{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T03:15:04Z","timestamp":1780715704485,"version":"3.54.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T00:00:00Z","timestamp":1464134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008730","name":"Norwegian Cancer Society","doi-asserted-by":"crossref","award":["0971"],"award-info":[{"award-number":["0971"]}],"id":[{"id":"10.13039\/100008730","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.tiv.2016.04.012","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T08:41:37Z","timestamp":1464079297000},"page":"55-65","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Epithelial-mesenchymal transition and FOXA genes during tobacco smoke carcinogen induced transformation of human bronchial epithelial cells"],"prefix":"10.1016","volume":"35","author":[{"given":"Audun","family":"Bersaas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yke Jildouw","family":"Arnoldussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Sj\u00f8berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aage","family":"Haugen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"Mollerup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2016.04.012_bb0005","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.1158\/0008-5472.CAN-05-3401","article-title":"N-cadherin gene expression in prostate carcinoma is modulated by integrin-dependent nuclear translocation of Twist1","volume":"66","author":"Alexander","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.tiv.2016.04.012_bb0010","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.celrep.2013.02.029","article-title":"Macrohistone variants preserve cell identity by preventing the gain of H3K4me2 during reprogramming to pluripotency","volume":"3","author":"Barrero","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.tiv.2016.04.012_bb0015","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.cell.2007.05.009","article-title":"High-resolution profiling of histone methylations in the human genome","volume":"129","author":"Barski","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.tiv.2016.04.012_bb0020","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.lungcan.2012.01.011","article-title":"Frequent downregulation of the transcription factor Foxa2 in lung cancer through epigenetic silencing","volume":"77","author":"Basseres","year":"2012","journal-title":"Lung Cancer"},{"key":"10.1016\/j.tiv.2016.04.012_bb0025","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/35000034","article-title":"The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells","volume":"2","author":"Batlle","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tiv.2016.04.012_bb0030","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1200\/JCO.2002.08.159","article-title":"High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer","volume":"20","author":"Bremnes","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.tiv.2016.04.012_bb0035","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cell.2005.05.008","article-title":"Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1","volume":"122","author":"Carroll","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.tiv.2016.04.012_bb0040","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1083\/jcb.200308162","article-title":"Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of \u03b2-catenin signaling, slug, and MAPK","volume":"163","author":"Conacci-Sorrell","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tiv.2016.04.012_bb0045","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1038\/nature09672","article-title":"Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability","volume":"470","author":"Cortazar","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.tiv.2016.04.012_bb0050","doi-asserted-by":"publisher","first-page":"9005","DOI":"10.1158\/0008-5472.CAN-08-1276","article-title":"Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells","volume":"68","author":"Damiani","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.tiv.2016.04.012_bb0055","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2011.09.001","article-title":"Lung cancer: epidemiology, etiology, and prevention","volume":"32","author":"Dela Cruz","year":"2011","journal-title":"Clin. Chest Med."},{"key":"10.1016\/j.tiv.2016.04.012_bb0060","doi-asserted-by":"publisher","first-page":"e22023","DOI":"10.1371\/journal.pone.0022023","article-title":"Multipotent capacity of immortalized human bronchial epithelial cells","volume":"6","author":"Delgado","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.tiv.2016.04.012_bb0065","first-page":"618","article-title":"Opposite Roles of FOXA1 and NKX2\u20131 in Lung Cancer Progression. Genes Chromosom","volume":"51","author":"Deutsch","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.tiv.2016.04.012_bb0070","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1038\/sj.onc.1208429","article-title":"DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells","volume":"24","author":"Eger","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.tiv.2016.04.012_bb0075","series-title":"Cancer Incidence and Mortality Worldwide: Sources, Methods and Major Patterns in GLOBOCAN 2012","first-page":"386","author":"Ferlay","year":"2015"},{"key":"10.1016\/j.tiv.2016.04.012_bb0080","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.lungcan.2009.12.005","article-title":"Lung cancer cell lines: useless artifacts or invaluable tools for medical science?","volume":"68","author":"Gazdar","year":"2010","journal-title":"Lung Cancer"},{"key":"10.1016\/j.tiv.2016.04.012_bb0085","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1126\/science.277.5323.225","article-title":"Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5","volume":"277","author":"Giannelli","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.tiv.2016.04.012_bb0090","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1023\/B:CACO.0000019485.74818.d6","article-title":"Smoking-adjusted incidence of lung cancer by occupation among Norwegian men","volume":"15","author":"Haldorsen","year":"2004","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.tiv.2016.04.012_bb0095","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s00423-006-0111-z","article-title":"Cigarette smoking: cancer risks, carcinogens, and mechanisms","volume":"391","author":"Hecht","year":"2006","journal-title":"Langenbeck's Arch. Surg."},{"key":"10.1016\/j.tiv.2016.04.012_bb0100","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1093\/ntr\/ntq216","article-title":"Research opportunities related to establishing standards for tobacco products under the Family Smoking Prevention and Tobacco Control Act","volume":"14","author":"Hecht","year":"2012","journal-title":"Nicotine Tob. Res."},{"key":"10.1016\/j.tiv.2016.04.012_bb0105","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1016\/j.yexcr.2007.03.040","article-title":"Novel functions of vimentin in cell adhesion, migration, and signaling","volume":"313","author":"Ivaska","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.tiv.2016.04.012_bb0110","doi-asserted-by":"publisher","first-page":"3725","DOI":"10.1158\/0008-5472.CAN-12-3468","article-title":"Androgen receptor-independent function of FoxA1 in prostate cancer metastasis","volume":"73","author":"Jin","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.tiv.2016.04.012_bb0115","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1101\/gr.229102","article-title":"The human genome browser at UCSC","volume":"12","author":"Kent","year":"2002","journal-title":"Genome Res."},{"key":"10.1016\/j.tiv.2016.04.012_bb0120","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/ng1400","article-title":"Evidence for nucleosome depletion at active regulatory regions genome-wide","volume":"36","author":"Lee","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tiv.2016.04.012_bb0125","series-title":"Transcr. Regul. SOX2 FOXA1 Gene Its Appl. Diagnosis Hum. Breast Lung Cancers","article-title":"The transcriptional regulation of SOX2 on FOXA1 gene and its application in diagnosis of human breast and lung cancers","author":"Li","year":"2013"},{"key":"10.1016\/j.tiv.2016.04.012_bb0130","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1016\/j.cell.2012.11.018","article-title":"Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation","volume":"151","author":"Li","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.tiv.2016.04.012_bb0135","first-page":"5273","article-title":"The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas","volume":"62","author":"Lin","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.tiv.2016.04.012_bb0140","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1128\/MCB.06306-11","article-title":"Critical and reciprocal regulation of KLF4 and SLUG in transforming growth factor-initiated prostate cancer epithelial-mesenchymal transition","volume":"32","author":"Liu","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tiv.2016.04.012_bb0145","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.tiv.2016.04.012_bb0150","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602996","article-title":"E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines","author":"Lombaerts","year":"2006","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.tiv.2016.04.012_bb0155","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/ncb2024","article-title":"miR-9, a MYC\/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis","volume":"12","author":"Ma","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tiv.2016.04.012_bb0160","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002723","article-title":"EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice","volume":"8","author":"Morel","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.tiv.2016.04.012_bb0165","article-title":"Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC-mediated downregulation of E-cadherin","volume":"47","author":"Nagathihalli","year":"2012","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.tiv.2016.04.012_bb0170","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.1158\/0008-5472.CAN-07-2938","article-title":"Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways","volume":"68","author":"Onder","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.tiv.2016.04.012_bb0175","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007559","article-title":"Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis","volume":"4","author":"Pozharskaya","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.tiv.2016.04.012_bb0180","doi-asserted-by":"publisher","first-page":"9027","DOI":"10.1158\/0008-5472.CAN-04-3703","article-title":"Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins","volume":"64","author":"Ramirez","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.tiv.2016.04.012_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2012.00068","article-title":"FoxA1 is a key mediator of hormonal response in breast and prostate cancer","volume":"3","author":"Robinson","year":"2012","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.tiv.2016.04.012_bb0190","series-title":"The Chemical Components of Tobacco and Tobacco Smoke","author":"Rodgman","year":"2013"},{"key":"10.1016\/j.tiv.2016.04.012_bb0195","doi-asserted-by":"publisher","first-page":"D56","DOI":"10.1093\/nar\/gks1172","article-title":"ENCODE data in the UCSC genome browser: year 5 update","volume":"41","author":"Rosenbloom","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tiv.2016.04.012_bb0200","doi-asserted-by":"publisher","first-page":"3486","DOI":"10.1128\/MCB.00694-14","article-title":"Cellular migration and invasion uncoupled: increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition","volume":"34","author":"Schaeffer","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tiv.2016.04.012_bb0205","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3322\/caac.21254","article-title":"Cancer statistics, 2015","volume":"65","author":"Siegel","year":"2015","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.tiv.2016.04.012_bb0210","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1158\/0008-5472.CAN-09-2979","article-title":"Loss of FOXA1\/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer","volume":"70","author":"Song","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.tiv.2016.04.012_bb0215","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/cr.2010.126","article-title":"FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers","volume":"21","author":"Tang","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.tiv.2016.04.012_bb0220","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/nrc822","article-title":"Epithelial-mesenchymal transitions in tumour progression","volume":"2","author":"Thiery","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tiv.2016.04.012_bb0225","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-mesenchymal transitions in development and disease","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.tiv.2016.04.012_bb0230","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.toxlet.2009.10.025","article-title":"Importance of CYP1A1 and CYP1B1 in bioactivation of benzo[a]pyrene in human lung cell lines","volume":"192","author":"Uppstad","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2016.04.012_bb0235","first-page":"4615","article-title":"Expression of type IV collagenase and procollagen genes and its correlation with the tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells","volume":"49","author":"Ura","year":"1989","journal-title":"Cancer Res."},{"key":"10.1016\/j.tiv.2016.04.012_bb0240","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.bbrc.2007.11.151","article-title":"Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer","volume":"367","author":"Vesuna","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tiv.2016.04.012_bb0245","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/0092-8674(91)90143-M","article-title":"Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role","volume":"66","author":"Vleminckx","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.tiv.2016.04.012_bb0250","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1186\/1471-2164-14-680","article-title":"A systematic approach identifies FOXA1 as a key factor in the loss of epithelial traits during the epithelial-to-mesenchymal transition in lung cancer","volume":"14","author":"Wang","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.tiv.2016.04.012_bb0255","doi-asserted-by":"publisher","first-page":"7416","DOI":"10.1073\/pnas.92.16.7416","article-title":"Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas","volume":"92","author":"Yoshiura","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tiv.2016.04.012_bb0260","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1126\/science.1186366","article-title":"Genome-wide evolutionary analysis of eukaryotic DNA methylation","volume":"328","author":"Zemach","year":"2010","journal-title":"Science"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233316300790?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233316300790?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:42:49Z","timestamp":1567968169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233316300790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":52,"alternative-id":["S0887233316300790"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2016.04.012","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epithelial-mesenchymal transition and FOXA genes during tobacco smoke carcinogen induced transformation of human bronchial epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2016.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}