{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:02:58Z","timestamp":1785304978584,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norwegian Research Council","doi-asserted-by":"publisher","award":["228877"],"award-info":[{"award-number":["228877"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIFES"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.tiv.2016.11.008","type":"journal-article","created":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T07:30:22Z","timestamp":1478935822000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["In vitro toxicity of pirimiphos-methyl in Atlantic salmon hepatocytes"],"prefix":"10.1016","volume":"39","author":[{"given":"P\u00e5l A.","family":"Olsvik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc H.G.","family":"Berntssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liv","family":"S\u00f8fteland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2016.11.008_bb0005","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.chembiol.2009.05.011","article-title":"Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effects","volume":"16","author":"Abassi","year":"2009","journal-title":"Chem. Biol."},{"key":"10.1016\/j.tiv.2016.11.008_bb0010","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0009-2797(02)00122-9","article-title":"Paraquat and menadione exposure of rainbow trout (Oncorhynchus mykiss) - studies of effects on the pentose-phosphate shunt and thiamine levels in liver and kidney","volume":"142","author":"Akerman","year":"2003","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tiv.2016.11.008_bb0015","first-page":"301","article-title":"Analysis of chlorpyrifos exposure and human health: expert panel report","volume":"B2","author":"Albers","year":"1999","journal-title":"J. Toxicol. Env. Heal."},{"key":"10.1016\/j.tiv.2016.11.008_bb0020","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.bcp.2007.05.027","article-title":"13-oxo-ODE is an endogenous ligand for PPAR gamma in human colonic epithelial cells","volume":"74","author":"Altmann","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tiv.2016.11.008_bb0025","first-page":"48","article-title":"Thiamine (vitamin B(1)) concentrations in salmon (Salmo salar), brown trout (Salmo trutta) and cod (Gadus morhua) from the Baltic sea","volume":"28","author":"Amcoff","year":"1999","journal-title":"Ambio"},{"key":"10.1016\/j.tiv.2016.11.008_bb0030","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.envpol.2004.11.001","article-title":"In vitro toxicity of selected pesticides on RTG-2 and RTL-W1 fish cell lines","volume":"135","author":"Babin","year":"2005","journal-title":"Environ. Poll."},{"key":"10.1016\/j.tiv.2016.11.008_bb0035","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. Royal Stat. Soc. Ser B."},{"key":"10.1016\/j.tiv.2016.11.008_bb0040","series-title":"The Toxicology of Fishes","first-page":"489","article-title":"The immune system of fish. A target organ of toxicity","author":"Carlson","year":"2008"},{"key":"10.1016\/j.tiv.2016.11.008_bb0045","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3748\/wjg.v16.i11.1366","article-title":"Hepatoprotective effects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury","volume":"16","author":"Cederbaum","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.tiv.2016.11.008_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2005.10.008","article-title":"Current issues in organophosphate toxicology","volume":"366","author":"Costa","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.tiv.2016.11.008_bb0055","author":"EFSA"},{"key":"10.1016\/j.tiv.2016.11.008_bb0060","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.bcp.2012.11.018","article-title":"Cloning, expression and analysis of the olfactory glutathione S-transferases in coho salmon","volume":"85","author":"Espinoza","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tiv.2016.11.008_bb0070","first-page":"9","article-title":"A review of early mortality syndrome (EMS) in great lakes salmonids: relationship with thiamine deficiency","volume":"28","author":"Fitzsimons","year":"1999","journal-title":"Ambio"},{"key":"10.1016\/j.tiv.2016.11.008_bb0075","series-title":"Organic Chemical Toxicology of Fishes","first-page":"309","article-title":"Insecticide toxicity in fish","author":"Fulton","year":"2014"},{"key":"10.1016\/j.tiv.2016.11.008_bb0080","author":"Genecards Database"},{"key":"10.1016\/j.tiv.2016.11.008_bb0085","first-page":"1","article-title":"Chlorpyrifos: ecological risk assessment in North American aquatic environments","volume":"160","author":"Giesy","year":"1999","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.tiv.2016.11.008_bb0090","doi-asserted-by":"crossref","first-page":"25702","DOI":"10.3402\/fnr.v59.25702","article-title":"Role of vitamin B6 status on antioxidant defenses, glutathione, and related enzyme activities in mice with homocysteine-induced oxidative stress","volume":"59","author":"Hsu","year":"2015","journal-title":"Food Nutr. Res."},{"key":"10.1016\/j.tiv.2016.11.008_bb0100","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.biochem.73.011303.073731","article-title":"Lysophospholipid receptors: signaling and biology","volume":"73","author":"Ishii","year":"2004","journal-title":"Ann. Rev. Biochem."},{"key":"10.1016\/j.tiv.2016.11.008_bb0105","author":"ISO"},{"key":"10.1016\/j.tiv.2016.11.008_bb0115","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.etap.2016.03.010","article-title":"Integrated biomarkers induced by chlorpyrifos in two different life stages of zebrafish (Danio rerio) for environmental risk assessment","volume":"43","author":"Jeon","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.tiv.2016.11.008_bb0120","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1080\/15287390701434372","article-title":"Evaluation of immunotoxicity induced by pirimiphos-methyl in male balb\/c mice following exposure to for 28days","volume":"70","author":"Kim","year":"2007","journal-title":"J. Toxicol. Environ. Health-Part A."},{"key":"10.1016\/j.tiv.2016.11.008_bb0125","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.aquatox.2010.09.002","article-title":"Microsomal biotransformation of chlorpyrifos, parathion and fenthion in rainbow trout (Oncorhynchus mykiss) and coho salmon (Oncorhynchus kisutch): mechanistic insights into interspecific differences in toxicity","volume":"101","author":"Lavado","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.tiv.2016.11.008_bb0130","first-page":"24","article-title":"Antioxidative systems, detoxifying enzymes and thiamine levels in Baltic salmon (Salmo salar) that develop M74","volume":"28","author":"Lundstrom","year":"1999","journal-title":"Ambio"},{"key":"10.1016\/j.tiv.2016.11.008_bb0135","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.aquatox.2010.10.006","article-title":"Environmentally induced oxidative stress in aquatic animals","volume":"101","author":"Lushchak","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.tiv.2016.11.008_bb0140","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/tox.21918","article-title":"Effects of chlorpyrifos on the transcription of CYP3A cDNA, activity of acetylcholinesterase, and oxidative stress response of goldfish (Carassius auratus)","volume":"30","author":"Ma","year":"2015","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.tiv.2016.11.008_bb0145","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1096\/fj.01-0401rev","article-title":"S-adenosylmethionine: a control switch that regulates liver function","volume":"16","author":"Mato","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.tiv.2016.11.008_bb0150","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.1007\/s11270-012-1328-9","article-title":"Acute toxicity of seven selected pesticides (alachlor, atrazine, dieldrin, diuron, pirimiphos-methyl, chlorpyrifos, diazinon) to the marine fish (turbot, Psetta maxima)","volume":"223","author":"Mhadhbi","year":"2012","journal-title":"Water Air Soil Poll."},{"key":"10.1016\/j.tiv.2016.11.008_bb0155","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1289\/ehp.7028","article-title":"The need to decide if all estrogens are intrinsically similar","volume":"112","author":"Moggs","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tiv.2016.11.008_bb0160","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1021\/jf405366n","article-title":"Screening of pesticides and polycyclic aromatic hydrocarbons in feeds and fish tissues by gas chromatography coupled to high-resolution mass spectrometry using atmospheric pressure chemical ionization","volume":"62","author":"Nacher-Mestre","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tiv.2016.11.008_bb0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119250","article-title":"Modifying effects of vitamin e on chlorpyrifos toxicity in Atlantic salmon","volume":"10","author":"Olsvik","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.tiv.2016.11.008_bb0170","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1007\/s00128-012-0548-4","article-title":"Oxidative stress responses and recovery patterns in the liver of Oreochromis niloticus exposed to chlorpyrifos-ethyl","volume":"88","author":"Oruc","year":"2012","journal-title":"B Environ. Contam. Tox."},{"key":"10.1016\/j.tiv.2016.11.008_bb0175","unstructured":"PAN AP (Pesticide Action Network Asia and the Pacific), 2013. Available: http:\/\/www.panap.net\/sites\/default\/files\/monograph-chlorpyrifos.pdf. Accessed (15 January 2016)."},{"key":"10.1016\/j.tiv.2016.11.008_bb0180","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.taap.2004.01.005","article-title":"Lysophospholipase inhibition by organophosphorus toxicants","volume":"196","author":"Quistad","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2016.11.008_bb0185","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pestbp.2006.10.003","article-title":"A review on the mechanisms involved in hyperglycemia induced by organophosphorus pesticides","volume":"88","author":"Rahimi","year":"2007","journal-title":"Pestic. Biochem. Phys."},{"key":"10.1016\/j.tiv.2016.11.008_bb0190","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1021\/jf00115a027","article-title":"Acute toxicity, bioconcentration, and persistence of Ac-222, 705, benthiocarb, chlorpyrifos, fenvalerate, methyl parathion, and permethrin in the estuarine environment","volume":"31","author":"Schimmel","year":"1983","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tiv.2016.11.008_bb0195","series-title":"The Toxicology of Fishes","first-page":"153","article-title":"Biotransformation in fishes","author":"Schlenk","year":"2008"},{"key":"10.1016\/j.tiv.2016.11.008_bb0200","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.etap.2010.11.005","article-title":"DNA damage and cholinesterase activity in occupational workers exposed to pesticides","volume":"31","author":"Singh","year":"2011","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.tiv.2016.11.008_bb0205","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.tiv.2009.07.014","article-title":"Factorial design applied for multiple endpoint toxicity evaluation in Atlantic salmon (Salmo salar L.) hepatocytes","volume":"23","author":"S\u00f8fteland","year":"2009","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.tiv.2016.11.008_bb0210","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.fct.2014.08.008","article-title":"Toxicological effect of single contaminants and contaminant mixtures associated with plant ingredients in novel salmon feeds","volume":"73","author":"S\u00f8fteland","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tiv.2016.11.008_bb0215","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.toxrep.2016.01.008","article-title":"Omega-3 and alpha-tocopherol provide more protection against contaminants in novel feeds for Atlantic salmon (Salmo salar L.) than omega-6 and gamma tocopherol","volume":"3","author":"S\u00f8fteland","year":"2016","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.tiv.2016.11.008_bb0220","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.bbalip.2014.07.020","article-title":"Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism","volume":"1851","author":"Spector","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tiv.2016.11.008_bb0225","first-page":"173","article-title":"Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment","volume":"103","author":"Sumpter","year":"1995","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tiv.2016.11.008_bb0230","first-page":"1201","article-title":"Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes","volume":"29","author":"Tang","year":"2001","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tiv.2016.11.008_bb0235","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1101\/gr.124321.111","article-title":"Differential expression in RNA-seq: a matter of depth","volume":"21","author":"Tarazona","year":"2011","journal-title":"Genome Res."},{"key":"10.1016\/j.tiv.2016.11.008_bb0245","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s12038-007-0028-x","article-title":"Dihydroxyoctadecamonoenoate esters inhibit the neutrophil respiratory burst","volume":"32","author":"Thompson","year":"2007","journal-title":"J. Biosci."},{"key":"10.1016\/j.tiv.2016.11.008_bb0250","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1579\/0044-7447(2007)36[168:MSIBSA]2.0.CO;2","article-title":"M74 syndrome in Baltic salmon and the possible role of oxidative stresses in its development: present knowledge and perspectives for future studies","volume":"36","author":"Vuori","year":"2007","journal-title":"Ambio"},{"key":"10.1016\/j.tiv.2016.11.008_bb0255","author":"WHO"},{"key":"10.1016\/j.tiv.2016.11.008_bb0260","author":"WHO"},{"key":"10.1016\/j.tiv.2016.11.008_bb0265","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.chemosphere.2014.01.002","article-title":"Effects of atrazine and chlorpyrifos on cytochrome P450 in common carp liver","volume":"104","author":"Xing","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.tiv.2016.11.008_bb0270","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.aquaculture.2015.06.023","article-title":"Utilisation of feed resources in production of Atlantic salmon (Salmo salar) in Norway","volume":"448","author":"Ytrest\u00f8yl","year":"2015","journal-title":"Aquaculture"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233316302302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233316302302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T15:01:58Z","timestamp":1718895718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233316302302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":50,"alternative-id":["S0887233316302302"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2016.11.008","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro toxicity of pirimiphos-methyl in Atlantic salmon hepatocytes","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2016.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}