{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:12:10Z","timestamp":1770725530105,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21377052"],"award-info":[{"award-number":["21377052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31370524"],"award-info":[{"award-number":["31370524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["021414380332"],"award-info":[{"award-number":["021414380332"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.tiv.2017.11.009","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T23:31:14Z","timestamp":1511307074000},"page":"79-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["MiR-301b-3p\/3584-5p enhances low-dose mono-n-butyl phthalate (MBP)\u2013induced proliferation by targeting Rasd1 in Sertoli cells"],"prefix":"10.1016","volume":"47","author":[{"given":"Xiaoqin","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruitong","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2017.11.009_bb0005","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.tiv.2017.11.009_bb0010","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1210\/en.2015-1936","article-title":"Prepubertal di-n-butyl phthalate exposure alters Sertoli and Leydig cell function and lowers bone density in adult male mice","volume":"157","author":"Bielanowicz","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.tiv.2017.11.009_bb0015","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1477-7827-9-126","article-title":"miRNA regulation of cytotoxic effects in mouse Sertoli cells exposed to nonylphenol","volume":"9","author":"Choi","year":"2011","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.tiv.2017.11.009_bb0020","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/12867","article-title":"Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling","volume":"17","author":"Cismowski","year":"1999","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tiv.2017.11.009_bb0025","doi-asserted-by":"crossref","first-page":"23421","DOI":"10.1074\/jbc.C000322200","article-title":"Activation of heterotrimeric G-protein signaling by a ras-related protein. Implications for signal integration","volume":"275","author":"Cismowski","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2017.11.009_bb0200","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrc2294","article-title":"The properties of high-dimensional data spaces: implications for exploring gene and protein expression data","volume":"8","author":"Clarke","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tiv.2017.11.009_bb0215","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1101\/gr.6202607","article-title":"A systems biology approach for pathway level analysis","volume":"17","author":"Draghici","year":"2007","journal-title":"Genome Res."},{"key":"10.1016\/j.tiv.2017.11.009_bb0030","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1261\/rna.1947110","article-title":"Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression","volume":"16","author":"Git","year":"2010","journal-title":"RNA"},{"key":"10.1016\/j.tiv.2017.11.009_bb0035","doi-asserted-by":"crossref","first-page":"10876","DOI":"10.1074\/jbc.M110397200","article-title":"Dexras1\/AGS-1 inhibits signal transduction from the Gi-coupled formyl peptide receptor to Erk-1\/2 MAP kinases","volume":"277","author":"Graham","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2017.11.009_bb0040","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.bbrc.2004.02.049","article-title":"Dexras1 inhibits adenylyl cyclase","volume":"316","author":"Graham","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tiv.2017.11.009_bb0045","first-page":"101","article-title":"Hypoxia induced upregulation of miR-301a\/b contributes to increased cell autophagy and viability of prostate cancer cells by targeting NDRG2","volume":"20","author":"Guo","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.tiv.2017.11.009_bb0050","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/toxsci\/kfg036","article-title":"Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure","volume":"72","author":"Higuchi","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2017.11.009_bb0055","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.fct.2011.12.012","article-title":"Analysis of combined effects of nonylphenol and Monobutyl phthalate on rat Sertoli cells applying two mathematical models","volume":"50","author":"Hu","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tiv.2017.11.009_bb0060","article-title":"Antagonistic effects of a mixture of low-dose nonylphenol and di-n-butyl phthalate (monobutyl phthalate) on the Sertoli cells and serum reproductive hormones in prepubertal male rats in vitro and in vivo","volume":"9","author":"Hu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.tiv.2017.11.009_bb0065","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1095\/biolreprod.107.064006","article-title":"Sertoli cell development and function in an animal model of testicular dysgenesis syndrome","volume":"78","author":"Hutchison","year":"2008","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tiv.2017.11.009_bb0070","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3390\/ijms15010296","article-title":"MiRNA-199a-3p regulates C2C12 myoblast differentiation through IGF-1\/AKT\/mTOR signal pathway","volume":"15","author":"Jia","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tiv.2017.11.009_bb0075","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.envint.2016.10.025","article-title":"Occurrence of phthalate esters in over-the-counter medicines from China and its implications for human exposure","volume":"98","author":"Jia","year":"2017","journal-title":"Environ. Int."},{"key":"10.1016\/j.tiv.2017.11.009_bb0080","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tig.2006.01.003","article-title":"Genomics of microRNA","volume":"22","author":"Kim","year":"2006","journal-title":"Trends Genet."},{"key":"10.1016\/j.tiv.2017.11.009_bb0085","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ng1536","article-title":"Combinatorial microRNA target predictions","volume":"37","author":"Krek","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tiv.2017.11.009_bb0090","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1038\/s41598-017-02684-2","article-title":"Dibutyl phthalate induced testicular dysgenesis originates after seminiferous cord formation in rats","volume":"7","author":"Lara","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tiv.2017.11.009_bb0095","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.etap.2011.12.015","article-title":"Microcystin-LR causes cytotoxicity effects in rat testicular Sertoli cells","volume":"33","author":"Li","year":"2012","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.tiv.2017.11.009_bb0100","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1007\/s00432-013-1470-9","article-title":"MicroRNAs targeting EGFR signalling pathway in colorectal cancer","volume":"139","author":"Mlcochova","year":"2013","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.tiv.2017.11.009_bb0105","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1177\/0192623317709091","article-title":"In utero exposure to Di(n-butyl)phthalate induces morphological and biochemical changes in rats postpuberty","volume":"45","author":"Okayama","year":"2017","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.tiv.2017.11.009_bb0110","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/ar.1092030408","article-title":"Proliferation of Sertoli cells in fetal and postnatal rats: a quantitative autoradiographic study","volume":"203","author":"Orth","year":"1982","journal-title":"Anat. Rec."},{"key":"10.1016\/j.tiv.2017.11.009_bb0115","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.reprotox.2006.04.007","article-title":"NTP-CERHR expert panel update on the reproductive and developmental toxicity of Di(2-ethylhexyl) phthalate","volume":"22","author":"Robert Kavlock","year":"2006","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tiv.2017.11.009_bb0120","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.mce.2014.10.004","article-title":"Phthalate esters affect maturation and function of primate testis tissue ectopically grafted in mice","volume":"398","author":"Rodriguez-Sosa","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.tiv.2017.11.009_bb0125","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1365-2605.2005.00567.x","article-title":"Human exposure to phthalates via consumer products","volume":"29","author":"Schettler","year":"2006","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.tiv.2017.11.009_bb0130","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1530\/jrf.0.1010193","article-title":"Temporal relationship between androgen-dependent changes in the volume of seminiferous tubule fluid, lumen size and seminiferous tubule protein secretion in rats","volume":"101","author":"Sharpe","year":"1994","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.tiv.2017.11.009_bb0135","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1530\/rep.0.1250769","article-title":"Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood","volume":"125","author":"Sharpe","year":"2003","journal-title":"Reproduction"},{"key":"10.1016\/j.tiv.2017.11.009_bb0140","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1038\/sj.onc.1207774","article-title":"The Ras-related protein AGS1\/RASD1 suppresses cell growth","volume":"23","author":"Vaidyanathan","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.tiv.2017.11.009_bb0145","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1530\/rep.1.00358","article-title":"FSH and testosterone signaling in Sertoli cells","volume":"130","author":"Walker","year":"2005","journal-title":"Reproduction"},{"key":"10.1016\/j.tiv.2017.11.009_bb0150","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.etap.2017.05.013","article-title":"Role of PI3K\/AKT\/mTOR signaling pathway in DBP-induced apoptosis of testicular sertoli cells in vitro","volume":"53","author":"Wang","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.tiv.2017.11.009_bb0205","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1093\/bioinformatics\/btg345","article-title":"A random variance model for detection of differential gene expression in small microarray experiments","volume":"19","author":"Wright","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.tiv.2017.11.009_bb0155","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/cpr.12264","article-title":"Hypoxia-induced microRNA-301b regulates apoptosis by targeting Bim in lung cancer","volume":"49","author":"Wu","year":"2016","journal-title":"Cell Prolif."},{"key":"10.1016\/j.tiv.2017.11.009_bb0210","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s10585-005-6244-6","article-title":"Metastasis predictive signature profiles pre-exist in normal tissues","volume":"22","author":"Yang","year":"2005","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.tiv.2017.11.009_bb0160","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/toxsci\/kfx092","article-title":"From the cover: metabolomics reveals a role of Betaine in prenatal DBP exposure-induced epigenetic Transgenerational failure of spermatogenesis in rats","volume":"158","author":"Yuan","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2017.11.009_bb0165","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/j.1939-4640.2002.tb02345.x","article-title":"Localization of androgen and estrogen receptors in adult male mouse reproductive tract","volume":"23","author":"Zhou","year":"2002","journal-title":"J. Androl."},{"key":"10.1016\/j.tiv.2017.11.009_bb0170","doi-asserted-by":"crossref","first-page":"6383","DOI":"10.1021\/es500152m","article-title":"Regulation of microcystin-LR-induced toxicity in mouse spermatogonia by miR-96","volume":"48","author":"Zhou","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tiv.2017.11.009_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2015.05.008","article-title":"Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity","volume":"287","author":"Zhou","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233317303612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233317303612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T21:52:42Z","timestamp":1719611562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233317303612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":39,"alternative-id":["S0887233317303612"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2017.11.009","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MiR-301b-3p\/3584-5p enhances low-dose mono-n-butyl phthalate (MBP)\u2013induced proliferation by targeting Rasd1 in Sertoli cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2017.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}