{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:53:23Z","timestamp":1787601203393,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.tiv.2018.06.021","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T06:20:57Z","timestamp":1530166857000},"page":"243-250","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"special_numbering":"C","title":["Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer"],"prefix":"10.1016","volume":"52","author":[{"given":"Beatrice","family":"Polini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Digiacomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3291-9009","authenticated-orcid":false,"given":"Sara","family":"Carpi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Bertini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Gado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Saccomanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Macchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Nieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clementina","family":"Manera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7845-2598","authenticated-orcid":false,"given":"Stefano","family":"Fogli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2018.06.021_bb0005","first-page":"3781","article-title":"Analysis of the antitumor activity of Clotrimazole on A375 human melanoma cells","volume":"35","author":"Adinolfi","year":"2015","journal-title":"Anticancer Res."},{"key":"10.1016\/j.tiv.2018.06.021_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097622","article-title":"Olive phenolics as c-met inhibitors: (\u2212)-Oleocanthal attenuates cell proliferation, invasiveness, and tumor growth in breast cancer models","volume":"9","author":"Akl","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.tiv.2018.06.021_bb0015","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/437045a","article-title":"Phytochemistry: ibuprofen-like activity in extra-virgin olive oil","volume":"437","author":"Beauchamp","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.tiv.2018.06.021_bb0020","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1093\/carcin\/21.11.2085","article-title":"Protective effect of topically applied olive oil against photocarcinogenesis following UVB exposure of mice","volume":"21","author":"Budiyanto","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.tiv.2018.06.021_bb5000","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.tiv.2017.01.018","article-title":"Tumor-promoting effects of cannabinoid receptor type 1 in human melanoma cells","volume":"40","author":"Carpi","year":"2017","journal-title":"Toxicol In Vitro"},{"key":"10.1016\/j.tiv.2018.06.021_bb0025","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3892\/ijo.2017.4049","article-title":"Oleocanthal exerts antitumor effects on human liver and colon cancer cells through ROS generation","volume":"51","author":"Cusimano","year":"2017","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.tiv.2018.06.021_bb0030","article-title":"Biofortification (Se): does it increase the content of phenolic compounds in virgin olive oil (VOO)?","volume":"12","author":"D'Amato","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.tiv.2018.06.021_bb0035","doi-asserted-by":"crossref","first-page":"12222","DOI":"10.3390\/ijms140612222","article-title":"UV radiation and the skin","volume":"14","author":"D'Orazio","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tiv.2018.06.021_bb0040","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1055\/s-0030-1270724","article-title":"(\u2212)-Oleocanthal as a c-Met inhibitor for the control of metastatic breast and prostate cancers","volume":"77","author":"Elnagar","year":"2011","journal-title":"Planta Med."},{"key":"10.1016\/j.tiv.2018.06.021_bb0045","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.4161\/cbt.29451","article-title":"Targeting c-Met in melanoma: mechanism of resistance and efficacy of novel combinatorial inhibitor therapy","volume":"15","author":"Etnyre","year":"2014","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.tiv.2018.06.021_bb0050","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1080\/01635581.2016.1180407","article-title":"Cytotoxic activity of oleocanthal isolated from virgin olive oil on human melanoma cells","volume":"68","author":"Fogli","year":"2016","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.tiv.2018.06.021_bb0055","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1042\/bj3470441","article-title":"Protein-tyrosine-phosphatase-mediated epidermal growth factor (EGF) receptor transinactivation and EGF receptor-independent stimulation of mitogen-activated protein kinase by bradykinin in A431 cells","volume":"347","author":"Graness","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.tiv.2018.06.021_bb0060","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1158\/1538-7445.AM2015-1635","article-title":"Abstract 1635: mechanistic investigation of neutropenia associated with palbociclib","volume":"75","author":"Hu","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.tiv.2018.06.021_bb0065","series-title":"Non-Surgical Treatment of Keratinocyte Skin Cancer","author":"Jemec","year":"2009"},{"key":"10.1016\/j.tiv.2018.06.021_bb0070","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1002\/ptr.5928","article-title":"Natural compound Licochalcone B induced extrinsic and intrinsic apoptosis in human skin melanoma (A375) and squamous cell carcinoma (A431) cells","volume":"31","author":"Kang","year":"2017","journal-title":"Phytother. Res."},{"key":"10.1016\/j.tiv.2018.06.021_bb0075","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1002\/ptr.5434","article-title":"Olive oil-derived oleocanthal as potent inhibitor of mammalian target of rapamycin: biological evaluation and molecular modeling studies","volume":"29","author":"Khanfar","year":"2015","journal-title":"Phytother. Res."},{"key":"10.1016\/j.tiv.2018.06.021_bb0080","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrc1838","article-title":"Modelling cancer in human skin tissue","volume":"6","author":"Khavari","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tiv.2018.06.021_bb0085","doi-asserted-by":"crossref","DOI":"10.1080\/23723556.2015.1006077","article-title":"(\u2212)-Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization (LMP)","author":"Legendre","year":"2015","journal-title":"Mol. Cell. Oncol."},{"key":"10.1016\/j.tiv.2018.06.021_bb0090","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2174\/138161209787002933","article-title":"Imatinib and its successors\u2014how modern chemistry has changed drug development","volume":"15","author":"M\u00fcller","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.tiv.2018.06.021_bb0095","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4161\/oxim.2.5.9498","article-title":"Plant polyphenols as dietary antioxidants in human health and disease","volume":"2","author":"Pandey","year":"2009","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.tiv.2018.06.021_bb0100","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1172\/JCI57415","article-title":"From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma","volume":"122","author":"Ratushny","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tiv.2018.06.021_bb0105","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1001\/archdermatol.2010.19","article-title":"Incidence estimate of nonmelanoma skin cancer in the United States, 2006","volume":"146","author":"Rogers","year":"2010","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.tiv.2018.06.021_bb0110","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1468-3083.2008.02579.x","article-title":"Actinic keratosis: an occupational and environmental disorder","volume":"22","author":"Schwartz","year":"2008","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.tiv.2018.06.021_bb0115","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/ijc.11581","article-title":"3-OH flavone inhibition of epidermal growth factor-induced proliferaton through blocking prostaglandin E2 production","volume":"108","author":"Shen","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.tiv.2018.06.021_bb0120","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3390\/antiox4030548","article-title":"Extraction, separation, and identification of phenolic compounds in virgin olive oil by HPLC-DAD and HPLC-MS","volume":"4","author":"Tasioula-Margari","year":"2015","journal-title":"Antioxidants (Basel)"},{"issue":"Suppl. 3","key":"10.1016\/j.tiv.2018.06.021_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2133.2007.07861.x","article-title":"Epidemiology of nonmelanoma skin cancer (NMSC) in Europe: accurate and comparable data are needed for effective public health monitoring and interventions","volume":"156","author":"Trakatelli","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.tiv.2018.06.021_bb0130","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4517492","article-title":"From normal skin to squamous cell carcinoma: a quest for novel biomarkers","volume":"2016","author":"Voiculescu","year":"2016","journal-title":"Dis. Markers"},{"key":"10.1016\/j.tiv.2018.06.021_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2005.08.062","article-title":"Chemoprevention of nonmelanoma skin cancer","volume":"54","author":"Wright","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.tiv.2018.06.021_bb0140","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1038\/onc.2016.434","article-title":"Phosphorylation of NFAT3 by CDK3 induces cell transformation and promotes tumor growth in skin cancer","volume":"36","author":"Xiao","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.tiv.2018.06.021_bb0145","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/mc.20716","article-title":"Fyn is induced by Ras\/PI3K\/Akt signaling and is required for enhanced invasion\/migration","volume":"50","author":"Yadav","year":"2011","journal-title":"Mol. Carcinog."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233318303114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233318303114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T07:34:30Z","timestamp":1535614470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233318303114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":30,"alternative-id":["S0887233318303114"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2018.06.021","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2018.06.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}