{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:58:32Z","timestamp":1769165912841,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.tiv.2015.01.010","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T02:33:13Z","timestamp":1422325993000},"page":"592-599","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["An evaluation of a human stem cell line to identify risk of developmental neurotoxicity with antiepileptic drugs"],"prefix":"10.1016","volume":"29","author":[{"given":"William S.","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Livesey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert F.","family":"Halliwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1420","key":"10.1016\/j.tiv.2015.01.010_b0005","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1098\/rstb.2002.1058","article-title":"From teratocarcinomas to embryonic stem cells","volume":"357","author":"Andrews","year":"2002","journal-title":"Philos. Trans. R. Soc. Lond. B. Biol. Sci."},{"issue":"1","key":"10.1016\/j.tiv.2015.01.010_b0010","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pnpbp.2010.09.019","article-title":"Effects of mood stabilizers on adult dentate gyrus-derived neural precursor cells","volume":"35","author":"Boku","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry."},{"issue":"1","key":"10.1016\/j.tiv.2015.01.010_b0015","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.expneurol.2012.06.023","article-title":"Developmental neurotoxicity screening using human embryonic stem cells","volume":"237","author":"Bosnjak","year":"2012","journal-title":"Exp. Neurol."},{"issue":"10","key":"10.1016\/j.tiv.2015.01.010_b0020","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1002\/stem.179","article-title":"A human stem cell-based model for identifying adverse effects of organic and inorganic chemicals on the developing nervous system","volume":"27","author":"Buzanska","year":"2009","journal-title":"Stem Cells."},{"key":"10.1016\/j.tiv.2015.01.010_b0025","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev.pharmtox.44.101802.121424","article-title":"Developmental neuropathology of environmental agents","volume":"44","author":"Costa","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"3","key":"10.1016\/j.tiv.2015.01.010_b0030","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.neuint.2011.01.022","article-title":"Neuropharmacological properties of neurons derived from human stem cells","volume":"59","author":"Coyne","year":"2011","journal-title":"Neurochem. Int."},{"issue":"4","key":"10.1016\/j.tiv.2015.01.010_b0035","first-page":"178","article-title":"An overview on antiepileptic drugs","volume":"6","author":"Das","year":"2012","journal-title":"Drug Discov. Ther."},{"key":"10.1016\/j.tiv.2015.01.010_b0040","unstructured":"DiPiro, J., Talbert, R.L., Yee, G., Matzke, G., Wells, B., Posey, L.M., 2014. Pharmacotherapy: A Pathophysiologic Approach. In: Weitz, M., Kearns, B., Eds., 9th ed., pp. 855\u2013882. ISBN: 978-0-07-180053-2."},{"issue":"Suppl. 1","key":"10.1016\/j.tiv.2015.01.010_b0045","doi-asserted-by":"crossref","first-page":"11S","DOI":"10.1046\/j.1365-2125.2001.00394.x","article-title":"Therapeutic drug monitoring\u2013antiepileptic drugs","volume":"52","author":"Eadie","year":"2001","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"2","key":"10.1016\/j.tiv.2015.01.010_b0050","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.envres.2006.06.008","article-title":"Comparison of human whole blood, plasma, and serum matrices for the determination of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA) and other fluorochemicals","volume":"103","author":"Ehresman","year":"2006","journal-title":"Environ. Res."},{"key":"10.1016\/j.tiv.2015.01.010_b0055","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fneur.2012.00182","article-title":"Neurological and psychiatric sequelae of developmental exposure to antiepileptic drugs","volume":"3","author":"Gedzelman","year":"2012","journal-title":"Front. Neurol."},{"issue":"3","key":"10.1016\/j.tiv.2015.01.010_b0060","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/026119290403200305","article-title":"Validation of the embryonic stem cell test in the international ECVAM validation study on three in vitro embryotoxicity tests","volume":"32","author":"Genschow","year":"2004","journal-title":"Altern. Lab. Anim."},{"issue":"4","key":"10.1016\/j.tiv.2015.01.010_b0065","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/jac\/31.4.457","article-title":"Antagonism of GABAA receptors by 4-quinolones","volume":"31","author":"Halliwell","year":"1993","journal-title":"J. Antimicrob. Chemother."},{"issue":"3","key":"10.1016\/j.tiv.2015.01.010_b0075","doi-asserted-by":"crossref","first-page":"e58822","DOI":"10.1371\/journal.pone.0058822","article-title":"Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development","volume":"8","author":"Hill","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.tiv.2015.01.010_b0080","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ejpn.2007.02.006","article-title":"Brain morphology alterations in the basal ganglia and the hypothalamus following prenatal exposure to antiepileptic drugs","volume":"11","author":"Ikonomidou","year":"2007","journal-title":"Eur. J. Paediatr. Neurol."},{"issue":"2","key":"10.1016\/j.tiv.2015.01.010_b0085","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1535-7511.2009.01350.x","article-title":"Prenatal effects of antiepileptic drugs","volume":"10","author":"Ikonomidou","year":"2010","journal-title":"Epilepsy Curr."},{"issue":"1","key":"10.1016\/j.tiv.2015.01.010_b0090","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.eplepsyres.2009.09.019","article-title":"Antiepileptic drugs and brain development","volume":"88","author":"Ikonomidou","year":"2010","journal-title":"Epilepsy Res."},{"issue":"1\u20133","key":"10.1016\/j.tiv.2015.01.010_b0095","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.tox.2012.01.005","article-title":"Perflurooctanoic acid induces developmental cardiotoxicity in chicken embryos and hatchlings","volume":"293","author":"Jiang","year":"2012","journal-title":"Toxicology"},{"issue":"2\u20133","key":"10.1016\/j.tiv.2015.01.010_b0100","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.eplepsyres.2010.07.007","article-title":"Serum levels of lamotrigine during delivery in mothers and their infants","volume":"91","author":"Kacirova","year":"2010","journal-title":"Epilepsy Res."},{"issue":"4","key":"10.1016\/j.tiv.2015.01.010_b0105","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00018-005-5348-0","article-title":"Antiepileptic drugs and the developing brain","volume":"63","author":"Kaindl","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"issue":"2","key":"10.1016\/j.tiv.2015.01.010_b0110","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1124\/jpet.107.123133","article-title":"Effects of lamotrigine alone and in combination with MK-801, phenobarbital or phenytoin on cell death in the neonatal rat brain","volume":"322","author":"Katz","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"7","key":"10.1016\/j.tiv.2015.01.010_b0115","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ijdevneu.2013.03.002","article-title":"A human pluripotent carcinoma stem cell-based model for in vitro developmental neurotoxicity testing: effects of methylmercury, lead and aluminum evaluated by gene expression studies","volume":"31","author":"Laurenza","year":"2013","journal-title":"Int. J. Dev. Neurosci."},{"issue":"3","key":"10.1016\/j.tiv.2015.01.010_b0120","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1177\/026119290903700314","article-title":"A review of the implementation of the embryonic stem cell test (EST). The report and recommendations of an ECVAM\/ReProTect Workshop","volume":"37","author":"Marx-Stoelting","year":"2009","journal-title":"Altern. Lab. Anim."},{"issue":"3","key":"10.1016\/j.tiv.2015.01.010_b0240","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S1474-4422(12)70323-X","article-title":"Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study","volume":"12","author":"Meador","year":"2013","journal-title":"Lancet Neurol."},{"issue":"6","key":"10.1016\/j.tiv.2015.01.010_b0130","doi-asserted-by":"crossref","first-page":"508","DOI":"10.2165\/00003088-198207060-00003","article-title":"Anticonvulsants during pregnancy and lactation. Transplacental, maternal and neonatal pharmacokinetics","volume":"7","author":"Nau","year":"1982","journal-title":"Clin. Pharmacokinet."},{"issue":"6","key":"10.1016\/j.tiv.2015.01.010_b0135","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1136\/adc.75.6.517","article-title":"Outcome of children born to epileptic mothers treated with carbamazepine during pregnancy","volume":"75","author":"Ornoy","year":"1996","journal-title":"Arch. Dis. Child."},{"issue":"6","key":"10.1016\/j.tiv.2015.01.010_b0140","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.neuropharm.2007.01.021","article-title":"mGluR5 is involved in dendrite differentiation and excitatory synaptic transmission in NTERA2 human embryonic carcinoma cell-derived neurons","volume":"52","author":"Park","year":"2007","journal-title":"Neuropharmacology"},{"issue":"10","key":"10.1016\/j.tiv.2015.01.010_b0145","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1046\/j.1460-9568.2000.00230.x","article-title":"Developmental regulation of neurogenesis in the pluripotent human embryonal carcinoma cell line NTERA-2","volume":"12","author":"Przyborski","year":"2000","journal-title":"Eur. J. Neurosci."},{"issue":"6","key":"10.1016\/j.tiv.2015.01.010_b0150","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1634\/stemcells.19-6-500","article-title":"Isolation of human embryonal carcinoma stem cells by immunomagnetic sorting","volume":"19","author":"Przyborski","year":"2001","journal-title":"Stem Cells"},{"issue":"4","key":"10.1016\/j.tiv.2015.01.010_b0155","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1089\/scd.2004.13.400","article-title":"Human embryonal carcinoma stem cells: models of embryonic development in humans","volume":"13","author":"Przyborski","year":"2004","journal-title":"Stem Cells Dev."},{"issue":"7","key":"10.1016\/j.tiv.2015.01.010_b0245","doi-asserted-by":"crossref","first-page":"e70267","DOI":"10.1371\/journal.pone.0070267","article-title":"Effect of antibiotics against Mycoplasma sp. on human embryonic stem cells undifferentiated status, pluripotency, cell viability and growth","volume":"8","author":"Romorini","year":"2013","journal-title":"PloS One"},{"issue":"8","key":"10.1016\/j.tiv.2015.01.010_b0165","doi-asserted-by":"crossref","first-page":"e42960","DOI":"10.1371\/journal.pone.0042960","article-title":"Fluoroquinolone-mediated inhibition of cell growth, S-G2\/M cell cycle arrest, and apoptosis in canine osteosarcoma cell lines","volume":"7","author":"Seo","year":"2012","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.tiv.2015.01.010_b0170","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.braindev.2009.03.012","article-title":"Effects of antiepileptic drugs on mRNA levels of BDNF and NT-3 and cell neogenesis in the developing rat brain","volume":"32","author":"Shi","year":"2010","journal-title":"Brain Dev."},{"issue":"4","key":"10.1016\/j.tiv.2015.01.010_b0175","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1517\/14740338.2013.796362","article-title":"Risks associated with the therapeutic use of fluoroquinolones","volume":"12","author":"Stahlmann","year":"2013","journal-title":"Expert Opin. Drug Saf."},{"issue":"1","key":"10.1016\/j.tiv.2015.01.010_b0180","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00204-013-1098-1","article-title":"Human Ntera2 cells as a predictive in vitro test system for developmental neurotoxicity","volume":"88","author":"Stern","year":"2014","journal-title":"Arch. Toxicol."},{"issue":"6","key":"10.1016\/j.tiv.2015.01.010_b0185","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1089\/scd.2004.13.646","article-title":"Human embryonal carcinoma stem cells expressing green fluorescent protein form functioning neurons in vitro: a research tool for co-culture studies","volume":"13","author":"Stewart","year":"2004","journal-title":"Stem Cells Dev."},{"issue":"5391","key":"10.1016\/j.tiv.2015.01.010_b0190","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thompson","year":"1998","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.tiv.2015.01.010_b0250","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S1474-4422(11)70107-7","article-title":"Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry","volume":"10","author":"Tomson","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.tiv.2015.01.010_b0200","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fneur.2012.00120","article-title":"Neuropathological sequelae of developmental exposure to antiepileptic and anesthetic drugs","volume":"3","author":"Turski","year":"2012","journal-title":"Front. Neurol."},{"issue":"5","key":"10.1016\/j.tiv.2015.01.010_b0205","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jocn.2013.09.022","article-title":"Effect of anti-epileptic drug therapy on the unborn child","volume":"21","author":"Vajda","year":"2014","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.tiv.2015.01.010_b0210","doi-asserted-by":"crossref","unstructured":"Verrotti, A., Scaparrotta, A., Cofini, M., Chiarelli, F., Tiboni, G.M., 2014. Developmental neurotoxicity and anticonvulsant drugs: a possible link. Reprod. Toxicol. Advance Access published May 5, 2014. doi: http:\/\/dx.doi.org\/10.1016\/j.reprotox.2014.04.005.","DOI":"10.1016\/j.reprotox.2014.04.005"},{"issue":"2","key":"10.1016\/j.tiv.2015.01.010_b0215","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neulet.2011.04.044","article-title":"Valproic acid induces apoptosis in differentiating hippocampal neurons by the release of tumor necrosis factor-\u03b1 from activated astrocytes","volume":"497","author":"Wang","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.tiv.2015.01.010_b0220","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0387-7604(02)00012-8","article-title":"The effects of antiepileptic drugs on spatial learning and hippocampal protein kinase C gamma in immature rats","volume":"24","author":"Wu","year":"2002","journal-title":"Brain Dev."},{"issue":"3","key":"10.1016\/j.tiv.2015.01.010_b0225","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neulet.2011.06.037","article-title":"Valproic acid inhibits neurosphere formation by adult subventricular cells by a lithium-sensitive mechanism","volume":"500","author":"Zhou","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.tiv.2015.01.010_b0230","first-page":"121","article-title":"Experimental study on the possibility of brain damage induced by chronic treatment with phenobarbital, clonazepam, valproic acid and topiramate in immature rats","volume":"45","author":"Zhu","year":"2007","journal-title":"Zhonghua Er Ke Za Zhi."},{"issue":"1","key":"10.1016\/j.tiv.2015.01.010_b0235","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tiv.2013.06.023","article-title":"Developmental stage dependent neural stem cells sensitivity to methylmercury chloride on different biofunctional surfaces","volume":"28","author":"Zychowicz","year":"2014","journal-title":"Toxicol. In Vitro"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233315000119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233315000119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:45:55Z","timestamp":1566261955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233315000119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S0887233315000119"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2015.01.010","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An evaluation of a human stem cell line to identify risk of developmental neurotoxicity with antiepileptic drugs","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2015.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}