{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:05:04Z","timestamp":1790521504943,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Netherlands Genomics Initiative\/Netherlands Organization for Scientific Research","award":["050-060-510"],"award-info":[{"award-number":["050-060-510"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.tiv.2017.07.024","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T05:47:35Z","timestamp":1501566455000},"page":"322-329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4912-8956","authenticated-orcid":false,"given":"Wim F.P.M.","family":"Van den Hof","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten L.J.","family":"Coonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"van Herwijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Brauers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyel","family":"Jennen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.M.","family":"Olde Damink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank G.","family":"Schaap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos C.S.","family":"Kleinjans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.tiv.2017.07.024_bb0005","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/toxsci\/kfn268","article-title":"Bile acid sulfation: a pathway of bile acid elimination and detoxification","volume":"108","author":"Alnouti","year":"2009","journal-title":"Toxicol. Sci."},{"issue":"4","key":"10.1016\/j.tiv.2017.07.024_bb0010","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1002\/hep.26160","article-title":"Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells","volume":"57","author":"Anth\u00e9rieu","year":"2013","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.tiv.2017.07.024_bb0015","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/hep.20800","article-title":"Outcome and prognostic markers in severe drug-induced liver disease","volume":"42","author":"Bj\u00f6rnsson","year":"2005","journal-title":"Hepatology"},{"issue":"0","key":"10.1016\/j.tiv.2017.07.024_bb0020","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0065-2571(94)90023-X","article-title":"ATP-dependent export pumps and their inhibition by cyclosporins","volume":"34","author":"B\u00f6hme","year":"1994","journal-title":"Adv. Enzym. Regul."},{"issue":"1","key":"10.1016\/j.tiv.2017.07.024_bb0025","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/carcin\/bgt278","article-title":"Assessing compound carcinogenicity in vitro using connectivity mapping","volume":"35","author":"Caiment","year":"2014","journal-title":"Carcinogenesis"},{"issue":"10","key":"10.1016\/j.tiv.2017.07.024_bb0030","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1194\/jlr.R900010-JLR200","article-title":"Bile acids: regulation of synthesis","volume":"50","author":"Chiang","year":"2009","journal-title":"J. Lipid Res."},{"issue":"11","key":"10.1016\/j.tiv.2017.07.024_bb0035","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1124\/dmd.32.11.","article-title":"Heterotropic modulation of sulfotransferase 2A1 activity by celecoxib: product ratio switching of ethynylestradiol sulfation","volume":"32","author":"Cui","year":"2004","journal-title":"Drug Metab. Dispos."},{"issue":"20","key":"10.1016\/j.tiv.2017.07.024_bb0040","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gni179","article-title":"Evolving gene\/transcript definitions significantly alter the interpretation of GeneChip data","volume":"33","author":"Dai","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"10.1016\/j.tiv.2017.07.024_bb0045","doi-asserted-by":"crossref","first-page":"W71","DOI":"10.1093\/nar\/gkt293","article-title":"User-friendly solutions for microarray quality control and pre-processing on ArrayAnalysis.org","volume":"41","author":"Eijssen","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.tiv.2017.07.024_bb0050","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2174\/1389200043335414","article-title":"Human hepatocytes in primary culture: the choice to investigate drug metabolism in man","volume":"5","author":"Gomez-Lechon","year":"2004","journal-title":"Curr. Drug Metab."},{"issue":"7252","key":"10.1016\/j.tiv.2017.07.024_bb0055","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/460208a","article-title":"Toxicology for the twenty-first century","volume":"460","author":"Hartung","year":"2009","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.tiv.2017.07.024_bb0060","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2217\/bmm.13.154","article-title":"Evaluation of database-derived pathway development for enabling biomarker discovery for hepatotoxicity","volume":"8","author":"Hebels","year":"2014","journal-title":"Biomark. Med"},{"issue":"0","key":"10.1016\/j.tiv.2017.07.024_bb0065","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.tox.2012.10.018","article-title":"Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2","volume":"303","author":"Hirsova","year":"2013","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.tiv.2017.07.024_bb0070","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"issue":"8","key":"10.1016\/j.tiv.2017.07.024_bb0075","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.tiv.2011.11.002","article-title":"BSEP inhibition \u2013 in vitro screens to assess cholestatic potential of drugs","volume":"26","author":"Kis","year":"2012","journal-title":"Toxicol. in Vitro"},{"issue":"5795","key":"10.1016\/j.tiv.2017.07.024_bb0080","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1126\/science.1132939","article-title":"The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease","volume":"313","author":"Lamb","year":"2006","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.tiv.2017.07.024_bb0085","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1124\/dmd.108.025775","article-title":"Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes","volume":"37","author":"Mathijs","year":"2009","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.tiv.2017.07.024_bb0090","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/toxsci\/kft176","article-title":"A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development","volume":"136","author":"Morgan","year":"2013","journal-title":"Toxicol. Sci."},{"issue":"1\u20132","key":"10.1016\/j.tiv.2017.07.024_bb0095","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"issue":"4","key":"10.1016\/j.tiv.2017.07.024_bb0100","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1002\/hep.24229","article-title":"Drug-induced cholestasis","volume":"53","author":"Padda","year":"2011","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.tiv.2017.07.024_bb0105","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/hep.22771","article-title":"High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis","volume":"49","author":"Schaap","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.tiv.2017.07.024_bb0110","series-title":"Bioinformatics and Computational Biology Solutions Using R and Bioconductor","first-page":"397","article-title":"Limma: linear models for microarray data","author":"Smyth","year":"2005"},{"key":"10.1016\/j.tiv.2017.07.024_bb0115","series-title":"R: A Language and Environment for Statistical Computing","author":"Team","year":"2013"},{"issue":"3","key":"10.1016\/j.tiv.2017.07.024_bb0120","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1021\/tx4004165","article-title":"Classification of hepatotoxicants using HepG2 cells: a proof of principle study","volume":"27","author":"Van den Hof","year":"2014","journal-title":"Chem. Res. Toxicol."},{"issue":"0","key":"10.1016\/j.tiv.2017.07.024_bb0125","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.tox.2014.06.003","article-title":"Integrative cross-omics analysis in primary mouse hepatocytes unravels mechanisms of cyclosporin A-induced hepatotoxicity","volume":"324","author":"Van den Hof","year":"2014","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.tiv.2017.07.024_bb0130","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/toxsci\/kft177","article-title":"Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury","volume":"136","author":"Vinken","year":"2013","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.tiv.2017.07.024_bb0135","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1055\/s-0030-1253225","article-title":"Nuclear receptor regulation of the adaptive response of bile acid transporters in cholestasis","volume":"30","author":"Wagner","year":"2010","journal-title":"Semin. Liver Dis."},{"issue":"11","key":"10.1016\/j.tiv.2017.07.024_bb0140","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1124\/dmd.104.000182","article-title":"The involvement of CYP3A4 and CYP2C9 in the metabolism of 17 alpha-ethinylestradiol","volume":"32","author":"Wang","year":"2004","journal-title":"Drug Metab. Dispos."},{"issue":"5","key":"10.1016\/j.tiv.2017.07.024_bb0145","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1002\/hep.23151","article-title":"Nuclear factor erythroid 2\u2013related factor 2 is a positive regulator of human bile salt export pump expression","volume":"50","author":"Weerachayaphorn","year":"2009","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.tiv.2017.07.024_bb0150","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.bcp.2010.06.045","article-title":"Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver\u2014a comparison with other phenothiazines","volume":"80","author":"W\u00f3jcikowski","year":"2010","journal-title":"Biochem. Pharmacol."},{"issue":"35","key":"10.1016\/j.tiv.2017.07.024_bb0155","doi-asserted-by":"crossref","first-page":"31441","DOI":"10.1074\/jbc.M200474200","article-title":"Lithocholic acid decreases expression of bile salt export pump through Farnesoid X receptor antagonist activity","volume":"277","author":"Yu","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.tiv.2017.07.024_bb0160","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1517\/17460440903413488","article-title":"Ariadne's ChemEffect and Pathway Studio knowledge base","volume":"4","author":"Yuryev","year":"2009","journal-title":"Expert Opin. Drug Discovery"},{"issue":"1","key":"10.1016\/j.tiv.2017.07.024_bb0165","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/1471-2105-10-236","article-title":"sscMap: an extensible Java application for connecting small-molecule drugs using gene-expression signatures","volume":"10","author":"Zhang","year":"2009","journal-title":"BMC Bioinf."},{"issue":"13\u201314","key":"10.1016\/j.tiv.2017.07.024_bb0170","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s10354-006-0312-7","article-title":"Molecular mechanisms of cholestasis","volume":"156","author":"Zollner","year":"2006","journal-title":"Wien. Med. Wochenschr."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233317302102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233317302102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T16:59:12Z","timestamp":1535561952000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233317302102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":34,"alternative-id":["S0887233317302102"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2017.07.024","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2017.07.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}