{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T16:01:21Z","timestamp":1772121681248,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canada Research Chair program"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.tiv.2019.02.013","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T02:47:10Z","timestamp":1550198830000},"page":"96-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Proteome changes in methylmercury-exposed mouse primary cerebellar granule neurons and astrocytes"],"prefix":"10.1016","volume":"57","author":[{"given":"Yueting","family":"Shao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2013-2225","authenticated-orcid":false,"given":"Patrick","family":"Langlois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gleb","family":"Mironov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4351-7483","authenticated-orcid":false,"given":"Hing Man","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2019.02.013_bb0005","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0006-8993(01)02628-2","article-title":"Methylmercury has a selective effect on mitochondria in cultured astrocytes in the presence of [U-(13)C]glutamate","volume":"908","author":"Allen","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.tiv.2019.02.013_bb0010","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1590\/S0100-879X2007000300001","article-title":"Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity","volume":"40","author":"Aschner","year":"2007","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.tiv.2019.02.013_bb0015","doi-asserted-by":"crossref","first-page":"e228","DOI":"10.1038\/cddis.2011.112","article-title":"Neurodegenerative processes in Huntington's disease","volume":"2","author":"Bano","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tiv.2019.02.013_bb0020","doi-asserted-by":"crossref","first-page":"8034","DOI":"10.1038\/s41598-017-08515-8","article-title":"Cellular toxicity pathways of inorganic and methyl mercury in the green microalga Chlamydomonas reinhardtii","volume":"7","author":"Beauvais-Fluck","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tiv.2019.02.013_bb0025","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","article-title":"ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks","volume":"25","author":"Bindea","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.tiv.2019.02.013_bb0030","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/bioinformatics\/btt019","article-title":"CluePedia Cytoscape plugin: pathway insights using integrated experimental and in silico data","volume":"29","author":"Bindea","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.tiv.2019.02.013_bb0035","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/(SICI)1097-4547(20000315)59:6<775::AID-JNR10>3.0.CO;2-T","article-title":"Early acute necrosis, delayed apoptosis and cytoskeletal breakdown in cultured cerebellar granule neurons exposed to methylmercury","volume":"59","author":"Castoldi","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.tiv.2019.02.013_bb0040","first-page":"135","article-title":"Mitochondrial dysfunction, metabolic deficits, and increased oxidative stress in Huntington's disease","volume":"34","author":"Chen","year":"2011","journal-title":"Chang Gung Med. J."},{"key":"10.1016\/j.tiv.2019.02.013_bb0045","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/neu.480230915","article-title":"Excitotoxic cell death","volume":"23","author":"Choi","year":"1992","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.tiv.2019.02.013_bb0050","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1080\/10408440600845619","article-title":"The toxicology of mercury and its chemical compounds","volume":"36","author":"Clarkson","year":"2006","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.tiv.2019.02.013_bb0055","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00216-012-6042-3","article-title":"Differential protein expression of hepatic cells associated with MeHg exposure: deepening into the molecular mechanisms of toxicity","volume":"404","author":"Cuello","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.tiv.2019.02.013_bb0060","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10863-013-9499-7","article-title":"Platelet oxygen consumption as a peripheral blood marker of brain energetics in a mouse model of severe neurotoxicity","volume":"45","author":"de Paula Martins","year":"2013","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.tiv.2019.02.013_bb0065","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ntt.2009.05.001","article-title":"Methylmercury inhibits dopaminergic function in rat pup synaptosomes in an age-dependent manner","volume":"31","author":"Dreiem","year":"2009","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.tiv.2019.02.013_bb0070","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.1021\/es305071v","article-title":"Mercury as a global pollutant: sources, pathways, and effects","volume":"47","author":"Driscoll","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tiv.2019.02.013_bb0075","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neuint.2012.12.006","article-title":"Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury","volume":"62","author":"Farina","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.tiv.2019.02.013_bb0080","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1152\/physrev.00024.2014","article-title":"Neuroglial transmission","volume":"95","author":"Gundersen","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tiv.2019.02.013_bb0085","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1109\/TBCAS.2016.2583920","article-title":"Complete neuron-astrocyte interaction model: digital Multiplierless design and networking mechanism","volume":"11","author":"Haghiri","year":"2017","journal-title":"IEEE Trans. Biomed. Circuits Syst."},{"key":"10.1016\/j.tiv.2019.02.013_bb0090","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2131\/jts.38.837","article-title":"Expression of VEGF-related proteins in cultured human brain microvascular endothelial cells and pericytes after exposure to methylmercury","volume":"38","author":"Hirooka","year":"2013","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tiv.2019.02.013_bb0095","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cbd.2009.01.002","article-title":"Proteome modifications of juvenile beluga (Huso huso) brain as an effect of dietary methylmercury","volume":"4","author":"Keyvanshokooh","year":"2009","journal-title":"Comp. Biochem. Physiol. D Genomics Proteomics"},{"key":"10.1016\/j.tiv.2019.02.013_bb0100","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1021\/pr400356v","article-title":"Chronic exposure of adult rats to low doses of methylmercury induced a state of metabolic deficit in the somatosensory cortex","volume":"12","author":"Kong","year":"2013","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.tiv.2019.02.013_bb0105","doi-asserted-by":"crossref","first-page":"22558","DOI":"10.3390\/ijms141122558","article-title":"Neuroprotective effects of psychotropic drugs in Huntington's disease","volume":"14","author":"Lauterbach","year":"2013","journal-title":"Int. J. Molec. Sci."},{"key":"10.1016\/j.tiv.2019.02.013_bb0110","first-page":"e990","article-title":"Isolation and culture of post-natal mouse cerebellar granule neuron progenitor cells and neurons","volume":"23","author":"Lee","year":"2009","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.tiv.2019.02.013_bb0115","first-page":"1","article-title":"Oxidative stress in neurodegenerative diseases: from molecular mechanisms to clinical applications","volume":"2017","author":"Liu","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.tiv.2019.02.013_bb0120","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jneumeth.2008.08.016","article-title":"Magnetic cell sorting: a fast and effective method of concurrent isolation of high purity viable astrocytes and microglia from neonatal mouse brain tissue","volume":"175","author":"Marek","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.tiv.2019.02.013_bb0125","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/toxsci\/kfq126","article-title":"Methylmercury induces acute oxidative stress, altering Nrf2 protein level in primary microglial cells","volume":"116","author":"Ni","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2019.02.013_bb0130","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.brainres.2009.03.035","article-title":"Acceleration of methylmercury-induced cell death of rat cerebellar neurons by brain-derived neurotrophic factor in vitro","volume":"1273","author":"Sakaue","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.tiv.2019.02.013_bb0135","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1002\/jnr.10066","article-title":"Identification and characterization of uptake systems for cystine and cysteine in cultured astrocytes and neurons: evidence for methylmercury-targeted disruption of astrocyte transport","volume":"66","author":"Shanker","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.tiv.2019.02.013_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/BTER:95:1:1","article-title":"Astrocyte-mediated methylmercury neurotoxicity","volume":"95","author":"Shanker","year":"2003","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tiv.2019.02.013_bb0145","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3109\/15376516.2015.1053654","article-title":"Effects of methylmercury on dopamine release in MN9D neuronal cells","volume":"25","author":"Shao","year":"2015","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.tiv.2019.02.013_bb0150","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/toxsci\/kfv069","article-title":"Proteomic analysis of cerebellum in common marmoset exposed to methylmercury","volume":"146","author":"Shao","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2019.02.013_bb0155","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tox.2016.03.001","article-title":"Proteome profiling reveals regional protein alteration in cerebrum of common marmoset (Callithrix jacchus) exposed to methylmercury","volume":"347","author":"Shao","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.tiv.2019.02.013_bb0160","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.taap.2007.10.010","article-title":"Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain","volume":"227","author":"Stringari","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2019.02.013_bb0165","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s12011-015-0609-8","article-title":"MeHg suppressed neuronal potency of hippocampal NSCs contributing to the Puberal spatial memory deficits","volume":"172","author":"Tian","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tiv.2019.02.013_bb0170","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s12011-012-9382-0","article-title":"The relation between human exposure to mercury and thyroid hormone status","volume":"148","author":"Ursinyova","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tiv.2019.02.013_bb0175","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1177\/0960327106070455","article-title":"Cell viability and proteomic analysis in cultured neurons exposed to methylmercury","volume":"26","author":"Vendrell","year":"2007","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.tiv.2019.02.013_bb0180","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.taap.2009.09.022","article-title":"Methylmercury disrupts the balance between phosphorylated and non-phosphorylated cofilin in primary cultures of mice cerebellar granule cells a proteomic study","volume":"242","author":"Vendrell","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2019.02.013_bb0185","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0891-5849(02)01360-6","article-title":"The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults","volume":"34","author":"Yant","year":"2003","journal-title":"Free Radic. Biol. Med."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233318304363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233318304363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T14:40:54Z","timestamp":1565188854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233318304363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":37,"alternative-id":["S0887233318304363"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2019.02.013","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735120191.793556809","asserted-by":"object"}]},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteome changes in methylmercury-exposed mouse primary cerebellar granule neurons and astrocytes","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2019.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}