tiv.2014.12.016_b0180","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/hep.510230518","article-title":"Molecular and functional characterization of bile acid transport in human hepatoblastoma HepG2 cells","volume":"23","author":"Kullak-Ublick","year":"1996","journal-title":"Hepatology"},{"issue":"1\u20132","key":"10.1016\/j.tiv.2014.12.016_b0185","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ejps.2006.01.004","article-title":"Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line","volume":"28","author":"Le Vee","year":"2006","journal-title":"Eur. J. Pharm. Sci."},{"issue":"5","key":"10.1016\/j.tiv.2014.12.016_b0190","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1056\/NEJMra021844","article-title":"Drug-induced hepatotoxicity","volume":"349","author":"Lee","year":"2003","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.tiv.2014.12.016_b0195","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.toxlet.2010.06.019","article-title":"MicroRNAs and their implications in toxicological research","volume":"198","author":"Lema","year":"2010","journal-title":"Toxicol. Lett."},{"issue":"10","key":"10.1016\/j.tiv.2014.12.016_b0200","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/S0022-2275(20)39774-1","article-title":"Bile acid synthesis in HepG2 cells: effect of cyclosporin","volume":"35","author":"Levy","year":"1994","journal-title":"J. Lipid Res."},{"issue":"1","key":"10.1016\/j.tiv.2014.12.016_b0205","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/03602532.2012.740048","article-title":"Nuclear receptors in bile acid metabolism","volume":"45","author":"Li","year":"2013","journal-title":"Drug Metab. Rev."},{"issue":"6","key":"10.1016\/j.tiv.2014.12.016_b0210","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1023\/A:1008398321079","article-title":"On the detection of environmental effects on complex matrices combining off-line liquid chromatography and 1H NMR","volume":"9","author":"Lommen","year":"1998","journal-title":"Biodegradation"},{"issue":"1","key":"10.1016\/j.tiv.2014.12.016_b0215","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/toxsci\/kfp088","article-title":"Toxicity testing in the 21st century: a view from the pharmaceutical industry","volume":"110","author":"MacDonald","year":"2009","journal-title":"Toxicol. Sci."},{"issue":"4","key":"10.1016\/j.tiv.2014.12.016_b0220","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1124\/dmd.31.4.421","article-title":"Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes","volume":"31","author":"Madan","year":"2003","journal-title":"Drug Metab. Dispos."},{"issue":"4","key":"10.1016\/j.tiv.2014.12.016_b0225","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jhep.2010.11.005","article-title":"Endoplasmic reticulum stress in liver disease","volume":"54","author":"Malhi","year":"2011","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.tiv.2014.12.016_b0230","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.plipres.2012.11.002","article-title":"Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis","volume":"52","author":"Musso","year":"2013","journal-title":"Prog. Lipid Res."},{"issue":"11","key":"10.1016\/j.tiv.2014.12.016_b0235","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1080\/004982599238047","article-title":"\u2018Metabonomics\u2019: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data","volume":"29","author":"Nicholson","year":"1999","journal-title":"Xenobiotica"},{"issue":"2","key":"10.1016\/j.tiv.2014.12.016_b0240","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrd728","article-title":"Metabonomics: a platform for studying drug toxicity and gene function","volume":"1","author":"Nicholson","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.tiv.2014.12.016_b0245","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/(SICI)1098-2744(199903)24:3<153::AID-MC1>3.0.CO;2-P","article-title":"Microarrays and toxicology: the advent of toxicogenomics","volume":"24","author":"Nuwaysir","year":"1999","journal-title":"Mol. Carcinogen."},{"key":"10.1016\/j.tiv.2014.12.016_b0250","first-page":"415","article-title":"In vitro cytotoxicity assessment","volume":"vol. 356","author":"O\u2019Brien","year":"2006"},{"issue":"9","key":"10.1016\/j.tiv.2014.12.016_b0255","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s00204-006-0091-3","article-title":"High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening","volume":"80","author":"O\u2019Brien","year":"2006","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tiv.2014.12.016_b0260","unstructured":"Oliveros, J.C., 2007. VENNY. An Interactive Tool for Comparing Lists with Venn Diagrams <http:\/\/bioinfogp.cnb.csic.es\/tools\/venny\/index.html>."},{"issue":"1","key":"10.1016\/j.tiv.2014.12.016_b0265","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/rtph.2000.1399","article-title":"Concordance of the toxicity of pharmaceuticals in humans and in animals","volume":"32","author":"Olson","year":"2000","journal-title":"Regul. Toxicol. Pharm."},{"issue":"4","key":"10.1016\/j.tiv.2014.12.016_b0270","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1002\/hep.24229","article-title":"Drug-induced cholestasis","volume":"53","author":"Padda","year":"2011","journal-title":"Hepatology"},{"issue":"14","key":"10.1016\/j.tiv.2014.12.016_b0275","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1161\/01.CIR.0000143163.76212.0B","article-title":"ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver","volume":"110","author":"Parini","year":"2004","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.tiv.2014.12.016_b0280","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ng0506-500","article-title":"GenePattern 2.0","volume":"38","author":"Reich","year":"2006","journal-title":"Nat. Genet."},{"issue":"6","key":"10.1016\/j.tiv.2014.12.016_b0285","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.bcp.2013.01.001","article-title":"FXR-dependent and -independent interaction of glucocorticoids with the regulatory pathways involved in the control of bile acid handling by the liver","volume":"85","author":"Rosales","year":"2013","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.tiv.2014.12.016_b0290","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/1471-2164-12-251","article-title":"An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"12","author":"Ruiz-Aracama","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1016\/j.tiv.2014.12.016_b0295","first-page":"401","article-title":"High-throughput screening for analysis of in vitro toxicity","volume":"vol. 99","author":"Schoonen","year":"2009"},{"issue":"1","key":"10.1016\/j.tiv.2014.12.016_b0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1747-5341-4-2","article-title":"Are animal models predictive for humans?","volume":"4","author":"Shanks","year":"2009","journal-title":"Philos. Ethics Humanit. Med."},{"issue":"9","key":"10.1016\/j.tiv.2014.12.016_b0305","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/nbt1239","article-title":"The MicroArray quality control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements","volume":"24","author":"Shi","year":"2006","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.tiv.2014.12.016_b0310","first-page":"65","article-title":"Effects of cyclosporin A on various indices of cholestasis in kidney transplant recipients","volume":"47","author":"Soresi","year":"1995","journal-title":"Minerva Urol. Nefrol."},{"issue":"5","key":"10.1016\/j.tiv.2014.12.016_b0315","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/hep.510280506","article-title":"Lipoprotein-X in patients with cirrhosis: its relationship to cholestasis and hypercholesterolemia","volume":"28","author":"Soros","year":"1998","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.tiv.2014.12.016_b0320","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1073\/pnas.0409794102","article-title":"Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury","volume":"102","author":"Stedman","year":"2005","journal-title":"P. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.tiv.2014.12.016_b0325","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0022-2275(20)38719-8","article-title":"Hepatic metabolism and secretion of a cholesterol-enriched lipoprotein fraction","volume":"28","author":"Stone","year":"1987","journal-title":"J. Lipid Res."},{"issue":"6928","key":"10.1016\/j.tiv.2014.12.016_b0330","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nature01510","article-title":"From genomics to proteomics","volume":"422","author":"Tyers","year":"2003","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.tiv.2014.12.016_b0335","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1093\/carcin\/bgh108","article-title":"Discrimination of genotoxic from non-genotoxic carcinogens by gene expression profiling","volume":"25","author":"van Delft","year":"2004","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.tiv.2014.12.016_b0340","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1186\/1471-2105-9-399","article-title":"Presenting and exploring biological pathways with PathVisio","volume":"9","author":"van Iersel","year":"2008","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"10.1016\/j.tiv.2014.12.016_b0345","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/toxsci\/kfq380","article-title":"Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells","volume":"120","author":"Van Summeren","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2014.12.016_b0350","doi-asserted-by":"crossref","DOI":"10.1089\/omi.2012.0079","article-title":"Screening for drug-induced hepatotoxicity in primary mouse hepatocytes using acetaminophen, amiodarone, and cyclosporin A as model compounds: an omics-guided approach","author":"Van Summeren","year":"2013","journal-title":"OMICS"},{"issue":"12","key":"10.1016\/j.tiv.2014.12.016_b0355","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/nrg1493","article-title":"Toxicogenomics and systems toxicology: aims and prospects","volume":"5","author":"Waters","year":"2004","journal-title":"Nat. Rev. Genet."},{"issue":"5","key":"10.1016\/j.tiv.2014.12.016_b0360","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1002\/hep.23151","article-title":"Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression","volume":"50","author":"Weerachayaphorn","year":"2009","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.tiv.2014.12.016_b0365","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mrgentox.2009.12.007","article-title":"The development of RAD51C, Cystatin A, p53 and Nrf2 luciferase-reporter assays in metabolically competent HepG2 cells for the assessment of mechanism-based genotoxicity and of oxidative stress in the early research phase of drug development","volume":"696","author":"Westerink","year":"2010","journal-title":"Mutat. Res.-Gen. Tox. En."},{"issue":"6","key":"10.1016\/j.tiv.2014.12.016_b0370","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1080\/01926230490518244","article-title":"Invited review: toxicoproteomics: proteomics applied to toxicology and pathology","volume":"32","author":"Wetmore","year":"2004","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.tiv.2014.12.016_b0375","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jprot.2012.11.022","article-title":"Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress","volume":"79","author":"Wilmes","year":"2013","journal-title":"J. Proteomics"},{"issue":"1","key":"10.1016\/j.tiv.2014.12.016_b0380","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0022-2275(20)37646-X","article-title":"Effects of cyclosporin on cholesterol 27-hydroxylation and LDL receptor activity in HepG2 cells","volume":"37","author":"Winegar","year":"1996","journal-title":"J. Lipid Res."},{"issue":"Suppl. 1","key":"10.1016\/j.tiv.2014.12.016_b0385","doi-asserted-by":"crossref","first-page":"D521","DOI":"10.1093\/nar\/gkl923","article-title":"HMDB: the human metabolome database","volume":"35","author":"Wishart","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"35","key":"10.1016\/j.tiv.2014.12.016_b0390","doi-asserted-by":"crossref","first-page":"31441","DOI":"10.1074\/jbc.M200474200","article-title":"Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity","volume":"277","author":"Yu","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.tiv.2014.12.016_b0395","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1517\/17460440903413488","article-title":"Ariadne\u2019s ChemEffect and pathway studio knowledge base","volume":"4","author":"Yuryev","year":"2009","journal-title":"Exp. Opin. Drug Dis."},{"issue":"5","key":"10.1016\/j.tiv.2014.12.016_b0400","doi-asserted-by":"crossref","first-page":"G798","DOI":"10.1152\/ajpgi.00319.2004","article-title":"Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver","volume":"289","author":"Zollner","year":"2005","journal-title":"Am. J. Physiol. Gastr. L."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233314002653?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233314002653?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T22:19:23Z","timestamp":1650925163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233314002653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":80,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S0887233314002653"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2014.12.016","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2014.12.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}