{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:51:53Z","timestamp":1772805113496,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31472285"],"award-info":[{"award-number":["31472285"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Scientists and Technicians Troop Construction Projects of Henan Province, China","award":["164200510001"],"award-info":[{"award-number":["164200510001"]}]},{"name":"Key Subjects of Biology and Ecology in Henan Province, China","award":["201604"],"award-info":[{"award-number":["201604"]}]},{"name":"Key Subjects of Biology and Ecology in Henan Province, China","award":["201606"],"award-info":[{"award-number":["201606"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.tiv.2016.12.016","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T07:45:13Z","timestamp":1483602313000},"page":"115-123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Alterations in transcription and protein expressions of HCC-related genes in HepG2 cells caused by microcystin-LR"],"prefix":"10.1016","volume":"40","author":[{"given":"Xiaoyu","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chune","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2016.12.016_bb0005","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1387-2656(05)11004-7","article-title":"Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction","volume":"11","author":"Berridge","year":"2005","journal-title":"Biotechnol. Annu. Rev."},{"key":"10.1016\/j.tiv.2016.12.016_bb0010","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.tox.2005.10.005","article-title":"Microcystin-LR induced cellular effects in mammalian and fish primary hepatocyte cultures and cell lines: a comparative study","volume":"218","author":"Boaru","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.tiv.2016.12.016_bb0015","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.toxlet.2003.12.005","article-title":"Microcystin-LR and nodularin induce intracellular glutathione alteration, reactive oxygen species production and lipid peroxidation in primary cultured rat hepatocytes","volume":"148","author":"Bouaicha","year":"2004","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2016.12.016_bb0020","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3390\/ijms11010268","article-title":"Molecular mechanism of microcystin toxicity in animal cells","volume":"11","author":"Campos","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tiv.2016.12.016_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12275-013-2549-3","article-title":"Toxin-producing cyanobacteria in freshwater: a review of the problems, impact on drinking water safety, and efforts for protecting public health","volume":"51","author":"Cheung","year":"2013","journal-title":"J. Microbiol."},{"key":"10.1016\/j.tiv.2016.12.016_bb0030","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.taap.2004.02.016","article-title":"Cyanobacterial toxins: risk management for health protection","volume":"203","author":"Codd","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2016.12.016_bb0035","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.gene.2012.12.106","article-title":"Gene expression signature of human HepG2 cell line","volume":"518","author":"Costantini","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.tiv.2016.12.016_bb0040","first-page":"1","article-title":"Genotoxicity of microcystin-LR in vitro and in vivo experimental models","author":"Dias","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.tiv.2016.12.016_bb0045","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/ijerph2005010043","article-title":"Health risk assessment of cyanobacterial (blue\u2013green algal) toxins in drinking water","volume":"2","author":"Falconer","year":"2005","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.tiv.2016.12.016_bb0050","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tox.2014.02.015","article-title":"Microcystin-LR stabilizes c-myc protein by inhibiting protein phosphatase 2A in HEK293 cells","volume":"319","author":"Fan","year":"2014","journal-title":"Toxicology"},{"key":"10.1016\/j.tiv.2016.12.016_bb0055","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.taap.2010.02.006","article-title":"The role of organic anion transporting polypeptides (OATPs\/SLCOs) in the toxicity of different microcystin congeners in vitro: a comparison of primary human hepatocytes and OATP-transfected HEK293 cells","volume":"245","author":"Fischer","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2016.12.016_bb0060","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/S1470-2045(06)70789-6","article-title":"Carcinogenicity of nitrate, nitrite, and cyanobacterial peptide toxins","volume":"7","author":"Grosse","year":"2006","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.tiv.2016.12.016_bb0065","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.cellsig.2015.02.031","article-title":"PKC\u03b5-mediated c-Met endosomal processing directs fluctuant c-Met-JNK-paxillin signaling for tumor progression of HepG2","volume":"27","author":"Hu","year":"2015","journal-title":"Cell. Signal."},{"key":"10.1016\/j.tiv.2016.12.016_bb0070","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/hep.510230518","article-title":"Molecular and functional characterization of bile acid transport in human hepatoblastoma HepG2 cells","volume":"23","author":"Kullak-Ublick","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.tiv.2016.12.016_bb0075","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.toxicon.2008.10.027","article-title":"In vivo study on the effects of microcystin extracts on the expression profiles of proto-oncogenes (c-fos, c-jun and c-myc) in liver, kidney and testis of male Wistar rats injected i.v. with toxins","volume":"53","author":"Li","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.tiv.2016.12.016_bb9000","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.chemosphere.2013.04.055","article-title":"Cloning of cytochrome P450 (CYP3A137) complementary DNA in silver carp and expression induction by ionic liquid.","volume":"92","author":"Li","year":"2013","journal-title":"Chemosphere"},{"key":"10.1016\/j.tiv.2016.12.016_bb0080","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jbt.21548","article-title":"c-Fos and c-jun expression in the liver of silver carp and the effect of microcystins","volume":"28","author":"Li","year":"2014","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.tiv.2016.12.016_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2015.04.010","article-title":"The role of PP2A-associated proteins and signal pathways in microcystin-LR toxicity","volume":"236","author":"Liu","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2016.12.016_bb0090","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.toxlet.2015.10.015","article-title":"Microcystin-LR promotes proliferation by activating Akt\/S6K1 pathway and disordering apoptosis and cell cycle associated proteins phosphorylation in HL7702 cells","volume":"240","author":"Liu","year":"2016","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2016.12.016_bb0095","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and 2(\u2212Delta Delta Ct) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.tiv.2016.12.016_bb0100","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.tox.2004.02.009","article-title":"Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents","volume":"198","author":"Mersch-Sundermann","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.tiv.2016.12.016_bb0105","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s00248-012-0159-y","article-title":"Harmful cyanobacterial blooms: causes, consequences, and controls","volume":"65","author":"Paerl","year":"2013","journal-title":"Microb. Ecol."},{"key":"10.1016\/j.tiv.2016.12.016_bb0110","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.3390\/md8051650","article-title":"On the chemistry, toxicology and genetics of the cyanobacterial toxins, microcystin, nodularin, saxitoxin and cylindrospermopsin","volume":"8","author":"Pearson","year":"2010","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.tiv.2016.12.016_bb0115","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.bbamcr.2007.01.012","article-title":"Ras oncogenes and their downstream targets","volume":"1773","author":"Rajalingam","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tiv.2016.12.016_bb0120","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11157-014-9334-6","article-title":"The cyanotoxin-microcystins: current overview","volume":"13","author":"Rastogi","year":"2014","journal-title":"Rev. Environ. Sci. Biotechnol."},{"key":"10.1016\/j.tiv.2016.12.016_bb0125","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/excr.2000.5130","article-title":"PTEN: life as a tumor suppressor","volume":"264","author":"Simpson","year":"2001","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.tiv.2016.12.016_bb0130","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1248\/bpb.27.606","article-title":"A tale of early response genes","volume":"27","author":"Sng","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.tiv.2016.12.016_bb0135","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/10590500903585382","article-title":"Molecular aspects of microcystin-induced hepatotoxicity and hepatocarcinogenesis","volume":"28","author":"Svir\u010dev","year":"2010","journal-title":"J. Environ. Sci. Health Part C"},{"key":"10.1016\/j.tiv.2016.12.016_bb0140","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/carcin\/17.6.1317","article-title":"Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay","volume":"17","author":"Ueno","year":"1996","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.tiv.2016.12.016_bb0145","series-title":"Addendum to Volume 2. Health Criteria and Other Supporting Information","article-title":"Guidelines for drinking-water quality","author":"WHO","year":"1998"},{"key":"10.1016\/j.tiv.2016.12.016_bb0150","first-page":"8801","article-title":"Promotion of melanoma cell invasion and tumor metastasis by microcystin-LR via phosphatidylinositol 3-kinase\/AKT pathway","volume":"47","author":"Xu","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tiv.2016.12.016_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12940-015-0026-7","article-title":"Cyanobacteria blooms and non-alcoholic liver disease: evidence from a county level ecological study in the United States","volume":"14","author":"Zhang","year":"2015","journal-title":"Environ. Health"},{"key":"10.1016\/j.tiv.2016.12.016_bb0160","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.toxicon.2015.05.005","article-title":"Mechanisms of microcystin-LR-induced cytoskeletal disruption in animal cells","volume":"101","author":"Zhou","year":"2015","journal-title":"Toxicon"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233316302727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233316302727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T05:51:03Z","timestamp":1536126663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233316302727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":33,"alternative-id":["S0887233316302727"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2016.12.016","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alterations in transcription and protein expressions of HCC-related genes in HepG2 cells caused by microcystin-LR","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2016.12.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}