{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:54:58Z","timestamp":1791453298182,"version":"4.3.3"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2015R1D1A1A01057931"],"award-info":[{"award-number":["NRF-2015R1D1A1A01057931"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health &Welfare, Republic of Korea","award":["HN15C0102"],"award-info":[{"award-number":["HN15C0102"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.tiv.2017.09.025","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T14:17:16Z","timestamp":1506349036000},"page":"194-202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"special_numbering":"C","title":["Investigation of dermal toxicity of ionic liquids in monolayer-cultured skin cells and 3D reconstructed human skin models"],"prefix":"10.1016","volume":"46","author":[{"given":"Jee-hyun","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeonji","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dal Woong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Taek","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1517-7680","authenticated-orcid":false,"given":"Kyung-Min","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2017.09.025_bb0005","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1021\/ar010065m","article-title":"Origins, current status, and future challenges of green chemistry","volume":"35","author":"Anastas","year":"2002","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.tiv.2017.09.025_bb0010","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1007\/s11095-015-1720-4","article-title":"Modeling and prediction of solvent effect on human skin permeability using support vector regression and random forest","volume":"3s2","author":"Baba","year":"2015","journal-title":"Pharm. Res."},{"key":"10.1016\/j.tiv.2017.09.025_bb0015","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1023\/A:1019540316060","article-title":"Environmental pollutants and skin cancer","volume":"18","author":"Baudouin","year":"2002","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.tiv.2017.09.025_bb0020","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1039\/b617536h","article-title":"What is a green solvent? A comprehensive framework for the environmental assessment of solvents","volume":"9","author":"Capello","year":"2007","journal-title":"Green Chem."},{"key":"10.1016\/j.tiv.2017.09.025_bb1000","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4062\/biomolther.2016.094","article-title":"Baicalein Inhibits the Migration and Invasion of B16F10 Mouse Melanoma Cells through Inactivation of the PI3K\/Akt Signaling Pathway","volume":"25","author":"Choi","year":"2017","journal-title":"Biomol. Ther. (Seoul)"},{"key":"10.1016\/j.tiv.2017.09.025_bb0025","first-page":"82","article-title":"Solvent selection guide: a guide to the integration of environmental, health and safety criteria into the selection of solvents","volume":"1","author":"Curzons","year":"1999","journal-title":"Clean Prod. Process."},{"key":"10.1016\/j.tiv.2017.09.025_bb0030","series-title":"ECHA publishes an updated list of pre-registered substances","author":"ECHA","year":"2016"},{"key":"10.1016\/j.tiv.2017.09.025_bb0035","doi-asserted-by":"crossref","first-page":"7719","DOI":"10.1038\/sj.onc.1203249","article-title":"More than one way to die: apoptosis, necrosis and reactive oxygen damage","volume":"18","author":"Fiers","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.tiv.2017.09.025_bb0040","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1039\/b914284n","article-title":"Toxicological evaluation on human colon carcinoma cell line (CaCo-2) of ionic liquids based on imidazolium, guanidinium, ammonium, phosphonium, pyridinium and pyrrolidinium cations","volume":"11","author":"Frade","year":"2009","journal-title":"Green Chem."},{"key":"10.1016\/j.tiv.2017.09.025_bb0045","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1471-2407-5-97","article-title":"Novel curcumin-and emodin-related compounds identified by in silico 2D\/3D conformer screening induce apoptosis in tumor cells","volume":"5","author":"F\u00fcllbeck","year":"2005","journal-title":"BMC Cancer"},{"key":"10.1016\/j.tiv.2017.09.025_bb0050","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.fct.2015.02.018","article-title":"An in vitro study on the cytotoxicity of bismuth oxychloride nanosheets in human HaCaT keratinocytes","volume":"80","author":"Gao","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tiv.2017.09.025_bb0055","doi-asserted-by":"crossref","DOI":"10.5620\/eht.e2016026","article-title":"Act on the Registration and Evaluation of Chemicals (K-REACH) and replacement, reduction or refinement best practices","volume":"31","author":"Ha","year":"2016","journal-title":"Environ. Health Toxicol."},{"key":"10.1016\/j.tiv.2017.09.025_bb0060","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1039\/b211971d","article-title":"How hazardous are ionic liquids? Structure\u2013activity relationships and biological testing as important elements for sustainability evaluation","volume":"5","author":"Jastorff","year":"2003","journal-title":"Green Chem."},{"key":"10.1016\/j.tiv.2017.09.025_bb0065","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/glia.20003","article-title":"Glutamine-induced free radical production in cultured astrocytes","volume":"46","author":"Jayakumar","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.tiv.2017.09.025_bb0070","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.tiv.2014.02.014","article-title":"KeraSkin\u2122-VM: a novel reconstructed human epidermis model for skin irritation tests","volume":"28","author":"Jung","year":"2014","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.tiv.2017.09.025_bb0075","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s12011-012-9492-8","article-title":"Zinc inhibits apoptosis and maintains NEP downregulation, induced by ropivacaine, in HaCaT cells","volume":"150","author":"Kontargiris","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tiv.2017.09.025_bb0080","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/tox.20443","article-title":"In vitro cytotoxicities of ionic liquids: effect of cation rings, functional groups, and anions","volume":"24","author":"Kumar","year":"2009","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.tiv.2017.09.025_bb0085","doi-asserted-by":"crossref","first-page":"191","DOI":"10.5487\/TR.2017.33.3.191","article-title":"Alternatives to in vivo draize rabbit eye and skin irritation tests with a focus on 3D reconstructed human cornea-like epithelium and epidermis models","volume":"33","author":"Lee","year":"2017","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.tiv.2017.09.025_bb0090","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2533\/000942906777836255","article-title":"Microwaves, power ultrasound, and ionic liquids. A new synergy in green organic synthesis","volume":"60","author":"L\u00e9v\u00eaque","year":"2006","journal-title":"CHIMIA Int. J. Chem"},{"key":"10.1016\/j.tiv.2017.09.025_bb0095","author":"Markets"},{"key":"10.1016\/j.tiv.2017.09.025_bb0100","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1039\/b705795d","article-title":"The influence of anion species on the toxicity of 1-alkyl-3-methylimidazolium ionic liquids observed in an (eco) toxicological test battery","volume":"9","author":"Matzke","year":"2007","journal-title":"Green Chem."},{"key":"10.1016\/j.tiv.2017.09.025_bb0105","series-title":"The Structure of Supported Ionic Liquids at the Interface","author":"Moosavi","year":"2013"},{"key":"10.1016\/j.tiv.2017.09.025_bb0110","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"Journal of immunological methods"},{"key":"10.1016\/j.tiv.2017.09.025_bb0115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.progpolymsci.2005.08.002","article-title":"Supercritical carbon dioxide as a green solvent for processing polymer melts: processing aspects and applications","volume":"31","author":"Nalawade","year":"2006","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.tiv.2017.09.025_bb0120","series-title":"OECD Guidelines for the Testing of Chemicals","article-title":"Test no. 439: in vitro skin irritation: reconstructed human epidermis test method","author":"OECD","year":"2013"},{"key":"10.1016\/j.tiv.2017.09.025_bb2000","doi-asserted-by":"crossref","first-page":"616","DOI":"10.4062\/biomolther.2016.022","article-title":"Baicalein Protects Human Skin Cells against Ultraviolet B-Induced Oxidative Stress","volume":"24","author":"Oh","year":"2016","journal-title":"Biomol. Ther. (Seoul)"},{"key":"10.1016\/j.tiv.2017.09.025_bb0125","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0887-2333(94)90033-7","article-title":"The use of in vitro reconstituted human skin in dermotoxicity testing","volume":"8","author":"Roguet","year":"1994","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.tiv.2017.09.025_bb0130","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1039\/B410891D","article-title":"Octanol\u2013water partition coefficients of imidazolium-based ionic liquids","volume":"7","author":"Ropel","year":"2005","journal-title":"Green Chem."},{"key":"10.1016\/j.tiv.2017.09.025_bb0135","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/j.ecoenv.2010.07.020","article-title":"Introduction of oxygenated side chain into imidazolium ionic liquids: evaluation of the effects at different biological organization levels","volume":"73","author":"Samor\u00ec","year":"2010","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tiv.2017.09.025_bb0140","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1191\/0960327104ht480oa","article-title":"Evaluating the cytotoxicity of ionic liquids using human cell line HeLa","volume":"23","author":"Stepnowski","year":"2004","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.tiv.2017.09.025_bb0145","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.fct.2016.07.027","article-title":"Cytotoxic effects of zearalenone and its metabolites and antioxidant cell defense in CHO-K1 cells","volume":"96","author":"Tatay","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tiv.2017.09.025_bb0150","series-title":"MSDS","author":"VelocityEHS","year":"2001"},{"key":"10.1016\/j.tiv.2017.09.025_bb0155","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1021\/cr980032t","article-title":"Room-temperature ionic liquids. Solvents for synthesis and catalysis","volume":"99","author":"Welton","year":"1999","journal-title":"Chem. Rev."},{"key":"10.1016\/j.tiv.2017.09.025_bb0160","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/620383","article-title":"Shikonin induces apoptosis, necrosis, and premature senescence of human A549 lung cancer cells through upregulation of p53 expression","volume":"2015","author":"Yeh","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.tiv.2017.09.025_bb0165","doi-asserted-by":"crossref","first-page":"13313","DOI":"10.1073\/pnas.1403995111","article-title":"Ionic liquids as a class of materials for transdermal delivery and pathogen neutralization","volume":"111","author":"Zakrewsky","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.tiv.2017.09.025_bb0170","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.toxlet.2014.03.007","article-title":"Basic Red 51, a permitted semi-permanent hair dye, is cytotoxic to human skin cells: studies in monolayer and 3D skin model using human keratinocytes (HaCaT)","volume":"227","author":"Zanoni","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2017.09.025_bb0175","first-page":"42","article-title":"Toxicity of ionic liquids, Clean-Soil Air Water","volume":"1","author":"Zhao","year":"2007","journal-title":"Clean: Soil, Air, Water"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233317302771?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233317302771?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T15:09:03Z","timestamp":1536332943000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233317302771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":37,"alternative-id":["S0887233317302771"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2017.09.025","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of dermal toxicity of ionic liquids in monolayer-cultured skin cells and 3D reconstructed human skin models","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2017.09.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}